sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3frd | DHF | Dihydrofolate reductase | 1.5.1.3 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3frd | DHF | Dihydrofolate reductase | 1.5.1.3 | 1.000 | |
| 3fyw | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.697 | |
| 3fre | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.628 | |
| 3fra | I2H | Dihydrofolate reductase | 1.5.1.3 | 0.616 | |
| 3frf | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.615 | |
| 3srq | Q19 | Dihydrofolate reductase | 1.5.1.3 | 0.612 | |
| 3fy9 | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.598 | |
| 4fgh | 0U6 | Dihydrofolate reductase | 1.5.1.3 | 0.597 | |
| 3jw5 | TOP | Dihydrofolate reductase | / | 0.591 | |
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.591 | |
| 4fgg | 0U5 | Dihydrofolate reductase | 1.5.1.3 | 0.575 | |
| 2w3v | TOP | Dihydrofolate reductase | / | 0.570 | |
| 1vj3 | TAB | Dihydrofolate reductase | 1.5.1.3 | 0.565 | |
| 2zza | FOL | Dihydrofolate reductase | / | 0.564 | |
| 3m08 | RAR | Dihydrofolate reductase | 1.5.1.3 | 0.562 | |
| 1dg5 | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.561 | |
| 3inv | C50 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.560 | |
| 3ia4 | MTX | Dihydrofolate reductase | / | 0.558 | |
| 3dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.557 | |
| 3kjs | DQ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.555 | |
| 2w9g | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.553 | |
| 3jwc | EKB | Dihydrofolate reductase | / | 0.553 | |
| 3fy8 | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.551 | |
| 3qlz | QLZ | Uncharacterized protein | / | 0.551 | |
| 3eej | 53R | Uncharacterized protein | / | 0.550 | |
| 3sh2 | 5DR | Dihydrofolate reductase | 1.5.1.3 | 0.550 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.549 | |
| 3srw | Q27 | Dihydrofolate reductase | 1.5.1.3 | 0.547 | |
| 3eel | 53T | Uncharacterized protein | / | 0.545 | |
| 3jw3 | TOP | Dihydrofolate reductase | / | 0.542 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.542 | |
| 3eek | 53S | Uncharacterized protein | / | 0.539 | |
| 3td8 | D2R | Dihydrofolate reductase | 1.5.1.3 | 0.539 | |
| 3cse | N22 | Uncharacterized protein | / | 0.536 | |
| 3qlx | QLR | Uncharacterized protein | / | 0.536 | |
| 3srr | Q20 | Dihydrofolate reductase | 1.5.1.3 | 0.536 | |
| 1ia1 | TQ3 | Dihydrofolate reductase | 1.5.1.3 | 0.534 | |
| 2fzh | DH1 | Dihydrofolate reductase | 1.5.1.3 | 0.534 | |
| 3sa1 | 6DR | Dihydrofolate reductase | / | 0.533 | |
| 1m78 | CLZ | Dihydrofolate reductase | 1.5.1.3 | 0.531 | |
| 1daj | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.530 | |
| 3eem | 53V | Uncharacterized protein | / | 0.529 | |
| 3fyv | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.529 | |
| 1cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.527 | |
| 3dga | RJ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.525 | |
| 2bl9 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.524 | |
| 1rx3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.522 | |
| 3ix9 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.521 | |
| 1ia2 | TQ4 | Dihydrofolate reductase | 1.5.1.3 | 0.520 | |
| 1m7a | MQU | Dihydrofolate reductase | 1.5.1.3 | 0.519 | |
| 4h98 | 14Q | Uncharacterized protein | / | 0.519 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.518 | |
| 3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.518 | |
| 3qly | 55V | Uncharacterized protein | / | 0.517 | |
| 4ixe | IXE | Dihydrofolate reductase | 1.5.1.3 | 0.517 | |
| 3qls | 55V | Dihydrofolate reductase | 1.5.1.3 | 0.514 | |
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 0.513 | |
| 3sru | Q26 | Dihydrofolate reductase | 1.5.1.3 | 0.513 | |
| 1j3k | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.512 | |
| 1dds | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.511 | |
| 3tqb | FOL | Dihydrofolate reductase | / | 0.509 | |
| 4elf | 35I | Dihydrofolate reductase | / | 0.508 | |
| 4h96 | 14Q | Dihydrofolate reductase | 1.5.1.3 | 0.507 | |
| 4ixg | IXG | Dihydrofolate reductase | 1.5.1.3 | 0.507 | |
| 4p66 | MTX | Dihydrofolate reductase | / | 0.506 | |
| 1df7 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.505 | |
| 4nx6 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.505 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.503 | |
| 3cd2 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.502 | |
| 3qlr | QLR | Dihydrofolate reductase | 1.5.1.3 | 0.499 | |
| 4elb | 34S | Dihydrofolate reductase | / | 0.497 | |
| 4nx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.497 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.496 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.495 | |
| 3qlw | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.495 | |
| 4m2x | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.495 | |
| 3dat | MTX | Dihydrofolate reductase | / | 0.494 | |
| 1dg7 | WRB | Dihydrofolate reductase | 1.5.1.3 | 0.492 | |
| 1m79 | MQ1 | Dihydrofolate reductase | 1.5.1.3 | 0.492 | |
| 3tq9 | MTX | Dihydrofolate reductase | / | 0.492 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.491 | |
| 1iwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.488 | |
| 3dau | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 3sgy | 06W | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 4kjj | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 1j3i | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.486 | |
| 3jwm | 5WB | Dihydrofolate reductase | / | 0.486 | |
| 4dph | P65 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.486 | |
| 1zrz | BI1 | Protein kinase C iota type | 2.7.11.13 | 0.484 | |
| 1dis | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.483 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.483 | |
| 4elh | 53I | Dihydrofolate reductase | / | 0.482 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.481 | |
| 2blc | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.481 | |
| 4kky | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.481 | |
| 3srs | M23 | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 3sa2 | 7DR | Dihydrofolate reductase | / | 0.478 | |
| 4x5g | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.478 | |
| 1j3j | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.477 | |
| 2qbn | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.477 | |
| 3sai | 9DR | Dihydrofolate reductase | / | 0.477 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 4ixf | IXF | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 1ly3 | COG | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 2aqk | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.474 | |
| 1og5 | SWF | Cytochrome P450 2C9 | / | 0.473 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.473 | |
| 1jom | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 1phg | MYT | Camphor 5-monooxygenase | 1.14.15.1 | 0.472 | |
| 3qyo | Q24 | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 2cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.470 | |
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.470 | |
| 3jsu | KA5 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.470 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.469 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 1eny | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.468 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.468 | |
| 3th8 | TH9 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.468 | |
| 4g8z | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 2vg7 | NNI | Gag-Pol polyprotein | 2.7.7.49 | 0.466 | |
| 2yee | 2EC | Heat shock protein HSP 90-alpha | / | 0.466 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.465 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.465 | |
| 3m09 | RAR | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.464 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.464 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.464 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.464 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.464 | |
| 1iwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.463 | |
| 1re7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 3mee | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.463 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.463 | |
| 4jvb | 1M0 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.463 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.462 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 2cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.462 | |
| 2idz | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.462 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.462 | |
| 3ml8 | ML8 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.462 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.461 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.460 | |
| 2zaw | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.460 | |
| 3clb | TMQ | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.460 | |
| 3opd | HIE | Heat shock protein 83 | / | 0.460 | |
| 1iid | NHM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.459 | |
| 1rc4 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1yi3 | LY2 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.459 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.459 | |
| 3irn | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.459 | |
| 4x5f | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.459 | |
| 2har | OCC | Vitamin D3 receptor | / | 0.458 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.458 | |
| 4lcg | 1WM | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.458 | |
| 1fpq | SAM | Isoliquiritigenin 2'-O-methyltransferase | / | 0.457 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.457 | |
| 2acw | UPG | Glycosyltransferase | / | 0.457 | |
| 3koo | 24D | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.457 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1uym | PU3 | Heat shock protein HSP 90-beta | / | 0.456 | |
| 2bxm | IMN | Serum albumin | / | 0.456 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.456 | |
| 3p3e | 3P3 | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.456 | |
| 4hgt | 15G | Casein kinase I isoform delta | 2.7.11.1 | 0.456 | |
| 4jvf | 17X | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.456 | |
| 4kl9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.455 | |
| 2c59 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.455 | |
| 2y3r | TRK | TamL | / | 0.455 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.454 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.454 | |
| 3d80 | Q22 | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.454 | |
| 3l3r | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.453 | |
| 2blb | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.453 | |
| 2itt | AEE | Epidermal growth factor receptor | 2.7.10.1 | 0.453 | |
| 3ey9 | TDP | Pyruvate dehydrogenase [ubiquinone] | 1.2.5.1 | 0.453 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.453 | |
| 1geb | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.452 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.452 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.452 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.452 | |
| 5cwa | 0GA | Anthranilate synthase component 1 | 4.1.3.27 | 0.452 | |
| 1uyu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.451 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.451 | |
| 4fhh | 0U3 | Vitamin D3 receptor A | / | 0.451 | |
| 4jv6 | 18F | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.451 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.451 | |
| 1t86 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.450 | |
| 2b0m | 201 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.450 | |
| 2vf0 | F89 | Thymidylate synthase | / | 0.450 | |
| 3inv | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.450 | |
| 1ly4 | COQ | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 2vzm | NRB | Cytochrome P450 monooxygenase PikC | / | 0.449 | |
| 3tea | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.449 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 4egn | TWO | Cytochrome P450 | / | 0.449 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1e7v | LY2 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.448 | |
| 1hzz | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.448 | |
| 1zga | HMK | Isoflavone 4'-O-methyltransferase | / | 0.448 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3a0i | AJI | Glucokinase | 2.7.1.2 | 0.448 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.448 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 4euf | NAD | Trans-2-enoyl-CoA reductase [NADH] | / | 0.448 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.448 | |
| 4wq5 | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.448 | |
| 1dg8 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1guf | NDP | Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial | 1.3.1.10 | 0.447 | |
| 1pjk | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.447 | |
| 1x7h | NDP | Putative ketoacyl reductase | 1.3.1 | 0.447 | |
| 2o4j | VD4 | Vitamin D3 receptor | / | 0.447 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 3czr | 3CZ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.447 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.447 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.447 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.447 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.447 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.447 | |
| 5hi6 | MTX | Dihydrofolate reductase | / | 0.447 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 1eup | ASD | 6-deoxyerythronolide B hydroxylase | / | 0.446 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.446 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 1phe | PIY | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 3cbs | R12 | Cellular retinoic acid-binding protein 2 | / | 0.446 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.446 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.446 | |
| 3wrl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.446 | |
| 1w1r | ZEA | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.445 | |
| 2hc4 | VDX | Vitamin D3 receptor A | / | 0.445 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.445 | |
| 2y4g | TIR | TamL | / | 0.445 | |
| 3inx | JZC | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.445 | |
| 3zw9 | NAD | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.445 | |
| 4g3r | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 4lch | 1WN | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.445 | |
| 4xiw | AZM | Carbonic anhydrase, alpha type | / | 0.445 | |
| 5dcy | NAP | Iridoid synthase | 1.3.1.99 | 0.445 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 2b37 | 8PS | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 2eq7 | NAD | Dihydrolipoyl dehydrogenase | / | 0.444 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.444 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.444 | |
| 2of4 | 979 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.444 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.444 | |
| 3ict | ADP | Coenzyme A disulfide reductase | / | 0.444 | |
| 3ua5 | 06X | Cytochrome P450 2B6 | 1.14.13 | 0.444 | |
| 3vjh | J35 | Peroxisome proliferator-activated receptor gamma | / | 0.444 | |
| 4f64 | 0S8 | Fibroblast growth factor receptor 1 | / | 0.444 | |
| 4fhi | 0S4 | Vitamin D3 receptor A | / | 0.444 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.444 | |
| 4l4c | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 5c8y | ACP | Tubulin tyrosine ligase | / | 0.444 | |
| 2uzh | IPE | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | / | 0.443 | |
| 2zb4 | 5OP | Prostaglandin reductase 2 | 1.3.1.48 | 0.443 | |
| 3clb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.443 | |
| 3csd | EMO | Putative ketoacyl reductase | 1.3.1 | 0.443 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.443 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.443 | |
| 4eev | L1X | Hepatocyte growth factor receptor | 2.7.10.1 | 0.443 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 4fjy | FJY | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 4hnc | 0UT | Mandelate racemase | / | 0.443 | |
| 4i7f | NVE | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.443 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.443 | |
| 5cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 5csh | ATP | Casein kinase II subunit alpha | 2.7.11.1 | 0.443 | |
| 1lco | PPY | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.442 | |
| 1lhw | ESM | Sex hormone-binding globulin | / | 0.442 | |
| 2bla | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.442 | |
| 2drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 2hw2 | RFP | Rifampin ADP-ribosyl transferase | / | 0.442 | |
| 2x6d | X6D | Aurora kinase A | 2.7.11.1 | 0.442 | |
| 3fl9 | TOP | Dihydrofolate reductase | / | 0.442 | |
| 3h1v | TK1 | Glucokinase | 2.7.1.2 | 0.442 | |
| 3o0g | 3O0 | Cyclin-dependent-like kinase 5 | 2.7.11.1 | 0.442 | |
| 3sx2 | NAD | Uncharacterized protein | / | 0.442 | |
| 3um8 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.442 | |
| 3uow | XMP | GMP synthase [glutamine-hydrolyzing] | / | 0.442 | |
| 3zu2 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.442 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.442 | |
| 4kne | 1CY | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 4q0a | 4OA | Vitamin D3 receptor A | / | 0.442 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.442 | |
| 1byg | STU | Tyrosine-protein kinase CSK | / | 0.441 | |
| 1jip | KTN | 6-deoxyerythronolide B hydroxylase | / | 0.441 | |
| 1s3y | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1tlc | F89 | Thymidylate synthase | / | 0.441 | |
| 2clq | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.441 | |
| 2hy8 | 1ST | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.441 | |
| 2ph5 | NAD | Homospermidine synthase | / | 0.441 | |
| 2prh | 238 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.441 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 2yei | XQI | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 2zbz | VDX | Vitamin D3 dihydroxylase | / | 0.441 | |
| 3cz0 | 9OD | Pheromone-binding protein ASP1 | / | 0.441 | |
| 3d0b | SNX | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 3d7k | D7K | Benzaldehyde lyase | / | 0.441 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.441 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.441 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.441 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.441 | |
| 4fic | 0UL | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.441 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.441 | |
| 1ek2 | CDU | Bifunctional epoxide hydrolase 2 | / | 0.440 | |
| 1men | GAR | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.440 | |
| 1osv | CHC | Bile acid receptor | / | 0.440 | |
| 1uye | PU9 | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 1yrc | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 2c3l | IDZ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 2xgs | 44P | Uncharacterized protein | / | 0.440 | |
| 3gbu | ATP | Uncharacterized sugar kinase PH1459 | 2.7.1 | 0.440 | |
| 3inw | JZB | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 3mnr | SD1 | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3vt4 | 5YI | Vitamin D3 receptor | / | 0.440 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 4c1i | EH9 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.440 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.440 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.440 |