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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3g5eQ74Aldose reductase1.1.1.21

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3g5eQ74Aldose reductase1.1.1.211.000
3ghuLDTAldose reductase1.1.1.210.762
1z3n3NAAldose reductase1.1.1.210.760
2qxwLDTAldose reductase1.1.1.210.724
1us0LDTAldose reductase1.1.1.210.716
1t40ID5Aldose reductase1.1.1.210.710
2i16LDTAldose reductase1.1.1.210.709
2hv5ZSTAldose reductase1.1.1.210.691
3ghsLDTAldose reductase1.1.1.210.689
3ghtLDTAldose reductase1.1.1.210.687
2i17LDTAldose reductase1.1.1.210.683
3ghrLDTAldose reductase1.1.1.210.681
2duxZSTAldose reductase1.1.1.210.680
2dv0ZSTAldose reductase1.1.1.210.673
1pwlBFIAldose reductase1.1.1.210.667
2hvoZSTAldose reductase1.1.1.210.666
2fz8ZSTAldose reductase1.1.1.210.664
2pzn393Aldose reductase1.1.1.210.652
3mb9ZSTAldose reductase1.1.1.210.647
2pdp393Aldose reductase1.1.1.210.635
2pdg47DAldose reductase1.1.1.210.623
2duzZSTAldose reductase1.1.1.210.619
2pdxZSTAldose reductase1.1.1.210.619
2iki388Aldose reductase1.1.1.210.617
2fz9ZSTAldose reductase1.1.1.210.616
2pdbZSTAldose reductase1.1.1.210.608
2pd5ZSTAldose reductase1.1.1.210.602
2pevNDPAldose reductase1.1.1.210.601
3t423T4Aldose reductase1.1.1.210.600
2pdc393Aldose reductase1.1.1.210.597
4gca2X9Aldose reductase1.1.1.210.597
2pdh47DAldose reductase1.1.1.210.596
2pdu393Aldose reductase1.1.1.210.594
3ld5LDTAldose reductase1.1.1.210.594
1t41ID5Aldose reductase1.1.1.210.593
1z8962PAldose reductase1.1.1.210.588
2fzdTOLAldose reductase1.1.1.210.588
3lenZSTAldose reductase1.1.1.210.586
3lz5LDTAldose reductase1.1.1.210.586
2pdn47DAldose reductase1.1.1.210.584
3lboLDTAldose reductase1.1.1.210.584
3lqlLDTAldose reductase1.1.1.210.584
3m0iZSTAldose reductase1.1.1.210.584
3mc5393Aldose reductase1.1.1.210.584
1frbZSTAldose reductase-related protein 2/0.578
2ikhLITAldose reductase1.1.1.210.578
2pdfZSTAldose reductase1.1.1.210.578
4yu153NAldose reductase1.1.1.210.572
1ieiZESAldose reductase1.1.1.210.558
2pdlTOLAldose reductase1.1.1.210.555
3m4h388Aldose reductase1.1.1.210.552
1zuaTOLAldo-keto reductase family 1 member B101.1.10.546
2ikj393Aldose reductase1.1.1.210.545
3m64393Aldose reductase1.1.1.210.542
2pdj393Aldose reductase1.1.1.210.541
1ah3TOLAldose reductase1.1.1.210.536
2is72CLAldose reductase1.1.1.210.533
2pdq47DAldose reductase1.1.1.210.529
4ga8SBIAldo-keto reductase family 1 member B101.1.10.499
2pdwFIDAldose reductase1.1.1.210.498
4dbw511Aldo-keto reductase family 1 member C3/0.489
1ekoI84Aldose reductase1.1.1.210.484
2f2kTGGAldose reductase1.1.1.210.476
2cekN8TAcetylcholinesterase3.1.1.70.473
1lnmDTXBilin-binding protein/0.471
3af4GCPPantothenate kinase2.7.1.330.469
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.469
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.468
4u163C0Muscarinic acetylcholine receptor M3/0.468
1ah0SBIAldose reductase1.1.1.210.467
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.467
1xf0ASDAldo-keto reductase family 1 member C3/0.467
2xufTZ4Acetylcholinesterase3.1.1.70.467
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.466
2fzbTOLAldose reductase1.1.1.210.466
1ry8RUTAldo-keto reductase family 1 member C3/0.465
5stdUNNScytalone dehydratase4.2.1.940.465
4lcnGNGCytidine and deoxycytidylate deaminase zinc-binding region/0.464
5liu388Aldo-keto reductase family 1 member B101.1.10.464
2nvcITAAldose reductase1.1.1.210.463
4lrhFOLFolate receptor alpha/0.462
1w4lGL8Acetylcholinesterase3.1.1.70.461
3v35NTIAldose reductase1.1.1.210.461
4jt81NRNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.460
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.459
1lkeDOGBilin-binding protein/0.458
1p91SAM23S rRNA (guanine(745)-N(1))-methyltransferase/0.458
2cbqTH2Neocarzinostatin/0.458
2xugTZ4Acetylcholinesterase3.1.1.70.458
4e0u0MVCyclic dipeptide N-prenyltransferase/0.458
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.457
3dyqIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.457
4kn2LYAFolate receptor beta/0.457
4mm729JNa(+):neurotransmitter symporter (Snf family)/0.457
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.456
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.456
1sa5BMVProtein farnesyltransferase subunit beta2.5.1.580.455
2xujTZ5Acetylcholinesterase3.1.1.70.455
3szfDCQSulfide-quinone reductase/0.455
1pj6FOLDimethylglycine oxidase1.5.3.100.454
3af1GDPPantothenate kinase2.7.1.330.454
3zc3FADFerredoxin--NADP reductase1.18.1.20.454
4wevSUZAldo-keto reductase family 1 member B101.1.10.454
3e33ED7Protein farnesyltransferase subunit beta2.5.1.580.453
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.453
3iakEV1cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.453
3u2cSUZAldose reductase1.1.1.210.453
3u3o3QVSulfotransferase 1A12.8.2.10.453
4gts7TPGeranylgeranyl transferase type-2 subunit beta2.5.1.600.453
1ry0PG2Aldo-keto reductase family 1 member C3/0.452
2ea4F79Methionine aminopeptidase 2/0.452
2pdkSBIAldose reductase1.1.1.210.452
2zs9ADPPantothenate kinase2.7.1.330.452
3uzzTES3-oxo-5-beta-steroid 4-dehydrogenase/0.452
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.451
2agtFIDAldose reductase1.1.1.210.451
2inzOHPAldose reductase1.1.1.210.451
2iqdLPAAldose reductase1.1.1.210.451
2pdmZSTAldose reductase1.1.1.210.451
2xupTZ5Acetylcholinesterase3.1.1.70.451
4dbs0HVAldo-keto reductase family 1 member C3/0.451
1rxjBNIStreptavidin/0.450
2f3815MAldo-keto reductase family 1 member C3/0.450
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.450
3hxeBD8Geranylgeranyl transferase type-2 subunit beta2.5.1.600.450
4eilFOLBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.450
1dgbNDPCatalase1.11.1.60.449
1el3I84Aldose reductase1.1.1.210.449
1fmlRTLRetinol dehydratase/0.449
1ro6ROLcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.449
1v08NTZ4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.449
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
2qimZEAClass 10 plant pathogenesis-related protein/0.449
3f3y4OABile salt sulfotransferase2.8.2.140.449
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.449
4fam0SZAldo-keto reductase family 1 member C3/0.449
4kn0MTXFolate receptor beta/0.449
2j9fTHV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial1.2.4.40.448
2j9fTHV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial1.2.4.40.448
2xuiTZ5Acetylcholinesterase3.1.1.70.448
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
3pz3PZ3Geranylgeranyl transferase type-2 subunit beta2.5.1.600.448
4jtrIZPAldo-keto reductase family 1 member C2/0.448
4kn104JFolate receptor beta/0.448
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
2pdyFIDAldose reductase1.1.1.210.447
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.447
4i5xFLFAldo-keto reductase family 1 member B101.1.10.447
4kmzFOLFolate receptor beta/0.447
1t47NTD4-hydroxyphenylpyruvate dioxygenase1.13.11.270.446
1u65CP0Acetylcholinesterase3.1.1.70.446
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
2zsaADPPantothenate kinase2.7.1.330.446
3c3xNAPEugenol synthase 11.1.1.3180.446
3sl6JN8cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.446
4jsr1NQNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.446
1ihiIU5Aldo-keto reductase family 1 member C2/0.445
1qtiGNTAcetylcholinesterase3.1.1.70.445
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.445
1x8lOXRRetinol dehydratase/0.445
2acuNAPAldose reductase1.1.1.210.445
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.445
3sfxJANUncharacterized protein/0.445
4d2dALA_ALA_ALADi-or tripeptide:H+ symporter/0.445
4pnmNU1Tankyrase-22.4.2.300.445
1nl4HFPProtein farnesyltransferase subunit beta2.5.1.580.444
1zgbA1EAcetylcholinesterase3.1.1.70.444
2wzySQXSoluble acetylcholine receptor/0.444
3aiqHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic3.2.1.1820.444
1jdzFMBPurine nucleoside phosphorylase/0.443
1odcA8BAcetylcholinesterase3.1.1.70.443
1sa4JANProtein farnesyltransferase subunit beta2.5.1.580.443
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
2fm0M98cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
2r2lPB9Protein farnesyltransferase subunit beta2.5.1.580.443
2v0mKLNCytochrome P450 3A4/0.443
2gmsP0PPutative pyridoxamine 5-phosphate-dependent dehydrase/0.442
2vt4P32Beta-1 adrenergic receptor/0.442
3af3GCPPantothenate kinase2.7.1.330.442
3tfuPL8Adenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.442
4gtr7TRProtein farnesyltransferase subunit beta2.5.1.580.442
4i9z5BAcGMP-specific 3',5'-cyclic phosphodiesterase/0.442
4x3uSVRChromobox protein homolog 7/0.442
1lgtBP3Biphenyl-2,3-diol 1,2-dioxygenase1.13.11.390.441
1upw444Oxysterols receptor LXR-beta/0.441
2x86ADPADP-L-glycero-D-manno-heptose-6-epimerase/0.441
3q7fED2Uncharacterized protein/0.441
4pabTHGDimethylglycine dehydrogenase, mitochondrial1.5.8.40.441
1q83TZ5Acetylcholinesterase3.1.1.70.440
1s7gNADNAD-dependent protein deacylase 2/0.440
1zgcA2EAcetylcholinesterase3.1.1.70.440
4ky404JBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.440
4oex5EOcGMP-specific 3',5'-cyclic phosphodiesterase/0.440