sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3k3k | A8S | Abscisic acid receptor PYR1 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3k3k | A8S | Abscisic acid receptor PYR1 | / | 1.000 | |
| 4lga | A2O | Abscisic acid receptor PYL2 | / | 0.647 | |
| 3zvu | A8S | Abscisic acid receptor PYR1 | / | 0.618 | |
| 3kdi | A8S | Abscisic acid receptor PYL2 | / | 0.612 | |
| 3kb3 | A8S | Abscisic acid receptor PYL2 | / | 0.610 | |
| 3ujl | A8S | Abscisic acid receptor PYL2 | / | 0.610 | |
| 3k90 | A8S | Abscisic acid receptor PYR1 | / | 0.600 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.599 | |
| 3neg | PYV | Abscisic acid receptor PYL1 | / | 0.592 | |
| 3kb0 | A8S | Abscisic acid receptor PYL2 | / | 0.589 | |
| 3nmn | PYV | Abscisic acid receptor PYL1 | / | 0.588 | |
| 3qn1 | A8S | Abscisic acid receptor PYR1 | / | 0.583 | |
| 4oic | A8S | Bet v I allergen-like | / | 0.582 | |
| 3kdj | A8S | Abscisic acid receptor PYL1 | / | 0.581 | |
| 4lg5 | A1O | Abscisic acid receptor PYL2 | / | 0.581 | |
| 4ds8 | A8S | Abscisic acid receptor PYL3 | / | 0.576 | |
| 4jda | A9S | Abscisic acid receptor PYL3 | / | 0.574 | |
| 3njo | P2M | Abscisic acid receptor PYR1 | / | 0.567 | |
| 4la7 | A1O | Abscisic acid receptor PYL2 | / | 0.563 | |
| 3nef | PYV | Abscisic acid receptor PYL1 | / | 0.557 | |
| 3r6p | A8S | Abscisic acid receptor PYL10 | / | 0.539 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.535 | |
| 3nmv | PYV | Abscisic acid receptor PYL2 | / | 0.530 | |
| 4dsc | A8S | Abscisic acid receptor PYL3 | / | 0.530 | |
| 3oqu | A8S | Abscisic acid receptor PYL9 | / | 0.524 | |
| 3w9r | A8S | Abscisic acid receptor PYL9 | / | 0.520 | |
| 3nmh | PYV | Abscisic acid receptor PYL2 | / | 0.517 | |
| 3oji | PYV | Abscisic acid receptor PYL3 | / | 0.506 | |
| 4fhi | 0S4 | Vitamin D3 receptor A | / | 0.505 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.501 | |
| 4ajw | VWN | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 2.7.1.153 | 0.498 | |
| 4dsb | A8S | Abscisic acid receptor PYL3 | / | 0.498 | |
| 3ml8 | ML8 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.494 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.492 | |
| 4kak | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 3l70 | JZV | Cytochrome b | / | 0.487 | |
| 2wot | ZZG | TGF-beta receptor type-1 | 2.7.11.30 | 0.482 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.482 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.482 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.481 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.481 | |
| 3tij | URI | Nucleoside permease | / | 0.481 | |
| 1gs4 | ZK5 | Androgen receptor | / | 0.479 | |
| 1jx0 | DFV | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.479 | |
| 4xdm | GDM | Heat shock cognate 90 kDa protein | / | 0.479 | |
| 5ccc | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.476 | |
| 3eek | 53S | Uncharacterized protein | / | 0.476 | |
| 4ixg | IXG | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 2bl9 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.475 | |
| 3v8w | 0G2 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.475 | |
| 3w5r | LOA | Vitamin D3 receptor | / | 0.475 | |
| 4dp3 | MMV | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.475 | |
| 1rkh | VD2 | Vitamin D3 receptor | / | 0.474 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.474 | |
| 4h98 | 14Q | Uncharacterized protein | / | 0.474 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.474 | |
| 1s0z | EB1 | Vitamin D3 receptor | / | 0.473 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.473 | |
| 1rk3 | VDX | Vitamin D3 receptor | / | 0.472 | |
| 2azz | TCH | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.470 | |
| 1qyw | 5SD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.469 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.469 | |
| 2o4r | VD5 | Vitamin D3 receptor | / | 0.469 | |
| 3pre | 3RE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.469 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.468 | |
| 1e1n | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.468 | |
| 1rx2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 3i8a | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 1ia1 | TQ3 | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.467 | |
| 3a78 | 3EV | Vitamin D3 receptor | / | 0.467 | |
| 3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 3w0i | O11 | Vitamin D3 receptor | / | 0.467 | |
| 4gue | QCT | Ribosomal protein S6 kinase alpha-3 | 2.7.11.1 | 0.467 | |
| 4pb2 | 5UD | Nucleoside permease | / | 0.467 | |
| 4pd5 | GEO | Nucleoside permease | / | 0.467 | |
| 4tv3 | ML9 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | / | 0.467 | |
| 1nq7 | ARL | Nuclear receptor ROR-beta | / | 0.466 | |
| 2blb | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.466 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.466 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 1q4x | G24 | Thyroid hormone receptor beta | / | 0.465 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.465 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.465 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.465 | |
| 4bfr | J82 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 2.7.1.153 | 0.465 | |
| 4fjy | FJY | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.465 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.464 | |
| 4eqc | XR1 | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.464 | |
| 1df7 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 1rx3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.463 | |
| 3c11 | GDM | ATP-dependent molecular chaperone HSP82 | / | 0.463 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.463 | |
| 4deg | 0JJ | Hepatocyte growth factor receptor | 2.7.10.1 | 0.463 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.463 | |
| 2b36 | 5PP | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.462 | |
| 2b5v | NAP | Glucose 1-dehydrogenase | / | 0.462 | |
| 2eb3 | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.462 | |
| 3r3b | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.462 | |
| 4g1d | 0VK | Vitamin D3 receptor A | / | 0.462 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.462 | |
| 4g20 | 484 | Vitamin D3 receptor A | / | 0.462 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.462 | |
| 2har | OCC | Vitamin D3 receptor | / | 0.461 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.461 | |
| 4dpy | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.461 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.461 | |
| 4gg7 | 0J8 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.461 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.461 | |
| 5akk | 1P8 | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.461 | |
| 1m17 | AQ4 | Epidermal growth factor receptor | 2.7.10.1 | 0.460 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 3l8s | BFF | Mitogen-activated protein kinase 14 | / | 0.460 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.460 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.459 | |
| 3ans | S38 | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.459 | |
| 3d90 | NOG | Progesterone receptor | / | 0.459 | |
| 3fp0 | FP0 | 15-O-acetyltransferase | / | 0.459 | |
| 3qlx | QLR | Uncharacterized protein | / | 0.459 | |
| 3sh2 | 5DR | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 3w0j | T08 | Vitamin D3 receptor | / | 0.459 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 4ruo | BIV | Vitamin D3 receptor A | / | 0.459 | |
| 5ai5 | BSU | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.459 | |
| 1boz | PRD | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 1e90 | MYC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.458 | |
| 1h1p | CMG | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.458 | |
| 2bdf | 24A | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.458 | |
| 2fai | 459 | Estrogen receptor | / | 0.458 | |
| 2qo6 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.458 | |
| 2vwc | BC2 | ATP-dependent molecular chaperone HSP82 | / | 0.458 | |
| 3cse | N22 | Uncharacterized protein | / | 0.458 | |
| 3d57 | 4HY | Thyroid hormone receptor beta | / | 0.458 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 4cav | MYA | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.458 | |
| 4i2p | G73 | Gag-Pol polyprotein | 2.7.7.49 | 0.458 | |
| 4m2x | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.457 | |
| 1j3i | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.457 | |
| 1pl8 | NAD | Sorbitol dehydrogenase | 1.1.1.14 | 0.457 | |
| 2idz | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.457 | |
| 2w3a | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 3gwu | SRE | Na(+):neurotransmitter symporter (Snf family) | / | 0.457 | |
| 3ntz | 3TZ | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 3qlr | QLR | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 3qlz | QLZ | Uncharacterized protein | / | 0.457 | |
| 4a9i | P9I | Bromodomain-containing protein 2 | / | 0.457 | |
| 4hlw | TES | Androgen receptor | / | 0.457 | |
| 4kxl | 6C6 | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | / | 0.457 | |
| 1e6e | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.456 | |
| 1j3j | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.456 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.456 | |
| 2exl | GDM | Endoplasmin | / | 0.456 | |
| 2vss | ACO | Hydroxycinnamoyl-CoA hydratase-lyase | 4.1.2.41 | 0.456 | |
| 3eej | 53R | Uncharacterized protein | / | 0.456 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.456 | |
| 3ict | ADP | Coenzyme A disulfide reductase | / | 0.456 | |
| 3koo | 24D | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.456 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.456 | |
| 4g1y | 0VO | Vitamin D3 receptor A | / | 0.456 | |
| 4g2h | 0VQ | Vitamin D3 receptor A | / | 0.456 | |
| 4xiv | ACP | Chemotaxis protein CheA | 2.7.13.3 | 0.456 | |
| 1fpq | SAM | Isoliquiritigenin 2'-O-methyltransferase | / | 0.455 | |
| 1lhw | ESM | Sex hormone-binding globulin | / | 0.455 | |
| 1t65 | DHT | Androgen receptor | / | 0.455 | |
| 1x7r | GEN | Estrogen receptor | / | 0.455 | |
| 1xp9 | AIJ | Estrogen receptor | / | 0.455 | |
| 2b1z | 17M | Estrogen receptor | / | 0.455 | |
| 2pkl | DHT | Androgen receptor | / | 0.455 | |
| 2uzh | IPE | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | / | 0.455 | |
| 2vwv | 7X3 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.455 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.455 | |
| 3m7r | VDX | Vitamin D3 receptor | / | 0.455 | |
| 3vtc | TK3 | Vitamin D3 receptor | / | 0.455 | |
| 4ifv | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.455 | |
| 4ixe | IXE | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 4mv4 | ACP | Biotin carboxylase | 6.3.4.14 | 0.455 | |
| 4pda | CTN | Nucleoside permease | / | 0.455 | |
| 4py6 | R78 | Bromodomain protein, putative | / | 0.455 | |
| 4z44 | FAD | Flavin-dependent tryptophan halogenase PrnA | 1.14.19.9 | 0.455 | |
| 5c03 | AGS | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.455 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.455 | |
| 2fyp | RDE | Endoplasmin | / | 0.454 | |
| 2o4j | VD4 | Vitamin D3 receptor | / | 0.454 | |
| 2q70 | DC8 | Estrogen receptor | / | 0.454 | |
| 2ywv | ADP | Phosphoribosylaminoimidazole-succinocarboxamide synthase | / | 0.454 | |
| 3ar4 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.454 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.454 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.454 | |
| 4rup | H97 | Vitamin D3 receptor A | / | 0.454 | |
| 1i58 | ACP | Chemotaxis protein CheA | 2.7.13.3 | 0.453 | |
| 1s6q | TPB | Gag-Pol polyprotein | 2.7.7.49 | 0.453 | |
| 1sd1 | FMC | S-methyl-5'-thioadenosine phosphorylase | / | 0.453 | |
| 2blc | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.453 | |
| 2esa | GDM | Endoplasmin | / | 0.453 | |
| 2v9j | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.453 | |
| 3c14 | FOK | Adenylate cyclase type 2 | / | 0.453 | |
| 3c14 | FOK | Adenylate cyclase type 5 | / | 0.453 | |
| 3pe6 | ZYH | Monoglyceride lipase | / | 0.453 | |
| 4eip | K2C | Putative FAD-monooxygenase | / | 0.453 | |
| 5h8t | RTL | Retinol-binding protein 1 | / | 0.453 | |
| 5hyr | EST | Estrogen receptor | / | 0.453 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.452 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.452 | |
| 1d2s | DHT | Sex hormone-binding globulin | / | 0.452 | |
| 1eny | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.452 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.452 | |
| 1rkg | VD1 | Vitamin D3 receptor | / | 0.452 | |
| 1t76 | DHT | Androgen receptor | / | 0.452 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.452 | |
| 3uvp | 048 | Mitogen-activated protein kinase 14 | / | 0.452 | |
| 4ejg | NCT | Cytochrome P450 2A13 | 1.14.14.1 | 0.452 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.452 | |
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1qkn | RAL | Estrogen receptor beta | / | 0.451 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.451 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.451 | |
| 2gn9 | UPG | UDP-N-acetylglucosamine 4,6-dehydratase (inverting) | 4.2.1.115 | 0.451 | |
| 2jfa | RAL | Estrogen receptor | / | 0.451 | |
| 2oci | TYC | Valacyclovir hydrolase | 3.1 | 0.451 | |
| 2ouz | C3D | Estrogen receptor | / | 0.451 | |
| 2pio | DHT | Androgen receptor | / | 0.451 | |
| 2v4l | ABJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.451 | |
| 3nxo | D2B | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 3qgt | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.451 | |
| 3sjz | GNP | Translation initiation factor 2 subunit gamma | / | 0.451 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.451 | |
| 3zk5 | Z18 | Cytochrome P450 monooxygenase PikC | / | 0.451 | |
| 4itf | TFY | Vitamin D3 receptor | / | 0.451 | |
| 4l43 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.451 | |
| 1e7v | LY2 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.450 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1s3w | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1x7j | GEN | Estrogen receptor beta | / | 0.450 | |
| 2cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 2cjp | VPR | Epoxide hydrolase | / | 0.450 | |
| 3iw1 | ASD | Steroid C26-monooxygenase | 1.14.13.141 | 0.450 | |
| 3lam | KRP | Gag-Pol polyprotein | 2.7.7.49 | 0.450 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.450 | |
| 3r33 | 6ME | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 3vru | YS3 | Vitamin D3 receptor | / | 0.450 | |
| 4bew | ACP | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.450 | |
| 4iu7 | 1GM | Estrogen receptor | / | 0.450 | |
| 4l45 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.450 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.450 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.449 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1oh0 | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.449 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1szm | BI4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.449 | |
| 1u3r | 338 | Estrogen receptor beta | / | 0.449 | |
| 3c0i | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.449 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.449 | |
| 3och | 2MX | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.449 | |
| 3vt4 | 5YI | Vitamin D3 receptor | / | 0.449 | |
| 4ffr | ATP | Uncharacterized protein | / | 0.449 | |
| 4ivy | 1GT | Estrogen receptor | / | 0.449 | |
| 4iyg | 1HU | Strictosidine synthase | 4.3.3.2 | 0.449 | |
| 4kl9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 4kwi | 1TJ | Reductase homolog | / | 0.449 | |
| 1dhi | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1k27 | MTM | S-methyl-5'-thioadenosine phosphorylase | / | 0.448 | |
| 1osf | KOS | Heat shock protein HSP 90-alpha | / | 0.448 | |
| 1uu8 | BI1 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.448 | |
| 2bla | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.448 | |
| 2pix | DHT | Androgen receptor | / | 0.448 | |
| 2ykc | YKC | Heat shock protein HSP 90-alpha | / | 0.448 | |
| 3ddw | 055 | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.448 | |
| 3vrv | YSD | Vitamin D3 receptor | / | 0.448 | |
| 3vt3 | VDX | Vitamin D3 receptor | / | 0.448 | |
| 4a9m | P9M | Bromodomain-containing protein 2 | / | 0.448 | |
| 4lsj | LSJ | Glucocorticoid receptor | / | 0.448 | |
| 4z07 | PCG | cGMP-dependent protein kinase 1 | 2.7.11.12 | 0.448 | |
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1f20 | FAD | Nitric oxide synthase, brain | 1.14.13.39 | 0.447 | |
| 1f5f | DHT | Sex hormone-binding globulin | / | 0.447 | |
| 1owl | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.447 | |
| 1q20 | PLO | Sulfotransferase family cytosolic 2B member 1 | 2.8.2.2 | 0.447 | |
| 1sn0 | T44 | Transthyretin | / | 0.447 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
| 3akz | GSU | Glutamate--tRNA ligase 2 | / | 0.447 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.447 | |
| 3nxr | D2D | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 3w0h | W12 | Vitamin D3 receptor | / | 0.447 | |
| 4asg | 814 | ATP-dependent molecular chaperone HSP82 | / | 0.447 | |
| 4g2i | 0VQ | Vitamin D3 receptor | / | 0.447 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 4nm9 | FAD | Bifunctional protein PutA | / | 0.447 | |
| 1e3k | R18 | Progesterone receptor | / | 0.446 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.446 | |
| 2b55 | D31 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.446 | |
| 2cci | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.446 | |
| 2cdz | 23D | Serine/threonine-protein kinase PAK 4 | 2.7.11.1 | 0.446 | |
| 2f2c | AP9 | Cyclin-dependent kinase 6 | 2.7.11.22 | 0.446 | |
| 2oax | SNL | Mineralocorticoid receptor | / | 0.446 | |
| 2zla | VDB | Vitamin D3 receptor | / | 0.446 | |
| 3ar5 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.446 | |
| 3mee | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.446 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.446 | |
| 3wrm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 4at3 | LTI | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.446 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 4hfn | CIY | 2-alkenal reductase (NADP(+)-dependent) | / | 0.446 | |
| 1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1h1q | 2A6 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 1m78 | CLZ | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1q97 | ATP | Serine/threonine-protein kinase SKY1 | 2.7.11.1 | 0.445 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.445 | |
| 1sr7 | MOF | Progesterone receptor | / | 0.445 | |
| 2acw | UPG | Glycosyltransferase | / | 0.445 | |
| 2apg | FAD | Flavin-dependent tryptophan halogenase PrnA | 1.14.19.9 | 0.445 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 2b00 | GCH | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.445 | |
| 2hl0 | A3S | Threonine--tRNA ligase | 6.1.1.3 | 0.445 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
| 2yjx | YJX | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 2yx6 | ADP | Uncharacterized protein | / | 0.445 | |
| 3bqd | DAY | Glucocorticoid receptor | / | 0.445 | |
| 3dmj | GWE | Pol protein | / | 0.445 | |
| 3fgo | ACP | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.445 | |
| 3inv | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.445 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.445 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.445 | |
| 3jrx | S1A | Acetyl-CoA carboxylase 2 | / | 0.445 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.445 | |
| 3qaq | QAQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 3u8d | U8D | Phospholipase A2, membrane associated | / | 0.445 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.445 | |
| 4asy | N5Y | Glucose-1-phosphate thymidylyltransferase | / | 0.445 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.445 | |
| 4gk4 | L90 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.445 | |
| 1cjc | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.444 | |
| 1drb | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.444 | |
| 1tl7 | FOK | Adenylate cyclase type 2 | / | 0.444 | |
| 1tl7 | FOK | Adenylate cyclase type 5 | / | 0.444 | |
| 1um0 | FMN | Chorismate synthase | / | 0.444 | |
| 1wxy | FRK | Adenosine deaminase | 3.5.4.4 | 0.444 | |
| 1yin | CM3 | Estrogen receptor | / | 0.444 | |
| 2gm1 | 2AZ | Kinesin-like protein KIF11 | / | 0.444 | |
| 2hc4 | VDX | Vitamin D3 receptor A | / | 0.444 | |
| 2i0z | FAD | NAD(FAD)-utilizing dehydrogenases | / | 0.444 | |
| 2q7k | TES | Androgen receptor | / | 0.444 | |
| 2w3w | VG9 | Dihydrofolate reductase | / | 0.444 | |
| 2w6q | OA5 | Biotin carboxylase | 6.3.4.14 | 0.444 | |
| 2ze2 | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.444 | |
| 3egv | SAH | Ribosomal protein L11 methyltransferase | 2.1.1 | 0.444 | |
| 3kjs | DQ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.444 | |
| 3lxi | CAM | Cytochrome P450 | / | 0.444 | |
| 3s2a | 2NQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.444 | |
| 4anu | EM7 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 4c1i | EH9 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.444 | |
| 4fad | 0TB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 4fhh | 0U3 | Vitamin D3 receptor A | / | 0.444 | |
| 4ivr | N50 | Thymidine kinase | / | 0.444 | |
| 4k7a | DHT | Androgen receptor | / | 0.444 | |
| 4krc | AGS | Cyclin-dependent protein kinase PHO85 | 2.7.11.22 | 0.444 | |
| 4l2i | FAD | Electron transfer flavoprotein alpha/beta-subunit | / | 0.444 | |
| 1hfp | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1phe | PIY | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 1s9q | OHT | Estrogen-related receptor gamma | / | 0.443 | |
| 1uof | PNN | Deacetoxycephalosporin C synthase | 1.14.20.1 | 0.443 | |
| 2bx8 | AZQ | Serum albumin | / | 0.443 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 2ovh | AS0 | Progesterone receptor | / | 0.443 | |
| 2vd5 | BI8 | Myotonin-protein kinase | 2.7.11.1 | 0.443 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.443 | |
| 2zv2 | 609 | Calcium/calmodulin-dependent protein kinase kinase 2 | 2.7.11.17 | 0.443 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 3gob | HXX | DdmC | / | 0.443 | |
| 3gxo | MQA | Mitomycin biosynthesis 6-O-methyltransferase | / | 0.443 | |
| 3oll | EST | Estrogen receptor beta | / | 0.443 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.443 | |
| 3vg9 | ZMA | Adenosine receptor A2a | / | 0.443 | |
| 3wow | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.443 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.443 | |
| 4dti | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 4ffl | ADP | Uncharacterized protein | / | 0.443 | |
| 4fhk | 0U0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 4mv8 | ACP | Biotin carboxylase | 6.3.4.14 | 0.443 | |
| 4n57 | ADP | APH(2'')-Id | / | 0.443 | |
| 4otp | ADP | Serine/threonine-protein kinase RIO1 | 2.7.11.1 | 0.443 | |
| 1fm7 | DFV | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.442 | |
| 1men | GAR | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.442 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.442 | |
| 1rjk | VDZ | Vitamin D3 receptor | / | 0.442 | |
| 1t63 | DHT | Androgen receptor | / | 0.442 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 2g44 | T3O | Estrogen receptor | / | 0.442 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.442 | |
| 2hk5 | 1BM | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.442 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.442 | |
| 2p1v | 5TN | Retinoic acid receptor RXR-alpha | / | 0.442 | |
| 2vw5 | BC6 | ATP-dependent molecular chaperone HSP82 | / | 0.442 | |
| 2ykj | YKJ | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 3d75 | NBB | Pheromone-binding protein ASP1 | / | 0.442 | |
| 3ioe | A7D | Pantothenate synthetase | 6.3.2.1 | 0.442 | |
| 3ml9 | ML9 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 3sgv | 2BJ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.442 | |
| 3zqt | TES | Androgen receptor | / | 0.442 | |
| 4dk5 | 0KO | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 4grb | 0XG | Casein kinase II subunit alpha | 2.7.11.1 | 0.442 | |
| 4i1n | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.442 | |
| 5prc | ATZ | Reaction center protein L chain | / | 0.442 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.442 | |
| 1hnv | TBO | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 1ia2 | TQ4 | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1jla | TNK | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 1kyo | SMA | Cytochrome b | / | 0.441 | |
| 1u3s | 797 | Estrogen receptor beta | / | 0.441 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.441 | |
| 2q7g | CCL | Pyrrolysine--tRNA ligase | / | 0.441 | |
| 3d74 | NBB | Pheromone-binding protein ASP1 | / | 0.441 | |
| 3hz1 | 42C | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 3hz5 | Z64 | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 4h96 | 14Q | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4jvb | 1M0 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.441 | |
| 4nmb | FAD | Bifunctional protein PutA | / | 0.441 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 1n4h | REA | Nuclear receptor ROR-beta | / | 0.440 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 1xls | REA | Retinoic acid receptor RXR-alpha | / | 0.440 | |
| 1yet | GDM | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 2cd8 | PXI | Cytochrome P450 monooxygenase PikC | / | 0.440 | |
| 2itt | AEE | Epidermal growth factor receptor | 2.7.10.1 | 0.440 | |
| 2piu | DHT | Androgen receptor | / | 0.440 | |
| 2pmn | K51 | Protein kinase 7 | / | 0.440 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 2ylp | TES | Androgen receptor | / | 0.440 | |
| 2zce | PYL | Pyrrolysine--tRNA ligase | / | 0.440 | |
| 2zl9 | VDA | Vitamin D3 receptor | / | 0.440 | |
| 3d73 | NBB | Pheromone-binding protein ASP1 | / | 0.440 | |
| 3g5q | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.440 | |
| 3gcu | R48 | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 3ken | ZZD | Kinesin-like protein KIF11 | / | 0.440 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 3qlw | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3vi7 | CBD | Hematopoietic prostaglandin D synthase | / | 0.440 | |
| 3w1f | 1O5 | Dual specificity protein kinase TTK | 2.7.12.1 | 0.440 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 4cby | KEE | Histone deacetylase 4 | 3.5.1.98 | 0.440 | |
| 4g2f | C07 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.440 | |
| 4m69 | ANP | Receptor-interacting serine/threonine-protein kinase 3 | 2.7.11.1 | 0.440 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 5jqb | IBP | Envelope glycoprotein | / | 0.440 |