Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3i0sRT7Gag-Pol polyprotein2.7.7.49

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3i0sRT7Gag-Pol polyprotein2.7.7.491.000
3i0rRT3Gag-Pol polyprotein2.7.7.490.653
4i7fNVEGag-Pol polyprotein2.7.7.490.625
1rt2TNKGag-Pol polyprotein2.7.7.490.599
3lanKBTGag-Pol polyprotein2.7.7.490.581
3ffi3OBGag-Pol polyprotein2.7.7.490.580
3lamKRPGag-Pol polyprotein2.7.7.490.568
3dleGFAGag-Pol polyprotein2.7.7.490.565
3is9AC7Gag-Pol polyprotein2.7.7.490.565
1hnvTBOGag-Pol polyprotein2.7.7.490.553
1hpzAAPGag-Pol polyprotein2.7.7.490.549
1s1vTNKGag-Pol polyprotein2.7.7.490.549
1klmSPPGag-Pol polyprotein2.7.7.490.548
1tvrTB9Gag-Pol polyprotein2.7.7.490.546
1c1bGCAGag-Pol polyprotein2.7.7.490.544
3nbpJGZGag-Pol polyprotein2.7.7.490.541
3mec65BGag-Pol polyprotein2.7.7.490.535
3m8qDJZGag-Pol polyprotein2.7.7.490.533
3di6PDZGag-Pol polyprotein2.7.7.490.531
1ep4S11Gag-Pol polyprotein2.7.7.490.526
1eetBFUGag-Pol polyprotein2.7.7.490.524
1revTB9Gag-Pol polyprotein2.7.7.490.523
1hquHBYGag-Pol polyprotein2.7.7.490.519
1jlaTNKGag-Pol polyprotein2.7.7.490.519
3irxUDRGag-Pol polyprotein2.7.7.490.518
2ban357Gag-Pol polyprotein2.7.7.490.516
2rf2MRXGag-Pol polyprotein2.7.7.490.515
3dmjGWEPol protein/0.515
3dolGWIPol protein/0.515
3megT27Gag-Pol polyprotein2.7.7.490.514
1tl1H18Gag-Pol polyprotein2.7.7.490.508
3m8p65BGag-Pol polyprotein2.7.7.490.508
1tktH12Gag-Pol polyprotein2.7.7.490.507
2ze2T27Gag-Pol polyprotein2.7.7.490.505
1s9eADBGag-Pol polyprotein2.7.7.490.503
1ikvEFZGag-Pol polyprotein2.7.7.490.500
5cyqT27Gag-Pol polyprotein2.7.7.490.500
1vruAAPGag-Pol polyprotein2.7.7.490.499
1ikwEFZGag-Pol polyprotein2.7.7.490.498
3med65BGag-Pol polyprotein2.7.7.490.496
1rt4UC1Gag-Pol polyprotein2.7.7.490.495
1rtiHEFGag-Pol polyprotein2.7.7.490.495
1s1wUC1Gag-Pol polyprotein2.7.7.490.493
1c1c612Gag-Pol polyprotein2.7.7.490.492
1hniAAAGag-Pol polyprotein2.7.7.490.489
3e01PZ2Gag-Pol polyprotein2.7.7.490.489
3tamM06Gag-Pol polyprotein2.7.7.490.488
3meeT27Gag-Pol polyprotein2.7.7.490.485
3drrR8EGag-Pol polyprotein2.7.7.490.483
1s6qTPBGag-Pol polyprotein2.7.7.490.481
4lsl1YQGag-Pol polyprotein2.7.7.490.481
1rt5UC2Gag-Pol polyprotein2.7.7.490.480
1tkzH16Gag-Pol polyprotein2.7.7.490.478
2jleI15Reverse transcriptase/RNaseH/0.478
2vn0TDZCytochrome P450 2C8/0.478
3t195MAGag-Pol polyprotein2.7.7.490.478
1rt1MKCGag-Pol polyprotein2.7.7.490.477
3be9P04Casein kinase II subunit alpha2.7.11.10.477
1jlcFTCGag-Pol polyprotein2.7.7.490.476
2vg7NNIGag-Pol polyprotein2.7.7.490.476
3hx4ANPCalmodulin-domain protein kinase 1/0.476
3qaiXNNKetohexokinase/0.476
2pvnP63Casein kinase II subunit alpha2.7.11.10.475
2ic3HBYGag-Pol polyprotein2.7.7.490.473
3qa2XNAKetohexokinase/0.473
4i2q1BTGag-Pol polyprotein2.7.7.490.472
1om1IQACasein kinase II subunit alpha2.7.11.10.470
4fki09KCyclin-dependent kinase 22.7.11.220.470
4ko0JLJGag-Pol polyprotein2.7.7.490.470
4id5T27Gag-Pol polyprotein2.7.7.490.469
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.469
3rmf20ZCyclin-dependent kinase 22.7.11.220.466
2vttLZDCyclin-dependent kinase 22.7.11.220.464
3owaFADAcyl-CoA dehydrogenase/0.464
4ig3T27Gag-Pol polyprotein2.7.7.490.463
3dyaPZLGag-Pol polyprotein2.7.7.490.461
1oirHDYCyclin-dependent kinase 22.7.11.220.460
4anmWULCasein kinase II subunit alpha2.7.11.10.460
4dgnLU2Casein kinase II subunit alpha2.7.11.10.460
4kko1REGag-Pol polyprotein2.7.7.490.460
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.459
3eb0DRKUncharacterized protein/0.459
4fkv61KCyclin-dependent kinase 22.7.11.220.459
1jlqSBNGag-Pol polyprotein2.7.7.490.458
1ikyMSDGag-Pol polyprotein2.7.7.490.457
1ykdCMPAdenylate cyclase/0.457
4mfb29TGag-Pol polyprotein2.7.7.490.457
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.455
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.455
2j3jHC4NADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.454
3lj3WYEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.454
2b365PPEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.453
2rkiTT1Gag-Pol polyprotein2.7.7.490.453
3qu0X40Cyclin-dependent kinase 22.7.11.220.453
4mq22C4Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.453
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.452
2ynfWHUGag-Pol polyprotein2.7.7.490.452
3nc9TR3Ketohexokinase/0.452
3q92XNBKetohexokinase/0.452
3triNAPPyrroline-5-carboxylate reductase/0.452
1gii1PUCyclin-dependent kinase 22.7.11.220.451
1aq1STUCyclin-dependent kinase 22.7.11.220.450
2b52D42Cyclin-dependent kinase 22.7.11.220.450
2hqpNDPDihydrofolate reductase1.5.1.30.450
2hw1ANPKetohexokinase/0.450
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.450
3vt8YI3Vitamin D3 receptor/0.450
2cig1DGDihydrofolate reductase1.5.1.30.449
2iw94SPCyclin-dependent kinase 22.7.11.220.448
2j09FMNDeoxyribodipyrimidine photo-lyase4.1.99.30.448
2xvv9DNSerum albumin/0.448
3nbvANPKetohexokinase/0.448
3wmxNADNAD dependent epimerase/dehydratase/0.448
4fkpLS5Cyclin-dependent kinase 22.7.11.220.448
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.447
3cs8BRLPeroxisome proliferator-activated receptor gamma/0.447
3pe6ZYHMonoglyceride lipase/0.447
1cqp803Integrin alpha-L/0.446
1urwI1PCyclin-dependent kinase 22.7.11.220.446
2ynhEURGag-Pol polyprotein2.7.7.490.446
3hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.446
3nr4PYVAbscisic acid receptor PYL2/0.446
3rpv26ZCyclin-dependent kinase 22.7.11.220.446
4c58824Cyclin-G-associated kinase2.7.11.10.446
4ig01FGGag-Pol polyprotein2.7.7.490.446
4jq8KJ8Epidermal growth factor receptor2.7.10.10.446
5bsfNADPyrroline-5-carboxylate reductase/0.446
2a0cCK9Cyclin-dependent kinase 22.7.11.220.445
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.445
2zjwREFCasein kinase II subunit alpha2.7.11.10.445
3r8pZ46Cyclin-dependent kinase 22.7.11.220.445
3r9oZ71Cyclin-dependent kinase 22.7.11.220.445
4aotGW8Serine/threonine-protein kinase 102.7.11.10.445
3l9nL9NcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
3lfnA27Cyclin-dependent kinase 22.7.11.220.444
3rak03ZCyclin-dependent kinase 22.7.11.220.444
1fkoEFZGag-Pol polyprotein2.7.7.490.443
2ejvNADL-threonine 3-dehydrogenase/0.443
2gr1FADFerredoxin reductase/0.443
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.443
2zv2609Calcium/calmodulin-dependent protein kinase kinase 22.7.11.170.443
4dbzNDPPutative ketoacyl reductase1.3.10.443
4h4uNDPBiphenyl dioxygenase ferredoxin reductase subunit/0.443
1oiyN41Cyclin-dependent kinase 22.7.11.220.442
1tkxGWBGag-Pol polyprotein2.7.7.490.442
2wufKEM4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase3.7.1.170.442
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.442
3ezvEZVCyclin-dependent kinase 22.7.11.220.442
3s1h56ZCyclin-dependent kinase 22.7.11.220.442
1f28UMPThymidylate synthase2.1.1.450.441
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.441
3qrwNDPPutative ketoacyl reductase1.3.10.441
3v9y24LPeroxisome proliferator-activated receptor gamma/0.441
4dgmAGICasein kinase II subunit alpha2.7.11.10.441
4ux9ANPMitogen-activated protein kinase 82.7.11.240.441
5bsgNAPPyrroline-5-carboxylate reductase/0.441
1jlgUC1Gag-Pol polyprotein2.7.7.490.440
1oitHDTCyclin-dependent kinase 22.7.11.220.440
1zy8FADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.440
2q59240Peroxisome proliferator-activated receptor gamma/0.440
3thrC2FGlycine N-methyltransferase2.1.1.200.440
3zw9NADPeroxisomal bifunctional enzyme1.1.1.350.440
4b4oNDPEpimerase family protein SDR39U1/0.440
4ebfNADPhosphonate dehydrogenase1.20.1.10.440
4ek816KCyclin-dependent kinase 22.7.11.220.440
4tuvCPZCytochrome P450 1191.140.440
4wsqKSAAP2-associated protein kinase 12.7.11.10.440