sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3kc0 | 2T5 | Fructose-1,6-bisphosphatase 1 | 3.1.3.11 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3kc0 | 2T5 | Fructose-1,6-bisphosphatase 1 | 3.1.3.11 | 1.000 | |
| 3kbz | 2T4 | Fructose-1,6-bisphosphatase 1 | 3.1.3.11 | 0.712 | |
| 3kc1 | 2T6 | Fructose-1,6-bisphosphatase 1 | 3.1.3.11 | 0.611 | |
| 2y5k | YCU | Fructose-1,6-bisphosphatase 1 | 3.1.3.11 | 0.564 | |
| 1lev | CLI | Fructose-1,6-bisphosphatase 1 | 3.1.3.11 | 0.562 | |
| 2fhy | A37 | Fructose-1,6-bisphosphatase 1 | 3.1.3.11 | 0.558 | |
| 2wbd | RO5 | Fructose-1,6-bisphosphatase 1 | 3.1.3.11 | 0.541 | |
| 2wbb | RO3 | Fructose-1,6-bisphosphatase 1 | 3.1.3.11 | 0.532 | |
| 3a29 | 2T0 | Fructose-1,6-bisphosphatase 1 | 3.1.3.11 | 0.530 | |
| 2jjk | R15 | Fructose-1,6-bisphosphatase 1 | 3.1.3.11 | 0.522 | |
| 4l3l | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.494 | |
| 3lfm | 3DT | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.492 | |
| 1ykd | CMP | Adenylate cyclase | / | 0.489 | |
| 4h4w | NAP | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.488 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.487 | |
| 4a99 | FAD | TetX family tetracycline inactivation enzyme | / | 0.485 | |
| 2d52 | COA | 5,7-dihydroxy-2-methylchromone synthase | 2.3.1.216 | 0.484 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.483 | |
| 3m6i | NAD | L-arabinitol 4-dehydrogenase | 1.1.1.12 | 0.482 | |
| 3ndr | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.481 | |
| 4h4y | NAP | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.480 | |
| 1b16 | NAQ | Alcohol dehydrogenase | 1.1.1.1 | 0.479 | |
| 1j39 | UPG | DNA beta-glucosyltransferase | / | 0.479 | |
| 1kc1 | NDP | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.479 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.479 | |
| 3b1j | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.479 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.479 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.478 | |
| 3zw9 | NAD | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.478 | |
| 2q4b | NAP | Uncharacterized protein At5g02240 | / | 0.477 | |
| 2wsb | NAD | Galactitol dehydrogenase | / | 0.477 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.476 | |
| 3n7u | NAD | Formate dehydrogenase, chloroplastic/mitochondrial | / | 0.474 | |
| 4fmx | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.474 | |
| 4a6n | FAD | TetX family tetracycline inactivation enzyme | / | 0.473 | |
| 2vwq | NAP | Glucose 1-dehydrogenase | / | 0.472 | |
| 3ijd | C2F | Methylenetetrahydrofolate reductase | / | 0.472 | |
| 5a3b | APR | SIR2 family protein | / | 0.472 | |
| 1f0y | CAA | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.471 | |
| 1mg5 | NAI | Alcohol dehydrogenase | 1.1.1.1 | 0.471 | |
| 2d3m | COA | 5,7-dihydroxy-2-methylchromone synthase | 2.3.1.216 | 0.471 | |
| 2xvu | 9DN | Serum albumin | / | 0.471 | |
| 3iw1 | ASD | Steroid C26-monooxygenase | 1.14.13.141 | 0.471 | |
| 4fuy | EK2 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.471 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.470 | |
| 3cgf | JNF | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.470 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.470 | |
| 4i02 | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.470 | |
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.470 | |
| 2nu9 | COA | Succinate--CoA ligase [ADP-forming] subunit alpha | 6.2.1.5 | 0.469 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.469 | |
| 4wji | NAP | Putative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase | / | 0.469 | |
| 1ffu | FAD | Carbon monoxide dehydrogenase medium chain | / | 0.468 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.467 | |
| 4is3 | NAD | 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 | 1.17.98.1 | 0.467 | |
| 1juv | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.466 | |
| 2hma | SAM | tRNA-specific 2-thiouridylase MnmA | / | 0.466 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.466 | |
| 3sp6 | IL2 | Peroxisome proliferator-activated receptor alpha | / | 0.466 | |
| 3tnl | NAD | Shikimate dehydrogenase (NADP(+)) | / | 0.466 | |
| 3wfj | NAD | 2-dehydropantoate 2-reductase | / | 0.466 | |
| 1aj8 | COA | Citrate synthase | / | 0.465 | |
| 1vl8 | NAP | Oxidoreductase, short chain dehydrogenase/reductase family | / | 0.465 | |
| 2ch6 | ADP | N-acetyl-D-glucosamine kinase | 2.7.1.59 | 0.465 | |
| 2hxl | 422 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.465 | |
| 2jds | L20 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.465 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.465 | |
| 2ztl | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.465 | |
| 3stv | 3HO | Methylketone synthase I | / | 0.465 | |
| 1pr9 | NAP | L-xylulose reductase | 1.1.1.10 | 0.464 | |
| 2gtk | 208 | Peroxisome proliferator-activated receptor gamma | / | 0.464 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.464 | |
| 3cly | ACP | Fibroblast growth factor receptor 2 | / | 0.464 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.464 | |
| 1fm7 | DFV | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.463 | |
| 1sby | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.463 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 4gk2 | L66 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.463 | |
| 4mih | FAD | Pyranose 2-oxidase | 1.1.3.10 | 0.463 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.463 | |
| 1cyd | NDP | Carbonyl reductase [NADPH] 2 | 1.1.1.184 | 0.462 | |
| 3ajr | NAD | NDP-sugar epimerase | / | 0.462 | |
| 1ju9 | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.461 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.461 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.461 | |
| 3we4 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.461 | |
| 5bsf | NAD | Pyrroline-5-carboxylate reductase | / | 0.461 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.460 | |
| 2d8a | NAD | L-threonine 3-dehydrogenase | / | 0.460 | |
| 2jdt | I5S | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.460 | |
| 2q61 | SF1 | Peroxisome proliferator-activated receptor gamma | / | 0.460 | |
| 2xcl | ANP | Phosphoribosylamine--glycine ligase | / | 0.460 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.460 | |
| 3mec | 65B | Gag-Pol polyprotein | 2.7.7.49 | 0.460 | |
| 3rj5 | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.460 | |
| 3t2k | FAD | Sulfide-quinone reductase | / | 0.460 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.460 | |
| 4gb9 | 0WR | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.460 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.460 | |
| 1xq6 | NAP | Uncharacterized protein At5g02240 | / | 0.459 | |
| 2c54 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.459 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.459 | |
| 3d3w | NAP | L-xylulose reductase | 1.1.1.10 | 0.459 | |
| 3d7k | D7K | Benzaldehyde lyase | / | 0.459 | |
| 3eej | 53R | Uncharacterized protein | / | 0.459 | |
| 3vdq | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.459 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.459 | |
| 4n5n | NAP | Acetoacetyl-CoA reductase | 1.1.1.36 | 0.459 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.458 | |
| 1npt | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.458 | |
| 1nqa | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.458 | |
| 1osv | CHC | Bile acid receptor | / | 0.458 | |
| 1u28 | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.458 | |
| 2nua | COA | Succinate--CoA ligase [ADP-forming] subunit alpha | 6.2.1.5 | 0.458 | |
| 2y6o | 1N1 | Ephrin type-A receptor 4 | 2.7.10.1 | 0.458 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.458 | |
| 4fsn | A58 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.458 | |
| 4kwi | 1TJ | Reductase homolog | / | 0.458 | |
| 5doz | NDP | JamJ | / | 0.458 | |
| 1b15 | NAE | Alcohol dehydrogenase | 1.1.1.1 | 0.457 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.457 | |
| 2brb | PFQ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.457 | |
| 3a4v | NAD | NDP-sugar epimerase | / | 0.457 | |
| 3img | BZ3 | Pantothenate synthetase | 6.3.2.1 | 0.457 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.457 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.457 | |
| 3w8d | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.457 | |
| 3zk5 | Z18 | Cytochrome P450 monooxygenase PikC | / | 0.457 | |
| 4h8n | NDP | NADPH-dependent conjugated polyketone reductase C2 | / | 0.457 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.456 | |
| 1gco | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.456 | |
| 1i7g | AZ2 | Peroxisome proliferator-activated receptor alpha | / | 0.456 | |
| 2gtm | LID | Mitogen-activated protein kinase 14 | / | 0.456 | |
| 2npa | MMB | Peroxisome proliferator-activated receptor alpha | / | 0.456 | |
| 2q2q | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.456 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.456 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.456 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.456 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.456 | |
| 3t4n | ADP | 5'-AMP-activated protein kinase subunit gamma | / | 0.456 | |
| 3zu2 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.456 | |
| 1e8x | ATP | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.455 | |
| 1gpd | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.455 | |
| 1ie3 | NAD | Malate dehydrogenase | / | 0.455 | |
| 1qo8 | FAD | Fumarate reductase flavoprotein subunit | / | 0.455 | |
| 1qr6 | NAD | NAD-dependent malic enzyme, mitochondrial | 1.1.1.38 | 0.455 | |
| 2c59 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.455 | |
| 2fto | CB3 | Thymidylate synthase | / | 0.455 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.455 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.455 | |
| 3jyn | NDP | Quinone oxidoreductase | / | 0.455 | |
| 3wv7 | ADP | Hmd co-occurring protein HcgE | / | 0.455 | |
| 4dkv | 0KW | Envelope glycoprotein gp160 | / | 0.455 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.455 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.454 | |
| 2c0o | L2G | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.454 | |
| 2gr1 | FAD | Ferredoxin reductase | / | 0.454 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.454 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.454 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.454 | |
| 3vt3 | VDX | Vitamin D3 receptor | / | 0.454 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 4fj0 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.454 | |
| 4l8u | 9AZ | Serum albumin | / | 0.454 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.454 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.453 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.453 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.453 | |
| 2oj9 | BMI | Insulin-like growth factor 1 receptor | 2.7.10.1 | 0.453 | |
| 2qbn | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.453 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.453 | |
| 2z0y | SAM | Ribosomal RNA small subunit methyltransferase E | / | 0.453 | |
| 3kjm | 245 | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.453 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.453 | |
| 3zvv | XAZ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.453 | |
| 4b8z | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.453 | |
| 4g09 | 0VD | Histidinol dehydrogenase | / | 0.453 | |
| 4iqg | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.453 | |
| 4kd1 | 1QK | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.453 | |
| 4ozn | ATP | Ammonium transporter | / | 0.453 | |
| 1ae1 | NAP | Tropinone reductase 1 | / | 0.452 | |
| 1l8a | TDP | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.452 | |
| 1lik | ADN | Adenosine kinase | 2.7.1.20 | 0.452 | |
| 1qlh | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.452 | |
| 1xkd | NAP | Isocitrate dehydrogenase [NADP] | / | 0.452 | |
| 2aqk | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.452 | |
| 2npx | NAD | NADH peroxidase | 1.11.1.1 | 0.452 | |
| 2vou | FAD | 2,6-dihydroxypyridine 3-monooxygenase | 1.14.13.10 | 0.452 | |
| 3ics | ADP | Coenzyme A disulfide reductase | / | 0.452 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.452 | |
| 3stx | BKA | Methylketone synthase I | / | 0.452 | |
| 4gev | CB3 | Thymidylate synthase | / | 0.452 | |
| 4gnc | ASO | Regucalcin | 3.1.1.17 | 0.452 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.452 | |
| 5i2h | AGI | O-methyltransferase family 2 | / | 0.452 | |
| 1e6w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.451 | |
| 1g4t | FTP | Thiamine-phosphate synthase | / | 0.451 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.451 | |
| 1jue | FMN | Dihydroorotate dehydrogenase A (fumarate) | 1.3.98.1 | 0.451 | |
| 1n2s | NAI | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.451 | |
| 1v9o | ADP | Signaling protein | / | 0.451 | |
| 2a5u | QYT | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.451 | |
| 2exm | ZIP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.451 | |
| 2i4z | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.451 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.451 | |
| 3p7n | FMN | Light-activated DNA-binding protein EL222 | / | 0.451 | |
| 3tqh | NDP | Quinone oxidoreductase | / | 0.451 | |
| 4hxy | NDP | Plm1 | / | 0.451 | |
| 4j4v | SVR | Nucleocapsid protein | / | 0.451 | |
| 4j7u | NAP | Sepiapterin reductase | 1.1.1.153 | 0.451 | |
| 4jx1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.451 | |
| 5hg0 | SAM | Pantothenate synthetase | / | 0.451 | |
| 1geg | NAD | Diacetyl reductase [(S)-acetoin forming] | 1.1.1.304 | 0.450 | |
| 1lrl | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.450 | |
| 1lsj | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.450 | |
| 2czf | XMP | Orotidine 5'-phosphate decarboxylase | 4.1.1.23 | 0.450 | |
| 2izr | BRK | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.450 | |
| 2ql6 | ADP | Nicotinamide riboside kinase 1 | / | 0.450 | |
| 2yke | YKE | Heat shock protein HSP 90-alpha | / | 0.450 | |
| 2yy7 | NAD | L-threonine dehydrogenase | / | 0.450 | |
| 3b7k | COA | Acyl-coenzyme A thioesterase 12 | 3.1.2.1 | 0.450 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 3lsi | FAD | Pyranose 2-oxidase | / | 0.450 | |
| 3ocg | OCG | Mitogen-activated protein kinase 14 | / | 0.450 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.450 | |
| 3tz3 | B36 | Acetyl-CoA carboxylase | / | 0.450 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.450 | |
| 3wmx | NAD | NAD dependent epimerase/dehydratase | / | 0.450 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 4ien | COA | Putative acyl-CoA hydrolase | / | 0.450 | |
| 4l4d | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 4lb2 | DM5 | Serum albumin | / | 0.450 | |
| 4o0r | X4Z | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.450 | |
| 4ryv | ZEA | Protein LlR18A | / | 0.450 | |
| 4z17 | PEP | Enolase | / | 0.450 | |
| 1a72 | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.449 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.449 | |
| 1lj8 | NAD | Mannitol dehydrogenase | / | 0.449 | |
| 1ot7 | CHC | Bile acid receptor | / | 0.449 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.449 | |
| 2h55 | DZ8 | Heat shock protein HSP 90-alpha | / | 0.449 | |
| 2z4b | DC8 | Estrogen receptor beta | / | 0.449 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.449 | |
| 3nug | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.449 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.449 | |
| 4hee | 14R | Peroxisome proliferator-activated receptor gamma | / | 0.449 | |
| 4jnq | FDA | Thioredoxin reductase | / | 0.449 | |
| 4mxx | DB8 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.449 | |
| 1adf | TAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.448 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.448 | |
| 1i6x | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.448 | |
| 1i8t | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.448 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.448 | |
| 1zem | NAD | Xylitol dehydrogenase | / | 0.448 | |
| 2a1o | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 2c27 | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.448 | |
| 3a9w | NAD | NDP-sugar epimerase | / | 0.448 | |
| 3cs8 | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.448 | |
| 3gst | GPR | Glutathione S-transferase Mu 1 | 2.5.1.18 | 0.448 | |
| 3mvm | 39P | Mitogen-activated protein kinase 14 | / | 0.448 | |
| 3opd | HIE | Heat shock protein 83 | / | 0.448 | |
| 3p19 | NDP | Putative blue fluorescent protein | / | 0.448 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.448 | |
| 4rcv | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.448 | |
| 4xum | IMN | Peroxisome proliferator-activated receptor gamma | / | 0.448 | |
| 5a3c | NAD | SIR2 family protein | / | 0.448 | |
| 5bsg | NAP | Pyrroline-5-carboxylate reductase | / | 0.448 | |
| 1a8r | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.447 | |
| 1dyi | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1iy8 | NAD | Levodione reductase | / | 0.447 | |
| 1orr | NAD | CDP-paratose 2-epimerase | / | 0.447 | |
| 1rkx | NAD | CDP-D-glucose-4,6-dehydratase | / | 0.447 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.447 | |
| 2o23 | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.447 | |
| 2yxu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.447 | |
| 3h4l | ANP | DNA mismatch repair protein PMS1 | / | 0.447 | |
| 3l9h | EMQ | Kinesin-like protein KIF11 | / | 0.447 | |
| 4g6h | NAI | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.447 | |
| 4kky | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 4kl9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 4kuh | CAA | 3-hydroxybutyryl-CoA dehydrogenase | / | 0.447 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.447 | |
| 1i7i | AZ2 | Peroxisome proliferator-activated receptor gamma | / | 0.446 | |
| 1ppj | ANY | Cytochrome b | / | 0.446 | |
| 1w78 | PD8 | Dihydrofolate synthase/folylpolyglutamate synthase | 6.3.2.12 | 0.446 | |
| 1wwk | NAD | 307aa long hypothetical phosphoglycerate dehydrogenase | / | 0.446 | |
| 2cea | ADP | ATP-dependent zinc metalloprotease FtsH | / | 0.446 | |
| 2hfp | NSI | Peroxisome proliferator-activated receptor gamma | / | 0.446 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.446 | |
| 3ak4 | NAD | NADH-dependent quinuclidinone reductase | / | 0.446 | |
| 3b2s | B2S | Trichothecene 3-O-acetyltransferase | / | 0.446 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 3cr3 | ADP | PTS-dependent dihydroxyacetone kinase, ADP-binding subunit DhaL | 2.7 | 0.446 | |
| 3fmj | FMJ | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 3img | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.446 | |
| 3mvq | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.446 | |
| 3zpt | M8Y | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 4f65 | 0S9 | Fibroblast growth factor receptor 1 | / | 0.446 | |
| 4i6a | HMG | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.88 | 0.446 | |
| 4jb1 | FAD | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.446 | |
| 4kz0 | 1UJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 4otp | ADP | Serine/threonine-protein kinase RIO1 | 2.7.11.1 | 0.446 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.446 | |
| 1edo | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic | 1.1.1.100 | 0.445 | |
| 1gil | GSP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.445 | |
| 1nzf | UPG | DNA beta-glucosyltransferase | / | 0.445 | |
| 1ot7 | IU5 | Bile acid receptor | / | 0.445 | |
| 1pmv | 537 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.445 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.445 | |
| 1sdm | ADP | Kinesin heavy chain-like protein | / | 0.445 | |
| 1t7j | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 1v9a | SAH | Uncharacterized protein | / | 0.445 | |
| 1wvg | APR | CDP-glucose 4,6-dehydratase | 4.2.1.45 | 0.445 | |
| 2g37 | FAD | Proline dehydrogenase | / | 0.445 | |
| 2hfu | MEV | Mevalonate kinase | / | 0.445 | |
| 2pmo | HMD | Protein kinase 7 | / | 0.445 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.445 | |
| 2q5p | 241 | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 2qfx | NDP | Isocitrate dehydrogenase [NADP], mitochondrial | 1.1.1.42 | 0.445 | |
| 2vhx | NAD | Alanine dehydrogenase | 1.4.1.1 | 0.445 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3ics | COA | Coenzyme A disulfide reductase | / | 0.445 | |
| 3meg | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.445 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.445 | |
| 4b4d | FAD | Ferredoxin-NADP reductase | / | 0.445 | |
| 4dxa | GSP | Ras-related protein Rap-1b | / | 0.445 | |
| 4hnc | 0UT | Mandelate racemase | / | 0.445 | |
| 4iql | FMN | Enoyl-(Acyl-carrier-protein) reductase II | / | 0.445 | |
| 1beu | IPL | Tryptophan synthase alpha chain | / | 0.444 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 1e3w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.444 | |
| 1g0n | NDP | Tetrahydroxynaphthalene reductase | 1.1.1.252 | 0.444 | |
| 1hdr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.444 | |
| 1lf2 | R37 | Plasmepsin-2 | 3.4.23.39 | 0.444 | |
| 1q0q | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.444 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.444 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1ybm | NAP | Uncharacterized protein At5g02240 | / | 0.444 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.444 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.444 | |
| 2i4p | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.444 | |
| 2p9c | NAI | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.444 | |
| 2q59 | 240 | Peroxisome proliferator-activated receptor gamma | / | 0.444 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.444 | |
| 2ww4 | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 2.7.1.148 | 0.444 | |
| 3bem | FMN | Putative NAD(P)H nitroreductase MhqN | 1 | 0.444 | |
| 3cjf | SAV | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.444 | |
| 3etg | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.444 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.444 | |
| 4d04 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.444 | |
| 4hbg | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.444 | |
| 4xgx | ADP | FAD:protein FMN transferase | / | 0.444 | |
| 4xld | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.444 | |
| 4xye | NAD | Formate dehydrogenase | / | 0.444 | |
| 1eyq | NAR | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.443 | |
| 1fpq | SAM | Isoliquiritigenin 2'-O-methyltransferase | / | 0.443 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.443 | |
| 1ma0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.443 | |
| 1u2g | APR | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.443 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 2bun | FAD | AppA protein | / | 0.443 | |
| 2pr5 | FMN | Blue-light photoreceptor | / | 0.443 | |
| 2rio | ADP | Serine/threonine-protein kinase/endoribonuclease IRE1 | 2.7.11.1 | 0.443 | |
| 2xvv | 9DN | Serum albumin | / | 0.443 | |
| 2y05 | NAP | Prostaglandin reductase 1 | / | 0.443 | |
| 2zgz | GNP | Plasmid segregation protein ParM | / | 0.443 | |
| 3clb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.443 | |
| 3dv3 | MEK | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.443 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.443 | |
| 3hk1 | B64 | Fatty acid-binding protein, adipocyte | / | 0.443 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.443 | |
| 3ncr | ADP | Nitrogen regulatory protein P-II (GlnB-2) | / | 0.443 | |
| 3pkp | DTP | Glucose-1-phosphate thymidylyltransferase | 2.7.7.24 | 0.443 | |
| 3r3s | NAD | Putative oxidoreductase | / | 0.443 | |
| 4bdh | WVI | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.443 | |
| 4btj | ATP | Tau-tubulin kinase 1 | 2.7.11.1 | 0.443 | |
| 4cta | ATP | CinA-like protein | / | 0.443 | |
| 4e4q | RRH | Peroxisome proliferator-activated receptor gamma | / | 0.443 | |
| 4i0b | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.443 | |
| 4ku3 | MYA | 3-oxoacyl-[ACP] synthase III | / | 0.443 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.443 | |
| 5cwa | 0GA | Anthranilate synthase component 1 | 4.1.3.27 | 0.443 | |
| 1d7a | AIR | N5-carboxyaminoimidazole ribonucleotide mutase | / | 0.442 | |
| 1e3e | NAI | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.442 | |
| 1f4f | TP3 | Thymidylate synthase | / | 0.442 | |
| 1k74 | 544 | Peroxisome proliferator-activated receptor gamma | / | 0.442 | |
| 1opb | RET | Retinol-binding protein 2 | / | 0.442 | |
| 1rfv | ADP | Pyridoxal kinase | 2.7.1.35 | 0.442 | |
| 1sny | NAP | LD36273p | / | 0.442 | |
| 1uu9 | BI3 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.442 | |
| 2b7a | IZA | Tyrosine-protein kinase JAK2 | / | 0.442 | |
| 2e0i | FAD | DNA photolyase | / | 0.442 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.442 | |
| 2m56 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.442 | |
| 3mb7 | 14I | Casein kinase II subunit alpha | 2.7.11.1 | 0.442 | |
| 3nx4 | NAP | Putative oxidoreductase | / | 0.442 | |
| 3rwp | ABQ | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.442 | |
| 4cvm | ANP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.442 | |
| 4g3e | 0WC | Mitogen-activated protein kinase kinase kinase 14 | 2.7.11.25 | 0.442 | |
| 4ho8 | THM | Glucose-1-phosphate thymidylyltransferase | / | 0.442 | |
| 4hy6 | FJ1 | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 4kwh | NAP | Reductase homolog | / | 0.442 | |
| 4l3j | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.442 | |
| 4lj9 | ACP | Chaperone protein ClpB | / | 0.442 | |
| 4yer | ADP | Antibiotic ABC transporter, ATP-binding protein, putative | / | 0.442 | |
| 4z24 | FAD | Putative GMC-type oxidoreductase R135 | 1 | 0.442 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.441 | |
| 1kvk | ATP | Mevalonate kinase | 2.7.1.36 | 0.441 | |
| 1p0h | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.441 | |
| 1rbq | KEU | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.441 | |
| 1ro9 | 8BR | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.441 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 2c47 | 5ID | Casein kinase I isoform gamma-2 | / | 0.441 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 3i6o | GR6 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.441 | |
| 4awm | KDH | Polymerase acidic protein | / | 0.441 | |
| 4eet | FMN | Phototropin-2 | 2.7.11.1 | 0.441 | |
| 4fsr | HKC | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.441 | |
| 4gyy | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.441 | |
| 4l42 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.441 | |
| 4o1p | ANP | Ribonuclease L | / | 0.441 | |
| 4pzd | NAD | 3-Hydroxyacyl-CoA dehydrogenase | / | 0.441 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.441 | |
| 5c41 | ACP | Ribokinase | / | 0.441 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.441 | |
| 1a7k | NAD | Glyceraldehyde-3-phosphate dehydrogenase, glycosomal | 1.2.1.12 | 0.440 | |
| 1axe | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.440 | |
| 1cjk | FOK | Adenylate cyclase type 2 | / | 0.440 | |
| 1cjk | FOK | Adenylate cyclase type 5 | / | 0.440 | |
| 1ee0 | CAA | 2-pyrone synthase | / | 0.440 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1k6p | XN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 1m75 | CAA | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.440 | |
| 1n3r | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.440 | |
| 1u8v | FAD | 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase | / | 0.440 | |
| 1xjj | DGT | Vitamin B12-dependent ribonucleotide reductase | / | 0.440 | |
| 1y4l | SVR | Basic phospholipase A2 homolog 2 | / | 0.440 | |
| 2ahr | NAP | Pyrroline-5-carboxylate reductase | / | 0.440 | |
| 2d1c | NAP | Isocitrate dehydrogenase [NADP] | 1.1.1.42 | 0.440 | |
| 2gcq | DOI | Adenylosuccinate synthetase | / | 0.440 | |
| 2h9i | EAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 2ivn | ANP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.440 | |
| 2lfo | GCH | Fatty acid-binding protein, liver | / | 0.440 | |
| 2ym2 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.440 | |
| 3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 3ict | ADP | Coenzyme A disulfide reductase | / | 0.440 | |
| 3pcf | FHB | Protocatechuate 3,4-dioxygenase beta chain | 1.13.11.3 | 0.440 | |
| 4b8w | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.440 | |
| 4dpu | AGS | Mevalonate diphosphate decarboxylase | / | 0.440 | |
| 4ebf | NAD | Phosphonate dehydrogenase | 1.20.1.1 | 0.440 | |
| 4fc7 | NAP | Peroxisomal 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.440 | |
| 4fti | H7K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 4k28 | NAD | Shikimate dehydrogenase family protein | / | 0.440 | |
| 4o0l | NDP | NADPH-dependent 3-quinuclidinone reductase | / | 0.440 | |
| 4ocp | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.440 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 5es7 | FON | Linear gramicidin synthase subunit A | / | 0.440 |