Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3hmm855TGF-beta receptor type-12.7.11.30

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3hmm855TGF-beta receptor type-12.7.11.301.000
1vjy460TGF-beta receptor type-12.7.11.300.678
3gxlQIGTGF-beta receptor type-12.7.11.300.672
4bgg844Activin receptor type-12.7.11.300.520
1eh4IC1Casein kinase I homolog 12.7.11.10.518
3mtfA3FActivin receptor type-12.7.11.300.512
3uyt0CKCasein kinase I isoform delta2.7.11.10.511
4dymIYZActivin receptor type-12.7.11.300.511
5e8ySTUTGF-beta receptor type-22.7.11.300.511
2wotZZGTGF-beta receptor type-12.7.11.300.507
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.507
2w17I19Cyclin-dependent kinase 22.7.11.220.495
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.495
2wouZZFTGF-beta receptor type-12.7.11.300.493
4aqc88ATyrosine-protein kinase JAK2/0.491
4hvi19STyrosine-protein kinase JAK32.7.10.20.489
5e8wSTUTGF-beta receptor type-12.7.11.300.489
4hge15VTyrosine-protein kinase JAK2/0.488
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.487
3w33W19Epidermal growth factor receptor2.7.10.10.485
5cnoANPEpidermal growth factor receptor2.7.10.10.484
4kbk1QGCasein kinase I isoform delta2.7.11.10.483
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.482
1dawANPCasein kinase II subunit alpha2.7.11.10.479
4lfiGNPCasein kinase II subunit alpha2.7.11.10.477
2pvhP19Casein kinase II subunit alpha2.7.11.10.476
4anmWULCasein kinase II subunit alpha2.7.11.10.475
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.473
1g5sI17Cyclin-dependent kinase 22.7.11.220.472
1py5PY1TGF-beta receptor type-12.7.11.300.472
3w32W32Epidermal growth factor receptor2.7.10.10.472
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.10.469
2vv9IM9Cyclin-dependent kinase 22.7.11.220.469
4dgnLU2Casein kinase II subunit alpha2.7.11.10.468
1aq1STUCyclin-dependent kinase 22.7.11.220.467
3zmmF9JTyrosine-protein kinase JAK2/0.467
3be9P04Casein kinase II subunit alpha2.7.11.10.466
3kvxFMYMitogen-activated protein kinase 102.7.11.240.464
3rak03ZCyclin-dependent kinase 22.7.11.220.464
5cnnANPEpidermal growth factor receptor2.7.10.10.462
4f081RSTyrosine-protein kinase JAK2/0.460
2b53D23Cyclin-dependent kinase 22.7.11.220.458
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.458
4btjADPTau-tubulin kinase 12.7.11.10.457
3gu83GUDeath-associated protein kinase 12.7.11.10.456
3lpbNVBTyrosine-protein kinase JAK2/0.456
3nynSGVG protein-coupled receptor kinase 62.7.11.160.455
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.455
4l7f1V5Mitogen-activated protein kinase 82.7.11.240.455
3w2sW2REpidermal growth factor receptor2.7.10.10.454
4j95ACPFibroblast growth factor receptor 2/0.454
1oirHDYCyclin-dependent kinase 22.7.11.220.453
1pmn984Mitogen-activated protein kinase 102.7.11.240.453
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.453
4ejn0R4RAC-alpha serine/threonine-protein kinase2.7.11.10.453
4fkv61KCyclin-dependent kinase 22.7.11.220.453
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.452
4btjATPTau-tubulin kinase 12.7.11.10.452
3rkb12ZCyclin-dependent kinase 22.7.11.220.451
1dayGNPCasein kinase II subunit alpha2.7.11.10.450
1pxoCK7Cyclin-dependent kinase 22.7.11.220.450
2b52D42Cyclin-dependent kinase 22.7.11.220.450
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.450
4e6d0NUTyrosine-protein kinase JAK2/0.450
3sheI85MAP kinase-activated protein kinase 32.7.11.10.449
4c02TAKActivin receptor type-12.7.11.300.449
1oitHDTCyclin-dependent kinase 22.7.11.220.447
1u4dDBQActivated CDC42 kinase 1/0.447
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.447
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.447
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.446
3ttiKBIMitogen-activated protein kinase 102.7.11.240.446
3s1h56ZCyclin-dependent kinase 22.7.11.220.445
4bznUGXSerine/threonine-protein kinase pim-12.7.11.10.445
3cgfJNFMitogen-activated protein kinase 102.7.11.240.443
3qu0X40Cyclin-dependent kinase 22.7.11.220.443
4ckiADNProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.443
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.442
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.442
4dgmAGICasein kinase II subunit alpha2.7.11.10.442
4fv6E57Mitogen-activated protein kinase 12.7.11.240.442
4jia1K3Tyrosine-protein kinase JAK2/0.442
3lfqA28Cyclin-dependent kinase 22.7.11.220.441
4fkg4CKCyclin-dependent kinase 22.7.11.220.441
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.441
4ux9ANPMitogen-activated protein kinase 82.7.11.240.441
2uzbC75Cyclin-dependent kinase 22.7.11.220.440
3rni21ZCyclin-dependent kinase 22.7.11.220.440
4f650S9Fibroblast growth factor receptor 1/0.440