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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/1.000
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.730
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.725
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.700
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.677
3dyqIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.656
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.643
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.625
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.607
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.604
2yy2IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.601
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.597
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.591
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.591
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.585
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.583
3dys5GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.581
3qi4IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.578
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.572
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.557