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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3hb8UMPThymidylate synthase2.1.1.45

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3hb8UMPThymidylate synthase2.1.1.451.000
4eb4UMPThymidylate synthase2.1.1.450.489
4xsdUMPThymidylate synthase2.1.1.450.479
4dq1UMPThymidylate synthase/0.466
4e5oUMPThymidylate synthase2.1.1.450.462
4irrUMPThymidylate synthase/0.460
2g89UMPThymidylate synthase/0.455
5by6UMPThymidylate synthase/0.450