sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3fml | FML | Mitogen-activated protein kinase 14 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3fml | FML | Mitogen-activated protein kinase 14 | / | 1.000 | |
| 3flz | FLZ | Mitogen-activated protein kinase 14 | / | 0.631 | |
| 3fly | FLY | Mitogen-activated protein kinase 14 | / | 0.629 | |
| 3fmn | 530 | Mitogen-activated protein kinase 14 | / | 0.594 | |
| 3flq | 891 | Mitogen-activated protein kinase 14 | / | 0.589 | |
| 3fmh | 533 | Mitogen-activated protein kinase 14 | / | 0.573 | |
| 3fmm | XI2 | Mitogen-activated protein kinase 14 | / | 0.571 | |
| 3fsk | RO6 | Mitogen-activated protein kinase 14 | / | 0.571 | |
| 3fi4 | FI4 | Mitogen-activated protein kinase 14 | / | 0.568 | |
| 3fls | FLS | Mitogen-activated protein kinase 14 | / | 0.568 | |
| 3fmj | FMJ | Mitogen-activated protein kinase 14 | / | 0.568 | |
| 1bl6 | SB6 | Mitogen-activated protein kinase 14 | / | 0.565 | |
| 1ouy | 094 | Mitogen-activated protein kinase 14 | / | 0.563 | |
| 3ha8 | 5JZ | Mitogen-activated protein kinase 14 | / | 0.561 | |
| 2gfs | PQB | Mitogen-activated protein kinase 14 | / | 0.558 | |
| 3fl4 | FL4 | Mitogen-activated protein kinase 14 | / | 0.556 | |
| 4dlj | 6RG | Mitogen-activated protein kinase 14 | / | 0.556 | |
| 3fkn | FKN | Mitogen-activated protein kinase 14 | / | 0.554 | |
| 2zaz | GK1 | Mitogen-activated protein kinase 14 | / | 0.553 | |
| 3itz | P66 | Mitogen-activated protein kinase 14 | / | 0.549 | |
| 1ywr | LI9 | Mitogen-activated protein kinase 14 | / | 0.548 | |
| 3dt1 | P40 | Mitogen-activated protein kinase 14 | / | 0.542 | |
| 3gc7 | B45 | Mitogen-activated protein kinase 14 | / | 0.540 | |
| 2zb0 | GK3 | Mitogen-activated protein kinase 14 | / | 0.539 | |
| 3zsh | 469 | Mitogen-activated protein kinase 14 | / | 0.538 | |
| 3fln | 3FN | Mitogen-activated protein kinase 14 | / | 0.536 | |
| 1m7q | DQO | Mitogen-activated protein kinase 14 | / | 0.532 | |
| 1ouk | 084 | Mitogen-activated protein kinase 14 | / | 0.531 | |
| 3gfe | P37 | Mitogen-activated protein kinase 14 | / | 0.527 | |
| 3hp5 | 52P | Mitogen-activated protein kinase 14 | / | 0.525 | |
| 1yqj | 6NP | Mitogen-activated protein kinase 14 | / | 0.523 | |
| 3fsf | FSS | Mitogen-activated protein kinase 14 | / | 0.522 | |
| 3fko | FKO | Mitogen-activated protein kinase 14 | / | 0.517 | |
| 3fkl | FKL | Mitogen-activated protein kinase 14 | / | 0.516 | |
| 3lfa | 1N1 | Mitogen-activated protein kinase 14 | / | 0.514 | |
| 3s4q | NK0 | Mitogen-activated protein kinase 14 | / | 0.514 | |
| 3l8s | BFF | Mitogen-activated protein kinase 14 | / | 0.513 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.513 | |
| 3nww | 3NW | Mitogen-activated protein kinase 14 | / | 0.513 | |
| 1ove | 358 | Mitogen-activated protein kinase 14 | / | 0.512 | |
| 1zyj | BI5 | Mitogen-activated protein kinase 14 | / | 0.510 | |
| 3fmk | FMK | Mitogen-activated protein kinase 14 | / | 0.509 | |
| 3uib | SB2 | Putative mitogen-activated protein kinase | / | 0.509 | |
| 4eh6 | 0ON | Mitogen-activated protein kinase 14 | / | 0.509 | |
| 4kip | 1R9 | Mitogen-activated protein kinase 14 | / | 0.506 | |
| 3iph | G11 | Mitogen-activated protein kinase 14 | / | 0.505 | |
| 1bl7 | SB4 | Mitogen-activated protein kinase 14 | / | 0.504 | |
| 3roc | 29A | Mitogen-activated protein kinase 14 | / | 0.504 | |
| 4eh5 | 0OM | Mitogen-activated protein kinase 14 | / | 0.504 | |
| 4nks | 2M2 | Fibroblast growth factor receptor 1 | / | 0.502 | |
| 3hll | I45 | Mitogen-activated protein kinase 14 | / | 0.501 | |
| 1zzl | TZY | Mitogen-activated protein kinase 14 | / | 0.500 | |
| 2zb1 | GK4 | Mitogen-activated protein kinase 14 | / | 0.500 | |
| 2ewa | SB2 | Mitogen-activated protein kinase 14 | / | 0.497 | |
| 3hl7 | I47 | Mitogen-activated protein kinase 14 | / | 0.496 | |
| 4lop | SB4 | Mitogen-activated protein kinase 14 | / | 0.496 | |
| 2qd9 | LGF | Mitogen-activated protein kinase 14 | / | 0.495 | |
| 1npv | L27 | Gag-Pol polyprotein | 3.4.23.16 | 0.494 | |
| 3iw5 | DF3 | Mitogen-activated protein kinase 14 | / | 0.491 | |
| 3fc1 | 52P | Mitogen-activated protein kinase 14 | / | 0.490 | |
| 3hv3 | R49 | Mitogen-activated protein kinase 14 | / | 0.490 | |
| 3ds6 | A17 | Mitogen-activated protein kinase 14 | / | 0.488 | |
| 3hub | 469 | Mitogen-activated protein kinase 14 | / | 0.488 | |
| 3vid | 4TT | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.487 | |
| 1bmk | SB5 | Mitogen-activated protein kinase 14 | / | 0.486 | |
| 3gcq | 1BU | Mitogen-activated protein kinase 14 | / | 0.484 | |
| 1t1r | IMB | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.483 | |
| 1mb9 | ATP | Carboxyethyl-arginine beta-lactam-synthase | 6.3.3.4 | 0.482 | |
| 4hyu | 1BK | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.481 | |
| 3a99 | ANP | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.480 | |
| 3bhe | BZN | Gag-Pol polyprotein | 3.4.23.16 | 0.480 | |
| 2acx | ANP | G protein-coupled receptor kinase 6 | 2.7.11.16 | 0.478 | |
| 4nka | 2K7 | Fibroblast growth factor receptor 1 | / | 0.478 | |
| 1jvs | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.477 | |
| 2ghm | LIC | Mitogen-activated protein kinase 14 | / | 0.477 | |
| 3ggg | NAD | Prephenate dehydrogenase | / | 0.477 | |
| 3oc1 | BMU | Mitogen-activated protein kinase 14 | / | 0.477 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.476 | |
| 4hi0 | GDP | Urease accessory protein UreG | / | 0.476 | |
| 3hvc | GG5 | Mitogen-activated protein kinase 14 | / | 0.475 | |
| 1v9a | SAH | Uncharacterized protein | / | 0.474 | |
| 2w1f | L0F | Aurora kinase A | 2.7.11.1 | 0.474 | |
| 4g6n | EK0 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.474 | |
| 4i4e | 1BQ | Focal adhesion kinase 1 | 2.7.10.2 | 0.474 | |
| 4upj | U04 | Gag-Pol polyprotein | / | 0.474 | |
| 1k6c | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.473 | |
| 1bdr | IM1 | Gag-Pol polyprotein | 3.4.23.16 | 0.472 | |
| 3bx5 | 304 | Mitogen-activated protein kinase 14 | / | 0.472 | |
| 3u8w | 09J | Mitogen-activated protein kinase 14 | / | 0.472 | |
| 4ebf | NAD | Phosphonate dehydrogenase | 1.20.1.1 | 0.472 | |
| 2bal | PQA | Mitogen-activated protein kinase 14 | / | 0.471 | |
| 4qmx | H8H | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.471 | |
| 3rwp | ABQ | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.470 | |
| 1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.469 | |
| 2etm | 7PY | Focal adhesion kinase 1 | 2.7.10.2 | 0.469 | |
| 2upj | U02 | Gag-Pol polyprotein | 3.4.23.16 | 0.469 | |
| 1w2x | RCP | Acetyl-CoA carboxylase | / | 0.468 | |
| 3mvl | 38P | Mitogen-activated protein kinase 14 | / | 0.468 | |
| 3nmh | PYV | Abscisic acid receptor PYL2 | / | 0.468 | |
| 1bv9 | XV6 | Gag-Pol polyprotein | 3.4.23.16 | 0.467 | |
| 3c5u | P41 | Mitogen-activated protein kinase 14 | / | 0.467 | |
| 3th8 | TH9 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.467 | |
| 4fuy | EK2 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.467 | |
| 1w84 | L12 | Mitogen-activated protein kinase 14 | / | 0.466 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.466 | |
| 3cjg | KIM | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.466 | |
| 3ml8 | ML8 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.466 | |
| 1t1s | CBQ | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.465 | |
| 2aid | THK | Gag-Pol polyprotein | 3.4.23.16 | 0.465 | |
| 2ibz | SMA | Cytochrome b | / | 0.465 | |
| 2obj | VRV | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.465 | |
| 2pyw | ADP | Methylthioribose kinase | 2.7.1.100 | 0.465 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.465 | |
| 3l8x | N4D | Mitogen-activated protein kinase 14 | / | 0.465 | |
| 3mzh | CMP | CRP-like cAMP-activated global transcriptional regulator | / | 0.465 | |
| 3zux | TCH | Transporter | / | 0.465 | |
| 2itq | ITQ | Epidermal growth factor receptor | 2.7.10.1 | 0.464 | |
| 4jvf | 17X | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.464 | |
| 4anq | VGH | ALK tyrosine kinase receptor | 2.7.10.1 | 0.463 | |
| 4ot2 | NPS | Serum albumin | / | 0.463 | |
| 2bts | U32 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.462 | |
| 2rg6 | 287 | Mitogen-activated protein kinase 14 | / | 0.462 | |
| 2yix | YIX | Mitogen-activated protein kinase 14 | / | 0.462 | |
| 3iqz | H4M | F420-dependent methylenetetrahydromethanopterin dehydrogenase | 1.5.98.1 | 0.462 | |
| 4ib4 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.462 | |
| 5br7 | FAD | UDP-galactopyranose mutase | / | 0.462 | |
| 2p4y | C03 | Peroxisome proliferator-activated receptor gamma | / | 0.461 | |
| 2q6b | HR2 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.34 | 0.461 | |
| 2xh9 | J01 | Uncharacterized protein | / | 0.461 | |
| 4hy6 | FJ1 | Heat shock protein HSP 90-alpha | / | 0.461 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.460 | |
| 2iya | ZIO | Oleandomycin glycosyltransferase | / | 0.460 | |
| 3ecg | 065 | Gag-Pol polyprotein | 3.4.23.47 | 0.460 | |
| 1bxo | PP7 | Penicillopepsin-1 | 3.4.23.20 | 0.459 | |
| 1xl2 | 189 | Gag-Pol polyprotein | 3.4.23.16 | 0.459 | |
| 1zar | ADP | RIO-type serine/threonine-protein kinase Rio2 | 2.7.11.1 | 0.459 | |
| 2e9n | 76A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.459 | |
| 3ics | ADP | Coenzyme A disulfide reductase | / | 0.459 | |
| 3nwq | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.459 | |
| 3vjo | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.459 | |
| 4bc6 | XZN | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.459 | |
| 4enx | Z20 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.459 | |
| 4ewq | MWL | Mitogen-activated protein kinase 14 | / | 0.459 | |
| 1b6k | PI5 | Gag-Pol polyprotein | 3.4.23.16 | 0.458 | |
| 1hii | C20 | Gag-Pol polyprotein | / | 0.458 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.458 | |
| 2w7x | D1A | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.458 | |
| 3aid | ARQ | Gag-Pol polyprotein | 3.4.23.16 | 0.458 | |
| 3dk1 | G05 | Gag-Pol polyprotein | 3.4.23.16 | 0.458 | |
| 3lij | ANP | Calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands | / | 0.458 | |
| 3ncg | BK1 | Calmodulin-domain protein kinase 1, putative | / | 0.458 | |
| 4f63 | 0S7 | Fibroblast growth factor receptor 1 | / | 0.458 | |
| 4loq | SB4 | Mitogen-activated protein kinase 14 | / | 0.458 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.458 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.457 | |
| 2xru | 400 | Aurora kinase A | 2.7.11.1 | 0.457 | |
| 3sgx | 0FW | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.457 | |
| 4aa4 | QC0 | Mitogen-activated protein kinase 14 | / | 0.457 | |
| 4qmn | DB8 | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.457 | |
| 1bdq | IM1 | Gag-Pol polyprotein | 3.4.23.16 | 0.456 | |
| 1d4h | BEH | Gag-Pol polyprotein | 3.4.23.16 | 0.456 | |
| 1e90 | MYC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.456 | |
| 2w0j | ZAT | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.456 | |
| 3mpt | 1GK | Mitogen-activated protein kinase 14 | / | 0.456 | |
| 3r3d | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.456 | |
| 4c4j | X21 | Dual specificity protein kinase TTK | 2.7.12.1 | 0.456 | |
| 4f64 | 0S8 | Fibroblast growth factor receptor 1 | / | 0.456 | |
| 6gsw | GPS | Glutathione S-transferase Mu 1 | 2.5.1.18 | 0.456 | |
| 1bvg | DMP | Gag-Pol polyprotein | 3.4.23.16 | 0.455 | |
| 1mes | DMP | Gag-Pol polyprotein | 3.4.23.16 | 0.455 | |
| 2ayp | 43A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.455 | |
| 2hog | 710 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.455 | |
| 2vzm | NRB | Cytochrome P450 monooxygenase PikC | / | 0.455 | |
| 3cd5 | 7HI | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.34 | 0.455 | |
| 3i6o | GR6 | Gag-Pol polyprotein | 3.4.23.16 | 0.455 | |
| 3w0a | DS5 | Vitamin D3 receptor | / | 0.455 | |
| 4fsq | HK3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.455 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.455 | |
| 4nxv | GDP | Mitochondrial dynamics protein MID51 | / | 0.455 | |
| 2q3k | MUW | Gag-Pol polyprotein | / | 0.454 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.454 | |
| 3w2o | 03P | Epidermal growth factor receptor | 2.7.10.1 | 0.454 | |
| 4aac | AAV | Mitogen-activated protein kinase 14 | / | 0.454 | |
| 4b7d | QLE | Cytochrome P450 monooxygenase PikC | / | 0.454 | |
| 4bcm | T7Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.454 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.454 | |
| 1rc1 | KT3 | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.453 | |
| 1sn5 | T3 | Transthyretin | / | 0.453 | |
| 2bpw | 1IN | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 2gst | GPS | Glutathione S-transferase Mu 1 | 2.5.1.18 | 0.453 | |
| 3kp4 | MII | Transcriptional regulator TcaR | / | 0.453 | |
| 4jhd | ANP | Actin-5C | / | 0.453 | |
| 4jrv | KJV | Epidermal growth factor receptor | 2.7.10.1 | 0.453 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.452 | |
| 2qd7 | 065 | Gag-Pol polyprotein | 3.4.23.16 | 0.452 | |
| 2vwu | 7X1 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.452 | |
| 2yir | YIR | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.452 | |
| 3d0b | SNX | Heat shock protein HSP 90-alpha | / | 0.452 | |
| 4eh7 | 0OO | Mitogen-activated protein kinase 14 | / | 0.452 | |
| 4ez5 | 0RS | Cyclin-dependent kinase 6 | 2.7.11.22 | 0.452 | |
| 4tzt | 468 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.452 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1qbt | 146 | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 2bpy | 3IN | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 2gek | GDP | Phosphatidyl-myo-inositol mannosyltransferase | 2.4.1.57 | 0.451 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.451 | |
| 2phk | ATP | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform | 2.7.11.19 | 0.451 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 3bv2 | P38 | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 3mxe | K54 | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 3rin | I2O | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 3t11 | 3T1 | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 4a6b | QG8 | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 4aa5 | NQB | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 4hms | FMN | Phenazine biosynthesis protein PhzG | 1.4 | 0.451 | |
| 4kl9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 4loo | SB4 | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 4rqk | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.451 | |
| 1me8 | RVP | Inosine-5'-monophosphate dehydrogenase | / | 0.450 | |
| 2zbz | VDX | Vitamin D3 dihydroxylase | / | 0.450 | |
| 3efw | AK8 | Aurora kinase A | 2.7.11.1 | 0.450 | |
| 3och | 2MX | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 3qd4 | 3Q6 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.450 | |
| 3w0j | T08 | Vitamin D3 receptor | / | 0.450 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1bve | DMP | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 1civ | NAP | Malate dehydrogenase [NADP], chloroplastic | 1.1.1.82 | 0.449 | |
| 2jed | LG8 | Protein kinase C theta type | 2.7.11.13 | 0.449 | |
| 2o0u | C0M | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.449 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 3w1f | 1O5 | Dual specificity protein kinase TTK | 2.7.12.1 | 0.449 | |
| 4aic | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.449 | |
| 4fhh | 0U3 | Vitamin D3 receptor A | / | 0.449 | |
| 1fvt | 106 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 1gqt | ACP | Ribokinase | / | 0.448 | |
| 1npa | 3NH | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 1npw | LGZ | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 1t3r | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 2e9c | B75 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.448 | |
| 2gd2 | CAA | Probable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase ) | / | 0.448 | |
| 2w1g | L0G | Aurora kinase A | 2.7.11.1 | 0.448 | |
| 2ycq | UPX | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.448 | |
| 2yit | YIT | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.448 | |
| 3iqe | F42 | F420-dependent methylenetetrahydromethanopterin dehydrogenase | 1.5.98.1 | 0.448 | |
| 3t9a | ANP | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 | / | 0.448 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.448 | |
| 4dwv | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.448 | |
| 4nfh | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.448 | |
| 4z34 | ON7 | Lysophosphatidic acid receptor 1 | / | 0.448 | |
| 1gii | 1PU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 1sdu | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 1wbn | L09 | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.447 | |
| 2j5x | GSP | ADP-ribosylation factor 6 | / | 0.447 | |
| 2yek | EAM | Bromodomain-containing protein 2 | / | 0.447 | |
| 3em6 | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 3icr | FAD | Coenzyme A disulfide reductase | / | 0.447 | |
| 3l9h | EMQ | Kinesin-like protein KIF11 | / | 0.447 | |
| 4fhi | 0S4 | Vitamin D3 receptor A | / | 0.447 | |
| 4fjy | FJY | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.447 | |
| 4g6o | E28 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.447 | |
| 4kf1 | HT5 | Aryldialkylphosphatase | 3.1.8.1 | 0.447 | |
| 4xx9 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.447 | |
| 1d4y | TPV | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 1ivq | 0PX | Gag-Pol polyprotein | / | 0.446 | |
| 1osv | CHC | Bile acid receptor | / | 0.446 | |
| 1p44 | GEQ | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 2ft9 | CHD | Fatty acid-binding protein 2, liver | / | 0.446 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.446 | |
| 2hxl | 422 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.446 | |
| 2jko | BIJ | Focal adhesion kinase 1 | 2.7.10.2 | 0.446 | |
| 2rg5 | 279 | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 3k4v | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 3nu9 | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 3upj | U03 | Gag-Pol polyprotein | / | 0.446 | |
| 4aot | GW8 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.446 | |
| 4bdi | HAU | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.446 | |
| 4hfm | NAP | 2-alkenal reductase (NADP(+)-dependent) | / | 0.446 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 5dt4 | ATP | Aurora kinase A | 2.7.11.1 | 0.446 | |
| 1meu | DMP | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.445 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 2hy0 | 306 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 2pv7 | NAD | T-protein | 1.3.1.12 | 0.445 | |
| 2qi0 | MZ3 | Gag-Pol polyprotein | / | 0.445 | |
| 2ycs | NXP | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.445 | |
| 3h0s | B38 | Acetyl-CoA carboxylase | / | 0.445 | |
| 3igo | ANP | Calmodulin-domain protein kinase 1, putative | / | 0.445 | |
| 3jvw | DMP | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 3nu3 | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 3qyw | 6PB | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.445 | |
| 3sa9 | A68 | Protease | / | 0.445 | |
| 3t54 | ATP | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 | / | 0.445 | |
| 3tqh | NDP | Quinone oxidoreductase | / | 0.445 | |
| 4a6c | QG9 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 4anw | O92 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 4bdb | ODO | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.445 | |
| 4e73 | 0NR | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.445 | |
| 4h3c | 0YZ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.445 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.445 | |
| 4nc3 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.445 | |
| 5ack | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.445 | |
| 5kj1 | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.445 | |
| 1c6z | ROC | Protease | / | 0.444 | |
| 1fg6 | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 1jgt | APC | Carboxyethyl-arginine beta-lactam-synthase | 6.3.3.4 | 0.444 | |
| 1met | DMP | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 2j7t | 274 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.444 | |
| 2o4r | VD5 | Vitamin D3 receptor | / | 0.444 | |
| 3ckt | YDP | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 3qaq | QAQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 3vwe | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.444 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 4f9w | LM4 | Mitogen-activated protein kinase 14 | / | 0.444 | |
| 4fic | 0UL | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.444 | |
| 4oav | ACP | 2-5A-dependent ribonuclease | 3.1.26 | 0.444 | |
| 4zrn | UPG | UDP-glucose 4-epimerase, putative | / | 0.444 | |
| 2dq7 | STU | Tyrosine-protein kinase Fyn | 2.7.10.2 | 0.443 | |
| 2eau | CZA | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.443 | |
| 2pwl | ACP | Fibroblast growth factor receptor 2 | / | 0.443 | |
| 2qbn | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 3h86 | AP5 | Adenylate kinase | / | 0.443 | |
| 3nf7 | CIW | Gag-Pol polyprotein | / | 0.443 | |
| 3q92 | XNB | Ketohexokinase | / | 0.443 | |
| 3qcx | 3Q2 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.443 | |
| 3s56 | ROC | Protease | / | 0.443 | |
| 4bdc | ODH | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.443 | |
| 4dqb | 017 | Gag-Pol polyprotein | / | 0.443 | |
| 4fnz | NZF | ALK tyrosine kinase receptor | 2.7.10.1 | 0.443 | |
| 4i3z | ADP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 4jv6 | 18F | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.443 | |
| 5cdg | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.443 | |
| 5es7 | FON | Linear gramicidin synthase subunit A | / | 0.443 | |
| 9hvp | 0E9 | Gag-Pol polyprotein | / | 0.443 | |
| 1a8g | 2Z4 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 1fpq | SAM | Isoliquiritigenin 2'-O-methyltransferase | / | 0.442 | |
| 1idb | 0DO | Gag-Pol polyprotein | / | 0.442 | |
| 1msm | JE2 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 1uuo | BRF | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.442 | |
| 1yw2 | PGJ | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 2ow3 | BIM | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.442 | |
| 2r43 | G3G | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 2rc6 | NAP | Ferredoxin--NADP reductase | / | 0.442 | |
| 2y05 | NAP | Prostaglandin reductase 1 | / | 0.442 | |
| 2yei | XQI | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 3hrf | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.442 | |
| 3qru | X19 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 3t3c | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 3t99 | ADP | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 | / | 0.442 | |
| 3w5p | 4OA | Vitamin D3 receptor | / | 0.442 | |
| 4brx | KGW | Focal adhesion kinase 1 | 2.7.10.2 | 0.442 | |
| 4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.442 | |
| 4l45 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.442 | |
| 4qi5 | FAD | Cellobiose dehydrogenase | / | 0.442 | |
| 1ml3 | NAD | Glyceraldehyde-3-phosphate dehydrogenase, glycosomal | 1.2.1.12 | 0.441 | |
| 1ny3 | ADP | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.441 | |
| 1qbs | DMP | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 1s0x | C3S | Nuclear receptor ROR-alpha | / | 0.441 | |
| 1wbk | 568 | Pol protein | / | 0.441 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 2hs2 | 017 | Protease | / | 0.441 | |
| 2hxq | 373 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 2j4d | MHF | Cryptochrome DASH, chloroplastic/mitochondrial | / | 0.441 | |
| 2oh0 | 2PY | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.441 | |
| 3el0 | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 3m8q | DJZ | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 3mwu | BK3 | Calmodulin-domain protein kinase 1, putative | / | 0.441 | |
| 3o9d | K19 | Pol polyprotein | / | 0.441 | |
| 3vth | AP2 | Carbamoyltransferase | / | 0.441 | |
| 3zw3 | ZW3 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 4anv | 751 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 4do0 | DZA | Histone lysine demethylase PHF8 | 1.14.11.27 | 0.441 | |
| 4dpw | AGS | Mevalonate diphosphate decarboxylase | / | 0.441 | |
| 4eh3 | NAR | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 4ic7 | ANP | Mitogen-activated protein kinase 7 | 2.7.11.24 | 0.441 | |
| 4jvb | 1M0 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.441 | |
| 4kbk | 1QG | Casein kinase I isoform delta | 2.7.11.1 | 0.441 | |
| 4nt0 | 3DU | Orotidine 5'-phosphate decarboxylase | 4.1.1.23 | 0.441 | |
| 4q1x | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 1g35 | AHF | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 1iyz | NDP | Probable quinone oxidoreductase | / | 0.440 | |
| 1j39 | UPG | DNA beta-glucosyltransferase | / | 0.440 | |
| 1lny | IMO | Adenylosuccinate synthetase isozyme 1 | / | 0.440 | |
| 1ppj | ANY | Cytochrome b | / | 0.440 | |
| 1q99 | ANP | Serine/threonine-protein kinase SKY1 | 2.7.11.1 | 0.440 | |
| 1w5v | BE3 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 2bpz | 3IN | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 2ekl | NAD | D-3-phosphoglycerate dehydrogenase | / | 0.440 | |
| 2f3k | RO1 | Protease | / | 0.440 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.440 | |
| 2itw | ITQ | Epidermal growth factor receptor | 2.7.10.1 | 0.440 | |
| 3apf | BMW | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 3djk | G55 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 3ggo | NAI | Prephenate dehydrogenase | / | 0.440 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.440 | |
| 3nga | 3NG | Casein kinase II subunit alpha | 2.7.11.1 | 0.440 | |
| 3ogq | AB1 | Pol polyprotein | / | 0.440 | |
| 4b1v | LAB | Actin, alpha skeletal muscle | / | 0.440 | |
| 4d4s | BI9 | Focal adhesion kinase 1 | 2.7.10.2 | 0.440 | |
| 4ezk | 0SD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 4hys | 1BJ | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.440 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.440 | |
| 4ieb | ANP | Calmodulin-domain protein kinase 1 | / | 0.440 | |
| 4jqe | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.440 | |
| 4mq1 | 2C3 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | 2.7.12.1 | 0.440 | |
| 4uya | AGS | Mitogen-activated protein kinase kinase kinase 21 | 2.7.11.25 | 0.440 | |
| 4wq5 | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.440 |