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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3hub469Mitogen-activated protein kinase 14

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3hub469Mitogen-activated protein kinase 14/1.000
3fl4FL4Mitogen-activated protein kinase 14/0.555
3zsh469Mitogen-activated protein kinase 14/0.553
2gfsPQBMitogen-activated protein kinase 14/0.551
3fknFKNMitogen-activated protein kinase 14/0.540
3ds6A17Mitogen-activated protein kinase 14/0.534
3fkoFKOMitogen-activated protein kinase 14/0.530
1zzlTZYMitogen-activated protein kinase 14/0.514
3hp552PMitogen-activated protein kinase 14/0.502
3hng8STVascular endothelial growth factor receptor 12.7.10.10.486
3fmmXI2Mitogen-activated protein kinase 14/0.485
3c5uP41Mitogen-activated protein kinase 14/0.481
3mpaSB2Mitogen-activated protein kinase 14/0.480
3itzP66Mitogen-activated protein kinase 14/0.474
1wbwLI4Mitogen-activated protein kinase 14/0.463
3vnt0JAVascular endothelial growth factor receptor 22.7.10.10.460
1w7h3IPMitogen-activated protein kinase 14/0.458
3efl706Vascular endothelial growth factor receptor 22.7.10.10.458
4eyjN61Mitogen-activated protein kinase 132.7.11.240.452
3cp9C19Vascular endothelial growth factor receptor 22.7.10.10.451
4o2z046Mitogen-activated protein kinase/0.451
3ha85JZMitogen-activated protein kinase 14/0.449
3uvqFS8Mitogen-activated protein kinase 14/0.448
3hv5R24Mitogen-activated protein kinase 14/0.447
3dtwA96Vascular endothelial growth factor receptor 22.7.10.10.446
4aseAV9Vascular endothelial growth factor receptor 22.7.10.10.446
3eta351Insulin receptor2.7.10.10.445
3sgx0FWDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.444
1iepSTITyrosine-protein kinase ABL12.7.10.20.442
3lfcZ86Mitogen-activated protein kinase 14/0.441
1ove358Mitogen-activated protein kinase 14/0.440
2yixYIXMitogen-activated protein kinase 14/0.440