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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3ffkATPActin, alpha skeletal muscle

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3ffkATPActin, alpha skeletal muscle/1.000
1c0fATPMajor actin/0.567
4pkgATPActin, alpha skeletal muscle/0.553
1h1vATPActin, alpha skeletal muscle/0.548
4k42ADPActin, alpha skeletal muscle/0.546
5ce3ATPActin/0.546
3m6gATPActin, alpha skeletal muscle/0.535
4pkhADPActin, alpha skeletal muscle/0.533
4jhdANPActin-5C/0.531
4m63ATPActin-5C/0.525
3mn9ATPActin-5C/0.524
3tu5ATPActin, alpha skeletal muscle/0.521
3mn6ATPActin-5C/0.520
1lotATPActin, alpha skeletal muscle/0.519
4pl8ATPActin, alpha skeletal muscle/0.514
3u9dATPActin, alpha skeletal muscle/0.512
1ijjATPActin, alpha skeletal muscle/0.510
4pkiATPActin, alpha skeletal muscle/0.504
2v51ATPActin, alpha skeletal muscle/0.499
1nmdATPMajor actin/0.497
3m1fATPActin, alpha skeletal muscle/0.496
1mduATPActin, alpha skeletal muscle/0.495
2q36ATPActin, alpha skeletal muscle/0.495
4ci6ATPActin/0.495
3chwATPMajor actin/0.476
1nm1ATPMajor actin/0.472
3w3dATPActin, gamma-enteric smooth muscle/0.471
1kxpATPActin, alpha skeletal muscle/0.470
4rwtANPActin-5C/0.467
2q97ATPActin, alpha skeletal muscle/0.463
1nlvATPMajor actin/0.459
3a5mATPMajor actin/0.454
3u4lATPActin, cytoplasmic 1/0.442