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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/1.000
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.677
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.667
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.633
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.631
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.623
2yy2IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.620
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.620
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.614
3qi4IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.612
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.597
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.593
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.589
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.585
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.577
3dyqIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.575
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.573
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.571
3dys5GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.552
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.549
2ovyPFJcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.486
3sl6JN8cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.463
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.460
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.460
4muw2F4cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.454
2h42VIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.451
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.450
4heu15JcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.449
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.441
4phlPILPhosphodiesterase/0.440