sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3f28 | S7B | Thermolysin | 3.4.24.27 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3f28 | S7B | Thermolysin | 3.4.24.27 | 1.000 | |
| 4h57 | 0PJ | Thermolysin | 3.4.24.27 | 0.765 | |
| 3fgd | BYA | Thermolysin | 3.4.24.27 | 0.717 | |
| 3f2p | S3B | Thermolysin | 3.4.24.27 | 0.699 | |
| 3for | ZNP | Thermolysin | 3.4.24.27 | 0.688 | |
| 2tmn | 0FA | Thermolysin | 3.4.24.27 | 0.615 | |
| 1qf2 | TI3 | Thermolysin | 3.4.24.27 | 0.605 | |
| 6tmn | 0PI | Thermolysin | 3.4.24.27 | 0.595 | |
| 4tln | LNO | Thermolysin | 3.4.24.27 | 0.586 | |
| 4d9w | X32 | Thermolysin | 3.4.24.27 | 0.580 | |
| 4tmn | 0PK | Thermolysin | 3.4.24.27 | 0.579 | |
| 3t8c | UBW | Thermolysin | 3.4.24.27 | 0.577 | |
| 3t8d | UBV | Thermolysin | 3.4.24.27 | 0.565 | |
| 3t87 | UBZ | Thermolysin | 3.4.24.27 | 0.563 | |
| 3t8h | UBS | Thermolysin | 3.4.24.27 | 0.540 | |
| 3t74 | UBY | Thermolysin | 3.4.24.27 | 0.537 | |
| 3fvp | UB2 | Thermolysin | 3.4.24.27 | 0.534 | |
| 3hy7 | 097 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.494 | |
| 3hy9 | 098 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.492 | |
| 3ivc | FG4 | Pantothenate synthetase | 6.3.2.1 | 0.489 | |
| 1f5f | DHT | Sex hormone-binding globulin | / | 0.488 | |
| 4a33 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.481 | |
| 1bnm | AL8 | Carbonic anhydrase 2 | 4.2.1.1 | 0.479 | |
| 1i90 | INM | Carbonic anhydrase 2 | 4.2.1.1 | 0.479 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.478 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.477 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.477 | |
| 1g05 | BBH | Stromelysin-1 | 3.4.24.17 | 0.475 | |
| 1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.475 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.475 | |
| 1efa | NPF | Lactose operon repressor | / | 0.474 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.474 | |
| 3r1r | ATP | Ribonucleoside-diphosphate reductase 1 subunit alpha | 1.17.4.1 | 0.474 | |
| 3aig | 0ZC | Snake venom metalloproteinase adamalysin-2 | 3.4.24.46 | 0.473 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.472 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.472 | |
| 3b8z | 294 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.472 | |
| 4a31 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.472 | |
| 4xba | 5GP | Aprataxin-like protein | 3 | 0.472 | |
| 3mje | NDP | AmphB | / | 0.471 | |
| 3bts | NAD | Galactose/lactose metabolism regulatory protein GAL80 | / | 0.470 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.469 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.469 | |
| 2gz7 | D3F | Orf1a polyprotein | / | 0.469 | |
| 4dpt | AGS | Mevalonate diphosphate decarboxylase | / | 0.469 | |
| 4n1g | CEI | Obelin | / | 0.469 | |
| 5ein | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.469 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.468 | |
| 3img | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.468 | |
| 3img | BZ3 | Pantothenate synthetase | 6.3.2.1 | 0.468 | |
| 4rrr | A3T | Threonine--tRNA ligase | 6.1.1.3 | 0.468 | |
| 1qyw | 5SD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.467 | |
| 2p8u | COA | Hydroxymethylglutaryl-CoA synthase, cytoplasmic | 2.3.3.10 | 0.467 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 4bqh | 9VU | UDP-N-acetylglucosamine pyrophosphorylase, putative | / | 0.467 | |
| 4fry | NAD | Putative signal-transduction protein with CBS domains | / | 0.467 | |
| 4rvn | COA | Phenylacetate-coenzyme A ligase | / | 0.467 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.466 | |
| 3dhc | CYK | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.466 | |
| 3ime | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.466 | |
| 2j5s | KTA | Alr4455 protein | / | 0.465 | |
| 2yki | YKI | Heat shock protein HSP 90-alpha | / | 0.465 | |
| 3bht | MFR | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.465 | |
| 3qgf | 46F | Genome polyprotein | 2.7.7.48 | 0.465 | |
| 4mr9 | 2BX | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.465 | |
| 4rww | 2BA | Lmo2692 protein | / | 0.465 | |
| 2xvw | 9NR | Serum albumin | / | 0.464 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.464 | |
| 4a95 | NHW | Glycylpeptide N-tetradecanoyltransferase | / | 0.464 | |
| 1icq | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.462 | |
| 1npd | NAD | Quinate/shikimate dehydrogenase | / | 0.462 | |
| 2fs4 | PZ1 | Renin | 3.4.23.15 | 0.462 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.462 | |
| 3elb | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.462 | |
| 3iqg | ASN_TRP_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.462 | |
| 3mpt | 1GK | Mitogen-activated protein kinase 14 | / | 0.462 | |
| 3qd4 | 3Q6 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.462 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.462 | |
| 4mr7 | 2BV | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.462 | |
| 4u15 | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.462 | |
| 1kqg | MGD | Formate dehydrogenase, nitrate-inducible, major subunit | 1.1.5.6 | 0.461 | |
| 1ndh | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.461 | |
| 2x06 | NAD | L-sulfolactate dehydrogenase | / | 0.461 | |
| 3hyg | 099 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.461 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.461 | |
| 4g67 | SAH | Uncharacterized ACR, COG1565 superfamily | / | 0.461 | |
| 4j3m | AJ8 | Tankyrase-2 | 2.4.2.30 | 0.461 | |
| 2b4t | AES | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.460 | |
| 2r6g | ATP | Maltose/maltodextrin import ATP-binding protein MalK | / | 0.460 | |
| 3fv4 | 1U4 | Thermolysin | 3.4.24.27 | 0.460 | |
| 1nw5 | SAM | Modification methylase RsrI | 2.1.1.72 | 0.459 | |
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.459 | |
| 2ha6 | SCK | Acetylcholinesterase | 3.1.1.7 | 0.459 | |
| 2iby | COA | Acetyl-CoA acetyltransferase, mitochondrial | 2.3.1.9 | 0.459 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.459 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.459 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.459 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.459 | |
| 3giy | FMN | (S)-mandelate dehydrogenase | 1.1.99.31 | 0.459 | |
| 4f0e | 0RU | Poly [ADP-ribose] polymerase 15 | 2.4.2.30 | 0.459 | |
| 4f9c | 0SX | Cell division cycle 7-related protein kinase | 2.7.11.1 | 0.459 | |
| 4pnr | G18 | Tankyrase-2 | 2.4.2.30 | 0.459 | |
| 1bdm | NAX | Malate dehydrogenase | / | 0.458 | |
| 1gve | NAP | Aflatoxin B1 aldehyde reductase member 3 | 1 | 0.458 | |
| 1i6k | TYM | Tryptophan--tRNA ligase | 6.1.1.2 | 0.458 | |
| 1uye | PU9 | Heat shock protein HSP 90-alpha | / | 0.458 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.458 | |
| 3e23 | SAM | Uncharacterized protein | / | 0.458 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.458 | |
| 1b8v | NAD | Malate dehydrogenase | / | 0.457 | |
| 1g8o | U5P | N-acetyllactosaminide alpha-1,3-galactosyltransferase | / | 0.457 | |
| 1iay | AVG | 1-aminocyclopropane-1-carboxylate synthase 2 | 4.4.1.14 | 0.457 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.457 | |
| 2bt4 | CA2 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.457 | |
| 2x7u | WZA | Carbonic anhydrase 2 | 4.2.1.1 | 0.457 | |
| 2ylz | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.457 | |
| 3hz5 | Z64 | Heat shock protein HSP 90-alpha | / | 0.457 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.457 | |
| 4lcj | NAD | C-terminal-binding protein 2 | / | 0.457 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.457 | |
| 5c77 | SAH | Protein arginine N-methyltransferase SFM1 | / | 0.457 | |
| 5hwr | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.457 | |
| 1zbd | GTP | Ras-related protein Rab-3A | / | 0.456 | |
| 2e9u | A25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.456 | |
| 2oc4 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.456 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 2xtn | GTP | GTPase IMAP family member 2 | / | 0.456 | |
| 2zev | B71 | Geranylgeranyl pyrophosphate synthase | / | 0.456 | |
| 3aty | FMN | Prostaglandin F2a synthase | / | 0.456 | |
| 3eft | 3BS | Carbonic anhydrase 2 | 4.2.1.1 | 0.456 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.456 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.456 | |
| 3zhu | TD8 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.456 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.456 | |
| 1lf2 | R37 | Plasmepsin-2 | 3.4.23.39 | 0.455 | |
| 2gtb | AZP | Orf1ab polyprotein | / | 0.455 | |
| 3ohh | 3HH | Beta-secretase 1 | 3.4.23.46 | 0.455 | |
| 3rdq | DTB | Streptavidin | / | 0.455 | |
| 4d9e | LCS | D-cysteine desulfhydrase | / | 0.455 | |
| 4fxy | 0W2 | Neurolysin, mitochondrial | 3.4.24.16 | 0.455 | |
| 1h6c | NDP | Glucose--fructose oxidoreductase | 1.1.99.28 | 0.454 | |
| 1m75 | CAA | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.454 | |
| 2du2 | FMN | Lactate oxidase | / | 0.454 | |
| 2ft0 | ACO | dTDP-fucosamine acetyltransferase | / | 0.454 | |
| 2w71 | L23 | Biotin carboxylase | 6.3.4.14 | 0.454 | |
| 3csj | CBL | Glutathione S-transferase P | 2.5.1.18 | 0.454 | |
| 3eo8 | FMN | Putative nitroreductase | / | 0.454 | |
| 3v2u | ATP | Protein GAL3 | / | 0.454 | |
| 3wqt | ANP | Cell division protein FtsA | / | 0.454 | |
| 1e2n | RCA | Thymidine kinase | / | 0.453 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.453 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.453 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 3otf | CMP | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | / | 0.453 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.453 | |
| 4ck2 | NVU | Integrase | / | 0.453 | |
| 4de0 | 0JB | Beta-lactamase | / | 0.453 | |
| 4fgc | PQ0 | NADPH-dependent 7-cyano-7-deazaguanine reductase | 1.7.1.13 | 0.453 | |
| 2gyw | OBI | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 1.2.4.4 | 0.452 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | 1.2.4.4 | 0.452 | |
| 2pg0 | FAD | Acyl-CoA dehydrogenase | / | 0.452 | |
| 2zvb | SAH | Precorrin-3 C17-methyltransferase | / | 0.452 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.452 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.452 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.452 | |
| 3vyf | VYF | Renin | 3.4.23.15 | 0.452 | |
| 4bzn | UGX | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.452 | |
| 4hjo | AQ4 | Epidermal growth factor receptor | 2.7.10.1 | 0.452 | |
| 5fsi | 8DG | 7,8-dihydro-8-oxoguanine triphosphatase | 3.6.1.55 | 0.452 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.451 | |
| 1sdm | ADP | Kinesin heavy chain-like protein | / | 0.451 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 2a8h | 4NH | Disintegrin and metalloproteinase domain-containing protein 17 | 3.4.24.86 | 0.451 | |
| 2ga2 | A19 | Methionine aminopeptidase 2 | / | 0.451 | |
| 2op1 | 8PC | Enoyl-ACP reductase | / | 0.451 | |
| 2vpr | TDC | Tetracycline repressor protein class H | / | 0.451 | |
| 2yxu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.451 | |
| 3cot | STR | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.451 | |
| 3g0g | RUM | Dipeptidyl peptidase 4 | / | 0.451 | |
| 3ie3 | N11 | Glutathione S-transferase P | 2.5.1.18 | 0.451 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.451 | |
| 3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase | / | 0.451 | |
| 1dx6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 1il0 | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.450 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.450 | |
| 1u1f | 183 | Uridine phosphorylase | 2.4.2.3 | 0.450 | |
| 1zvx | FIN | Neutrophil collagenase | 3.4.24.34 | 0.450 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.450 | |
| 2oz0 | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.450 | |
| 2xaa | NAD | Secondary alcohol dehydrogenase | / | 0.450 | |
| 2xvv | 9DN | Serum albumin | / | 0.450 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 3mdz | EZL | Carbonic anhydrase 7 | 4.2.1.1 | 0.450 | |
| 3n4l | 842 | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 3ov7 | ATP | CCA-adding enzyme | 2.7.7.72 | 0.450 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.450 | |
| 4cf6 | CBD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.450 | |
| 4d03 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.450 | |
| 4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.450 | |
| 4hwk | NAP | Sepiapterin reductase | 1.1.1.153 | 0.450 | |
| 4wec | NAD | Short chain dehydrogenase | / | 0.450 | |
| 1a8r | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.449 | |
| 1g54 | FFB | Carbonic anhydrase 2 | 4.2.1.1 | 0.449 | |
| 1hk2 | T44 | Serum albumin | / | 0.449 | |
| 1ta6 | 177 | Prothrombin | 3.4.21.5 | 0.449 | |
| 1yum | NCN | Probable nicotinate-nucleotide adenylyltransferase | 2.7.7.18 | 0.449 | |
| 2b58 | COA | Diamine acetyltransferase 1 | / | 0.449 | |
| 2cjp | VPR | Epoxide hydrolase | / | 0.449 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.449 | |
| 2h23 | SAH | Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic | 2.1.1.127 | 0.449 | |
| 2qen | ADP | Walker-Type ATPase | / | 0.449 | |
| 2ym2 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.449 | |
| 3eku | CY9 | Actin-5C | / | 0.449 | |
| 3g0b | T22 | Dipeptidyl peptidase 4 | / | 0.449 | |
| 3iob | A4D | Pantothenate synthetase | 6.3.2.1 | 0.449 | |
| 3kig | DA4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.449 | |
| 4pgh | SAM | Caffeic acid O-methyltransferase | / | 0.449 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.448 | |
| 1t86 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 1u4o | NDD | L-lactate dehydrogenase | 1.1.1.27 | 0.448 | |
| 1vf2 | GTX | Glutathione S-transferase 3 | 2.5.1.18 | 0.448 | |
| 1wze | NAD | Malate dehydrogenase | / | 0.448 | |
| 2brn | DF1 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.448 | |
| 2ewv | ADP | Twitching motility protein PilT | / | 0.448 | |
| 2gvd | FKP | Adenylate cyclase type 2 | / | 0.448 | |
| 2gvd | FKP | Adenylate cyclase type 5 | / | 0.448 | |
| 2ii6 | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.448 | |
| 2vwq | NAP | Glucose 1-dehydrogenase | / | 0.448 | |
| 3bbp | GTP | Ras-related protein Rab-6A | / | 0.448 | |
| 3exn | ACO | Probable acetyltransferase | / | 0.448 | |
| 4a86 | H35 | Major pollen allergen Bet v 1-A | / | 0.448 | |
| 4b66 | NAP | L-ornithine N(5)-monooxygenase | / | 0.448 | |
| 4eu4 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.448 | |
| 4nvk | 2NY | Peroxidase | / | 0.448 | |
| 1rt9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.447 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.447 | |
| 2std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.447 | |
| 2xs3 | ALA_PHE_THR_SER | Karilysin | 3.4.24 | 0.447 | |
| 3dv3 | MEK | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.447 | |
| 3k8q | 22A | Purine nucleoside phosphorylase | 2.4.2.1 | 0.447 | |
| 3kmc | 403 | Disintegrin and metalloproteinase domain-containing protein 17 | 3.4.24.86 | 0.447 | |
| 3n0t | OPY | Dipeptidyl peptidase 2 | 3.4.14.2 | 0.447 | |
| 3oy0 | OY0 | Carbonic anhydrase 2 | 4.2.1.1 | 0.447 | |
| 4arb | C57 | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 4c72 | TLG | 3-oxoacyl-ACP synthase | / | 0.447 | |
| 4cym | GCP | Ras-related protein Rab-32 | / | 0.447 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.447 | |
| 4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.447 | |
| 4lxb | 7R9 | Prothrombin | 3.4.21.5 | 0.447 | |
| 4xnh | ACO | N-terminal acetyltransferase A complex subunit NAT5 | 2.3.1 | 0.447 | |
| 4y9q | C2E | Uncharacterized protein | / | 0.447 | |
| 5hwo | HMG | Hydroxymethylglutaryl-CoA synthase | / | 0.447 | |
| 1n77 | ATP | Glutamate--tRNA ligase | 6.1.1.17 | 0.446 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.446 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.446 | |
| 1wl4 | COA | Acetyl-CoA acetyltransferase, cytosolic | 2.3.1.9 | 0.446 | |
| 1yrc | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 1zsb | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.446 | |
| 1zxm | ANP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.446 | |
| 2g26 | 3LG | Renin | 3.4.23.15 | 0.446 | |
| 2gil | GTP | Ras-related protein Rab-6A | / | 0.446 | |
| 2jsd | NGH | Matrix metalloproteinase-20 | 3.4.24 | 0.446 | |
| 2v13 | C40 | Renin | 3.4.23.15 | 0.446 | |
| 3dd1 | 25D | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.446 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 3jus | BCD | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.446 | |
| 3phj | DHK | Shikimate dehydrogenase (NADP(+)) | / | 0.446 | |
| 3rbq | GLY_ALA_GLY_DAO | Protein unc-119 homolog A | / | 0.446 | |
| 3s79 | ASD | Aromatase | 1.14.14.14 | 0.446 | |
| 3uxv | GUN | NADPH-dependent 7-cyano-7-deazaguanine reductase | / | 0.446 | |
| 3vdq | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.446 | |
| 3zsr | O3N | Integrase | / | 0.446 | |
| 4cez | O3N | Integrase | / | 0.446 | |
| 4dzz | ADP | Plasmid partitioning protein ParF | / | 0.446 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.446 | |
| 4jnk | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.446 | |
| 4qnu | GEK | tRNA U34 carboxymethyltransferase | / | 0.446 | |
| 4yp6 | NAP | Nicotinamide-nucleotide adenylyltransferase | 2.7.7.1 | 0.446 | |
| 9gss | GTX | Glutathione S-transferase P | 2.5.1.18 | 0.446 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 2bri | ANP | Uridylate kinase | 2.7.4.22 | 0.445 | |
| 2bvs | 2CE | Prothrombin | 3.4.21.5 | 0.445 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.445 | |
| 2vf3 | GVS | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.445 | |
| 2ycn | P61 | Tyrosine phenol-lyase | 4.1.99.2 | 0.445 | |
| 2zc9 | 22U | Prothrombin | 3.4.21.5 | 0.445 | |
| 3bxo | UPP | dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose | / | 0.445 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.445 | |
| 3iph | G11 | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.445 | |
| 3vfq | AR6 | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.445 | |
| 3zhq | TPP | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.445 | |
| 4b42 | 942 | Glucose-1-phosphate thymidylyltransferase | / | 0.445 | |
| 4e2d | FMN | Dehydrogenase | / | 0.445 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.445 | |
| 4fpy | 0V8 | Sialidase B | 3.2.1.18 | 0.445 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4ho6 | UTP | Glucose-1-phosphate thymidylyltransferase | / | 0.445 | |
| 4krs | 1SX | Tankyrase-1 | 2.4.2.30 | 0.445 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.445 | |
| 1gpn | HUB | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.444 | |
| 1okm | SAB | Carbonic anhydrase 2 | 4.2.1.1 | 0.444 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.444 | |
| 1std | BFS | Scytalone dehydratase | 4.2.1.94 | 0.444 | |
| 1szg | FNS | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.444 | |
| 2a84 | ATP | Pantothenate synthetase | 6.3.2.1 | 0.444 | |
| 2anm | CDO | Prothrombin | 3.4.21.5 | 0.444 | |
| 2bxm | IMN | Serum albumin | / | 0.444 | |
| 2ibw | COA | Acetyl-CoA acetyltransferase, mitochondrial | 2.3.1.9 | 0.444 | |
| 2pgt | GPR | Glutathione S-transferase P | 2.5.1.18 | 0.444 | |
| 3h2s | NDP | Putative NADH-flavin reductase | / | 0.444 | |
| 3ioc | A5D | Pantothenate synthetase | 6.3.2.1 | 0.444 | |
| 3mkn | DNB | Pyrimidine-specific ribonucleoside hydrolase RihB | / | 0.444 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.444 | |
| 3pb5 | F63 | Endothiapepsin | 3.4.23.22 | 0.444 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.444 | |
| 4a6b | QG8 | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 4bqz | GNP | Ectonucleoside triphosphate diphosphohydrolase 2 | / | 0.444 | |
| 4eu9 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.444 | |
| 4ew3 | DXZ | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.444 | |
| 4g2r | H1L | Probable propionyl-CoA carboxylase beta chain 6 | 6.4.1.3 | 0.444 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.444 | |
| 4hyv | PEP | Pyruvate kinase 1 | 2.7.1.40 | 0.444 | |
| 4img | NGF | N-acetylneuraminate lyase | / | 0.444 | |
| 4jau | ADP | Sensor histidine kinase | / | 0.444 | |
| 4xrb | NDP | Possible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc | / | 0.444 | |
| 4xvu | ATP | ATPase GET3 | / | 0.444 | |
| 4zj8 | SUV | Orexin receptor type 1 | / | 0.444 | |
| 1gw2 | FER | Peroxidase C1A | 1.11.1.7 | 0.443 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 2bjf | DXC | Choloylglycine hydrolase | 3.5.1.24 | 0.443 | |
| 2brb | PFQ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 2nli | FMN | Lactate oxidase | / | 0.443 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.443 | |
| 2yph | QQY | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.443 | |
| 3geg | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.443 | |
| 3mnr | SD1 | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 3nl6 | TPS | Uncharacterized protein | / | 0.443 | |
| 3uaw | ADN | Purine nucleoside phosphorylase DeoD-type | / | 0.443 | |
| 4a32 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.443 | |
| 4bk2 | FAD | Probable salicylate monooxygenase | / | 0.443 | |
| 4j57 | FAD | Thioredoxin reductase 2 | 1.8.1.9 | 0.443 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.443 | |
| 4o71 | CPB | Bromodomain-containing protein 4 | / | 0.443 | |
| 1beu | IPL | Tryptophan synthase alpha chain | / | 0.442 | |
| 1g45 | FSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.442 | |
| 1g4k | HQQ | Stromelysin-1 | 3.4.24.17 | 0.442 | |
| 1gia | GSP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.442 | |
| 1i7p | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.442 | |
| 1olm | VTQ | SEC14-like protein 2 | / | 0.442 | |
| 1pjc | NAD | Alanine dehydrogenase | / | 0.442 | |
| 1trk | TPP | Transketolase 1 | 2.2.1.1 | 0.442 | |
| 1ysl | COA | Hydroxymethylglutaryl-CoA synthase | 2.3.3.10 | 0.442 | |
| 2p9g | NAI | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.442 | |
| 2xlp | FAD | Putative flavin-containing monooxygenase | / | 0.442 | |
| 2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 2zi2 | 24U | Prothrombin | 3.4.21.5 | 0.442 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3g1r | FIT | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.442 | |
| 3jun | AJD | Phenazine biosynthesis protein A/B | / | 0.442 | |
| 3l7g | M44 | Xaa-Pro dipeptidase | 3.4.13.9 | 0.442 | |
| 3nju | ANN | Acidic phospholipase A2 3 | 3.1.1.4 | 0.442 | |
| 3sxn | COA | N-acetyltransferase Eis | / | 0.442 | |
| 3vt3 | VDX | Vitamin D3 receptor | / | 0.442 | |
| 4buu | F38 | Tankyrase-2 | 2.4.2.30 | 0.442 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.442 | |
| 4eph | 0RK | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.442 | |
| 4g8j | THM | Uridine phosphorylase | / | 0.442 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.442 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.442 | |
| 4la7 | A1O | Abscisic acid receptor PYL2 | / | 0.442 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.442 | |
| 4v2g | CTC | Tetracycline repressor protein class D | / | 0.442 | |
| 6std | MS2 | Scytalone dehydratase | 4.2.1.94 | 0.442 | |
| 1eii | RTL | Retinol-binding protein 2 | / | 0.441 | |
| 1fx9 | MJI | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.441 | |
| 1ib0 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.441 | |
| 1ix1 | BB2 | Peptide deformylase | / | 0.441 | |
| 1jd0 | AZM | Carbonic anhydrase 12 | 4.2.1.1 | 0.441 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1r6t | TYM | Tryptophan--tRNA ligase, cytoplasmic | 6.1.1.2 | 0.441 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 1xts | GTP | GTP-binding protein Rheb | / | 0.441 | |
| 1xuz | MMN | Capsule biosynthesis protein | / | 0.441 | |
| 2c31 | TZD | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.441 | |
| 2i47 | INN | Disintegrin and metalloproteinase domain-containing protein 17 | 3.4.24.86 | 0.441 | |
| 2i47 | KGY | Disintegrin and metalloproteinase domain-containing protein 17 | 3.4.24.86 | 0.441 | |
| 2ojg | 19A | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.441 | |
| 2wya | HMG | Hydroxymethylglutaryl-CoA synthase, mitochondrial | 2.3.3.10 | 0.441 | |
| 2yoz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.441 | |
| 2yp0 | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.441 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3opm | LUI | Dipeptidyl peptidase 4 | / | 0.441 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.441 | |
| 3s7b | NH5 | N-lysine methyltransferase SMYD2 | / | 0.441 | |
| 3tyc | XHP | Dihydropteroate synthase | / | 0.441 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.441 | |
| 4a99 | FAD | TetX family tetracycline inactivation enzyme | / | 0.441 | |
| 4an4 | DUD | Putative glycosyl transferase | / | 0.441 | |
| 4do3 | 0LA | Fatty-acid amide hydrolase 1 | 3.5.1.99 | 0.441 | |
| 4eqs | COA | Coenzyme A disulfide reductase | / | 0.441 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.441 | |
| 4oqy | NDP | (S)-imine reductase | / | 0.441 | |
| 4uov | AZM | Carbonate dehydratase | / | 0.441 | |
| 1dli | UDX | UDP-glucose 6-dehydrogenase | / | 0.440 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.440 | |
| 1piw | NAP | NADP-dependent alcohol dehydrogenase 6 | 1.1.1.2 | 0.440 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.440 | |
| 1ype | UIP | Prothrombin | 3.4.21.5 | 0.440 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.440 | |
| 2a5k | AZP | Replicase polyprotein 1ab | 3.4.22 | 0.440 | |
| 2hdj | NDP | Aldo-keto reductase family 1 member C2 | / | 0.440 | |
| 2z7q | ACP | Ribosomal protein S6 kinase alpha-1 | 2.7.11.1 | 0.440 | |
| 3ck7 | ACX | Starch-binding protein SusD | / | 0.440 | |
| 3eks | CY9 | Actin-5C | / | 0.440 | |
| 3inv | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.440 | |
| 3mhi | J90 | Carbonic anhydrase 2 | 4.2.1.1 | 0.440 | |
| 3pmu | F7L | Endothiapepsin | 3.4.23.22 | 0.440 | |
| 3t7p | 7SP | Endothiapepsin | 3.4.23.22 | 0.440 | |
| 4b1u | LAB | Actin, alpha skeletal muscle | / | 0.440 | |
| 4ddh | MS0 | Pantothenate synthetase | 6.3.2.1 | 0.440 | |
| 4ey7 | E20 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.440 | |
| 4fvq | ATP | Tyrosine-protein kinase JAK2 | / | 0.440 | |
| 4prx | ADP | DNA gyrase subunit B | / | 0.440 | |
| 5hwq | CAA | Hydroxymethylglutaryl-CoA synthase | / | 0.440 |