sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3i8a | N22 | Dihydrofolate reductase | 1.5.1.3 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3i8a | N22 | Dihydrofolate reductase | 1.5.1.3 | 1.000 | |
| 3fre | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.574 | |
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.566 | |
| 2w3w | VG9 | Dihydrofolate reductase | / | 0.562 | |
| 3jwc | EKB | Dihydrofolate reductase | / | 0.559 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.554 | |
| 3sh2 | 5DR | Dihydrofolate reductase | 1.5.1.3 | 0.553 | |
| 4h98 | 14Q | Uncharacterized protein | / | 0.551 | |
| 1cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.547 | |
| 3fyw | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.546 | |
| 3qfx | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.543 | |
| 4dp3 | MMV | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.543 | |
| 3qlr | QLR | Dihydrofolate reductase | 1.5.1.3 | 0.541 | |
| 4h96 | 14Q | Dihydrofolate reductase | 1.5.1.3 | 0.538 | |
| 3eem | 53V | Uncharacterized protein | / | 0.537 | |
| 2w3v | TOP | Dihydrofolate reductase | / | 0.531 | |
| 1lud | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.529 | |
| 1rx3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.528 | |
| 3eek | 53S | Uncharacterized protein | / | 0.528 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.525 | |
| 3kjs | DQ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.521 | |
| 3ia4 | MTX | Dihydrofolate reductase | / | 0.519 | |
| 1j3i | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.518 | |
| 3qlz | QLZ | Uncharacterized protein | / | 0.514 | |
| 5ccc | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.512 | |
| 3ml8 | ML8 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.509 | |
| 1dg5 | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.508 | |
| 3qlx | QLR | Uncharacterized protein | / | 0.507 | |
| 3eej | 53R | Uncharacterized protein | / | 0.504 | |
| 3inv | C50 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.504 | |
| 3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.503 | |
| 3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.501 | |
| 3eel | 53T | Uncharacterized protein | / | 0.500 | |
| 4bzo | 676 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.498 | |
| 4gg7 | 0J8 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.498 | |
| 1e90 | MYC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.497 | |
| 4p66 | MTX | Dihydrofolate reductase | / | 0.496 | |
| 1re7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.495 | |
| 3qls | 55V | Dihydrofolate reductase | 1.5.1.3 | 0.495 | |
| 3irn | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.494 | |
| 4ixe | IXE | Dihydrofolate reductase | 1.5.1.3 | 0.494 | |
| 4x5f | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.494 | |
| 1ra2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.493 | |
| 3rg9 | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.493 | |
| 4kjj | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.493 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.492 | |
| 3sqy | Q11 | Dihydrofolate reductase | 1.5.1.3 | 0.492 | |
| 3qlw | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.491 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.488 | |
| 4fhb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 4kbn | 25U | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 2cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.487 | |
| 3a4p | DFQ | Hepatocyte growth factor receptor | 2.7.10.1 | 0.487 | |
| 4dph | P65 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.487 | |
| 3bgq | VX2 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.485 | |
| 3ngl | NAP | Bifunctional protein FolD | / | 0.485 | |
| 1dds | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.484 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.483 | |
| 1boz | PRD | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
| 3inv | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.482 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.482 | |
| 1rx2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.481 | |
| 4ap7 | F47 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.480 | |
| 4ixg | IXG | Dihydrofolate reductase | 1.5.1.3 | 0.480 | |
| 4kd7 | 9DR | Dihydrofolate reductase | 1.5.1.3 | 0.480 | |
| 2blb | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.478 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.478 | |
| 4kak | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.478 | |
| 2hw2 | RFP | Rifampin ADP-ribosyl transferase | / | 0.477 | |
| 3dga | RJ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.477 | |
| 3frf | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 3jsu | KA5 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.477 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.477 | |
| 4ixf | IXF | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 4o71 | CPB | Bromodomain-containing protein 4 | / | 0.477 | |
| 1szm | BI4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.476 | |
| 4nx6 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 2f2c | AP9 | Cyclin-dependent kinase 6 | 2.7.11.22 | 0.474 | |
| 2zza | FOL | Dihydrofolate reductase | / | 0.474 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.474 | |
| 1dr4 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 3el8 | PD5 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.473 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.473 | |
| 5a3b | APR | SIR2 family protein | / | 0.473 | |
| 1nq7 | ARL | Nuclear receptor ROR-beta | / | 0.472 | |
| 3c14 | FOK | Adenylate cyclase type 2 | / | 0.472 | |
| 3c14 | FOK | Adenylate cyclase type 5 | / | 0.472 | |
| 4dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 1og5 | SWF | Cytochrome P450 2C9 | / | 0.471 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.471 | |
| 4fjy | FJY | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.471 | |
| 4p68 | MTX | Dihydrofolate reductase | / | 0.471 | |
| 3ql3 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 1u2g | APR | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.469 | |
| 1x7h | NDP | Putative ketoacyl reductase | 1.3.1 | 0.469 | |
| 2bl9 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.469 | |
| 3ans | S38 | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.469 | |
| 3qaq | QAQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.469 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.469 | |
| 1dyi | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 1sej | F89 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.468 | |
| 2chz | 093 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.468 | |
| 3p8i | FMN | Pentaerythritol tetranitrate reductase | / | 0.468 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.468 | |
| 4jq7 | KJQ | Epidermal growth factor receptor | 2.7.10.1 | 0.468 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.467 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.467 | |
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.466 | |
| 2c3l | IDZ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.466 | |
| 3a78 | 3EV | Vitamin D3 receptor | / | 0.466 | |
| 3r04 | UNQ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.466 | |
| 3zze | 6XP | Hepatocyte growth factor receptor | 2.7.10.1 | 0.466 | |
| 1ia2 | TQ4 | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.465 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.465 | |
| 4n70 | 2HX | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.465 | |
| 4qmy | STU | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.465 | |
| 4x5j | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 7dfr | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 1ml6 | GBX | Glutathione S-transferase A2 | 2.5.1.18 | 0.464 | |
| 2ejz | SAH | Diphthine synthase | / | 0.464 | |
| 2fpc | SCG | Strictosidine synthase | 4.3.3.2 | 0.464 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.464 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.464 | |
| 4ucn | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.464 | |
| 1lhw | ESM | Sex hormone-binding globulin | / | 0.463 | |
| 2drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.463 | |
| 1dhi | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 1g4s | TPS | Thiamine-phosphate synthase | / | 0.462 | |
| 1iyz | NDP | Probable quinone oxidoreductase | / | 0.462 | |
| 1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.462 | |
| 3cy3 | JN5 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.462 | |
| 3f7z | 34O | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.462 | |
| 4h4x | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.462 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.462 | |
| 1ddr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 1dra | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.461 | |
| 1i58 | ACP | Chemotaxis protein CheA | 2.7.13.3 | 0.461 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.461 | |
| 2b37 | 8PS | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.461 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.461 | |
| 3koo | 24D | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.461 | |
| 3r33 | 6ME | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 4a33 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.461 | |
| 4c2z | MYA | Glycylpeptide N-tetradecanoyltransferase 1 | / | 0.461 | |
| 4qa2 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.461 | |
| 5a27 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.461 | |
| 5a3c | NAD | SIR2 family protein | / | 0.461 | |
| 5d7q | AR6 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.461 | |
| 1hfp | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1xws | BI1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.460 | |
| 2oci | TYC | Valacyclovir hydrolase | 3.1 | 0.460 | |
| 2wsa | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.460 | |
| 2wug | HPK | 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | 3.7.1.17 | 0.460 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.460 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.460 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.460 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.460 | |
| 4elg | 52J | Dihydrofolate reductase | / | 0.460 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.460 | |
| 5ai5 | BSU | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.460 | |
| 5jy1 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.460 | |
| 1dyr | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.459 | |
| 2itt | AEE | Epidermal growth factor receptor | 2.7.10.1 | 0.459 | |
| 3ant | S82 | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.459 | |
| 3c3d | FO1 | 2-phospho-L-lactate transferase | / | 0.459 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.459 | |
| 3qk0 | QK0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.459 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.459 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.459 | |
| 4zas | TYD | CalS13 | / | 0.459 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.458 | |
| 1rx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.458 | |
| 2v1a | FMN | NPH1-1 | / | 0.458 | |
| 2w3a | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 3lj3 | WYE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.458 | |
| 3qly | 55V | Uncharacterized protein | / | 0.458 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.458 | |
| 4wbo | ANW | Rhodopsin kinase | / | 0.458 | |
| 1tez | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.457 | |
| 2j2i | LY4 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.457 | |
| 2oal | FAD | Flavin-dependent tryptophan halogenase RebH | 1.14.19.9 | 0.457 | |
| 3iqz | H4M | F420-dependent methylenetetrahydromethanopterin dehydrogenase | 1.5.98.1 | 0.457 | |
| 3l9l | L9L | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.457 | |
| 3qiy | QI1 | Botulinum neurotoxin type A | 3.4.24.69 | 0.457 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.457 | |
| 4awo | 99B | Heat shock protein HSP 90-alpha | / | 0.457 | |
| 4c2y | MYA | Glycylpeptide N-tetradecanoyltransferase 1 | / | 0.457 | |
| 4deg | 0JJ | Hepatocyte growth factor receptor | 2.7.10.1 | 0.457 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.457 | |
| 4rra | A3T | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.457 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.457 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.456 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.456 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.456 | |
| 2vss | ACO | Hydroxycinnamoyl-CoA hydratase-lyase | 4.1.2.41 | 0.456 | |
| 3frd | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 3nd1 | SAH | Precorrin-6A synthase (Deacetylating) | / | 0.456 | |
| 3nxo | D2B | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.456 | |
| 4l7s | G7K | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.456 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.455 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.455 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.455 | |
| 2i40 | BLZ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.455 | |
| 3nmn | PYV | Abscisic acid receptor PYL1 | / | 0.455 | |
| 4c02 | TAK | Activin receptor type-1 | 2.7.11.30 | 0.455 | |
| 4fhk | 0U0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.455 | |
| 4qa1 | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.455 | |
| 1e7q | NAP | GDP-L-fucose synthase | / | 0.454 | |
| 1yi4 | ADN | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.454 | |
| 2gr1 | FAD | Ferredoxin reductase | / | 0.454 | |
| 3btj | DEQ | HTH-type transcriptional regulator QacR | / | 0.454 | |
| 4x5g | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.454 | |
| 1iwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.453 | |
| 1rjk | VDZ | Vitamin D3 receptor | / | 0.453 | |
| 1tdr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 2wot | ZZG | TGF-beta receptor type-1 | 2.7.11.30 | 0.453 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.453 | |
| 3s79 | ASD | Aromatase | 1.14.14.14 | 0.453 | |
| 3ua5 | 06X | Cytochrome P450 2B6 | 1.14.13 | 0.453 | |
| 3w5r | LOA | Vitamin D3 receptor | / | 0.453 | |
| 4cax | MYA | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.453 | |
| 4fhj | 0TZ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.453 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.453 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 1rt4 | UC1 | Gag-Pol polyprotein | 2.7.7.49 | 0.452 | |
| 1tl1 | H18 | Gag-Pol polyprotein | 2.7.7.49 | 0.452 | |
| 1y0s | 331 | Peroxisome proliferator-activated receptor delta | / | 0.452 | |
| 1yin | CM3 | Estrogen receptor | / | 0.452 | |
| 2jed | LG8 | Protein kinase C theta type | 2.7.11.13 | 0.452 | |
| 2xab | VHD | Heat shock protein HSP 90-alpha | / | 0.452 | |
| 2yn8 | STU | Ephrin type-B receptor 4 | 2.7.10.1 | 0.452 | |
| 3bgp | VX1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.452 | |
| 3c4e | C4E | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.452 | |
| 3dds | 26B | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.452 | |
| 4l0q | NAD | Alcohol dehydrogenase class-3 | / | 0.452 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.452 | |
| 1bvr | THT | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.451 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.451 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.451 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1jum | BER | HTH-type transcriptional regulator QacR | / | 0.451 | |
| 1suo | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.451 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.451 | |
| 2dq7 | STU | Tyrosine-protein kinase Fyn | 2.7.10.2 | 0.451 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 3g70 | A5T | Renin | 3.4.23.15 | 0.451 | |
| 3tq8 | TOP | Dihydrofolate reductase | / | 0.451 | |
| 3tq9 | MTX | Dihydrofolate reductase | / | 0.451 | |
| 4anu | EM7 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.451 | |
| 4geb | 0LD | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.451 | |
| 4k0y | 1OA | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.451 | |
| 5d7p | OCZ | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.451 | |
| 1eny | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 1fpq | SAM | Isoliquiritigenin 2'-O-methyltransferase | / | 0.450 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1kl2 | FON | Serine hydroxymethyltransferase | / | 0.450 | |
| 1owm | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.450 | |
| 2owf | SAH | Diphthine synthase | / | 0.450 | |
| 2wue | KEK | 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | 3.7.1.17 | 0.450 | |
| 2wuf | KEM | 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | 3.7.1.17 | 0.450 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 3wrl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 4bqp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 4egn | TWO | Cytochrome P450 | / | 0.450 | |
| 4pd5 | GEO | Nucleoside permease | / | 0.450 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.450 | |
| 1mp0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.449 | |
| 1oky | STU | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.449 | |
| 1s3w | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 1thn | ADP | Anti-sigma F factor | / | 0.449 | |
| 1ung | ALH | Cyclin-dependent-like kinase 5 | 2.7.11.1 | 0.449 | |
| 2bla | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.449 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 3k1w | BFX | Renin | 3.4.23.15 | 0.449 | |
| 3mnr | SD1 | Heat shock protein HSP 90-alpha | / | 0.449 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.449 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 3sgy | 06W | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 3w5t | LHP | Vitamin D3 receptor | / | 0.449 | |
| 4anw | O92 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.449 | |
| 4dpy | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.449 | |
| 4l23 | X6K | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | / | 0.449 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.449 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.448 | |
| 1hpz | AAP | Gag-Pol polyprotein | 2.7.7.49 | 0.448 | |
| 1iid | NHM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.448 | |
| 1kqg | MGD | Formate dehydrogenase, nitrate-inducible, major subunit | 1.1.5.6 | 0.448 | |
| 1lrh | NLA | Auxin-binding protein 1 | / | 0.448 | |
| 1ndz | FR5 | Adenosine deaminase | 3.5.4.4 | 0.448 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.448 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 2blc | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.448 | |
| 2c4j | GSO | Glutathione S-transferase Mu 2 | 2.5.1.18 | 0.448 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.448 | |
| 2ds1 | 1CD | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.448 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.448 | |
| 3l08 | ZIG | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.448 | |
| 4gg5 | 0J3 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.448 | |
| 4gk2 | L66 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.448 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.448 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.447 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.447 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.447 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.447 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 2o4r | VD5 | Vitamin D3 receptor | / | 0.447 | |
| 2vg7 | NNI | Gag-Pol polyprotein | 2.7.7.49 | 0.447 | |
| 2zl9 | VDA | Vitamin D3 receptor | / | 0.447 | |
| 3cgc | COA | Coenzyme A disulfide reductase | / | 0.447 | |
| 3gbu | ATP | Uncharacterized sugar kinase PH1459 | 2.7.1 | 0.447 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.447 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.447 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 3um8 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.447 | |
| 3zy6 | GFB | GDP-fucose protein O-fucosyltransferase 1 | 2.4.1.221 | 0.447 | |
| 4apu | A2K | Progesterone receptor | / | 0.447 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 4ezj | 0SC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.447 | |
| 4ho8 | THM | Glucose-1-phosphate thymidylyltransferase | / | 0.447 | |
| 4iql | FMN | Enoyl-(Acyl-carrier-protein) reductase II | / | 0.447 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 4lmu | QUE | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.447 | |
| 4mxx | DB8 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.447 | |
| 4yaf | 2AM | NADPH--cytochrome P450 reductase | / | 0.447 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.446 | |
| 1d2s | DHT | Sex hormone-binding globulin | / | 0.446 | |
| 1ikw | EFZ | Gag-Pol polyprotein | 2.7.7.49 | 0.446 | |
| 1ly3 | COG | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1qnf | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.446 | |
| 1tvr | TB9 | Gag-Pol polyprotein | 2.7.7.49 | 0.446 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 2qd5 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.446 | |
| 2ybo | SAH | Methyltransferase | / | 0.446 | |
| 2ykb | YKB | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 2z2w | 770 | Wee1-like protein kinase | 2.7.10.2 | 0.446 | |
| 3och | 2MX | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3qlh | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.446 | |
| 3r9d | X6B | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.446 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.446 | |
| 4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 4euf | NAD | Trans-2-enoyl-CoA reductase [NADH] | / | 0.446 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.446 | |
| 4jq8 | KJ8 | Epidermal growth factor receptor | 2.7.10.1 | 0.446 | |
| 4k18 | 1OB | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.446 | |
| 5cyq | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.446 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.446 | |
| 1rkg | VD1 | Vitamin D3 receptor | / | 0.445 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.445 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.445 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 2rht | C1E | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase | 3.7.1.8 | 0.445 | |
| 2tpr | FAD | Trypanothione reductase | 1.8.1.12 | 0.445 | |
| 2x7g | PVB | SRSF protein kinase 2 | 2.7.11.1 | 0.445 | |
| 3akz | GSU | Glutamate--tRNA ligase 2 | / | 0.445 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.445 | |
| 3n0t | OPY | Dipeptidyl peptidase 2 | 3.4.14.2 | 0.445 | |
| 3oji | PYV | Abscisic acid receptor PYL3 | / | 0.445 | |
| 3pm0 | BHF | Cytochrome P450 1B1 | / | 0.445 | |
| 3tqb | FOL | Dihydrofolate reductase | / | 0.445 | |
| 4hnc | 0UT | Mandelate racemase | / | 0.445 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.445 | |
| 4ib4 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.445 | |
| 4lm5 | Q17 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.445 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 1dyh | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1g6c | IFP | Thiamine-phosphate synthase | / | 0.444 | |
| 1jlc | FTC | Gag-Pol polyprotein | 2.7.7.49 | 0.444 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.444 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.444 | |
| 1xuo | LA1 | Integrin alpha-L | / | 0.444 | |
| 2bik | BI1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.444 | |
| 2etr | Y27 | Rho-associated protein kinase 1 | 2.7.11.1 | 0.444 | |
| 2fyp | RDE | Endoplasmin | / | 0.444 | |
| 2o65 | MYF | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.444 | |
| 2uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.444 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.444 | |
| 3fzn | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.444 | |
| 3kdi | A8S | Abscisic acid receptor PYL2 | / | 0.444 | |
| 3ndr | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.444 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.444 | |
| 3zbx | 6XE | Hepatocyte growth factor receptor | 2.7.10.1 | 0.444 | |
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.444 | |
| 4fad | 0TB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 4fhh | 0U3 | Vitamin D3 receptor A | / | 0.444 | |
| 4g20 | 484 | Vitamin D3 receptor A | / | 0.444 | |
| 4g2g | TDH | Mycocyclosin synthase | 1.14.21.9 | 0.444 | |
| 4hyh | 1AM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.444 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.444 | |
| 4kko | 1RE | Gag-Pol polyprotein | 2.7.7.49 | 0.444 | |
| 4oqy | NDP | (S)-imine reductase | / | 0.444 | |
| 4xiv | ADP | Chemotaxis protein CheA | 2.7.13.3 | 0.444 | |
| 5l6w | AGS | LIM domain kinase 1 | 2.7.11.1 | 0.444 | |
| 1fp2 | HMO | Isoflavone-7-O-methyltransferase 8 | 2.1.1.150 | 0.443 | |
| 1j3k | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.443 | |
| 1jt6 | DEQ | HTH-type transcriptional regulator QacR | / | 0.443 | |
| 1q1r | FAD | Putidaredoxin reductase | 1.18.1.5 | 0.443 | |
| 1rk3 | VDX | Vitamin D3 receptor | / | 0.443 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.443 | |
| 1u54 | ACP | Activated CDC42 kinase 1 | / | 0.443 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.443 | |
| 2ehl | SAH | Diphthine synthase | / | 0.443 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.443 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.443 | |
| 2izr | BRK | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.443 | |
| 3d7k | D7K | Benzaldehyde lyase | / | 0.443 | |
| 3dol | GWI | Pol protein | / | 0.443 | |
| 3lu8 | IQX | Serum albumin | / | 0.443 | |
| 3neg | PYV | Abscisic acid receptor PYL1 | / | 0.443 | |
| 3o0i | P54 | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 3oag | LPQ | Renin | 3.4.23.15 | 0.443 | |
| 3srq | Q19 | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 3w0a | DS5 | Vitamin D3 receptor | / | 0.443 | |
| 4bzn | UGX | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.443 | |
| 4cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 4ezl | 0SE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 4h4z | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.443 | |
| 4l49 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 4mf0 | 29Z | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.443 | |
| 4o1g | AGS | Adenosine kinase | 2.7.1.20 | 0.443 | |
| 5cvh | ADP | Casein kinase II subunit alpha | 2.7.11.1 | 0.443 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.443 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1e7v | LY2 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 1pl8 | NAD | Sorbitol dehydrogenase | 1.1.1.14 | 0.442 | |
| 1qxl | FR8 | Adenosine deaminase | 3.5.4.4 | 0.442 | |
| 1rd7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1yhs | STU | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.442 | |
| 2dr3 | ADP | UPF0273 protein PH0284 | / | 0.442 | |
| 2pmn | K51 | Protein kinase 7 | / | 0.442 | |
| 3aez | GDP | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 3fyv | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3lam | KRP | Gag-Pol polyprotein | 2.7.7.49 | 0.442 | |
| 3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.442 | |
| 3u9n | 09H | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 3wv7 | ADP | Hmd co-occurring protein HcgE | / | 0.442 | |
| 4awq | 592 | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 4cuk | NAI | D-lactate dehydrogenase | / | 0.442 | |
| 4gqk | ADP | Actin cross-linking toxin VgrG1 | / | 0.442 | |
| 4i0t | 1B6 | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.442 | |
| 4i2p | G73 | Gag-Pol polyprotein | 2.7.7.49 | 0.442 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.442 | |
| 4klr | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.442 | |
| 5akk | 1P8 | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.442 | |
| 5csh | ATP | Casein kinase II subunit alpha | 2.7.11.1 | 0.442 | |
| 1qxo | FMN | Chorismate synthase | / | 0.441 | |
| 1rc4 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1s0z | EB1 | Vitamin D3 receptor | / | 0.441 | |
| 2e7r | SAH | Diphthine synthase | / | 0.441 | |
| 2hc4 | VDX | Vitamin D3 receptor A | / | 0.441 | |
| 2ph5 | NAD | Homospermidine synthase | / | 0.441 | |
| 2pkn | ACP | Adenosine kinase | 2.7.1.20 | 0.441 | |
| 2y7j | B49 | Phosphorylase b kinase gamma catalytic chain, liver/testis isoform | 2.7.11.19 | 0.441 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.441 | |
| 3cgd | COA | Coenzyme A disulfide reductase | / | 0.441 | |
| 3dmj | GWE | Pol protein | / | 0.441 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 3gph | OID | Cytochrome P450 2E1 | 1.14.13 | 0.441 | |
| 3inx | JZC | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 3jpv | 1DR | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.441 | |
| 3nwq | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 3pd4 | A3G | Threonine--tRNA ligase | 6.1.1.3 | 0.441 | |
| 3zbn | COA | 3-ketoacyl-CoA thiolase-like protein | / | 0.441 | |
| 4bbh | NHW | Glycylpeptide N-tetradecanoyltransferase | / | 0.441 | |
| 4c3y | ANB | 3-ketosteroid dehydrogenase | / | 0.441 | |
| 4dk5 | 0KO | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 4f1s | F1S | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 4i22 | IRE | Epidermal growth factor receptor | 2.7.10.1 | 0.441 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.441 | |
| 4qoe | FAD | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.441 | |
| 4rrh | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.441 | |
| 4u97 | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.441 | |
| 4yau | FAD | NADPH--cytochrome P450 reductase | / | 0.441 | |
| 1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1drb | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1hvy | D16 | Thymidylate synthase | 2.1.1.45 | 0.440 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 2ayr | L4G | Estrogen receptor | / | 0.440 | |
| 2e8q | SAH | Diphthine synthase | / | 0.440 | |
| 2eh5 | SAH | Diphthine synthase | / | 0.440 | |
| 2j9g | ANP | Biotin carboxylase | 6.3.4.14 | 0.440 | |
| 2o12 | FMN | Chorismate synthase | / | 0.440 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 2xiz | XIZ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.440 | |
| 2xke | WI2 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.440 | |
| 2yei | XQI | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.440 | |
| 3c11 | GDM | ATP-dependent molecular chaperone HSP82 | / | 0.440 | |
| 3cd2 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3jw3 | TOP | Dihydrofolate reductase | / | 0.440 | |
| 3qgt | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.440 | |
| 3v49 | PK0 | Androgen receptor | / | 0.440 | |
| 3vt4 | 5YI | Vitamin D3 receptor | / | 0.440 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.440 | |
| 3vtb | TKA | Vitamin D3 receptor | / | 0.440 | |
| 3zux | TCH | Transporter | / | 0.440 | |
| 4b8z | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.440 | |
| 4ezk | 0SD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 4f70 | 0ST | Cyclin-dependent kinase 8 | 2.7.11.22 | 0.440 | |
| 4j4v | SVR | Nucleocapsid protein | / | 0.440 | |
| 4ko0 | JLJ | Gag-Pol polyprotein | 2.7.7.49 | 0.440 | |
| 4riy | ADP | Epidermal growth factor receptor | 2.7.10.1 | 0.440 | |
| 4x5i | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.440 |