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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3fzsB96Protein-tyrosine kinase 2-beta2.7.10.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3fzsB96Protein-tyrosine kinase 2-beta2.7.10.21.000
3fzt4JZProtein-tyrosine kinase 2-beta2.7.10.20.537
4h1j0YHProtein-tyrosine kinase 2-beta2.7.10.20.530
4k9yK9YFocal adhesion kinase 12.7.10.20.512
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.506
2btrU73Cyclin-dependent kinase 22.7.11.220.492
2hog710Serine/threonine-protein kinase Chk12.7.11.10.490
2btsU32Cyclin-dependent kinase 22.7.11.220.470
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.469
4fnyI3KALK tyrosine kinase receptor2.7.10.10.469
1ke6LS2Cyclin-dependent kinase 22.7.11.220.467
4elb34RDihydrofolate reductase/0.467
2c6o4SPCyclin-dependent kinase 22.7.11.220.465
2owb626Serine/threonine-protein kinase PLK12.7.11.210.465
1ckpPVBCyclin-dependent kinase 22.7.11.220.464
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.464
3qruX19Cyclin-dependent kinase 22.7.11.220.463
1b39ATPCyclin-dependent kinase 22.7.11.220.462
1ke5LS1Cyclin-dependent kinase 22.7.11.220.461
3qtuX44Cyclin-dependent kinase 22.7.11.220.461
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.461
3s2pPMUCyclin-dependent kinase 22.7.11.220.460
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.460
3qzhX69Cyclin-dependent kinase 22.7.11.220.459
1ke7LS3Cyclin-dependent kinase 22.7.11.220.458
4equG6ISerine/threonine-protein kinase 102.7.11.10.457
3ral04ZCyclin-dependent kinase 22.7.11.220.455
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.455
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.455
1h1r6CPCyclin-dependent kinase 22.7.11.220.454
2ix5FADAcyl-coenzyme A oxidase 4, peroxisomal1.3.3.60.453
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.453
3r7iX9ICyclin-dependent kinase 22.7.11.220.453
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.453
1ke9LS5Cyclin-dependent kinase 22.7.11.220.451
2c4g514Cyclin-dependent kinase 22.7.11.220.451
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.451
3tubFPUTyrosine-protein kinase SYK2.7.10.20.451
3zkpERBErythromycin C-12 hydroxylase1.14.13.1540.451
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.451
1h1s4SPCyclin-dependent kinase 22.7.11.220.450
3qqfX07Cyclin-dependent kinase 22.7.11.220.450
3r1sX73Cyclin-dependent kinase 22.7.11.220.450
3sheI85MAP kinase-activated protein kinase 32.7.11.10.450
4a4l939Serine/threonine-protein kinase PLK12.7.11.210.450
4bcmT7ZCyclin-dependent kinase 22.7.11.220.450
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.450
1fxfMJIPhospholipase A2, major isoenzyme3.1.1.40.449
2j0m4STFocal adhesion kinase 12.7.10.20.449
2y7jB49Phosphorylase b kinase gamma catalytic chain, liver/testis isoform2.7.11.190.449
3ma301ISerine/threonine-protein kinase pim-12.7.11.10.449
3t8oATPRhodopsin kinase/0.449
1jstATPCyclin-dependent kinase 22.7.11.220.448
3rm719ZCyclin-dependent kinase 22.7.11.220.448
1e1xNW1Cyclin-dependent kinase 22.7.11.220.447
3roy22ZCyclin-dependent kinase 22.7.11.220.447
1h0w207Cyclin-dependent kinase 22.7.11.220.446
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.446
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.446
3fl8RARDihydrofolate reductase/0.446
4bgh3I6Cyclin-dependent kinase 22.7.11.220.446
4kaoKAOFocal adhesion kinase 12.7.10.20.446
1oguST8Cyclin-dependent kinase 22.7.11.220.445
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.445
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.445
3sqq99ZCyclin-dependent kinase 22.7.11.220.445
2etm7PYFocal adhesion kinase 12.7.10.20.444
2uzoC62Cyclin-dependent kinase 22.7.11.220.444
3c4xATPRhodopsin kinase/0.444
4a4o664Serine/threonine-protein kinase PLK12.7.11.210.444
1w0xOLOCyclin-dependent kinase 22.7.11.220.443
1wvxBD4Death-associated protein kinase 12.7.11.10.443
2w06FRVCyclin-dependent kinase 22.7.11.220.443
3qtxX43Cyclin-dependent kinase 22.7.11.220.443
3qu0X40Cyclin-dependent kinase 22.7.11.220.443
4fkr45KCyclin-dependent kinase 22.7.11.220.443
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.443
1finATPCyclin-dependent kinase 22.7.11.220.442
3ig7EFPCyclin-dependent kinase 22.7.11.220.442
3r28XA0Cyclin-dependent kinase 22.7.11.220.442
3rk507ZCyclin-dependent kinase 22.7.11.220.442
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.442
1ove358Mitogen-activated protein kinase 14/0.441
2fvdLIACyclin-dependent kinase 22.7.11.220.441
4fx360KCyclin-dependent kinase 22.7.11.220.441
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.440
3r73X87Cyclin-dependent kinase 22.7.11.220.440
3ttjJBIMitogen-activated protein kinase 102.7.11.240.440
3unj0BXCyclin-dependent kinase 22.7.11.220.440
5auvAGIDeath-associated protein kinase 12.7.11.10.440
5k2bZMAAdenosine receptor A2a/0.440