sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
3ey4	352	Corticosteroid 11-beta-dehydrogenase isozyme 1	1.1.1.146

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
3ey4	352	Corticosteroid 11-beta-dehydrogenase isozyme 1	1.1.1.146	1.000
3oq1	3OQ	Corticosteroid 11-beta-dehydrogenase isozyme 1	1.1.1.146	0.526
2rbe	ZMG	Corticosteroid 11-beta-dehydrogenase isozyme 1	1.1.1.146	0.520
3ch6	311	Corticosteroid 11-beta-dehydrogenase isozyme 1	1.1.1.146	0.516
4bb6	HD1	Corticosteroid 11-beta-dehydrogenase isozyme 1	1.1.1.146	0.485
4hfr	14M	Corticosteroid 11-beta-dehydrogenase isozyme 1	1.1.1.146	0.473
3bzu	A21	Corticosteroid 11-beta-dehydrogenase isozyme 1	1.1.1.146	0.472
1xu7	CPS	Corticosteroid 11-beta-dehydrogenase isozyme 1	1.1.1.146	0.443
3gmd	2M3	Corticosteroid 11-beta-dehydrogenase isozyme 1	1.1.1.146	0.440