sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3gfx | C2E | Uncharacterized protein |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3gfx | C2E | Uncharacterized protein | / | 1.000 | |
| 3gg1 | C2E | Uncharacterized protein | / | 0.569 | |
| 3gg0 | C2E | Uncharacterized protein | / | 0.554 | |
| 3gfz | C2E | Uncharacterized protein | / | 0.514 | |
| 1e90 | MYC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.507 | |
| 3ujl | A8S | Abscisic acid receptor PYL2 | / | 0.505 | |
| 1itz | TPP | Transketolase, chloroplastic | 2.2.1.1 | 0.504 | |
| 2q7g | CCL | Pyrrolysine--tRNA ligase | / | 0.503 | |
| 1hfp | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.498 | |
| 2zce | PYL | Pyrrolysine--tRNA ligase | / | 0.498 | |
| 3neg | PYV | Abscisic acid receptor PYL1 | / | 0.497 | |
| 4ds8 | A8S | Abscisic acid receptor PYL3 | / | 0.496 | |
| 4lg5 | A1O | Abscisic acid receptor PYL2 | / | 0.496 | |
| 3zvu | A8S | Abscisic acid receptor PYR1 | / | 0.492 | |
| 3ow3 | SMY | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.490 | |
| 4m2x | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.486 | |
| 3uud | EST | Estrogen receptor | / | 0.484 | |
| 2uw5 | GVN | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.482 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.481 | |
| 2vo0 | M03 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.481 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.480 | |
| 1nd5 | 2BF | Prostatic acid phosphatase | 3.1.3.2 | 0.480 | |
| 4lga | A2O | Abscisic acid receptor PYL2 | / | 0.480 | |
| 3k3k | A8S | Abscisic acid receptor PYR1 | / | 0.479 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.479 | |
| 4la7 | A1O | Abscisic acid receptor PYL2 | / | 0.479 | |
| 3ely | SAH | Methyltransferase | / | 0.478 | |
| 3jrx | S1A | Acetyl-CoA carboxylase 2 | / | 0.478 | |
| 3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.478 | |
| 3o0g | 3O0 | Cyclin-dependent-like kinase 5 | 2.7.11.1 | 0.477 | |
| 3kb0 | A8S | Abscisic acid receptor PYL2 | / | 0.476 | |
| 3ml8 | ML8 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.476 | |
| 4nj3 | 2KD | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.476 | |
| 2phk | ATP | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform | 2.7.11.19 | 0.475 | |
| 3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.473 | |
| 4fad | 0TB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.473 | |
| 4fex | 0TO | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.473 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.472 | |
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 3k90 | A8S | Abscisic acid receptor PYR1 | / | 0.471 | |
| 3nmh | PYV | Abscisic acid receptor PYL2 | / | 0.471 | |
| 4kd7 | 9DR | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 5ccc | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 1x7e | 244 | Estrogen receptor | / | 0.469 | |
| 2px2 | SAH | Genome polyprotein | 2.7.7.48 | 0.469 | |
| 3lq2 | TDP | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.469 | |
| 3ols | EST | Estrogen receptor beta | / | 0.469 | |
| 3kdj | A8S | Abscisic acid receptor PYL1 | / | 0.468 | |
| 4dsc | A8S | Abscisic acid receptor PYL3 | / | 0.468 | |
| 2j5s | KTA | Alr4455 protein | / | 0.467 | |
| 3r8z | Z63 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.467 | |
| 4bfr | J82 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 2.7.1.153 | 0.467 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.466 | |
| 2g44 | T3O | Estrogen receptor | / | 0.465 | |
| 2yja | EST | Estrogen receptor | / | 0.464 | |
| 3cse | N22 | Uncharacterized protein | / | 0.464 | |
| 3qly | 55V | Uncharacterized protein | / | 0.464 | |
| 4k6i | 9RA | Retinoic acid receptor RXR-alpha | / | 0.464 | |
| 1sd1 | FMC | S-methyl-5'-thioadenosine phosphorylase | / | 0.463 | |
| 2v4l | ABJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.463 | |
| 2xau | ADP | Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43 | 3.6.4.13 | 0.463 | |
| 2i40 | BLZ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.462 | |
| 3kb3 | A8S | Abscisic acid receptor PYL2 | / | 0.462 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.462 | |
| 3zbx | 6XE | Hepatocyte growth factor receptor | 2.7.10.1 | 0.462 | |
| 4kak | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.462 | |
| 2in6 | 839 | Wee1-like protein kinase | 2.7.10.2 | 0.461 | |
| 3bgs | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.461 | |
| 3tnw | F18 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.461 | |
| 4hw3 | 19G | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.461 | |
| 1boz | PRD | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 2fai | 459 | Estrogen receptor | / | 0.460 | |
| 2jdt | I5S | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.460 | |
| 2nnq | T4B | Fatty acid-binding protein, adipocyte | / | 0.460 | |
| 4ai8 | DZA | Hypoxia-inducible factor 1-alpha inhibitor | 1.14.11.30 | 0.460 | |
| 1syn | F89 | Thymidylate synthase | / | 0.459 | |
| 2a9z | 26A | Adenosine kinase | 2.7.1.20 | 0.459 | |
| 2pul | ACP | Methylthioribose kinase | 2.7.1.100 | 0.459 | |
| 2wms | ZYS | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.459 | |
| 3ag9 | A02 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.459 | |
| 3l03 | 4OH | Estrogen receptor | / | 0.459 | |
| 4a9e | 3PF | Bromodomain-containing protein 2 | / | 0.459 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 1u3s | 797 | Estrogen receptor beta | / | 0.458 | |
| 1v0o | INR | Cell division control protein 2 homolog | 2.7.11.22 | 0.458 | |
| 2b36 | 5PP | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.458 | |
| 2blc | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.458 | |
| 2kfx | WW7 | Troponin C, slow skeletal and cardiac muscles | / | 0.458 | |
| 4a9h | TVP | Bromodomain-containing protein 2 | / | 0.458 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.458 | |
| 1d7a | AIR | N5-carboxyaminoimidazole ribonucleotide mutase | / | 0.457 | |
| 1gwr | EST | Estrogen receptor | / | 0.457 | |
| 1sm2 | STU | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.457 | |
| 1wpg | ADP | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.457 | |
| 2mjp | ANP | dITP/XTP pyrophosphatase | 3.6.1.19 | 0.457 | |
| 3qaq | QAQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.457 | |
| 3qlr | QLR | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 3vjo | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.457 | |
| 4ajw | VWN | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 2.7.1.153 | 0.457 | |
| 4fjy | FJY | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.457 | |
| 2vnw | M01 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.456 | |
| 2vo3 | M04 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.456 | |
| 3dha | C6L | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.456 | |
| 3o73 | O73 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.456 | |
| 4c3y | ANB | 3-ketosteroid dehydrogenase | / | 0.456 | |
| 3uza | T4G | Adenosine receptor A2a | / | 0.456 | |
| 1d7o | TCL | Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic | 1.3.1.9 | 0.455 | |
| 1j3j | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.455 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.455 | |
| 3njo | P2M | Abscisic acid receptor PYR1 | / | 0.455 | |
| 4ap1 | NAP | Steroid monooxygenase | / | 0.455 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 4kla | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.455 | |
| 1gpe | FAD | Glucose oxidase | 1.1.3.4 | 0.454 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.454 | |
| 2cch | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.454 | |
| 2j9l | ATP | H(+)/Cl(-) exchange transporter 5 | / | 0.454 | |
| 3q95 | ESL | Estrogen receptor | / | 0.454 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.454 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 2v2z | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.453 | |
| 3oll | EST | Estrogen receptor beta | / | 0.453 | |
| 3v1m | HPK | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase | 3.7.1.8 | 0.453 | |
| 4eqc | XR1 | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.453 | |
| 5fsx | ADP | Uncharacterized protein | / | 0.453 | |
| 1kmv | LII | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.452 | |
| 2b1z | 17M | Estrogen receptor | / | 0.452 | |
| 2b51 | UTP | RNA editing complex protein MP57 | / | 0.452 | |
| 2v95 | HCY | Corticosteroid-binding globulin | / | 0.452 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.452 | |
| 3v5w | 8PR | Beta-adrenergic receptor kinase 1 | 2.7.11.15 | 0.452 | |
| 4eol | 1RO | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.452 | |
| 4lm4 | JPZ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.452 | |
| 4oic | A8S | Bet v I allergen-like | / | 0.452 | |
| 1tou | B1V | Fatty acid-binding protein, adipocyte | / | 0.451 | |
| 2p1v | 5TN | Retinoic acid receptor RXR-alpha | / | 0.451 | |
| 2prh | 238 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.451 | |
| 3keq | NAD | Redox-sensing transcriptional repressor Rex | / | 0.451 | |
| 3pej | BC2 | Endoplasmin homolog, putative | / | 0.451 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.451 | |
| 5htp | ANP | Probable sugar kinase | / | 0.451 | |
| 5iub | CLR | Adenosine receptor A2a | / | 0.451 | |
| 1aq1 | STU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.450 | |
| 1g50 | EST | Estrogen receptor | / | 0.450 | |
| 1w78 | PD8 | Dihydrofolate synthase/folylpolyglutamate synthase | 6.3.2.12 | 0.450 | |
| 2ab2 | SNL | Mineralocorticoid receptor | / | 0.450 | |
| 2ji9 | TPW | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.450 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.450 | |
| 3pjc | PJC | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.450 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.450 | |
| 1e7v | LY2 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.449 | |
| 3m4n | PA9 | N-acetylornithine carbamoyltransferase | 2.1.3.9 | 0.449 | |
| 3nmv | PYV | Abscisic acid receptor PYL2 | / | 0.449 | |
| 4eip | K2C | Putative FAD-monooxygenase | / | 0.449 | |
| 4h4x | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.449 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 4ocv | ANP | Aminoglycoside phosphotransferase | / | 0.449 | |
| 4ubt | COA | Steroid 3-ketoacyl-CoA thiolase | / | 0.449 | |
| 1dhi | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1uye | PU9 | Heat shock protein HSP 90-alpha | / | 0.448 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 2ym5 | YM5 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.448 | |
| 3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 4igf | CHV | Enoyl-acyl carrier reductase | / | 0.448 | |
| 4p6x | HCY | Glucocorticoid receptor | / | 0.448 | |
| 1rg9 | SAM | S-adenosylmethionine synthase | 2.5.1.6 | 0.447 | |
| 3a8w | ATP | Protein kinase C iota type | 2.7.11.13 | 0.447 | |
| 3nxr | D2D | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 3p0h | FSE | Putative tyrosyl-tRNA synthetase | / | 0.447 | |
| 4bgb | ADP | Predicted molecular chaperone distantly related to HSP70-fold metalloproteases | / | 0.447 | |
| 4ixg | IXG | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 4pp6 | STL | Estrogen receptor | / | 0.447 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.447 | |
| 1d3h | A26 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.446 | |
| 1f20 | FAD | Nitric oxide synthase, brain | 1.14.13.39 | 0.446 | |
| 1l9k | SAH | Genome polyprotein | 2.7.7.48 | 0.446 | |
| 1ne4 | RP1 | cAMP-dependent protein kinase type I-alpha regulatory subunit | / | 0.446 | |
| 1td2 | PXL | Pyridoxal kinase PdxY | / | 0.446 | |
| 2ouz | C3D | Estrogen receptor | / | 0.446 | |
| 2p1t | 3TN | Retinoic acid receptor RXR-alpha | / | 0.446 | |
| 2yk2 | YJW | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 3gwu | SRE | Na(+):neurotransmitter symporter (Snf family) | / | 0.446 | |
| 4a9m | P9M | Bromodomain-containing protein 2 | / | 0.446 | |
| 4few | PP2 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.446 | |
| 1cjc | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.445 | |
| 1lbb | KAI | Glutamate receptor 2 | / | 0.445 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.445 | |
| 1xha | R68 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.445 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 2yhd | TES | Androgen receptor | / | 0.445 | |
| 3w5q | 3KL | Vitamin D3 receptor | / | 0.445 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.445 | |
| 4a4o | 664 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.445 | |
| 4ddr | MMV | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4jda | A9S | Abscisic acid receptor PYL3 | / | 0.445 | |
| 4kfb | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.445 | |
| 4l43 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.445 | |
| 4m0l | GDP | Translation initiation factor 2 subunit gamma | / | 0.445 | |
| 4ndn | SAM | S-adenosylmethionine synthase isoform type-2 | 2.5.1.6 | 0.445 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.445 | |
| 1s3y | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1yy4 | 4NA | Estrogen receptor beta | / | 0.444 | |
| 1z2n | ADP | Inositol-tetrakisphosphate 1-kinase | 2.7.1.134 | 0.444 | |
| 2cjf | RP4 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.444 | |
| 2f7e | 2EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.444 | |
| 2nv7 | 555 | Estrogen receptor beta | / | 0.444 | |
| 2w8y | NDR | Progesterone receptor | / | 0.444 | |
| 2ywv | ADP | Phosphoribosylaminoimidazole-succinocarboxamide synthase | / | 0.444 | |
| 3dnd | LL2 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.444 | |
| 3e8e | G98 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.444 | |
| 3s2a | 2NQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 3v49 | PK0 | Androgen receptor | / | 0.444 | |
| 4axa | RKD | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.444 | |
| 4gg7 | 0J8 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.444 | |
| 5hbs | RTL | Retinol-binding protein 1 | / | 0.444 | |
| 5g53 | NEC | Adenosine receptor A2a | / | 0.444 | |
| 1kdk | DHT | Sex hormone-binding globulin | / | 0.443 | |
| 1rek | B8L | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.443 | |
| 1u3g | THF | 5-formyltetrahydrofolate cyclo-ligase | 6.3.3.2 | 0.443 | |
| 1zky | 689 | Estrogen receptor | / | 0.443 | |
| 2op0 | 7PC | Enoyl-ACP reductase | / | 0.443 | |
| 2pda | TPP | Pyruvate synthase | / | 0.443 | |
| 2w5b | AGS | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.443 | |
| 3c1x | CKK | Hepatocyte growth factor receptor | 2.7.10.1 | 0.443 | |
| 3gcq | 1BU | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 3kdi | A8S | Abscisic acid receptor PYL2 | / | 0.443 | |
| 3l05 | SN0 | N-acetylornithine carbamoyltransferase | 2.1.3.9 | 0.443 | |
| 3q2j | CKI | Aminoglycoside 3'-phosphotransferase | 2.7.1.95 | 0.443 | |
| 4dlx | GNP | GTPase HRas | / | 0.443 | |
| 4f70 | 0ST | Cyclin-dependent kinase 8 | 2.7.11.22 | 0.443 | |
| 1nv8 | SAM | Release factor glutamine methyltransferase | 2.1.1.297 | 0.442 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.442 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 2azy | CHD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.442 | |
| 2bla | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.442 | |
| 2o21 | 43B | Apoptosis regulator Bcl-2 | / | 0.442 | |
| 2pkl | DHT | Androgen receptor | / | 0.442 | |
| 2vwv | 7X3 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.442 | |
| 3clb | TMQ | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.442 | |
| 3qj5 | 022 | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.442 | |
| 3qn1 | A8S | Abscisic acid receptor PYR1 | / | 0.442 | |
| 4a4x | JUP | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.442 | |
| 4app | N53 | Serine/threonine-protein kinase PAK 4 | 2.7.11.1 | 0.442 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.442 | |
| 1jla | TNK | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 1l2i | ETC | Estrogen receptor | / | 0.441 | |
| 1q66 | KMB | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.441 | |
| 1u72 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 2fwz | H71 | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 2olc | ADP | Methylthioribose kinase | 2.7.1.100 | 0.441 | |
| 3a7d | FBN | Catechol O-methyltransferase | 2.1.1.6 | 0.441 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.441 | |
| 3dne | LL1 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.441 | |
| 3eem | 53V | Uncharacterized protein | / | 0.441 | |
| 3vi5 | M4M | Hematopoietic prostaglandin D synthase | / | 0.441 | |
| 3zra | ORB | Progesterone receptor | / | 0.441 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.441 | |
| 4gue | QCT | Ribosomal protein S6 kinase alpha-3 | 2.7.11.1 | 0.441 | |
| 4kbn | 25U | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4zhi | ADP | Kinesin-like protein KIF11 | / | 0.441 | |
| 5dxg | EST | Estrogen receptor | / | 0.441 | |
| 5hyr | EST | Estrogen receptor | / | 0.441 | |
| 5je2 | SAH | Methyl transferase | / | 0.441 | |
| 1cbq | RE9 | Cellular retinoic acid-binding protein 2 | / | 0.440 | |
| 1hnv | TBO | Gag-Pol polyprotein | 2.7.7.49 | 0.440 | |
| 1it7 | GUN | tRNA-guanine(15) transglycosylase | 2.4.2.48 | 0.440 | |
| 1q65 | BHB | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.440 | |
| 1s9q | OHT | Estrogen-related receptor gamma | / | 0.440 | |
| 2ao6 | R18 | Androgen receptor | / | 0.440 | |
| 2brn | DF1 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 2qkr | IXM | Cdc2-like CDK2/CDC28 like protein kinase | / | 0.440 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.440 | |
| 3qdd | 94M | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 5h8t | RTL | Retinol-binding protein 1 | / | 0.440 |