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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3gxlQIGTGF-beta receptor type-12.7.11.30

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3gxlQIGTGF-beta receptor type-12.7.11.301.000
3hmm855TGF-beta receptor type-12.7.11.300.715
1vjy460TGF-beta receptor type-12.7.11.300.652
5e8wSTUTGF-beta receptor type-12.7.11.300.592
2wotZZGTGF-beta receptor type-12.7.11.300.559
1rw8580TGF-beta receptor type-12.7.11.300.541
3mtfA3FActivin receptor type-12.7.11.300.513
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.512
4dymIYZActivin receptor type-12.7.11.300.506
4c02TAKActivin receptor type-12.7.11.300.504
4gmy0X5Tyrosine-protein kinase JAK2/0.497
4qmpDKISerine/threonine-protein kinase 242.7.11.10.495
4qmzB49Serine/threonine-protein kinase 242.7.11.10.495
1eh4IC1Casein kinase I homolog 12.7.11.10.493
1bygSTUTyrosine-protein kinase CSK/0.491
3gubGUBDeath-associated protein kinase 12.7.11.10.491
5e8ySTUTGF-beta receptor type-22.7.11.300.491
4anmWULCasein kinase II subunit alpha2.7.11.10.489
4jqeANPCasein kinase II subunit alpha2.7.11.10.489
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.488
5e8xSTUTGF-beta receptor type-12.7.11.300.488
2qo9ANPEphrin type-A receptor 32.7.10.10.487
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.483
2x2kX2KProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.482
3l8p0CEAngiopoietin-1 receptor2.7.10.10.482
2wouZZFTGF-beta receptor type-12.7.11.300.481
3be9P04Casein kinase II subunit alpha2.7.11.10.481
3rak03ZCyclin-dependent kinase 22.7.11.220.479
4aqc88ATyrosine-protein kinase JAK2/0.479
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.478
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.476
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.475
1u54ACPActivated CDC42 kinase 1/0.474
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.474
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.473
3oom507Activin receptor type-12.7.11.300.472
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.472
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.471
1py5PY1TGF-beta receptor type-12.7.11.300.470
3qtxX43Cyclin-dependent kinase 22.7.11.220.470
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.470
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.470
4e4m0NHTyrosine-protein kinase JAK2/0.470
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.470
4qmlANPSerine/threonine-protein kinase 242.7.11.10.470
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.469
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.469
3ttjJBIMitogen-activated protein kinase 102.7.11.240.469
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.469
3qu0X40Cyclin-dependent kinase 22.7.11.220.468
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.468
4jia1K3Tyrosine-protein kinase JAK2/0.468
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.467
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.466
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.466
1m2pHNACasein kinase II subunit alpha2.7.11.10.465
1om1IQACasein kinase II subunit alpha2.7.11.10.465
3uyt0CKCasein kinase I isoform delta2.7.11.10.465
3uzp0CKCasein kinase I isoform delta2.7.11.10.465
4bgg844Activin receptor type-12.7.11.300.465
4dgnLU2Casein kinase II subunit alpha2.7.11.10.465
4dgo0JWCasein kinase II subunit alpha2.7.11.10.465
4j97ACPFibroblast growth factor receptor 2/0.465
2x9fX9FEphrin type-B receptor 42.7.10.10.464
3rkb12ZCyclin-dependent kinase 22.7.11.220.464
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.464
4ux9ANPMitogen-activated protein kinase 82.7.11.240.464
1y91CT9Cyclin-dependent kinase 22.7.11.220.463
3s1h56ZCyclin-dependent kinase 22.7.11.220.463
4ckiADNProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.463
4gk3L87Ephrin type-A receptor 32.7.10.10.463
4hnf16WCasein kinase I isoform delta2.7.11.10.463
4ji91M3Tyrosine-protein kinase JAK2/0.463
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.462
2x1nX1NCyclin-dependent kinase 22.7.11.220.462
3iok1P6Tyrosine-protein kinase JAK2/0.462
3sw418KCyclin-dependent kinase 22.7.11.220.462
1g5sI17Cyclin-dependent kinase 22.7.11.220.461
2y6o1N1Ephrin type-A receptor 42.7.10.10.461
3rmf20ZCyclin-dependent kinase 22.7.11.220.461
3zh8C58Protein kinase C iota type2.7.11.130.461
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.461
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.460
2in6839Wee1-like protein kinase2.7.10.20.460
2w05FRTCyclin-dependent kinase 22.7.11.220.460
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.460
3zewSTUEphrin type-B receptor 42.7.10.10.460
4fkr45KCyclin-dependent kinase 22.7.11.220.460
4iwd1JCHepatocyte growth factor receptor2.7.10.10.460
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.460
4hvi19STyrosine-protein kinase JAK32.7.10.20.459
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.459
1oirHDYCyclin-dependent kinase 22.7.11.220.458
4fkv61KCyclin-dependent kinase 22.7.11.220.458
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.458
4yuqKS1Calmodulin-like domain protein kinase/0.458
2pvhP19Casein kinase II subunit alpha2.7.11.10.457
3ttiKBIMitogen-activated protein kinase 102.7.11.240.457
3r9oZ71Cyclin-dependent kinase 22.7.11.220.456
1di8DTQCyclin-dependent kinase 22.7.11.220.455
1m2qMNXCasein kinase II subunit alpha2.7.11.10.455
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.455
1xjdSTUProtein kinase C theta type2.7.11.130.455
2excJNKMitogen-activated protein kinase 102.7.11.240.455
3i60E86Mitogen-activated protein kinase 12.7.11.240.455
3kvxFMYMitogen-activated protein kinase 102.7.11.240.455
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.455
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.455
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.455
4c61LMMTyrosine-protein kinase JAK2/0.455
1gii1PUCyclin-dependent kinase 22.7.11.220.454
1w0xOLOCyclin-dependent kinase 22.7.11.220.454
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.454
2w06FRVCyclin-dependent kinase 22.7.11.220.454
3qtzX42Cyclin-dependent kinase 22.7.11.220.454
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.454
4g170VNCasein kinase I isoform gamma-32.7.11.10.454
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.454
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.454
5dr9SKEAurora kinase A2.7.11.10.454
1fvv107Cyclin-dependent kinase 22.7.11.220.453
2iw84SPCyclin-dependent kinase 22.7.11.220.453
2pvnP63Casein kinase II subunit alpha2.7.11.10.453
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.453
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.453
4fko20KCyclin-dependent kinase 22.7.11.220.453
4hvh19RTyrosine-protein kinase JAK32.7.10.20.453
5e92ANPTGF-beta receptor type-22.7.11.300.453
1h1s4SPCyclin-dependent kinase 22.7.11.220.452
1oitHDTCyclin-dependent kinase 22.7.11.220.452
2w17I19Cyclin-dependent kinase 22.7.11.220.452
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.452
5drdATPAurora kinase A2.7.11.10.452
3a7jADPSerine/threonine-protein kinase 242.7.11.10.451
3eljGS7Mitogen-activated protein kinase 82.7.11.240.451
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.451
3rk708ZCyclin-dependent kinase 22.7.11.220.451
4acm7YGCyclin-dependent kinase 22.7.11.220.451
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.450
3ddqRRCCyclin-dependent kinase 22.7.11.220.450
3ggfGVDSerine/threonine-protein kinase 26/0.450
3sheI85MAP kinase-activated protein kinase 32.7.11.10.450
4btjATPTau-tubulin kinase 12.7.11.10.450
4eor4SPCyclin-dependent kinase 22.7.11.220.450
4gvjADPNon-receptor tyrosine-protein kinase TYK22.7.10.20.450
1aq1STUCyclin-dependent kinase 22.7.11.220.449
1dawANPCasein kinase II subunit alpha2.7.11.10.449
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.449
2xa4AZ5Tyrosine-protein kinase JAK2/0.449
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.449
4hge15VTyrosine-protein kinase JAK2/0.449
4k33ACPFibroblast growth factor receptor 32.7.10.10.449
1pmn984Mitogen-activated protein kinase 102.7.11.240.448
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.448
3r6sCMPCRP-like cAMP-activated global transcriptional regulator/0.448
3rni21ZCyclin-dependent kinase 22.7.11.220.448
4jajXU1Aurora kinase A2.7.11.10.448
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.448
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.447
2b7aIZATyrosine-protein kinase JAK2/0.447
2xikJ60Serine/threonine-protein kinase 252.7.11.10.447
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.447
4fkw62KCyclin-dependent kinase 22.7.11.220.447
5dmzADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.447
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.446
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.446
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.446
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.446
4fkg4CKCyclin-dependent kinase 22.7.11.220.446
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.446
5dr6SKEAurora kinase A2.7.11.10.446
1ke5LS1Cyclin-dependent kinase 22.7.11.220.445
2dwbANPAurora kinase A2.7.11.10.445
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.445
3zpsEQMGag-Pol polyprotein3.4.23.160.445
4kbk1QGCasein kinase I isoform delta2.7.11.10.445
2o0uC0MMitogen-activated protein kinase 102.7.11.240.444
3hx4ANPCalmodulin-domain protein kinase 1/0.444
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.444
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.444
4g2fC07Ephrin type-A receptor 32.7.10.10.444
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.443
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.443
5amnDTQProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.443
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.443
1urwI1PCyclin-dependent kinase 22.7.11.220.442
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.442
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.442
2zdt46CMitogen-activated protein kinase 102.7.11.240.442
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.442
3il1B5DGlutamate receptor 2/0.442
3vs3VSETyrosine-protein kinase HCK2.7.10.20.442
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4dn5AGSMitogen-activated protein kinase kinase kinase 142.7.11.250.442
4gii0X6Non-receptor tyrosine-protein kinase TYK22.7.10.20.442
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.441
2b1pAIZMitogen-activated protein kinase 102.7.11.240.441
2btsU32Cyclin-dependent kinase 22.7.11.220.441
3zep1NXTyrosine-protein kinase JAK32.7.10.20.441
4dgmAGICasein kinase II subunit alpha2.7.11.10.441
4gk4L90Ephrin type-A receptor 32.7.10.10.441
4hgt15GCasein kinase I isoform delta2.7.11.10.441
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.441
1oiuN76Cyclin-dependent kinase 22.7.11.220.440
2b53D23Cyclin-dependent kinase 22.7.11.220.440
2i0y5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.440
2vttLZDCyclin-dependent kinase 22.7.11.220.440
3gc9B45Mitogen-activated protein kinase 112.7.11.240.440
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.440
3r83Z14Cyclin-dependent kinase 22.7.11.220.440
4f081RSTyrosine-protein kinase JAK2/0.440
4fob0USALK tyrosine kinase receptor2.7.10.10.440