sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3jqr | FAD | Ferredoxin--NADP reductase, apicoplast |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3jqr | FAD | Ferredoxin--NADP reductase, apicoplast | / | 1.000 | |
| 1bx0 | FAD | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.602 | |
| 1fnb | FAD | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.595 | |
| 1bx1 | FAD | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.588 | |
| 3zc3 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.586 | |
| 1fnd | FAD | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.585 | |
| 1gaw | FAD | Ferredoxin | / | 0.585 | |
| 4af7 | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.580 | |
| 1fnc | FDA | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.565 | |
| 1gjr | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.562 | |
| 3mhp | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.562 | |
| 1gaq | FAD | Ferredoxin | / | 0.557 | |
| 3vo2 | FAD | Ferredoxin--NADP reductase | / | 0.557 | |
| 1h42 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.554 | |
| 2ok8 | FAD | Ferredoxin--NADP reductase, apicoplast | / | 0.552 | |
| 1w35 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.548 | |
| 3w5u | FAD | Ferredoxin | / | 0.548 | |
| 1bjk | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.544 | |
| 4af6 | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.541 | |
| 1sm4 | FAD | Ferredoxin--NADP reductase | / | 0.534 | |
| 1que | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.530 | |
| 2rc6 | FAD | Ferredoxin--NADP reductase | / | 0.523 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.518 | |
| 1h85 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.517 | |
| 1gr1 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.516 | |
| 4c43 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.513 | |
| 1ogi | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.512 | |
| 1qh0 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.512 | |
| 1ogj | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.509 | |
| 1e62 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.506 | |
| 2b5o | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.505 | |
| 4z87 | GDP | Inosine-5'-monophosphate dehydrogenase | / | 0.503 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.502 | |
| 3fpk | FAD | Ferredoxin-NADP reductase | / | 0.501 | |
| 2e8u | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.500 | |
| 4bpr | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.500 | |
| 1w87 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.499 | |
| 4fse | 0VA | Beta-secretase 1 | 3.4.23.46 | 0.497 | |
| 1e64 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.496 | |
| 4hfp | 15U | Prothrombin | 3.4.21.5 | 0.495 | |
| 1qgy | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.494 | |
| 2ejz | SAH | Diphthine synthase | / | 0.493 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.492 | |
| 1fap | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.489 | |
| 1fap | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.489 | |
| 4gv0 | 8ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.489 | |
| 5ah5 | LSS | Leucine--tRNA ligase | / | 0.489 | |
| 1e63 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.487 | |
| 1go2 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.487 | |
| 2a2d | ANP | N-acetylgalactosamine kinase | 2.7.1.157 | 0.486 | |
| 3g1r | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.486 | |
| 4e32 | DWN | Methyltransferase | / | 0.486 | |
| 3zbt | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.485 | |
| 4a3u | FMN | NADH:flavin oxidoreductase/NADH oxidase | / | 0.485 | |
| 2wat | COA | Fatty acid synthase subunit alpha | 2.3.1.86 | 0.484 | |
| 4oma | LCS | Methionine gamma-lyase | / | 0.484 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.483 | |
| 1qgz | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.481 | |
| 3opx | U5P | Suppressor of disruption of TFIIS | / | 0.481 | |
| 3jyo | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.480 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.479 | |
| 4b1e | 6T6 | Beta-secretase 1 | 3.4.23.46 | 0.479 | |
| 2hxz | H7J | Cathepsin S | 3.4.22.27 | 0.478 | |
| 3c1o | NAP | Eugenol synthase | / | 0.477 | |
| 1ja1 | FAD | NADPH--cytochrome P450 reductase | / | 0.476 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.476 | |
| 1tka | N3T | Transketolase 1 | 2.2.1.1 | 0.475 | |
| 2geu | COK | Pantothenate kinase | 2.7.1.33 | 0.475 | |
| 3qft | FAD | NADPH--cytochrome P450 reductase | / | 0.475 | |
| 1nqu | RDL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.474 | |
| 1t4c | COA | Formyl-CoA:oxalate CoA-transferase | / | 0.474 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.474 | |
| 2fut | H1S | Heparin and heparin-sulfate lyase | / | 0.473 | |
| 2z4y | 252 | Geranylgeranyl pyrophosphate synthase | / | 0.473 | |
| 3f6s | FMN | Flavodoxin | / | 0.473 | |
| 3lzw | NAP | Ferredoxin--NADP reductase 2 | 1.18.1.2 | 0.473 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.472 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.472 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.472 | |
| 2jl1 | NAP | Triphenylmethane reductase | / | 0.471 | |
| 2uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.471 | |
| 3qfc | FAD | NADPH--cytochrome P450 reductase | / | 0.471 | |
| 3uax | NOS | Purine nucleoside phosphorylase DeoD-type | / | 0.471 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.470 | |
| 1k4m | NAD | Nicotinate-nucleotide adenylyltransferase | 2.7.7.18 | 0.470 | |
| 1x2b | STX | Proline iminopeptidase | 3.4.11.5 | 0.470 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.470 | |
| 1yw7 | A41 | Methionine aminopeptidase 2 | / | 0.470 | |
| 2gby | BRN | HTH-type transcriptional regulator QacR | / | 0.470 | |
| 4c77 | N01 | Phenylacetone monooxygenase | 1.14.13.92 | 0.470 | |
| 4i10 | 1BS | Beta-secretase 1 | 3.4.23.46 | 0.470 | |
| 1a26 | CNA | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.469 | |
| 1n4p | CYS_VAL_ILE_LEU_GER | Geranylgeranyl transferase type-1 subunit beta | 2.5.1.59 | 0.469 | |
| 1r5h | AO2 | Methionine aminopeptidase 2 | / | 0.469 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.469 | |
| 2ij7 | TPF | Mycocyclosin synthase | 1.14.21.9 | 0.469 | |
| 3hmv | HBT | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.469 | |
| 1w6j | R71 | Lanosterol synthase | 5.4.99.7 | 0.468 | |
| 2poq | ISD | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase | 1.3.1.20 | 0.468 | |
| 3keq | NAD | Redox-sensing transcriptional repressor Rex | / | 0.468 | |
| 4d03 | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.468 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.467 | |
| 3ou2 | SAH | SAM-dependent methyltransferase | / | 0.467 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.467 | |
| 1til | ATP | Anti-sigma F factor | / | 0.466 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.466 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.466 | |
| 4h6r | FDA | Proline dehydrogenase | / | 0.466 | |
| 4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.466 | |
| 1e7q | NAP | GDP-L-fucose synthase | / | 0.465 | |
| 3c4h | DRL | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.465 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.465 | |
| 4ypa | SAM | Histone-lysine N-methyltransferase ASH1L | 2.1.1.43 | 0.465 | |
| 1kw9 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.464 | |
| 1x27 | ASP_ASP_TYR_VAL_PTR | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.464 | |
| 2idv | M7G | Eukaryotic translation initiation factor 4E-1 | / | 0.464 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.464 | |
| 4eph | 0RK | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.464 | |
| 2cda | NAP | Glucose 1-dehydrogenase | / | 0.463 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.463 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.463 | |
| 3gnc | QQQ | Glutaryl-CoA dehydrogenase | / | 0.463 | |
| 4ypu | SAM | Histone-lysine N-methyltransferase ASH1L | 2.1.1.43 | 0.463 | |
| 5a4v | QUE | Glutathione S-transferase F2 | 2.5.1.18 | 0.463 | |
| 5bn3 | ADP | V-type ATP synthase alpha chain | / | 0.463 | |
| 5bn3 | ADP | NEQ263 | / | 0.463 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.462 | |
| 1pl6 | 572 | Sorbitol dehydrogenase | 1.1.1.14 | 0.462 | |
| 1x2e | ATX | Proline iminopeptidase | 3.4.11.5 | 0.462 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.462 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.462 | |
| 1yw9 | A84 | Methionine aminopeptidase 2 | / | 0.462 | |
| 2qe2 | 452 | Polyprotein | / | 0.462 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.462 | |
| 4yao | FAD | NADPH--cytochrome P450 reductase | / | 0.462 | |
| 1dr4 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 2x06 | NAD | L-sulfolactate dehydrogenase | / | 0.461 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.461 | |
| 3dop | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.461 | |
| 2rc5 | FAD | Ferredoxin--NADP reductase | / | 0.460 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.460 | |
| 3f90 | FMN | Flavodoxin | / | 0.460 | |
| 3rth | RTH | Beta-secretase 1 | 3.4.23.46 | 0.460 | |
| 4jtq | FLP | Aldo-keto reductase family 1 member C2 | / | 0.460 | |
| 4kxj | P34 | Nucleoprotein | / | 0.460 | |
| 4z4p | SAH | Histone-lysine N-methyltransferase 2D | 2.1.1.43 | 0.460 | |
| 5cmx | 0G6 | Prothrombin | 3.4.21.5 | 0.460 | |
| 2wzy | SQX | Soluble acetylcholine receptor | / | 0.459 | |
| 3klb | FMN | Uncharacterized protein | / | 0.459 | |
| 3rvi | RVI | Beta-secretase 1 | 3.4.23.46 | 0.459 | |
| 4q7f | 3D1 | Uncharacterized protein | / | 0.459 | |
| 1f8g | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.458 | |
| 1h66 | RH1 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.458 | |
| 1ye6 | NAP | NAD(P)H-dependent D-xylose reductase | 1.1.1.307 | 0.458 | |
| 2r8p | T6F | Transketolase 1 | / | 0.458 | |
| 2w02 | ATP | AcsD | / | 0.458 | |
| 2zev | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.458 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.457 | |
| 2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.457 | |
| 3elb | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.457 | |
| 4usq | FAD | Pyridine nucleotide-disulfide oxidoreductase | / | 0.457 | |
| 1fwy | UD1 | Bifunctional protein GlmU | / | 0.456 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.456 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.456 | |
| 1tkc | M6T | Transketolase 1 | 2.2.1.1 | 0.456 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.456 | |
| 3ce0 | P34 | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.456 | |
| 3i0p | NAD | Malate dehydrogenase, putative | / | 0.456 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.456 | |
| 4gv4 | MEJ | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.456 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.455 | |
| 1efy | BZC | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.455 | |
| 1ohh | ANP | ATP synthase subunit alpha, mitochondrial | / | 0.455 | |
| 1ohh | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.455 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.455 | |
| 1sdw | IYT | Peptidyl-glycine alpha-amidating monooxygenase | 1.14.17.3 | 0.455 | |
| 2c31 | ADP | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.455 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.455 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.455 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.455 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.455 | |
| 3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase | / | 0.455 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.455 | |
| 1fxs | NAP | GDP-L-fucose synthase | / | 0.454 | |
| 1j8q | FMN | Flavodoxin | / | 0.454 | |
| 1kyv | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.454 | |
| 1q45 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.454 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.454 | |
| 2ffq | GSP | Ras-related protein Rab-6B | / | 0.454 | |
| 3dlp | 174 | 4-chlorobenzoyl CoA ligase | / | 0.454 | |
| 3jyp | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.454 | |
| 3sxn | COA | N-acetyltransferase Eis | / | 0.454 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.454 | |
| 1dgh | NDP | Catalase | 1.11.1.6 | 0.453 | |
| 1jqd | SAH | Histamine N-methyltransferase | 2.1.1.8 | 0.453 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 1.2.4.4 | 0.453 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | 1.2.4.4 | 0.453 | |
| 2v19 | FMN | Dodecin | / | 0.453 | |
| 3jyq | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.453 | |
| 3n39 | FMN | Protein NrdI | / | 0.453 | |
| 3sl8 | JN7 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.453 | |
| 3zj7 | C1K | Strictosidine-O-beta-D-glucosidase | 3.2.1.105 | 0.453 | |
| 4j7g | TRH | PCZA361.3 | / | 0.453 | |
| 4uxq | 0LI | Fibroblast growth factor receptor 4 | 2.7.10.1 | 0.453 | |
| 1c9w | NAP | Aldose reductase-related protein 2 | / | 0.452 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.452 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.452 | |
| 1w19 | T5P | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.452 | |
| 2z7h | GG3 | Geranylgeranyl pyrophosphate synthase | / | 0.452 | |
| 3aez | GDP | Pantothenate kinase | 2.7.1.33 | 0.452 | |
| 3bgx | MEF | Thymidylate synthase | / | 0.452 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 3iex | GMP | Purine nucleoside phosphorylase | / | 0.452 | |
| 3ivc | FG4 | Pantothenate synthetase | 6.3.2.1 | 0.452 | |
| 3qfs | FAD | NADPH--cytochrome P450 reductase | / | 0.452 | |
| 3ska | 053 | Genome polyprotein | 2.7.7.48 | 0.452 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.452 | |
| 4l1x | NAP | Aldo-keto reductase family 1 member C2 | / | 0.452 | |
| 4lcw | 1VY | Major histocompatibility complex class I-related gene protein | / | 0.452 | |
| 1c7o | PPG | Hemolysin | / | 0.451 | |
| 1fwm | CB3 | Thymidylate synthase | / | 0.451 | |
| 1qzy | TDE | Methionine aminopeptidase 2 | / | 0.451 | |
| 2puc | GUN | HTH-type transcriptional repressor PurR | / | 0.451 | |
| 2zsb | ADP | Pantothenate kinase | 2.7.1.33 | 0.451 | |
| 3eku | CY9 | Actin-5C | / | 0.451 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.451 | |
| 4ts7 | ADP | Purine phosphoribosyltransferase (GpT-1) | / | 0.451 | |
| 4wec | NAD | Short chain dehydrogenase | / | 0.451 | |
| 1k7f | IAV | Tryptophan synthase alpha chain | / | 0.450 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.450 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.450 | |
| 2ji9 | ADP | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.450 | |
| 2uxh | QUE | HTH-type transcriptional regulator TtgR | / | 0.450 | |
| 3e6e | DCS | Alanine racemase | / | 0.450 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.450 | |
| 3sfy | 3FY | Uncharacterized protein | / | 0.450 | |
| 3uzx | AOM | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.450 | |
| 4b68 | NAP | L-ornithine N(5)-monooxygenase | / | 0.450 | |
| 4drj | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.450 | |
| 4drj | RAP | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.450 | |
| 4dvi | 2IW | Tankyrase-1 | 2.4.2.30 | 0.450 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 4jq3 | NAP | Aldo-keto reductase family 1 member C2 | / | 0.450 | |
| 5hwr | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.450 | |
| 1uae | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.449 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.449 | |
| 2xlp | FAD | Putative flavin-containing monooxygenase | / | 0.449 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 3lz6 | A0D | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.449 | |
| 3mau | EXT | Putative sphingosine-1-phosphate lyase | / | 0.449 | |
| 3vmm | P0D | Alanine--anticapsin ligase | / | 0.449 | |
| 4bqz | GNP | Ectonucleoside triphosphate diphosphohydrolase 2 | / | 0.449 | |
| 1jf0 | CZH | Obelin | / | 0.448 | |
| 1opm | IYG | Peptidyl-glycine alpha-amidating monooxygenase | 1.14.17.3 | 0.448 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.448 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.448 | |
| 2pk3 | GDD | GDP-6-deoxy-D-mannose reductase | / | 0.448 | |
| 2reh | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.448 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 3hyg | 099 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.448 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 3pzc | GAP | Amino acid--[acyl-carrier-protein] ligase 1 | 6.2.1.n2 | 0.448 | |
| 3vyf | VYF | Renin | 3.4.23.15 | 0.448 | |
| 1dgf | NDP | Catalase | 1.11.1.6 | 0.447 | |
| 1ja0 | FAD | NADPH--cytochrome P450 reductase | / | 0.447 | |
| 1jdz | FMB | Purine nucleoside phosphorylase | / | 0.447 | |
| 1w19 | T1P | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.447 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
| 2zev | B71 | Geranylgeranyl pyrophosphate synthase | / | 0.447 | |
| 3ggs | 2FD | Purine nucleoside phosphorylase | 2.4.2.1 | 0.447 | |
| 3mau | PLR | Putative sphingosine-1-phosphate lyase | / | 0.447 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 3u5y | SCG | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.447 | |
| 3ziu | LSS | Leucyl-tRNA synthetase | / | 0.447 | |
| 4fsl | 0VB | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 4nec | SAH | Putative SAM-dependent methyltransferase | / | 0.447 | |
| 5f59 | SAH | Histone-lysine N-methyltransferase 2C | 2.1.1.43 | 0.447 | |
| 1amo | FAD | NADPH--cytochrome P450 reductase | / | 0.446 | |
| 1ex7 | 5GP | Guanylate kinase | 2.7.4.8 | 0.446 | |
| 1uk0 | FRM | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.446 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.446 | |
| 2cb3 | MLD | Peptidoglycan-recognition protein LE | / | 0.446 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 2uxu | NAR | HTH-type transcriptional regulator TtgR | / | 0.446 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.446 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.446 | |
| 3fap | ARD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.446 | |
| 3fap | ARD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.446 | |
| 3h7r | NAP | Aldo-keto reductase family 4 member C8 | / | 0.446 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 3t4e | NAD | Quinate/shikimate dehydrogenase | / | 0.446 | |
| 4bc7 | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.446 | |
| 4h1e | 10J | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.446 | |
| 4lm4 | JPZ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 4rh1 | 0TT | Spore photoproduct lyase | / | 0.446 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.446 | |
| 4yal | 2AM | NADPH--cytochrome P450 reductase | / | 0.446 | |
| 3vw7 | VPX | Proteinase-activated receptor 1 | / | 0.446 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.445 | |
| 1j9z | FAD | NADPH--cytochrome P450 reductase | / | 0.445 | |
| 2aou | CQA | Histamine N-methyltransferase | 2.1.1.8 | 0.445 | |
| 2c1z | KMP | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.445 | |
| 2ga2 | A19 | Methionine aminopeptidase 2 | / | 0.445 | |
| 2gz8 | F3F | Orf1a polyprotein | / | 0.445 | |
| 3akz | GSU | Glutamate--tRNA ligase 2 | / | 0.445 | |
| 3b03 | VNR | Isopentenyl-diphosphate delta-isomerase | / | 0.445 | |
| 3fkt | SII | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 3ngl | NAP | Bifunctional protein FolD | / | 0.445 | |
| 3oet | NAD | Erythronate-4-phosphate dehydrogenase | / | 0.445 | |
| 3tqx | PLP | 2-amino-3-ketobutyrate coenzyme A ligase | / | 0.445 | |
| 3v2u | ATP | Protein GAL3 | / | 0.445 | |
| 4e7r | 0NW | Prothrombin | 3.4.21.5 | 0.445 | |
| 4iil | RBF | Membrane lipoprotein TpN38(b) | / | 0.445 | |
| 1qx4 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.444 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.444 | |
| 2oaz | I96 | Methionine aminopeptidase 2 | / | 0.444 | |
| 2r8o | T5X | Transketolase 1 | / | 0.444 | |
| 3er9 | 3AT | Poly(A) polymerase catalytic subunit | 2.7.7.19 | 0.444 | |
| 3w6h | AZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.444 | |
| 3x2f | NAI | Adenosylhomocysteinase | / | 0.444 | |
| 4ckr | DI1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.444 | |
| 4e0u | 0MV | Cyclic dipeptide N-prenyltransferase | / | 0.444 | |
| 4l09 | 1UR | Tankyrase-2 | 2.4.2.30 | 0.444 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.444 | |
| 4p9c | DCM | Deoxycytidylate deaminase | / | 0.444 | |
| 4xbj | IN5 | Alanine racemase, biosynthetic | / | 0.444 | |
| 5dsy | UHB | Poly [ADP-ribose] polymerase 2 | 2.4.2.30 | 0.444 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.444 | |
| 1kw6 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.443 | |
| 1sq5 | ADP | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 1vbm | YSA | Tyrosine--tRNA ligase | 6.1.1.1 | 0.443 | |
| 1z41 | FMN | NADPH dehydrogenase | / | 0.443 | |
| 1z48 | FMN | NADPH dehydrogenase | / | 0.443 | |
| 2cf9 | 348 | Prothrombin | 3.4.21.5 | 0.443 | |
| 2dsh | SAH | Diphthine synthase | / | 0.443 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.443 | |
| 3ai0 | PNW | Beta-glucosidase | / | 0.443 | |
| 3wag | TYD | Glycosyltransferase | / | 0.443 | |
| 3wqu | ATP | Cell division protein FtsA | / | 0.443 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.443 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 4dbc | 3QP | Aspartate aminotransferase | 2.6.1.1 | 0.443 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 4q36 | CO8 | Uncharacterized protein | / | 0.443 | |
| 4rtb | SAM | Putative thiazole biosynthesis protein ThiH | / | 0.443 | |
| 4yaw | 2AM | NADPH--cytochrome P450 reductase | / | 0.443 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.442 | |
| 1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.442 | |
| 1gg5 | E09 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.442 | |
| 1k9s | FM1 | Purine nucleoside phosphorylase DeoD-type | / | 0.442 | |
| 1lvu | 9PP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.442 | |
| 1odn | APV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1r5g | AO1 | Methionine aminopeptidase 2 | / | 0.442 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.442 | |
| 1v3q | 2DI | Purine nucleoside phosphorylase | 2.4.2.1 | 0.442 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.442 | |
| 1xud | PB4 | Collagenase 3 | 3.4.24 | 0.442 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.442 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.442 | |
| 2q1t | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.442 | |
| 2r86 | ATP | 5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase | / | 0.442 | |
| 2tpl | HPP | Tyrosine phenol-lyase | 4.1.99.2 | 0.442 | |
| 2vyq | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.442 | |
| 2wvm | GDD | Mannosyl-3-phosphogylcerate synthase | / | 0.442 | |
| 3br3 | ET | HTH-type transcriptional regulator QacR | / | 0.442 | |
| 3p0f | BAU | Uridine phosphorylase 2 | 2.4.2.3 | 0.442 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.442 | |
| 3pm1 | ET | HTH-type transcriptional regulator QacR | / | 0.442 | |
| 3rtn | RTN | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 4hhy | 15R | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.442 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.442 | |
| 1d9i | 00P | Prothrombin | 3.4.21.5 | 0.441 | |
| 1h8h | ADP | ATP synthase subunit alpha, mitochondrial | / | 0.441 | |
| 1h8h | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.441 | |
| 1hi0 | GTP | RNA-directed RNA polymerase | 2.7.7.48 | 0.441 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.441 | |
| 1xzq | FON | tRNA modification GTPase MnmE | 3.6.5 | 0.441 | |
| 1zdw | FLV | Prenyltransferase | / | 0.441 | |
| 2b82 | ADN | Class B acid phosphatase | 3.1.3.2 | 0.441 | |
| 2yvw | EPU | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.441 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.441 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.441 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3hgg | CHD | CmeR | / | 0.441 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.441 | |
| 3qgf | 46F | Genome polyprotein | 2.7.7.48 | 0.441 | |
| 3qvi | K95 | HAP protein | / | 0.441 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.441 | |
| 4bv9 | NDP | Ketimine reductase mu-crystallin | 1.5.1.25 | 0.441 | |
| 4df2 | FMN | NADPH dehydrogenase | / | 0.441 | |
| 4j0v | 1H7 | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4j7h | TRH | PCZA361.3 | / | 0.441 | |
| 4qai | FMN | NADPH dehydrogenase | / | 0.441 | |
| 4rel | KMP | Glycosyltransferase | / | 0.441 | |
| 5jy1 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.441 | |
| 4xnw | 2ID | P2Y purinoceptor 1 | / | 0.441 | |
| 1ndz | FR5 | Adenosine deaminase | 3.5.4.4 | 0.440 | |
| 1o5g | CR9 | Prothrombin | 3.4.21.5 | 0.440 | |
| 2ges | COK | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 3iu7 | FCD | Methionine aminopeptidase 2 | / | 0.440 | |
| 4hmz | 18T | dTDP-4-dehydro-6-deoxyglucose 3-epimerase | 5.1.3.27 | 0.440 | |
| 4m0f | 1YK | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 4nbj | D3Y | D-tyrosyl-tRNA(Tyr) deacylase | / | 0.440 | |
| 4zqc | F6F | Tryptophan synthase alpha chain | / | 0.440 | |
| 5c8d | 5AD | Probable transcriptional regulator | / | 0.440 | |
| 5p2p | DHG | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.440 |