sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3kaq | FMN | Flavodoxin |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3kaq | FMN | Flavodoxin | / | 1.000 | |
| 3kap | FMN | Flavodoxin | / | 0.647 | |
| 1fx1 | FMN | Flavodoxin | / | 0.629 | |
| 1j9g | FMN | Flavodoxin | / | 0.617 | |
| 2fx2 | FMN | Flavodoxin | / | 0.617 | |
| 1azl | FMN | Flavodoxin | / | 0.597 | |
| 1aku | FMN | Flavodoxin | / | 0.586 | |
| 1wsb | FMN | Flavodoxin | / | 0.586 | |
| 1akr | FMN | Flavodoxin | / | 0.578 | |
| 1j8q | FMN | Flavodoxin | / | 0.565 | |
| 1akw | FMN | Flavodoxin | / | 0.559 | |
| 3f6r | FMN | Flavodoxin | / | 0.557 | |
| 4fx2 | FMN | Flavodoxin | / | 0.550 | |
| 1xyv | FMN | Flavodoxin | / | 0.549 | |
| 3f90 | FMN | Flavodoxin | / | 0.547 | |
| 5fx2 | FMN | Flavodoxin | / | 0.529 | |
| 1bu5 | RBF | Flavodoxin | / | 0.521 | |
| 1c7f | FMN | Flavodoxin | / | 0.518 | |
| 3qgi | 33F | Genome polyprotein | 2.7.7.48 | 0.516 | |
| 4y7c | FMN | NADPH--cytochrome P450 reductase | / | 0.516 | |
| 5xr8 | FMN | Cannabinoid receptor 1 | / | 0.516 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.513 | |
| 2fcr | FMN | Flavodoxin | / | 0.509 | |
| 2whq | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.509 | |
| 5xra | FMN | Cannabinoid receptor 1 | / | 0.509 | |
| 3f6s | FMN | Flavodoxin | / | 0.507 | |
| 3mau | PLR | Putative sphingosine-1-phosphate lyase | / | 0.506 | |
| 5tgz | FMN | Cannabinoid receptor 1 | / | 0.505 | |
| 1xyy | FMN | Flavodoxin | / | 0.504 | |
| 4n82 | FMN | Ribonucleotide reductase (NrdI family protein), putative | / | 0.503 | |
| 1ahn | FMN | Flavodoxin 1 | / | 0.496 | |
| 3pke | Y10 | Methionine aminopeptidase 2 | / | 0.496 | |
| 1j9z | FAD | NADPH--cytochrome P450 reductase | / | 0.494 | |
| 4oxx | FMN | Cindoxin | / | 0.491 | |
| 1tou | B1V | Fatty acid-binding protein, adipocyte | / | 0.490 | |
| 3pkb | Y16 | Methionine aminopeptidase 2 | / | 0.488 | |
| 1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.486 | |
| 2a9z | 26A | Adenosine kinase | 2.7.1.20 | 0.486 | |
| 2onf | COA | Uncharacterized protein | / | 0.484 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.484 | |
| 3mau | EXT | Putative sphingosine-1-phosphate lyase | / | 0.483 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.481 | |
| 3ggs | 2FD | Purine nucleoside phosphorylase | 2.4.2.1 | 0.479 | |
| 1lvu | 9PP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.478 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.478 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.478 | |
| 4bmp | FMN | Protein NrdI | / | 0.478 | |
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.478 | |
| 1k4g | AIQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.477 | |
| 1zis | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.477 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.477 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.477 | |
| 3zj6 | VM2 | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.477 | |
| 4x9d | U5P | Uncharacterized protein MJ1435 | / | 0.477 | |
| 1rr6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.476 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.476 | |
| 3esz | FMN | Flavodoxin | / | 0.476 | |
| 1gjr | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.475 | |
| 3fpk | FAD | Ferredoxin-NADP reductase | / | 0.475 | |
| 4rp8 | ASC | Ascorbate-specific PTS system EIIC component | / | 0.475 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.475 | |
| 4u16 | 3C0 | Muscarinic acetylcholine receptor M3 | / | 0.475 | |
| 1x2e | ATX | Proline iminopeptidase | 3.4.11.5 | 0.474 | |
| 2a2d | ANP | N-acetylgalactosamine kinase | 2.7.1.157 | 0.474 | |
| 2mok | FMN | Flavodoxin 1 | / | 0.474 | |
| 3jyo | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.474 | |
| 4lcn | GNG | Cytidine and deoxycytidylate deaminase zinc-binding region | / | 0.474 | |
| 4xnw | 2ID | P2Y purinoceptor 1 | / | 0.474 | |
| 1ofv | FMN | Flavodoxin | / | 0.473 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.473 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.473 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.473 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.473 | |
| 1ib0 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.472 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.472 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.472 | |
| 3nu0 | 3TU | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.471 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.471 | |
| 3klb | FMN | Uncharacterized protein | / | 0.470 | |
| 3ojx | FMN | NADPH--cytochrome P450 reductase | / | 0.470 | |
| 3sqx | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.470 | |
| 5bt9 | NAP | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.470 | |
| 1gaw | FAD | Ferredoxin | / | 0.469 | |
| 1kw8 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.469 | |
| 1pwy | AC2 | Purine nucleoside phosphorylase | 2.4.2.1 | 0.469 | |
| 2v5u | FMN | Flavodoxin | / | 0.469 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.469 | |
| 3jun | AJD | Phenazine biosynthesis protein A/B | / | 0.469 | |
| 3nyt | ULP | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.469 | |
| 3v0p | 4GW | Histo-blood group ABO system transferase | / | 0.469 | |
| 1yqz | COA | Coenzyme A disulfide reductase | / | 0.468 | |
| 2clm | F6F | Tryptophan synthase alpha chain | / | 0.468 | |
| 2nmt | MIM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.468 | |
| 2v2z | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.468 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.468 | |
| 4jxz | ATP | Glutamine--tRNA ligase | 6.1.1.18 | 0.468 | |
| 1efz | PRF | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.467 | |
| 1m9h | NAD | 2,5-diketo-D-gluconic acid reductase A | 1.1.1.346 | 0.467 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.467 | |
| 2p99 | YE6 | Methionine aminopeptidase | / | 0.467 | |
| 3fr4 | F8A | Fatty acid-binding protein, adipocyte | / | 0.467 | |
| 4b63 | NAP | L-ornithine N(5)-monooxygenase | / | 0.467 | |
| 1czn | FMN | Flavodoxin | / | 0.466 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.466 | |
| 3c1o | NAP | Eugenol synthase | / | 0.466 | |
| 3pka | Y02 | Methionine aminopeptidase 2 | / | 0.466 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.466 | |
| 4d96 | 5PA | D-cysteine desulfhydrase | / | 0.465 | |
| 1c3x | 8IG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.464 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.464 | |
| 3cop | ADP | Glycogen synthase | 2.4.1.21 | 0.464 | |
| 3esy | FMN | Flavodoxin | / | 0.464 | |
| 3jqr | FAD | Ferredoxin--NADP reductase, apicoplast | / | 0.464 | |
| 3wqu | ATP | Cell division protein FtsA | / | 0.464 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.464 | |
| 1cs4 | FOK | Adenylate cyclase type 2 | / | 0.463 | |
| 1cs4 | FOK | Adenylate cyclase type 5 | / | 0.463 | |
| 1e66 | HUX | Acetylcholinesterase | 3.1.1.7 | 0.463 | |
| 1kwc | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.463 | |
| 2ga2 | A19 | Methionine aminopeptidase 2 | / | 0.463 | |
| 3ryk | TYD | dTDP-4-dehydrorhamnose 3,5-epimerase | / | 0.463 | |
| 4b67 | NAP | L-ornithine N(5)-monooxygenase | / | 0.463 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.463 | |
| 1nzq | 162 | Prothrombin | 3.4.21.5 | 0.462 | |
| 1xvv | CCQ | L-carnitine CoA-transferase | / | 0.462 | |
| 3eku | CY9 | Actin-5C | / | 0.462 | |
| 3ox2 | 79X | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.462 | |
| 3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase | / | 0.462 | |
| 4fpy | 0V8 | Sialidase B | 3.2.1.18 | 0.462 | |
| 1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.461 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.461 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.461 | |
| 2ok8 | FAD | Ferredoxin--NADP reductase, apicoplast | / | 0.461 | |
| 3ge7 | AFQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.461 | |
| 1kw6 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.460 | |
| 1q5m | NDP | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.460 | |
| 2aq7 | TL5 | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | 2.3.1.41 | 0.460 | |
| 2rc6 | FAD | Ferredoxin--NADP reductase | / | 0.460 | |
| 2vf3 | GVS | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.460 | |
| 3b1d | PLS | BetaC-S lyase | / | 0.460 | |
| 4xcz | T3Q | Qdtf | / | 0.460 | |
| 1h42 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.459 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 2f2s | COA | Acetyl-CoA acetyltransferase, mitochondrial | 2.3.1.9 | 0.459 | |
| 3ox1 | 695 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.459 | |
| 3w2f | NAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.459 | |
| 4o9c | COA | Acetyl-CoA acetyltransferase | 2.3.1.9 | 0.459 | |
| 4pmj | NAP | Putative oxidoreductase | / | 0.459 | |
| 4u9y | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.459 | |
| 1lke | DOG | Bilin-binding protein | / | 0.458 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.458 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.458 | |
| 2evm | FC2 | Methionine aminopeptidase | / | 0.458 | |
| 2uuk | 897 | Prothrombin | 3.4.21.5 | 0.458 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.458 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.458 | |
| 3exf | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.458 | |
| 3exf | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.458 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.458 | |
| 3u5y | SCG | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.458 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.458 | |
| 4b1i | A8P | Poly(ADP-ribose) glycohydrolase | 3.2.1.143 | 0.458 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.458 | |
| 4fli | Y16 | Methionine aminopeptidase 1 | / | 0.458 | |
| 1a9c | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.457 | |
| 1v3q | 2DI | Purine nucleoside phosphorylase | 2.4.2.1 | 0.457 | |
| 3zc3 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.457 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.457 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.456 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.456 | |
| 1w6r | GNT | Acetylcholinesterase | 3.1.1.7 | 0.456 | |
| 2a2c | ADP | N-acetylgalactosamine kinase | 2.7.1.157 | 0.456 | |
| 2g5w | 8PG | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.456 | |
| 2po3 | T4K | 4-dehydrase | / | 0.456 | |
| 3lzw | NAP | Ferredoxin--NADP reductase 2 | 1.18.1.2 | 0.456 | |
| 4eph | 0RK | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.456 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
| 2e8u | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.455 | |
| 2o3u | NGD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.455 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.455 | |
| 4jjk | FOL | Formate--tetrahydrofolate ligase | / | 0.455 | |
| 1n5v | NOM | ActVA 6 protein | / | 0.454 | |
| 1qpl | 587 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.454 | |
| 1rt9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.454 | |
| 1ut6 | A8N | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 1w19 | T1P | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.454 | |
| 2hxd | DUP | dCTP deaminase, dUMP-forming | 3.5.4.30 | 0.454 | |
| 2p98 | YE7 | Methionine aminopeptidase | / | 0.454 | |
| 2rd2 | QSI | Glutamine--tRNA ligase | 6.1.1.18 | 0.454 | |
| 3gam | MXX | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.454 | |
| 3hxd | BD7 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.454 | |
| 4jt8 | 1NR | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.454 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.453 | |
| 3ce0 | P34 | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.453 | |
| 3qft | FAD | NADPH--cytochrome P450 reductase | / | 0.453 | |
| 3rvi | RVI | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 1bx0 | FAD | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.452 | |
| 1rft | PXM | Pyridoxal kinase | 2.7.1.35 | 0.452 | |
| 1rkw | PNT | HTH-type transcriptional regulator QacR | / | 0.452 | |
| 2geu | COK | Pantothenate kinase | 2.7.1.33 | 0.452 | |
| 2gyw | OBI | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 2v8p | CDP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.452 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 3fsj | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.452 | |
| 3gnc | QQQ | Glutaryl-CoA dehydrogenase | / | 0.452 | |
| 3h7r | NAP | Aldo-keto reductase family 4 member C8 | / | 0.452 | |
| 3juo | AJD | Phenazine biosynthesis protein A/B | / | 0.452 | |
| 3ndj | JHZ | Methyltransferase | / | 0.452 | |
| 4e32 | DWN | Methyltransferase | / | 0.452 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 4rel | KMP | Glycosyltransferase | / | 0.452 | |
| 1cnf | FAD | Nitrate reductase [NADH] | 1.7.1.1 | 0.451 | |
| 1lgt | BP3 | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.451 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.451 | |
| 1w6j | R71 | Lanosterol synthase | 5.4.99.7 | 0.451 | |
| 1y52 | BTN | Avidin-related protein 4/5 | / | 0.451 | |
| 1y5x | E89 | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.451 | |
| 1ycf | FMN | Nitric oxide reductase | 1 | 0.451 | |
| 2aj4 | ANP | Galactokinase | 2.7.1.6 | 0.451 | |
| 2zev | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.451 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 3zj7 | C1K | Strictosidine-O-beta-D-glucosidase | 3.2.1.105 | 0.451 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.451 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.451 | |
| 4b1h | AR6 | Poly(ADP-ribose) glycohydrolase | 3.2.1.143 | 0.451 | |
| 4mbs | MRV | C-C chemokine receptor type 5 | / | 0.451 | |
| 4x5f | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1frb | ZST | Aldose reductase-related protein 2 | / | 0.450 | |
| 1rfg | GMP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.450 | |
| 1xp8 | AGS | Protein RecA | / | 0.450 | |
| 2fzm | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.450 | |
| 2ha6 | SCK | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 2xje | U5P | Cytosolic purine 5'-nucleotidase | 3.1.3.5 | 0.450 | |
| 3gc5 | 2MQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.450 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 3u57 | DH8 | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.450 | |
| 1lcw | SHM | Streptavidin | / | 0.449 | |
| 1r58 | AO5 | Methionine aminopeptidase 2 | / | 0.449 | |
| 2gyu | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 2hxz | H7J | Cathepsin S | 3.4.22.27 | 0.449 | |
| 2w6p | OA4 | Biotin carboxylase | 6.3.4.14 | 0.449 | |
| 3buv | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.449 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.449 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 3uzx | AOM | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.449 | |
| 4af6 | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.449 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.449 | |
| 4bpr | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.449 | |
| 4e2w | JHZ | Methyltransferase | / | 0.449 | |
| 4gtp | 7TP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.449 | |
| 1trg | CB3 | Thymidylate synthase | / | 0.448 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
| 2a3b | CFF | Endochitinase B1 | 3.2.1.14 | 0.448 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.448 | |
| 2gms | P0P | Putative pyridoxamine 5-phosphate-dependent dehydrase | / | 0.448 | |
| 2q7o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.448 | |
| 3rdq | DTB | Streptavidin | / | 0.448 | |
| 4br3 | U85 | Choline kinase alpha | 2.7.1.32 | 0.448 | |
| 4c73 | TLH | 3-oxoacyl-ACP synthase | / | 0.448 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.448 | |
| 4ixt | 1H1 | Halohydrin dehalogenase | / | 0.448 | |
| 4lay | I63 | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.448 | |
| 1nc9 | IMI | Streptavidin | / | 0.447 | |
| 1qrs | ATP | Glutamine--tRNA ligase | 6.1.1.18 | 0.447 | |
| 1vot | HUP | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.447 | |
| 2b3d | FAD | Modulator of drug activity B | / | 0.447 | |
| 2gvd | FKP | Adenylate cyclase type 2 | / | 0.447 | |
| 2gvd | FKP | Adenylate cyclase type 5 | / | 0.447 | |
| 2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 3sff | 0DI | Histone deacetylase 8 | 3.5.1.98 | 0.447 | |
| 4du6 | GTP | GTP cyclohydrolase 1 | / | 0.447 | |
| 4f3g | KAI | Glutamate receptor 3 | / | 0.447 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 4gh1 | 0WX | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.447 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.447 | |
| 4n9q | FMN | FMN-dependent NADH-azoreductase 1 | / | 0.447 | |
| 4nbi | D3Y | D-tyrosyl-tRNA(Tyr) deacylase | / | 0.447 | |
| 5fd8 | A5A | Putative carboxypeptidase yocD | / | 0.447 | |
| 1ex7 | 5GP | Guanylate kinase | 2.7.4.8 | 0.446 | |
| 1h66 | RH1 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.446 | |
| 1ulb | GUN | Purine nucleoside phosphorylase | 2.4.2.1 | 0.446 | |
| 1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 2c1a | I5S | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.446 | |
| 2q94 | A04 | Methionine aminopeptidase | / | 0.446 | |
| 3aos | JH2 | Hemolymph juvenile hormone binding protein | / | 0.446 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.446 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.446 | |
| 3hxc | BD6 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.446 | |
| 3uzx | AOX | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.446 | |
| 3zv7 | NHG | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.446 | |
| 4ax8 | SAM | O-antigen chain terminator bifunctional methyltransferase/kinase WbdD | / | 0.446 | |
| 4kp7 | 1UQ | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic | 1.1.1.267 | 0.446 | |
| 4tnz | TTP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.446 | |
| 1gzu | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.445 | |
| 1n3s | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.445 | |
| 1qsn | COA | HAT A1 | / | 0.445 | |
| 3bgs | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.445 | |
| 3eks | CY9 | Actin-5C | / | 0.445 | |
| 4b1j | A1R | Poly(ADP-ribose) glycohydrolase | 3.2.1.143 | 0.445 | |
| 4ixd | 1HV | Integrin alpha-L | / | 0.445 | |
| 4j1e | 1HM | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 4rnv | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.445 | |
| 1dx6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 1w19 | T5P | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.444 | |
| 1w87 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.444 | |
| 1yw7 | A41 | Methionine aminopeptidase 2 | / | 0.444 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 2q1t | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.444 | |
| 2zat | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.444 | |
| 3ai0 | PNW | Beta-glucosidase | / | 0.444 | |
| 3pkd | Y10 | Methionine aminopeptidase 2 | / | 0.444 | |
| 3pn1 | IVH | DNA ligase | / | 0.444 | |
| 4br0 | AU1 | Ectonucleoside triphosphate diphosphohydrolase 2 | / | 0.444 | |
| 4bri | UNP | Ectonucleoside triphosphate diphosphohydrolase I | / | 0.444 | |
| 4f7i | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.444 | |
| 4gv0 | 8ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.444 | |
| 4rnx | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.444 | |
| 5a8a | ADP | Riboflavin biosynthesis protein RibF | 2.7.1.26 | 0.444 | |
| 5cxv | 0HK | Muscarinic acetylcholine receptor M1 | / | 0.444 | |
| 1ftl | DNQ | Glutamate receptor 2 | / | 0.443 | |
| 1ix1 | BB2 | Peptide deformylase | / | 0.443 | |
| 1que | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.443 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1uhh | CZP | Aequorin-2 | / | 0.443 | |
| 1woo | THG | Aminomethyltransferase | / | 0.443 | |
| 1ygj | RMC | Pyridoxal kinase | 2.7.1.35 | 0.443 | |
| 2gfx | PMN | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.443 | |
| 2ojg | 19A | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.443 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 2xug | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.443 | |
| 2zsb | ADP | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 3c14 | FOK | Adenylate cyclase type 2 | / | 0.443 | |
| 3c14 | FOK | Adenylate cyclase type 5 | / | 0.443 | |
| 3gf4 | U5P | UDP-galactopyranose mutase | 5.4.99.9 | 0.443 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.443 | |
| 3wqt | ANP | Cell division protein FtsA | / | 0.443 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.443 | |
| 4j7h | TRH | PCZA361.3 | / | 0.443 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.443 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.443 | |
| 1kw9 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.442 | |
| 1lb9 | DNQ | Glutamate receptor 2 | / | 0.442 | |
| 1ogi | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.442 | |
| 1sg0 | STL | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.442 | |
| 2clf | F6F | Tryptophan synthase alpha chain | / | 0.442 | |
| 2p4s | DIH | AGAP005945-PA | / | 0.442 | |
| 2q96 | A18 | Methionine aminopeptidase | / | 0.442 | |
| 3f7u | AG4 | Carbonic anhydrase 4 | 4.2.1.1 | 0.442 | |
| 3o73 | O73 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.442 | |
| 3ufl | 508 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 4b1e | 6T6 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 4h6u | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.442 | |
| 4na4 | A1R | Poly(ADP-ribose) glycohydrolase | 3.2.1.143 | 0.442 | |
| 4u14 | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.442 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.441 | |
| 1eir | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.441 | |
| 1f3e | DPZ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.441 | |
| 1gm7 | PNN | Penicillin G acylase | 3.5.1.11 | 0.441 | |
| 1gt5 | BZQ | Odorant-binding protein | / | 0.441 | |
| 1kqn | NAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.441 | |
| 1lv8 | 9PP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.441 | |
| 1ni1 | 2C5 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.441 | |
| 1pl6 | 572 | Sorbitol dehydrogenase | 1.1.1.14 | 0.441 | |
| 1qgz | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.441 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.441 | |
| 1ycg | FMN | Nitric oxide reductase | 1 | 0.441 | |
| 2gg8 | U15 | Methionine aminopeptidase | / | 0.441 | |
| 2ggb | U17 | Methionine aminopeptidase | / | 0.441 | |
| 2nnq | T4B | Fatty acid-binding protein, adipocyte | / | 0.441 | |
| 2o7p | NAP | Riboflavin biosynthesis protein RibD | / | 0.441 | |
| 2xi4 | AFT | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 3i8p | 840 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.441 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3o57 | ZG2 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.441 | |
| 3pkc | Y08 | Methionine aminopeptidase 2 | / | 0.441 | |
| 4b66 | NAP | L-ornithine N(5)-monooxygenase | / | 0.441 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 4c43 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.441 | |
| 4c71 | 7RD | 3-oxoacyl-ACP synthase | / | 0.441 | |
| 4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4ubt | COA | Steroid 3-ketoacyl-CoA thiolase | / | 0.441 | |
| 5cc9 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1jwt | BLI | Prothrombin | 3.4.21.5 | 0.440 | |
| 1kmy | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.440 | |
| 1nqv | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.440 | |
| 1rpw | DID | HTH-type transcriptional regulator QacR | / | 0.440 | |
| 1rsg | FAD | Polyamine oxidase FMS1 | / | 0.440 | |
| 2bd0 | BIO | Sepiapterin reductase | / | 0.440 | |
| 2bn4 | FMN | NADPH--cytochrome P450 reductase | / | 0.440 | |
| 2ckm | AA7 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.440 | |
| 2iu8 | UD1 | UDP-3-O-acylglucosamine N-acyltransferase | 2.3.1 | 0.440 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.440 | |
| 2qxx | TTP | dCTP deaminase | 3.5.4.13 | 0.440 | |
| 2r4t | ADP | Glycogen synthase | 2.4.1.21 | 0.440 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.440 | |
| 2vb8 | TLM | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | 2.3.1.41 | 0.440 | |
| 3dzi | RGT | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.440 | |
| 3fp0 | FP0 | 15-O-acetyltransferase | / | 0.440 | |
| 3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.440 | |
| 3hv3 | R49 | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 3koz | Z97 | D-ornithine 4,5-aminomutase subunit beta | / | 0.440 | |
| 3n3b | FMN | Protein NrdI | / | 0.440 | |
| 3t4h | MD5 | Alpha-ketoglutarate-dependent dioxygenase AlkB | 1.14.11.33 | 0.440 | |
| 4af7 | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.440 | |
| 4b65 | NDP | L-ornithine N(5)-monooxygenase | / | 0.440 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.440 | |
| 4flk | Y10 | Methionine aminopeptidase 1 | / | 0.440 | |
| 4g2y | NI5 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.440 | |
| 4ho6 | UTP | Glucose-1-phosphate thymidylyltransferase | / | 0.440 | |
| 4u3j | GTP | Tubulin beta chain | / | 0.440 |