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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3eyhIZATyrosine-protein kinase JAK1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3eyhIZATyrosine-protein kinase JAK1/1.000
2b7aIZATyrosine-protein kinase JAK2/0.560
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.554
4k771Q4Tyrosine-protein kinase JAK1/0.543
3r83Z14Cyclin-dependent kinase 22.7.11.220.540
4e6d0NUTyrosine-protein kinase JAK2/0.538
4iwd1JCHepatocyte growth factor receptor2.7.10.10.536
1oirHDYCyclin-dependent kinase 22.7.11.220.534
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.527
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.526
3iok1P6Tyrosine-protein kinase JAK2/0.525
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.522
3pj8404Cyclin-dependent kinase 22.7.11.220.522
4fv6E57Mitogen-activated protein kinase 12.7.11.240.522
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.521
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.521
1aq1STUCyclin-dependent kinase 22.7.11.220.520
1vjy460TGF-beta receptor type-12.7.11.300.519
4aqc88ATyrosine-protein kinase JAK2/0.517
3lxpIZANon-receptor tyrosine-protein kinase TYK22.7.10.20.516
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.516
3rvg17PTyrosine-protein kinase JAK2/0.516
4hge15VTyrosine-protein kinase JAK2/0.516
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.515
2x1nX1NCyclin-dependent kinase 22.7.11.220.512
1h1s4SPCyclin-dependent kinase 22.7.11.220.511
3gu83GUDeath-associated protein kinase 12.7.11.10.511
3zh8C58Protein kinase C iota type2.7.11.130.510
4dgnLU2Casein kinase II subunit alpha2.7.11.10.510
2btrU73Cyclin-dependent kinase 22.7.11.220.509
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.508
3zmmF9JTyrosine-protein kinase JAK2/0.508
4ehzJAKTyrosine-protein kinase JAK1/0.506
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.505
3sheI85MAP kinase-activated protein kinase 32.7.11.10.505
1y91CT9Cyclin-dependent kinase 22.7.11.220.504
1g5sI17Cyclin-dependent kinase 22.7.11.220.503
1u4dDBQActivated CDC42 kinase 1/0.503
3nlb5BESerine/threonine-protein kinase Chk12.7.11.10.503
4ivc1J6Tyrosine-protein kinase JAK1/0.503
3le62BZCyclin-dependent kinase 22.7.11.220.502
4eon1ROCyclin-dependent kinase 22.7.11.220.502
4fod0UVALK tyrosine kinase receptor2.7.10.10.502
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.501
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.500
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.500
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.500
2a0cCK9Cyclin-dependent kinase 22.7.11.220.499
4ivb1J5Tyrosine-protein kinase JAK1/0.499
2wmrZYRSerine/threonine-protein kinase Chk12.7.11.10.497
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.497
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.497
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.497
4ek816KCyclin-dependent kinase 22.7.11.220.497
3vf80JETyrosine-protein kinase SYK2.7.10.20.496
4f650S9Fibroblast growth factor receptor 1/0.496
4ji91M3Tyrosine-protein kinase JAK2/0.496
4erwSTUCyclin-dependent kinase 22.7.11.220.495
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.494
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.494
4e93GUITyrosine-protein kinase Fes/Fps2.7.10.20.494
4e5w0NTTyrosine-protein kinase JAK1/0.493
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.493
2c6tDT5Cyclin-dependent kinase 22.7.11.220.492
4c02TAKActivin receptor type-12.7.11.300.492
4ewhT77Activated CDC42 kinase 1/0.492
2b53D23Cyclin-dependent kinase 22.7.11.220.491
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.491
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.490
1xjdSTUProtein kinase C theta type2.7.11.130.489
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.489
4fkg4CKCyclin-dependent kinase 22.7.11.220.489
4hvi19STyrosine-protein kinase JAK32.7.10.20.489
4y95746Tyrosine-protein kinase/0.489
5dt3ATPAurora kinase A2.7.11.10.489
1ke6LS2Cyclin-dependent kinase 22.7.11.220.488
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.488
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.488
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.488
2wotZZGTGF-beta receptor type-12.7.11.300.488
3lxkMI1Tyrosine-protein kinase JAK32.7.10.20.488
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.488
4jboWPHAurora kinase A2.7.11.10.488
1eh4IC1Casein kinase I homolog 12.7.11.10.487
2xikJ60Serine/threonine-protein kinase 252.7.11.10.487
4ek610KCyclin-dependent kinase 22.7.11.220.487
4eor4SPCyclin-dependent kinase 22.7.11.220.487
4i0s1B5Tyrosine-protein kinase SYK2.7.10.20.487
4iva1J5Tyrosine-protein kinase JAK2/0.487
2pvhP19Casein kinase II subunit alpha2.7.11.10.486
3rk909ZCyclin-dependent kinase 22.7.11.220.486
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.486
1py5PY1TGF-beta receptor type-12.7.11.300.485
4f081RSTyrosine-protein kinase JAK2/0.485
4fkpLS5Cyclin-dependent kinase 22.7.11.220.485
4k8aK8AFocal adhesion kinase 12.7.10.20.485
1p4fDRGDeath-associated protein kinase 12.7.11.10.484
2zv2609Calcium/calmodulin-dependent protein kinase kinase 22.7.11.170.484
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.484
4k6z1Q3Tyrosine-protein kinase JAK1/0.484
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.484
1h1r6CPCyclin-dependent kinase 22.7.11.220.483
1pxlCK4Cyclin-dependent kinase 22.7.11.220.483
2evaADNMitogen-activated protein kinase kinase kinase 72.7.11.250.483
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.483
2xa4AZ5Tyrosine-protein kinase JAK2/0.483
3bhtMFRCyclin-dependent kinase 22.7.11.220.483
3m42HGFMAP kinase-activated protein kinase 22.7.11.10.483
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.482
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.481
3uyt0CKCasein kinase I isoform delta2.7.11.10.481
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.481
4dgmAGICasein kinase II subunit alpha2.7.11.10.481
4fklCK2Cyclin-dependent kinase 22.7.11.220.481
1h1q2A6Cyclin-dependent kinase 22.7.11.220.480
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.480
2uzeC95Cyclin-dependent kinase 22.7.11.220.480
3oibFDAPutative acyl-CoA dehydrogenase/0.480
4a4o664Serine/threonine-protein kinase PLK12.7.11.210.480
4e4m0NHTyrosine-protein kinase JAK2/0.480
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.480
1e1xNW1Cyclin-dependent kinase 22.7.11.220.479
2w06FRVCyclin-dependent kinase 22.7.11.220.479
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.479
3lfqA28Cyclin-dependent kinase 22.7.11.220.479
1diuBDMDihydrofolate reductase1.5.1.30.478
2x2mX2MProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.478
4bcoT6QCyclin-dependent kinase 22.7.11.220.478
4fkq42KCyclin-dependent kinase 22.7.11.220.478
4im01FVSerine/threonine-protein kinase TBK12.7.11.10.478
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.477
3nynSGVG protein-coupled receptor kinase 62.7.11.160.477
3qqlX03Cyclin-dependent kinase 22.7.11.220.477
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.477
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.477
5e8ySTUTGF-beta receptor type-22.7.11.300.477
2dwbANPAurora kinase A2.7.11.10.476
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.475
3q43D66M1 family aminopeptidase3.4.110.475
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.475
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.475
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.475
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.474
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.474
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.474
3lfnA27Cyclin-dependent kinase 22.7.11.220.474
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.474
3rni21ZCyclin-dependent kinase 22.7.11.220.474
1dr3HBIDihydrofolate reductase1.5.1.30.473
2bhhRYUCyclin-dependent kinase 22.7.11.220.473
2hckQUETyrosine-protein kinase HCK2.7.10.20.473
2iw94SPCyclin-dependent kinase 22.7.11.220.473
4fkj11KCyclin-dependent kinase 22.7.11.220.473
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.472
3w8qAGSDual specificity mitogen-activated protein kinase kinase 12.7.12.20.472
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.472
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.472
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.472
1oitHDTCyclin-dependent kinase 22.7.11.220.471
1rx8NAPDihydrofolate reductase1.5.1.30.471
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.471
4ct2ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.471
4fkt48KCyclin-dependent kinase 22.7.11.220.471
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.471
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.471
4jia1K3Tyrosine-protein kinase JAK2/0.471
5dnrATPAurora kinase A2.7.11.10.471
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.470
2a4lRRCCyclin-dependent kinase 22.7.11.220.470
3a62STURibosomal protein S6 kinase beta-12.7.11.10.470
3kc3MK2MAP kinase-activated protein kinase 22.7.11.10.470
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.470
4dgo0JWCasein kinase II subunit alpha2.7.11.10.470
4y93746Tyrosine-protein kinase/0.470
4ckiADNProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.469
4e1z0MXNon-receptor tyrosine-protein kinase TYK22.7.10.20.469
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.469
5dr6SKEAurora kinase A2.7.11.10.469
1unlRRCCyclin-dependent-like kinase 52.7.11.10.468
1ykr628Cyclin-dependent kinase 22.7.11.220.468
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.468
4e200MYNon-receptor tyrosine-protein kinase TYK22.7.10.20.468
4foc0UUALK tyrosine kinase receptor2.7.10.10.468
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.468
2bkzSBCCyclin-dependent kinase 22.7.11.220.467
2btsU32Cyclin-dependent kinase 22.7.11.220.467
3pxkPXKFocal adhesion kinase 12.7.10.20.467
3zlx5EZDual specificity mitogen-activated protein kinase kinase 12.7.12.20.467
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.467
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.467
1vyw292Cyclin-dependent kinase 22.7.11.220.466
2wmvZYVSerine/threonine-protein kinase Chk12.7.11.10.466
3ezrEZRCyclin-dependent kinase 22.7.11.220.466
3hmm855TGF-beta receptor type-12.7.11.300.466
4ivd15TTyrosine-protein kinase JAK1/0.466
1di8DTQCyclin-dependent kinase 22.7.11.220.465
1e9hINRCyclin-dependent kinase 22.7.11.220.465
1h0w207Cyclin-dependent kinase 22.7.11.220.465
2w9hTOPDihydrofolate reductase1.5.1.30.465
3ddpRC8Cyclin-dependent kinase 22.7.11.220.465
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.465
4btjADPTau-tubulin kinase 12.7.11.10.465
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.464
1oguST8Cyclin-dependent kinase 22.7.11.220.464
2ggsNDPdTDP-4-dehydrorhamnose reductase/0.464
2gmhFADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial1.5.5.10.464
2r3wG3GGag-Pol polyprotein3.4.23.160.464
3gubGUBDeath-associated protein kinase 12.7.11.10.464
3i60E86Mitogen-activated protein kinase 12.7.11.240.464
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.464
3rpo24ZCyclin-dependent kinase 22.7.11.220.464
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.464
1gih1PUCyclin-dependent kinase 22.7.11.220.463
2c5nCK8Cyclin-dependent kinase 22.7.11.220.463
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.463
2w1gL0GAurora kinase A2.7.11.10.463
2wmtZYTSerine/threonine-protein kinase Chk12.7.11.10.463
2xneASHAurora kinase A2.7.11.10.463
3mtfA3FActivin receptor type-12.7.11.300.463
3rk708ZCyclin-dependent kinase 22.7.11.220.463
4acm7YGCyclin-dependent kinase 22.7.11.220.463
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.463
4btmF8ETau-tubulin kinase 12.7.11.10.463
1ke7LS3Cyclin-dependent kinase 22.7.11.220.462
2w1fL0FAurora kinase A2.7.11.10.462
2w1hL0FCyclin-dependent kinase 22.7.11.220.462
3eljGS7Mitogen-activated protein kinase 82.7.11.240.462
3gxlQIGTGF-beta receptor type-12.7.11.300.462
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.462
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.462
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.462
4wsqKSAAP2-associated protein kinase 12.7.11.10.462
5drdATPAurora kinase A2.7.11.10.462
1fxsNAPGDP-L-fucose synthase/0.461
1m78NDPDihydrofolate reductase1.5.1.30.461
2ds11CDCyclin-dependent kinase 22.7.11.220.461
2eufLQQCyclin-dependent kinase 62.7.11.220.461
2pvnP63Casein kinase II subunit alpha2.7.11.10.461
3lpkZ76Beta-secretase 13.4.23.460.461
4dymIYZActivin receptor type-12.7.11.300.461
4gfg0XFTyrosine-protein kinase SYK2.7.10.20.461
1om1IQACasein kinase II subunit alpha2.7.11.10.460
2cchATPCyclin-dependent kinase 22.7.11.220.460
2r3jSCJCyclin-dependent kinase 22.7.11.220.460
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.460
3be9P04Casein kinase II subunit alpha2.7.11.10.460
3hztJ60Calmodulin-like domain protein kinase isoform 3/0.460
4ei40Q2Tyrosine-protein kinase JAK1/0.460
4fki09KCyclin-dependent kinase 22.7.11.220.460
4fks46KCyclin-dependent kinase 22.7.11.220.460
1ke5LS1Cyclin-dependent kinase 22.7.11.220.459
1xl5190Gag-Pol polyprotein3.4.23.160.459
1ydrIQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.459
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.459
4jajXU1Aurora kinase A2.7.11.10.459
1ia1NDPDihydrofolate reductase1.5.1.30.458
1ol5ADPAurora kinase A2.7.11.10.458
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.458
3hllI45Mitogen-activated protein kinase 14/0.458
4i22IREEpidermal growth factor receptor2.7.10.10.458
1bwsNDPGDP-L-fucose synthase/0.457
1n2sNAIdTDP-4-dehydrorhamnose reductase1.1.1.1330.457
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.457
2c6lDT4Cyclin-dependent kinase 22.7.11.220.457
2pvlP55Casein kinase II subunit alpha2.7.11.10.457
2vtlLZ5Cyclin-dependent kinase 22.7.11.220.457
3oqkS52Renin3.4.23.150.457
3t8oATPRhodopsin kinase/0.457
4anmWULCasein kinase II subunit alpha2.7.11.10.457
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.457
4fl3ANPTyrosine-protein kinase SYK2.7.10.20.457
4mf029ZTyrosine-protein kinase ITK/TSK2.7.10.20.457
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.457
1dr3TAPDihydrofolate reductase1.5.1.30.456
1hbvGANGag-Pol polyprotein/0.456
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.456
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.456
2exmZIPCyclin-dependent kinase 22.7.11.220.456
2jkqVG8Focal adhesion kinase 12.7.10.20.456
4aojV4ZHigh affinity nerve growth factor receptor2.7.10.10.456
4fkv61KCyclin-dependent kinase 22.7.11.220.456
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.456
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.456
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.456
1bsvNDPGDP-L-fucose synthase/0.455
1m2rMNYCasein kinase II subunit alpha2.7.11.10.455
1qy5NECEndoplasmin/0.455
1w0xOLOCyclin-dependent kinase 22.7.11.220.455
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
3invNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.455
3lpiZ74Beta-secretase 13.4.23.460.455
3qd33Q53-phosphoinositide-dependent protein kinase 12.7.11.10.455
3tqaNDPDihydrofolate reductase/0.455
4k28NADShikimate dehydrogenase family protein/0.455
2hog710Serine/threonine-protein kinase Chk12.7.11.10.454
2ou2ACOHistone acetyltransferase KAT5/0.454
3qlsNDPDihydrofolate reductase1.5.1.30.454
3r8vZ62Cyclin-dependent kinase 22.7.11.220.454
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.454
4bgg844Activin receptor type-12.7.11.300.454
4qmpDKISerine/threonine-protein kinase 242.7.11.10.454
1kvkATPMevalonate kinase2.7.1.360.453
2b52D42Cyclin-dependent kinase 22.7.11.220.453
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
2vv9IM9Cyclin-dependent kinase 22.7.11.220.453
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.453
2x8eX8ESerine/threonine-protein kinase Chk12.7.11.10.453
3bheBZNGag-Pol polyprotein3.4.23.160.453
3ezvEZVCyclin-dependent kinase 22.7.11.220.453
3qqkX02Cyclin-dependent kinase 22.7.11.220.453
3r7uX96Cyclin-dependent kinase 22.7.11.220.453
4fob0USALK tyrosine kinase receptor2.7.10.10.453
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.453
4fv4EK7Mitogen-activated protein kinase 12.7.11.240.453
1w8cN69Cyclin-dependent kinase 22.7.11.220.452
2brnDF1Serine/threonine-protein kinase Chk12.7.11.10.452
2dsgSAHDiphthine synthase/0.452
2j0m4STFocal adhesion kinase 12.7.10.20.452
2vttLZDCyclin-dependent kinase 22.7.11.220.452
3hekBD0Heat shock protein HSP 90-alpha/0.452
3zlyYSODual specificity mitogen-activated protein kinase kinase 12.7.12.20.452
4aacAAVMitogen-activated protein kinase 14/0.452
4f9c0SXCell division cycle 7-related protein kinase2.7.11.10.452
5dt0SKEAurora kinase A2.7.11.10.452
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.451
1pxoCK7Cyclin-dependent kinase 22.7.11.220.451
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.451
2ckeIQUDeath-associated protein kinase 2/0.451
2el0SAHDiphthine synthase/0.451
2hfuMEVMevalonate kinase/0.451
2nnkROCProtease/0.451
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.451
2xb7GUIALK tyrosine kinase receptor2.7.10.10.451
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.451
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
3em4DR7Gag-Pol polyprotein3.4.23.160.451
3kgaLX9MAP kinase-activated protein kinase 22.7.11.10.451
3r8lZ30Cyclin-dependent kinase 22.7.11.220.451
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.451
4enyJ19Serine/threonine-protein kinase pim-12.7.11.10.451
1pxjCK2Cyclin-dependent kinase 22.7.11.220.450
2j0lANPFocal adhesion kinase 12.7.10.20.450
2vtqLZACyclin-dependent kinase 22.7.11.220.450
2vuw5IDSerine/threonine-protein kinase haspin2.7.11.10.450
2wxvWXVCyclin-dependent kinase 22.7.11.220.450
3k5uPFQAurora kinase A2.7.11.10.450
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.450
3qn8NI7Gag-Pol polyprotein3.4.23.160.450
4f09JAKTyrosine-protein kinase JAK2/0.450
4fk60UJTyrosine-protein kinase JAK1/0.450
4h8nNDPNADPH-dependent conjugated polyketone reductase C2/0.450
4lyn1YGCyclin-dependent kinase 22.7.11.220.450
4xgxADPFAD:protein FMN transferase/0.450
1rx1NAPDihydrofolate reductase1.5.1.30.449
2duv371Cyclin-dependent kinase 22.7.11.220.449
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.449
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
3ggfGVDSerine/threonine-protein kinase 26/0.449
3kfs3TLGag-Pol polyprotein/0.449
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.449
3l9lL9LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
3w551FMMitogen-activated protein kinase 12.7.11.240.449
4ftq4HKSerine/threonine-protein kinase Chk12.7.11.10.449
4gii0X6Non-receptor tyrosine-protein kinase TYK22.7.10.20.449
5cyoGDPSeptin-9/0.449
1dr2TAPDihydrofolate reductase1.5.1.30.448
1sxjAGSReplication factor C subunit 1/0.448
1vdcFADThioredoxin reductase 1, mitochondrial1.8.1.90.448
1y8yCT7Cyclin-dependent kinase 22.7.11.220.448
2cmjNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.448
2e15SAHDiphthine synthase/0.448
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.448
2oj9BMIInsulin-like growth factor 1 receptor2.7.10.10.448
2r38G4GGag-Pol polyprotein3.4.23.160.448
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.448
3rlq3RQHeat shock protein HSP 90-alpha/0.448
4c61LMMTyrosine-protein kinase JAK2/0.448
4fcr0TMHeat shock protein HSP 90-alpha/0.448
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.448
4l7f1V5Mitogen-activated protein kinase 82.7.11.240.448
4loqSB4Mitogen-activated protein kinase 14/0.448
4pd6URINucleoside permease/0.448
1me6IVSPlasmepsin-23.4.23.390.447
1ol7ADPAurora kinase A2.7.11.10.447
1z5mLI83-phosphoinositide-dependent protein kinase 12.7.11.10.447
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.447
2q631UNGag-Pol polyprotein3.4.23.160.447
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
2ydkYDKSerine/threonine-protein kinase Chk12.7.11.10.447
3s2pPMUCyclin-dependent kinase 22.7.11.220.447
3slz3TLPutative gag-pro-pol polyprotein/0.447
4deaNHIAurora kinase A2.7.11.10.447
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.447
4ocvANPAminoglycoside phosphotransferase/0.447
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.446
1xelUPGUDP-glucose 4-epimerase5.1.3.20.446
2bb9AKCGag-Pol polyprotein3.4.23.160.446
2emuSAHDiphthine synthase/0.446
2qnnQN1Gag-Pol polyprotein3.4.23.160.446
2wpa889Cyclin-dependent kinase 22.7.11.220.446
3gy0NAPNAD(P)-dependent oxidoreductase/0.446
3r4pFU7Heat shock protein HSP 90-alpha/0.446
4dt9GMPAPH(2'')-Id/0.446
4hbgNDP3-oxoacyl-[acyl-carrier-protein] reductase1.1.1.1000.446
4ijp1EHSerine/threonine-protein kinase PRP4 homolog2.7.11.10.446
4iqlFMNEnoyl-(Acyl-carrier-protein) reductase II/0.446
4ysjADPCalmodulin-like domain protein kinase/0.446
1mrwK57Gag-Pol polyprotein3.4.23.160.445
2bpw1INGag-Pol polyprotein3.4.23.160.445
2bqvA1AProtease/0.445
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.445
2c6kDT2Cyclin-dependent kinase 22.7.11.220.445
2csnCKICasein kinase I homolog 12.7.11.10.445
2p3b3TLV-1 PROTEASE protein/0.445
2p3b3TLV-1 protease/0.445
3gggNADPrephenate dehydrogenase/0.445
3orkAGSSerine/threonine protein kinase/0.445
3qlrNDPDihydrofolate reductase1.5.1.30.445
3ttp017Gag-Pol polyprotein3.4.23.160.445
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.445
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.445
4idtT28Mitogen-activated protein kinase kinase kinase 142.7.11.250.445
4mgiCMPRap guanine nucleotide exchange factor 4/0.445
4oacADPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.445
4zlaBESCytosol aminopeptidase3.4.11.10.445
1snyNAPLD36273p/0.444
1xl2189Gag-Pol polyprotein3.4.23.160.444
2fxeDR7Gag-Pol polyprotein3.4.23.160.444
2owkSAHDiphthine synthase/0.444
2p5fSAHDiphthine synthase/0.444
2vthLZ2Cyclin-dependent kinase 22.7.11.220.444
2y9qANPMitogen-activated protein kinase 12.7.11.240.444
2z54AB1Gag-Pol polyprotein3.4.23.160.444
3nxxNDPDihydrofolate reductase1.5.1.30.444
3r1yX76Cyclin-dependent kinase 22.7.11.220.444
3rk507ZCyclin-dependent kinase 22.7.11.220.444
3t4nADP5'-AMP-activated protein kinase subunit gamma/0.444
3tkuM77Serine/threonine-protein kinase MRCK beta2.7.11.10.444
4bgh3I6Cyclin-dependent kinase 22.7.11.220.444
4o0wADNAurora kinase A2.7.11.10.444
4y3jHICEndothiapepsin3.4.23.220.444
5cnnANPEpidermal growth factor receptor2.7.10.10.444
5eccNAPDehydrofolate reductase type I/0.444
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.443
1lf2R37Plasmepsin-23.4.23.390.443
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.443
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.443
2jamJ60Calcium/calmodulin-dependent protein kinase type 1G2.7.11.170.443
2vu3LZECyclin-dependent kinase 22.7.11.220.443
2xngA0HAurora kinase A2.7.11.10.443
2zjwREFCasein kinase II subunit alpha2.7.11.10.443
3kf03TLGag-Pol polyprotein/0.443
3nu3478Gag-Pol polyprotein3.4.23.160.443
3t113T1Gag-Pol polyprotein3.4.23.160.443
3w33W19Epidermal growth factor receptor2.7.10.10.443
4fv7E94Mitogen-activated protein kinase 12.7.11.240.443
4j54G52Gag-Pol polyprotein3.4.23.160.443
4o0sADNAurora kinase A2.7.11.10.443
1ay0TPPTransketolase 12.2.1.10.442
1dg8NDPDihydrofolate reductase1.5.1.30.442
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.442
1hvsA77Gag-Pol polyprotein/0.442
1mruAGSSerine/threonine-protein kinase PknB2.7.11.10.442
1pjkANPCasein kinase II subunit alpha2.7.11.10.442
1sbgIM1Gag-Pol polyprotein/0.442
1vikBAYGag-Pol polyprotein/0.442
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.442
2gnhH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
2iw84SPCyclin-dependent kinase 22.7.11.220.442
2nniMTKCytochrome P450 2C8/0.442
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.442
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.442
3clbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.442
3fklFKLMitogen-activated protein kinase 14/0.442
3iaeD7KBenzaldehyde lyase/0.442
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.442
3lpbNVBTyrosine-protein kinase JAK2/0.442
3q44D50M1 family aminopeptidase3.4.110.442
3qu0X40Cyclin-dependent kinase 22.7.11.220.442
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.442
3vdqNAD3-hydroxybutyrate dehydrogenase/0.442
3w16P9JAurora kinase A2.7.11.10.442
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4ienCOAPutative acyl-CoA hydrolase/0.442
4jik1KOSerine/threonine-protein kinase Chk12.7.11.10.442
4wucANPDNA gyrase subunit B/0.442
1kvuUPGUDP-glucose 4-epimerase5.1.3.20.441
1oiyN41Cyclin-dependent kinase 22.7.11.220.441
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.441
2yaaATPDeath-associated protein kinase 2/0.441
3kjrNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.441
3lshFADPyranose 2-oxidase/0.441
3lzs017Gag-Pol polyprotein3.4.23.160.441
3w8dNAD3-hydroxybutyrate dehydrogenase/0.441
4eok4SPCyclin-dependent kinase 22.7.11.220.441
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4g73NAIRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.441
4hvh19RTyrosine-protein kinase JAK32.7.10.20.441
4m6jNDPDihydrofolate reductase1.5.1.30.441
4qxp1YEStimulator of interferon genes protein/0.441
1gii1PUCyclin-dependent kinase 22.7.11.220.440
1mq4ADPAurora kinase A2.7.11.10.440
1oiuN76Cyclin-dependent kinase 22.7.11.220.440
1pmv537Mitogen-activated protein kinase 102.7.11.240.440
1zemNADXylitol dehydrogenase/0.440
2f2uM77Rho-associated protein kinase 22.7.11.10.440
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.440
2oapANPType II secretion system protein (GspE-2)/0.440
2p5cSAHDiphthine synthase/0.440
2r43G3GGag-Pol polyprotein3.4.23.160.440
2xmyCDKCyclin-dependent kinase 22.7.11.220.440
2zjmF1MBeta-secretase 13.4.23.460.440
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.440
3nu5478Gag-Pol polyprotein3.4.23.160.440
3q3cNADNAD-dependent L-serine dehydrogenase/0.440
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.440
3r4nFU5Heat shock protein HSP 90-alpha/0.440
4a6cQG9Gag-Pol polyprotein3.4.23.160.440
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.440
4kz01UJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.440
5esoTDP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.440