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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3kc3MK2MAP kinase-activated protein kinase 22.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3kc3MK2MAP kinase-activated protein kinase 22.7.11.11.000
3sheI85MAP kinase-activated protein kinase 32.7.11.10.461
1y91CT9Cyclin-dependent kinase 22.7.11.220.450
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.449