sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3hv7 | 1AU | Mitogen-activated protein kinase 14 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3hv7 | 1AU | Mitogen-activated protein kinase 14 | / | 1.000 | |
| 3hv6 | R39 | Mitogen-activated protein kinase 14 | / | 0.708 | |
| 3p5k | P5K | Mitogen-activated protein kinase 14 | / | 0.650 | |
| 3k3j | F4C | Mitogen-activated protein kinase 14 | / | 0.638 | |
| 3p7b | P7B | Mitogen-activated protein kinase 14 | / | 0.636 | |
| 2puu | G2G | Mitogen-activated protein kinase 14 | / | 0.631 | |
| 3uvr | 06F | Mitogen-activated protein kinase 14 | / | 0.618 | |
| 3p79 | P79 | Mitogen-activated protein kinase 14 | / | 0.611 | |
| 4l8m | F46 | Mitogen-activated protein kinase 14 | / | 0.611 | |
| 1kv1 | BMU | Mitogen-activated protein kinase 14 | / | 0.602 | |
| 3nnx | EDD | Mitogen-activated protein kinase 14 | / | 0.601 | |
| 3gi3 | B10 | Mitogen-activated protein kinase 14 | / | 0.596 | |
| 1kv2 | B96 | Mitogen-activated protein kinase 14 | / | 0.593 | |
| 3gcu | R48 | Mitogen-activated protein kinase 14 | / | 0.583 | |
| 3o8u | BMU | Mitogen-activated protein kinase 14 | / | 0.583 | |
| 2yis | YIS | Mitogen-activated protein kinase 14 | / | 0.572 | |
| 3p78 | P78 | Mitogen-activated protein kinase 14 | / | 0.558 | |
| 1wbt | WBT | Mitogen-activated protein kinase 14 | / | 0.553 | |
| 3p7a | P7A | Mitogen-activated protein kinase 14 | / | 0.552 | |
| 1wbv | LI3 | Mitogen-activated protein kinase 14 | / | 0.551 | |
| 3nnu | EDB | Mitogen-activated protein kinase 14 | / | 0.547 | |
| 1wbs | LI2 | Mitogen-activated protein kinase 14 | / | 0.545 | |
| 3ugc | 046 | Tyrosine-protein kinase JAK2 | / | 0.543 | |
| 3kq7 | KQ7 | Mitogen-activated protein kinase 14 | / | 0.539 | |
| 3e93 | 19B | Mitogen-activated protein kinase 14 | / | 0.538 | |
| 3npc | B96 | Mitogen-activated protein kinase 9 | 2.7.11.24 | 0.538 | |
| 4aa0 | AA0 | Mitogen-activated protein kinase 14 | / | 0.536 | |
| 1wbn | L09 | Mitogen-activated protein kinase 14 | / | 0.535 | |
| 2yiw | YIW | Mitogen-activated protein kinase 14 | / | 0.534 | |
| 3hv4 | L51 | Mitogen-activated protein kinase 14 | / | 0.533 | |
| 1w82 | L10 | Mitogen-activated protein kinase 14 | / | 0.529 | |
| 4u0i | 0LI | Mast/stem cell growth factor receptor Kit | 2.7.10.1 | 0.521 | |
| 2e2b | 406 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.506 | |
| 3p7c | P7C | Mitogen-activated protein kinase 14 | / | 0.503 | |
| 3d83 | GK6 | Mitogen-activated protein kinase 14 | / | 0.502 | |
| 4h1m | 0YJ | Protein-tyrosine kinase 2-beta | 2.7.10.2 | 0.500 | |
| 3vhe | 42Q | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.496 | |
| 2hiw | 7MP | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.494 | |
| 2hz0 | GIN | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.494 | |
| 5hi2 | BAX | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.492 | |
| 4fc0 | 0T2 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.490 | |
| 3nnw | EDD | Mitogen-activated protein kinase 14 | / | 0.489 | |
| 3wze | BAX | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.489 | |
| 2bts | U32 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.486 | |
| 5hid | B1E | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.482 | |
| 3cs9 | NIL | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.481 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.481 | |
| 4h4x | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.478 | |
| 3bu5 | ATP | Insulin receptor | 2.7.10.1 | 0.477 | |
| 3gcv | SS6 | Mitogen-activated protein kinase 14 | / | 0.475 | |
| 1c6x | 3IN | Protease | / | 0.474 | |
| 3ed1 | GA3 | Gibberellin receptor GID1 | / | 0.474 | |
| 4g1w | G1W | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.474 | |
| 3lfb | Z87 | Mitogen-activated protein kinase 14 | / | 0.471 | |
| 1xl2 | 189 | Gag-Pol polyprotein | 3.4.23.16 | 0.470 | |
| 2r38 | G4G | Gag-Pol polyprotein | 3.4.23.16 | 0.470 | |
| 2vwp | NDP | Glucose 1-dehydrogenase | / | 0.470 | |
| 3aid | ARQ | Gag-Pol polyprotein | 3.4.23.16 | 0.470 | |
| 3orz | BI4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.470 | |
| 4h4r | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.470 | |
| 2pml | ANP | Uncharacterized protein | / | 0.469 | |
| 3vnt | 0JA | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.469 | |
| 1j39 | UPG | DNA beta-glucosyltransferase | / | 0.468 | |
| 1e1l | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.467 | |
| 1uvr | BI8 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.467 | |
| 2xbj | XBJ | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.467 | |
| 3nu3 | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.467 | |
| 2gr1 | FAD | Ferredoxin reductase | / | 0.466 | |
| 4n6h | EJ4 | Delta-type opioid receptor | / | 0.466 | |
| 3niz | ADP | Cdc2-like CDK2/CDC28 like protein kinase | / | 0.465 | |
| 4dqc | 017 | Gag-Pol polyprotein | / | 0.465 | |
| 4jrn | ANP | Rhoptry kinase family protein | / | 0.465 | |
| 1n07 | FMN | Riboflavin kinase | 2.7.1.26 | 0.464 | |
| 1uu7 | BI2 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.464 | |
| 3ekx | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.464 | |
| 4k1b | 1OC | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.464 | |
| 4ks8 | B49 | Serine/threonine-protein kinase PAK 6 | 2.7.11.1 | 0.464 | |
| 1hos | PHP | Gag-Pol polyprotein | / | 0.463 | |
| 1meu | DMP | Gag-Pol polyprotein | 3.4.23.16 | 0.463 | |
| 1mrw | K57 | Gag-Pol polyprotein | 3.4.23.16 | 0.463 | |
| 2hma | SAM | tRNA-specific 2-thiouridylase MnmA | / | 0.463 | |
| 3a99 | ANP | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.463 | |
| 3el4 | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.463 | |
| 4eom | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.463 | |
| 1q3q | ANP | Thermosome subunit alpha | / | 0.462 | |
| 1wvy | STU | Death-associated protein kinase 1 | 2.7.11.1 | 0.462 | |
| 4eyj | N61 | Mitogen-activated protein kinase 13 | 2.7.11.24 | 0.462 | |
| 3qak | UKA | Adenosine receptor A2a | / | 0.462 | |
| 2eb3 | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.461 | |
| 3el5 | 1UN | Gag-Pol polyprotein | / | 0.461 | |
| 3zpu | M8B | Gag-Pol polyprotein | 3.4.23.16 | 0.461 | |
| 4dk5 | 0KO | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.461 | |
| 1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.460 | |
| 2wtc | VGM | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.460 | |
| 3c50 | ADP | Rhodopsin kinase | / | 0.460 | |
| 3gvu | STI | Abelson tyrosine-protein kinase 2 | 2.7.10.2 | 0.460 | |
| 3ufn | ROC | Gag-Pol polyprotein | / | 0.460 | |
| 4bdg | P3J | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.460 | |
| 4ccb | OFG | ALK tyrosine kinase receptor | 2.7.10.1 | 0.460 | |
| 1c6y | MK1 | Protease | / | 0.459 | |
| 1mdu | ATP | Actin, alpha skeletal muscle | / | 0.459 | |
| 1sh9 | RIT | Gag-Pol polyprotein | 3.4.23.16 | 0.459 | |
| 3c4w | ATP | Rhodopsin kinase | / | 0.459 | |
| 4eh6 | 0ON | Mitogen-activated protein kinase 14 | / | 0.459 | |
| 4hw7 | 64M | Macrophage colony-stimulating factor 1 receptor | 2.7.10.1 | 0.459 | |
| 4s32 | ANP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.459 | |
| 5av3 | KMP | Death-associated protein kinase 1 | 2.7.11.1 | 0.459 | |
| 1mer | DMQ | Gag-Pol polyprotein | 3.4.23.16 | 0.458 | |
| 1wvx | BD4 | Death-associated protein kinase 1 | 2.7.11.1 | 0.458 | |
| 2y9q | ANP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.458 | |
| 3nu9 | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.458 | |
| 3o9a | K14 | Pol polyprotein | / | 0.458 | |
| 1cm8 | ANP | Mitogen-activated protein kinase 12 | / | 0.457 | |
| 1xr1 | ANP | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.457 | |
| 2hog | 710 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.457 | |
| 2qkr | IXM | Cdc2-like CDK2/CDC28 like protein kinase | / | 0.457 | |
| 2vgp | AD6 | Aurora kinase B-A | 2.7.11.1 | 0.457 | |
| 3cjg | KIM | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.457 | |
| 3nwx | KVS | Gag-Pol polyprotein | 3.4.23.16 | 0.457 | |
| 3qrt | X14 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.457 | |
| 4rqk | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.457 | |
| 1k6v | XN2 | Gag-Pol polyprotein | 3.4.23.16 | 0.456 | |
| 1t7j | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.456 | |
| 2r3w | G3G | Gag-Pol polyprotein | 3.4.23.16 | 0.456 | |
| 4h4u | NDP | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.456 | |
| 4ic7 | ANP | Mitogen-activated protein kinase 7 | 2.7.11.24 | 0.456 | |
| 1d4h | BEH | Gag-Pol polyprotein | 3.4.23.16 | 0.455 | |
| 2b9i | ADP | Mitogen-activated protein kinase FUS3 | 2.7.11.24 | 0.455 | |
| 2brh | DFW | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.455 | |
| 2hs2 | 017 | Protease | / | 0.455 | |
| 2phk | ATP | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform | 2.7.11.19 | 0.455 | |
| 2vtn | LZ7 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.455 | |
| 3tl9 | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.455 | |
| 3v01 | 3V0 | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.455 | |
| 4eh9 | 0OQ | Mitogen-activated protein kinase 14 | / | 0.455 | |
| 4g17 | 0VN | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.455 | |
| 4l3j | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.455 | |
| 3uzc | T4E | Adenosine receptor A2a | / | 0.455 | |
| 1bdr | IM1 | Gag-Pol polyprotein | 3.4.23.16 | 0.454 | |
| 1c6z | ROC | Protease | / | 0.454 | |
| 1ir3 | ANP | Insulin receptor | 2.7.10.1 | 0.454 | |
| 2b7z | MK1 | Gag-Pol polyprotein | / | 0.454 | |
| 3em6 | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.454 | |
| 3qih | FG7 | Gag-Pol polyprotein | 3.4.23.16 | 0.454 | |
| 4j33 | FAD | Kynurenine 3-monooxygenase | / | 0.454 | |
| 4ksp | 1SU | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.454 | |
| 4rvo | ADP | Phenylacetate-coenzyme A ligase | / | 0.454 | |
| 1pf9 | ADP | 60 kDa chaperonin | / | 0.453 | |
| 2bpx | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 2br1 | PFP | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.453 | |
| 2gst | GPS | Glutathione S-transferase Mu 1 | 2.5.1.18 | 0.453 | |
| 3ckt | YDP | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 4ehv | 0SJ | Mitogen-activated protein kinase 14 | / | 0.453 | |
| 4iwo | 1H4 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.453 | |
| 4ki8 | ADP | 60 kDa chaperonin | / | 0.453 | |
| 4q1x | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 1z1r | HBH | Gag-Pol polyprotein | 3.4.23.16 | 0.452 | |
| 2pyn | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.452 | |
| 2vo0 | M03 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.452 | |
| 3kkv | B99 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.452 | |
| 3pwr | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.452 | |
| 3uvp | 048 | Mitogen-activated protein kinase 14 | / | 0.452 | |
| 4a6b | QG8 | Gag-Pol polyprotein | 3.4.23.16 | 0.452 | |
| 4f64 | 0S8 | Fibroblast growth factor receptor 1 | / | 0.452 | |
| 4feq | 0T8 | Tyrosine-protein kinase receptor TYRO3 | 2.7.10.1 | 0.452 | |
| 4fmq | ANP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.452 | |
| 4q1y | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.452 | |
| 4zgn | ATP | Cell division cycle protein 123 | / | 0.452 | |
| 1hii | C20 | Gag-Pol polyprotein | / | 0.451 | |
| 1k6p | XN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 1z1h | HBB | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 1zar | ADP | RIO-type serine/threonine-protein kinase Rio2 | 2.7.11.1 | 0.451 | |
| 2b55 | D31 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.451 | |
| 2qi5 | MZ7 | Gag-Pol polyprotein | / | 0.451 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.451 | |
| 2uxz | HI1 | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 3el9 | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 3epo | MP5 | Phosphomethylpyrimidine synthase | / | 0.451 | |
| 3zsh | 469 | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 4c8b | 0LI | Receptor-interacting serine/threonine-protein kinase 2 | 2.7.11.1 | 0.451 | |
| 4fv9 | E71 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.451 | |
| 4yhj | AN2 | G protein-coupled receptor kinase 4 | 2.7.11.16 | 0.451 | |
| 1k6c | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 1kxp | ATP | Actin, alpha skeletal muscle | / | 0.450 | |
| 1kzk | JE2 | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 1m17 | AQ4 | Epidermal growth factor receptor | 2.7.10.1 | 0.450 | |
| 1tvo | FRZ | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.450 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.450 | |
| 2avv | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 2duv | 371 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.450 | |
| 2itp | AEE | Epidermal growth factor receptor | 2.7.10.1 | 0.450 | |
| 2izs | BRQ | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.450 | |
| 2pwc | G3G | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 3a62 | STU | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.450 | |
| 4h4z | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.450 | |
| 4l44 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.450 | |
| 5av2 | KMP | Death-associated protein kinase 1 | 2.7.11.1 | 0.450 | |
| 1csn | ATP | Casein kinase I homolog 1 | 2.7.11.1 | 0.449 | |
| 2bpv | 1IN | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 2itx | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.449 | |
| 2q55 | MU0 | Protease | / | 0.449 | |
| 2qhc | AB1 | Protease | / | 0.449 | |
| 2qi6 | MZ8 | Gag-Pol polyprotein | / | 0.449 | |
| 2xcl | ANP | Phosphoribosylamine--glycine ligase | / | 0.449 | |
| 3kfs | 3TL | Gag-Pol polyprotein | / | 0.449 | |
| 4fux | E75 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.449 | |
| 1a8g | 2Z4 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 1hpx | KNI | Gag-Pol polyprotein | / | 0.448 | |
| 1hsg | MK1 | Gag-Pol polyprotein | / | 0.448 | |
| 1zth | ADP | RIO-type serine/threonine-protein kinase Rio1 | 2.7.11.1 | 0.448 | |
| 2qi4 | MZ6 | Gag-Pol polyprotein | / | 0.448 | |
| 2r43 | G3G | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 3i7e | DJR | Gag-Pol polyprotein | / | 0.448 | |
| 3l08 | ZIG | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.448 | |
| 3tkh | 07S | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.448 | |
| 3zpt | M8Y | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 4ft7 | H3K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.448 | |
| 4j5j | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 4kbk | 1QG | Casein kinase I isoform delta | 2.7.11.1 | 0.448 | |
| 4o2z | 046 | Mitogen-activated protein kinase | / | 0.448 | |
| 1d4j | MSC | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 1jst | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 1k2c | 0Q4 | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 1qcj | APT | Antiviral protein I | 3.2.2.22 | 0.447 | |
| 1rdw | LAR | Actin, alpha skeletal muscle | / | 0.447 | |
| 1uu3 | LY4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.447 | |
| 1wbk | 568 | Pol protein | / | 0.447 | |
| 1yt9 | OIS | Gag-Pol polyprotein | / | 0.447 | |
| 2pqz | G0G | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 2pym | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 3ml8 | ML8 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.447 | |
| 3nu5 | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 3nwq | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 3o9h | K2E | Gag-Pol polyprotein | / | 0.447 | |
| 3pm9 | FAD | Putative oxidoreductase | / | 0.447 | |
| 3r1s | X73 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.447 | |
| 4ii5 | ADP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 4jq7 | KJQ | Epidermal growth factor receptor | 2.7.10.1 | 0.447 | |
| 4xlv | ACP | Insulin receptor | 2.7.10.1 | 0.447 | |
| 1mc5 | AHE | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.446 | |
| 1mru | AGS | Serine/threonine-protein kinase PknB | 2.7.11.1 | 0.446 | |
| 1ohr | 1UN | V-1 PROTEASE protein | / | 0.446 | |
| 1sx4 | ADP | 60 kDa chaperonin | / | 0.446 | |
| 2b9f | ADP | Mitogen-activated protein kinase FUS3 | 2.7.11.24 | 0.446 | |
| 2c3l | IDZ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.446 | |
| 2hxl | 422 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.446 | |
| 2p55 | MRA | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.446 | |
| 2qi0 | MZ3 | Gag-Pol polyprotein | / | 0.446 | |
| 3i64 | DNA | 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase | / | 0.446 | |
| 3orm | AGS | Serine/threonine protein kinase | / | 0.446 | |
| 3qp0 | NI8 | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 4a99 | FAD | TetX family tetracycline inactivation enzyme | / | 0.446 | |
| 4an9 | 2P7 | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.446 | |
| 4fsu | HK5 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.446 | |
| 4j36 | FAD | Kynurenine 3-monooxygenase | / | 0.446 | |
| 4l2i | FAD | Electron transfer flavoprotein alpha/beta-subunit | / | 0.446 | |
| 4lj7 | MNT | Chaperone protein ClpB | / | 0.446 | |
| 4nm9 | FAD | Bifunctional protein PutA | / | 0.446 | |
| 5dhh | DGW | Nociceptin receptor | / | 0.446 | |
| 1sdu | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 1w5v | BE3 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 2bpw | 1IN | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 2bpy | 3IN | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 2brb | PFQ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 2hxq | 373 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 2hy0 | 306 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 2wti | WTI | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.445 | |
| 2y8q | ADP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.445 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 3gu7 | ADP | Death-associated protein kinase 1 | 2.7.11.1 | 0.445 | |
| 3ijw | ACO | Aminoglycoside N3-acetyltransferase | / | 0.445 | |
| 3mxd | K53 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 3nuu | JOZ | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.445 | |
| 3qbf | JHG | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 4kh0 | ATP | Aspartate carbamoyltransferase regulatory chain {ECO:0000256|HAMAP-Rule:MF_00002} | / | 0.445 | |
| 4yzc | STU | Serine/threonine-protein kinase/endoribonuclease IRE1 | 2.7.11.1 | 0.445 | |
| 1e8z | STU | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 1e90 | MYC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 1mui | AB1 | Protease | / | 0.444 | |
| 1o6y | ACP | Serine/threonine-protein kinase PknB | 2.7.11.1 | 0.444 | |
| 2b9j | ADP | Mitogen-activated protein kinase FUS3 | 2.7.11.24 | 0.444 | |
| 2qd8 | 065 | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 3chw | ATP | Major actin | / | 0.444 | |
| 3hz1 | 42C | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 3n0t | OPY | Dipeptidyl peptidase 2 | 3.4.14.2 | 0.444 | |
| 3o99 | K13 | Pol polyprotein | / | 0.444 | |
| 3sa9 | A68 | Protease | / | 0.444 | |
| 4l9i | 8PR | Rhodopsin kinase | / | 0.444 | |
| 4q5j | ANP | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.444 | |
| 1lhv | NOG | Sex hormone-binding globulin | / | 0.443 | |
| 1qbr | XV6 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 1sgu | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 2hzn | KIN | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.443 | |
| 2qqf | A1R | NAD-dependent protein deacetylase HST2 | 3.5.1 | 0.443 | |
| 2wou | ZZF | TGF-beta receptor type-1 | 2.7.11.30 | 0.443 | |
| 2x5z | GDD | Mannose-1-phosphate guanylyltransferase | / | 0.443 | |
| 3djk | G55 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 3el1 | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 3kfn | 3TL | Gag-Pol polyprotein | / | 0.443 | |
| 3lzv | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 3o9g | F53 | Gag-Pol polyprotein | / | 0.443 | |
| 3rga | LSB | Epoxide hydrolase LasB | 5.5.1 | 0.443 | |
| 4anv | 751 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 4ezj | 0SC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 4hvb | 19P | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.443 | |
| 5ack | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.443 | |
| 1d4l | PI9 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 1ivq | 0PX | Gag-Pol polyprotein | / | 0.442 | |
| 1ovm | TPP | Indole-3-pyruvate decarboxylase | 4.1.1.74 | 0.442 | |
| 1u3d | FAD | Cryptochrome-1 | / | 0.442 | |
| 2a5u | QYT | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 2brm | DFZ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 2pwr | G4G | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 2uw4 | L15 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.442 | |
| 3e8e | G98 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.442 | |
| 3ekv | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 3gst | GPR | Glutathione S-transferase Mu 1 | 2.5.1.18 | 0.442 | |
| 3kfr | 3TL | Gag-Pol polyprotein | / | 0.442 | |
| 3o9d | K19 | Pol polyprotein | / | 0.442 | |
| 3os3 | 3OS | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.442 | |
| 3s2a | 2NQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 4c9p | CAM | Cytochrome P450 | / | 0.442 | |
| 4dta | ADN | APH(2'')-Id | / | 0.442 | |
| 4fsm | HK1 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 4hni | 16W | Casein kinase I isoform epsilon | 2.7.11.1 | 0.442 | |
| 4otp | ADP | Serine/threonine-protein kinase RIO1 | 2.7.11.1 | 0.442 | |
| 4wq5 | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.442 | |
| 5eku | SAH | Arginine N-methyltransferase, putative | / | 0.442 | |
| 3uza | T4G | Adenosine receptor A2a | / | 0.442 | |
| 1dmp | DMQ | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 1eby | BEB | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 2gn9 | UPG | UDP-N-acetylglucosamine 4,6-dehydratase (inverting) | 4.2.1.115 | 0.441 | |
| 2gqw | FAD | Ferredoxin reductase | / | 0.441 | |
| 2i4x | KGQ | Protease | / | 0.441 | |
| 2itn | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.441 | |
| 2nnp | ROC | Protease | / | 0.441 | |
| 2q5k | AB1 | Protease | / | 0.441 | |
| 2qak | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 2uy0 | HV1 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 2wl0 | 5AH | Gag-Pol polyprotein | / | 0.441 | |
| 3bhe | BZN | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 3fpb | CZA | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.441 | |
| 3nu6 | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 3otu | BI4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.441 | |
| 3qih | NI7 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 3vjo | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.441 | |
| 3we4 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.441 | |
| 4asd | BAX | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.441 | |
| 4dqh | 017 | Gag-Pol polyprotein | / | 0.441 | |
| 4l42 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.441 | |
| 4z69 | DIF | Serum albumin | / | 0.441 | |
| 1bwa | XV6 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 1di8 | DTQ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 1hpo | UNI | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 1hvi | A77 | Protease | / | 0.440 | |
| 1hxw | RIT | Gag-Pol polyprotein | / | 0.440 | |
| 1mes | DMP | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 1nmd | ATP | Major actin | / | 0.440 | |
| 1ojt | FAD | Dihydrolipoyl dehydrogenase | / | 0.440 | |
| 1szc | CNA | NAD-dependent protein deacetylase HST2 | 3.5.1 | 0.440 | |
| 1t1r | IMB | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.440 | |
| 2e9v | 85A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 2f8g | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 2q64 | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 2qnp | QN2 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 2qnq | QN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 2r5q | 1UN | Gag-Pol polyprotein | / | 0.440 | |
| 2vo3 | M04 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 2w0j | ZAT | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.440 | |
| 2wtd | ZZK | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.440 | |
| 2ycs | NXP | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.440 | |
| 3b8r | 887 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.440 | |
| 3e8n | VRA | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.440 | |
| 3tm5 | SFG | Uncharacterized protein | / | 0.440 | |
| 3tu5 | ATP | Actin, alpha skeletal muscle | / | 0.440 | |
| 4e73 | 0NR | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.440 | |
| 4h4t | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.440 | |
| 4nt0 | 3DU | Orotidine 5'-phosphate decarboxylase | 4.1.1.23 | 0.440 | |
| 4oau | ADP | 2-5A-dependent ribonuclease | 3.1.26 | 0.440 |