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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3gvuSTIAbelson tyrosine-protein kinase 22.7.10.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3gvuSTIAbelson tyrosine-protein kinase 22.7.10.21.000
2hiw7MPTyrosine-protein kinase ABL12.7.10.20.590
2e2b406Tyrosine-protein kinase ABL12.7.10.20.503
4hw764MMacrophage colony-stimulating factor 1 receptor2.7.10.10.503
2hz0GINTyrosine-protein kinase ABL12.7.10.20.495
4asdBAXVascular endothelial growth factor receptor 22.7.10.10.488
3ugc046Tyrosine-protein kinase JAK2/0.469
1g67TZPThiamine-phosphate synthase/0.466
3p79P79Mitogen-activated protein kinase 14/0.464
3p5kP5KMitogen-activated protein kinase 14/0.456
1j39UPGDNA beta-glucosyltransferase/0.454
4dfrMTXDihydrofolate reductase1.5.1.30.453
5hidB1ESerine/threonine-protein kinase B-raf2.7.11.10.453
1d3hA26Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.452
1wc0APCAdenylate cyclase/0.452
3p6nDSOCamphor 5-monooxygenase1.14.15.10.452
4r7iSTIMacrophage colony-stimulating factor 1 receptor2.7.10.10.452
2j8zNAPQuinone oxidoreductase PIG310.446
4p8rNADGlyceraldehyde-3-phosphate dehydrogenase/0.446
2b00GCHPhospholipase A2, major isoenzyme3.1.1.40.443
3hv71AUMitogen-activated protein kinase 14/0.442
3k3jF4CMitogen-activated protein kinase 14/0.442
1qipGNBLactoylglutathione lyase4.4.1.50.441
3p6pA6BCamphor 5-monooxygenase1.14.15.10.441
3uvr06FMitogen-activated protein kinase 14/0.441
3nnxEDDMitogen-activated protein kinase 14/0.440
4u0i0LIMast/stem cell growth factor receptor Kit2.7.10.10.440