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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/1.000
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.695
3qi4IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.665
2yy2IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.663
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.662
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.657
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.643
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.640
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.635
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.634
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.632
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.632
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.628
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.626
3dys5GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.625
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.620
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.615
3dyqIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.608
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.592
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.581
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.487
2h42VIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.459
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.458
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.456
2ovyPFJcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.454
3v94WYQPhosphodiesterase/0.453
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.451
4heu15JcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.451
3sl6JN8cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.450
2y0jAXCcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.449
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.448
3sl8JN7cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.446
3wd9QPCcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.445
3tvxPNXcAMP-specific 3',5'-cyclic phosphodiesterase 4A3.1.4.530.444
1ro6ROLcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.443
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
4phlPILPhosphodiesterase/0.442
4fcb0T7cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440