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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3hxfBD9Geranylgeranyl transferase type-2 subunit beta2.5.1.60

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3hxfBD9Geranylgeranyl transferase type-2 subunit beta2.5.1.601.000
3pz23PZGeranylgeranyl transferase type-2 subunit beta2.5.1.600.530
2h6iCYS_VAL_LEU_SER_GERProtein farnesyltransferase subunit beta2.5.1.580.487
3pz3PZ3Geranylgeranyl transferase type-2 subunit beta2.5.1.600.480
3e33ED7Protein farnesyltransferase subunit beta2.5.1.580.476
3e30ED4Protein farnesyltransferase subunit beta2.5.1.580.470
1n95HFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.468
1n95HFPProtein farnesyltransferase subunit beta2.5.1.580.468
1s63778Protein farnesyltransferase subunit beta2.5.1.580.467
1n95FTHProtein farnesyltransferase subunit beta2.5.1.580.466
1sa4JANProtein farnesyltransferase subunit beta2.5.1.580.466
1jcq739Protein farnesyltransferase subunit beta2.5.1.580.465
1n4qLYS_CYS_VAL_ILE_LEUGeranylgeranyl transferase type-1 subunit beta2.5.1.590.464
1mzcBNEProtein farnesyltransferase subunit beta2.5.1.580.460
1s64778Geranylgeranyl transferase type-1 subunit beta2.5.1.590.458
1n4sCYS_VAL_ILE_LEU_GERGeranylgeranyl transferase type-1 subunit beta2.5.1.590.457
4gtr7TRProtein farnesyltransferase subunit beta2.5.1.580.455
3eu5GBOProtein farnesyltransferase subunit beta2.5.1.580.454
1nl4HFPProtein farnesyltransferase subunit beta2.5.1.580.453
3hxeBD8Geranylgeranyl transferase type-2 subunit beta2.5.1.600.453
3e32ED2Protein farnesyltransferase subunit beta2.5.1.580.451
3pz43PZProtein farnesyltransferase subunit beta2.5.1.580.445
1o1s1NHProtein farnesyltransferase subunit beta2.5.1.580.441
3ksqZ96Protein farnesyltransferase subunit beta2.5.1.580.441
4gtm7TMProtein farnesyltransferase subunit beta2.5.1.580.441
1sa5BMVProtein farnesyltransferase subunit beta2.5.1.580.440