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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.53

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.531.000
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.600
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.566
4myq19TcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.550
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.499
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.496
3sl6JN8cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.495
3tvxPNXcAMP-specific 3',5'-cyclic phosphodiesterase 4A3.1.4.530.488
3wd9QPCcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.479
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.472
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.460
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.460
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.452
3sl8JN7cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.451
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
1y2bDEEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.441