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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3eppSFGmRNA cap guanine-N7 methyltransferase2.1.1.56

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3eppSFGmRNA cap guanine-N7 methyltransferase2.1.1.561.000
3bgvSAHmRNA cap guanine-N7 methyltransferase2.1.1.560.620
5je2SAHMethyl transferase/0.576
3uj8SFGPhosphoethanolamine N-methyltransferase/0.524
4az0S61Lysosomal protective protein3.4.16.50.515
4r6xSAHPhosphoethanolamine N-methyltransferase/0.514
1x7jGENEstrogen receptor beta/0.509
3b5iSAHIndole-3-acetate O-methyltransferase 1/0.509
1sojIBMcGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.506
3qakUKAAdenosine receptor A2a/0.500
4p68MTXDihydrofolate reductase/0.499
4fex0TOAminoglycoside 3'-phosphotransferase AphA1-IAB/0.496
4twpAXITyrosine-protein kinase ABL12.7.10.20.492
3c11GDMATP-dependent molecular chaperone HSP82/0.491
4k9yK9YFocal adhesion kinase 12.7.10.20.490
4mwzSAMPhosphoethanolamine N-methyltransferase, putative/0.490
3el7PD3Proto-oncogene tyrosine-protein kinase Src2.7.10.20.488
4az3S35Lysosomal protective protein3.4.16.50.488
3iakEV1cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.487
2zjwREFCasein kinase II subunit alpha2.7.11.10.486
2ea1GPGRibonuclease I3.1.27.60.485
3ix8TX3Transcriptional activator protein LasR/0.485
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.484
3fy9XCFDihydrofolate reductase1.5.1.30.484
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.484
4qtuSAM18S rRNA (guanine(1575)-N(7))-methyltransferase/0.484
1x76697Estrogen receptor beta/0.483
2fai459Estrogen receptor/0.483
2wgjVGHHepatocyte growth factor receptor2.7.10.10.483
3ix4TX1Transcriptional activator protein LasR/0.483
3sglSAMtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC/0.483
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.482
4fevPP1Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.482
4l23X6KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/0.482
2oi6UD1Bifunctional protein GlmU/0.481
3wd9QPCcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.481
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.480
2fszOHTEstrogen receptor beta/0.480
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.480
4llkMEWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.479
1qknRALEstrogen receptor beta/0.477
2in6839Wee1-like protein kinase2.7.10.20.477
3c1xCKKHepatocyte growth factor receptor2.7.10.10.477
3p9kSAHCaffeic acid O-methyltransferase/0.477
4ap7F47Hepatocyte growth factor receptor2.7.10.10.477
4iv0SAMPhosphoethanolamine N-methyltransferase, putative/0.477
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.476
2bfpH4BPteridine reductase 11.5.1.330.476
3a4pDFQHepatocyte growth factor receptor2.7.10.10.476
4htfSAMtRNA 5-carboxymethoxyuridine methyltransferase/0.476
1y2bDEEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.475
4gg50J3Hepatocyte growth factor receptor2.7.10.10.475
1so2666cGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.474
1uaeUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.474
1vruAAPGag-Pol polyprotein2.7.7.490.474
1zky689Estrogen receptor/0.474
2jj3JJ3Estrogen receptor beta/0.474
3uj7SAMPhosphoethanolamine N-methyltransferase/0.474
4bchT7ZCyclin-dependent kinase 92.7.11.220.474
3i8aN22Dihydrofolate reductase1.5.1.30.473
3zbx6XEHepatocyte growth factor receptor2.7.10.10.473
4bwaN0BPyrrolysine--tRNA ligase/0.473
4aoi4K0Hepatocyte growth factor receptor2.7.10.10.472
4b1fKRHGlutamate racemase/0.472
2g44T3OEstrogen receptor/0.471
3anlNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.471
3gc9B45Mitogen-activated protein kinase 112.7.11.240.471
3tq8TOPDihydrofolate reductase/0.471
4feu537Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.471
4pxmESTEstrogen receptor/0.471
1y2d4DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.470
2pmlANPUncharacterized protein/0.470
4ixgIXGDihydrofolate reductase1.5.1.30.470
5iu4ZMAAdenosine receptor A2a/0.470
1x0pFADTll0078 protein/0.469
3ansS38Bifunctional epoxide hydrolase 23.3.2.100.469
4m2xTMQDihydrofolate reductase1.5.1.30.469
5dx3ESTEstrogen receptor/0.469
3h4vDVPPteridine reductase 11.5.1.330.468
3wznBTNStreptavidin/0.468
1bozPRDDihydrofolate reductase1.5.1.30.467
1synF89Thymidylate synthase/0.467
1x7e244Estrogen receptor/0.467
1yimCM4Estrogen receptor/0.467
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.467
2zthSAMCatechol O-methyltransferase2.1.1.60.467
3eeiMTM5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/0.467
3sh25DRDihydrofolate reductase1.5.1.30.467
4hvh19RTyrosine-protein kinase JAK32.7.10.20.467
4ixeIXEDihydrofolate reductase1.5.1.30.467
1jomFFODihydrofolate reductase1.5.1.30.466
2p1dSAHGenome polyprotein2.7.7.480.466
4bmzMTAAminodeoxyfutalosine nucleosidase/0.466
4deg0JJHepatocyte growth factor receptor2.7.10.10.466
4gqkADPActin cross-linking toxin VgrG1/0.466
3l034OHEstrogen receptor/0.465
4hy6FJ1Heat shock protein HSP 90-alpha/0.465
4oew5IOcGMP-specific 3',5'-cyclic phosphodiesterase/0.465
1u3s797Estrogen receptor beta/0.464
2j7yE3OEstrogen receptor beta/0.464
3kr6UD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.464
3s7a684Dihydrofolate reductase1.5.1.30.464
3tq9MTXDihydrofolate reductase/0.464
3wv9FEGHmd co-occurring protein HcgE/0.464
1ai9NDPDihydrofolate reductase1.5.1.30.463
1fw0KAIGlutamate receptor 2/0.463
1uioHPRAdenosine deaminase3.5.4.40.463
1x7b041Estrogen receptor beta/0.463
1xwsBI1Serine/threonine-protein kinase pim-12.7.11.10.463
2qe4JJ3Estrogen receptor/0.463
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.463
4amjCVDBeta-1 adrenergic receptor/0.463
4kak06UDihydrofolate reductase1.5.1.30.463
4xcxSAHSmall RNA 2'-O-methyltransferase/0.463
2ycxP32Beta-1 adrenergic receptor/0.463
5k2cZMAAdenosine receptor A2a/0.463
1cqsEQUSteroid Delta-isomerase5.3.3.10.462
1fwyUD1Bifunctional protein GlmU/0.462
1j8uH4BPhenylalanine-4-hydroxylase1.14.16.10.462
1u3r338Estrogen receptor beta/0.462
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.462
2z2w770Wee1-like protein kinase2.7.10.20.462
4cdmFO1Deoxyribodipyrimidine photolyase/0.462
1jtqLY3Thymidylate synthase/0.461
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.461
3gluLYS_VAL_METNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.461
3qfvNM7Serine/threonine-protein kinase MRCK beta2.7.11.10.461
4lm5Q17Serine/threonine-protein kinase pim-12.7.11.10.461
5iu86DZAdenosine receptor A2a/0.461
5iua6DXAdenosine receptor A2a/0.461
1e92HBIPteridine reductase 11.5.1.330.460
1x7rGENEstrogen receptor/0.460
1zaf789Estrogen receptor beta/0.460
2bilBI1Serine/threonine-protein kinase pim-12.7.11.10.460
2i0v6C3Macrophage colony-stimulating factor 1 receptor2.7.10.10.460
2ojg19AMitogen-activated protein kinase 12.7.11.240.460
3f82353Hepatocyte growth factor receptor2.7.10.10.460
3l8sBFFMitogen-activated protein kinase 14/0.460
3o9lLPNRenin3.4.23.150.460
4eiyZMAAdenosine receptor A2a/0.460
4ezj0SCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.460
1e8zSTUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.459
2yerTQ1Serine/threonine-protein kinase Chk12.7.11.10.459
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.459
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.459
3olsESTEstrogen receptor beta/0.459
3q2jCKIAminoglycoside 3'-phosphotransferase2.7.1.950.459
3vrtYS2Vitamin D3 receptor/0.459
4dk50KOPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.459
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.459
4fnyI3KALK tyrosine kinase receptor2.7.10.10.459
4hvb19PPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.459
4iw61GUEstrogen receptor/0.459
4o71CPBBromodomain-containing protein 4/0.459
2b1z17MEstrogen receptor/0.458
2j7xESTEstrogen receptor beta/0.458
2x9vTMQPteridine reductase/0.458
2yjaESTEstrogen receptor/0.458
3cquCQURAC-alpha serine/threonine-protein kinase2.7.11.10.458
3rsv3RSBeta-secretase 13.4.23.460.458
4ajfF03cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.458
4ajwVWNPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform2.7.1.1530.458
4gg70J8Hepatocyte growth factor receptor2.7.10.10.458
4tv3ML9Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/0.458
5uviZMAAdenosine receptor A2a/0.458
1jpaANPEphrin type-B receptor 22.7.10.10.457
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
1yye196Estrogen receptor beta/0.457
4hni16WCasein kinase I isoform epsilon2.7.11.10.457
4pahLNRPhenylalanine-4-hydroxylase1.14.16.10.457
5d4vSAHUncharacterized protein MJ0489/0.457
1ju6LYAThymidylate synthase2.1.1.450.456
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.456
2fhnBNIAvidin-related protein 4/5/0.456
3d3p20AcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.456
3x0a5GPPhosphatidylinositol 5-phosphate 4-kinase type-2 beta2.7.1.1490.456
4eoi1ROCyclin-dependent kinase 22.7.11.220.456
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.456
4pdaCTNNucleoside permease/0.456
3pwhZMAAdenosine receptor A2a/0.456
1ludTRRDihydrofolate reductase1.5.1.30.455
1rx1NAPDihydrofolate reductase1.5.1.30.455
1u9e397Estrogen receptor beta/0.455
1wxyFRKAdenosine deaminase3.5.4.40.455
1yi4ADNSerine/threonine-protein kinase pim-12.7.11.10.455
2aq7TL53-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.455
2g2hP16Tyrosine-protein kinase ABL12.7.10.20.455
2rl52RLVascular endothelial growth factor receptor 22.7.10.10.455
2w3wVG9Dihydrofolate reductase/0.455
2xauADPPre-mRNA-splicing factor ATP-dependent RNA helicase PRP433.6.4.130.455
3fknFKNMitogen-activated protein kinase 14/0.455
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.455
3qtrX36Cyclin-dependent kinase 22.7.11.220.455
3s2a2NQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.455
3t7x4SHEndothiapepsin3.4.23.220.455
3uxhUXHRibosyldihydronicotinamide dehydrogenase [quinone]/0.455
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.455
4l8vNAPInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase1.1.1.180.455
2h00SAHU6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase/0.454
3biz61EWee1-like protein kinase2.7.10.20.454
3kpzZNEVitamin D3 receptor/0.454
3ozc4CTS-methyl-5'-thioadenosine phosphorylase/0.454
3p5sAVUCD38 molecule/0.454
4af3VX6Aurora kinase B2.7.11.10.454
1axwMTXThymidylate synthase/0.453
1dr4HBIDihydrofolate reductase1.5.1.30.453
1eqbFFOSerine hydroxymethyltransferase2.1.2.10.453
1fduESTEstradiol 17-beta-dehydrogenase 11.1.1.620.453
1fkxPRHAdenosine deaminase3.5.4.40.453
1ni4TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.453
1ni4TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.453
1zzlTZYMitogen-activated protein kinase 14/0.453
2bfmTOPPteridine reductase 11.5.1.330.453
3dleGFAGag-Pol polyprotein2.7.7.490.453
3nxtD2EDihydrofolate reductase1.5.1.30.453
3vbq0F5Serine/threonine-protein kinase pim-12.7.11.10.453
4at0FADPossible succinate dehydrogenase/0.453
4bbxLKFcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.453
5dgzL20Serine/threonine-protein kinase pim-12.7.11.10.453
5iubCLRAdenosine receptor A2a/0.453
5pahLDPPhenylalanine-4-hydroxylase1.14.16.10.453
1e1qADPATP synthase subunit beta, mitochondrial3.6.3.140.452
1m78NDPDihydrofolate reductase1.5.1.30.452
1ozqPRFQueuine tRNA-ribosyltransferase2.4.2.290.452
1p33MTXPteridine reductase 11.5.1.330.452
1qxlFR8Adenosine deaminase3.5.4.40.452
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.452
1yolS03Proto-oncogene tyrosine-protein kinase Src2.7.10.20.452
2b365PPEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.452
2wo7ASVIsopenicillin N synthase1.21.3.10.452
2ydoADNAdenosine receptor A2a/0.452
2zv2609Calcium/calmodulin-dependent protein kinase kinase 22.7.11.170.452
3fl4FL4Mitogen-activated protein kinase 14/0.452
3h4vNAPPteridine reductase 11.5.1.330.452
3nga3NGCasein kinase II subunit alpha2.7.11.10.452
3pe2E1BCasein kinase II subunit alpha2.7.11.10.452
3q95ESLEstrogen receptor/0.452
3r1sX73Cyclin-dependent kinase 22.7.11.220.452
3rpr25ZCyclin-dependent kinase 22.7.11.220.452
3sni546cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.452
3tqbFOLDihydrofolate reductase/0.452
4aqlTXCGuanine deaminase3.5.4.30.452
4ezk0SDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.452
4h4xFADBiphenyl dioxygenase ferredoxin reductase subunit/0.452
1ay0TPPTransketolase 12.2.1.10.451
1lhnAONSex hormone-binding globulin/0.451
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.451
1p6xTHMThymidine kinase/0.451
1qzfFOLBifunctional dihydrofolate reductase-thymidylate synthase/0.451
1sd1FMCS-methyl-5'-thioadenosine phosphorylase/0.451
2bkkADPAminoglycoside 3'-phosphotransferase2.7.1.950.451
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.451
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.451
2oalFADFlavin-dependent tryptophan halogenase RebH1.14.19.90.451
2z4y252Geranylgeranyl pyrophosphate synthase/0.451
3dd125DGlycogen phosphorylase, liver form2.4.1.10.451
3g5qFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.451
3nwe662Catechol O-methyltransferase2.1.1.60.451
3nxrD2DDihydrofolate reductase1.5.1.30.451
3rdqDTBStreptavidin/0.451
3zze6XPHepatocyte growth factor receptor2.7.10.10.451
4bqpNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.451
4fkxCDPNucleoside diphosphate kinase/0.451
1efaNPFLactose operon repressor/0.450
1nceCB3Thymidylate synthase/0.450
2azzTCHPhospholipase A2, major isoenzyme3.1.1.40.450
2ih2NEAModification methylase TaqI2.1.1.720.450
2vttLZDCyclin-dependent kinase 22.7.11.220.450
4at3LTIBDNF/NT-3 growth factors receptor2.7.10.10.450
4dma0L8Estrogen receptor/0.450
4gfo0X2Non-receptor tyrosine-protein kinase TYK22.7.10.20.450
4iw8KN3Estrogen receptor/0.450
4kjjFOLDihydrofolate reductase1.5.1.30.450
4nx6FOLDihydrofolate reductase1.5.1.30.450
4wdb2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.450
5cccDDFDihydrofolate reductase1.5.1.30.450
5iqiGNPBifunctional AAC/APH2.3.10.450
5d5aCAUBeta-2 adrenergic receptor/0.450
1k27MTMS-methyl-5'-thioadenosine phosphorylase/0.449
1orhSAHProtein arginine N-methyltransferase 1/0.449
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
1s3vTQDDihydrofolate reductase1.5.1.30.449
2baqPQBMitogen-activated protein kinase 14/0.449
2c3u2TPPyruvate synthase/0.449
2dwpACP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 32.7.1.1050.449
2giuFBREstrogen receptor beta/0.449
2nv7555Estrogen receptor beta/0.449
2oh4GIGVascular endothelial growth factor receptor 22.7.10.10.449
2v4lABJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
2vagV25Dual specificity protein kinase CLK12.7.12.10.449
2xx513NATP-dependent molecular chaperone HSP82/0.449
2ydkYDKSerine/threonine-protein kinase Chk12.7.11.10.449
3dzl3OCPhenazine biosynthesis protein A/B/0.449
4jq7KJQEpidermal growth factor receptor2.7.10.10.449
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.449
4mf029ZTyrosine-protein kinase ITK/TSK2.7.10.20.449
4n6z2HWSerine/threonine-protein kinase pim-12.7.11.10.449
2a14SAHIndolethylamine N-methyltransferase2.1.1.490.448
2c94TSF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.448
2vssACOHydroxycinnamoyl-CoA hydratase-lyase4.1.2.410.448
2w3aTOPDihydrofolate reductase1.5.1.30.448
3iro2CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.448
3qqgX06Cyclin-dependent kinase 22.7.11.220.448
3sgy06WDihydrofolate reductase1.5.1.30.448
3upkUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.448
4fad0TBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
4j03FVSBifunctional epoxide hydrolase 23.1.3.760.448
4kzl20DTankyrase-22.4.2.300.448
1j3jCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.447
1ro6ROLcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.447
1w1rZEACytokinin dehydrogenase 11.5.99.120.447
1z6tADPApoptotic protease-activating factor 1/0.447
2i1m5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.447
2ouzC3DEstrogen receptor/0.447
2p15EZTEstrogen receptor/0.447
3c34KAIGlutamate receptor ionotropic, kainate 1/0.447
3cluFADElectron transfer flavoprotein subunit alpha/0.447
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.447
3fkoFKOMitogen-activated protein kinase 14/0.447
3fy8XCFDihydrofolate reductase1.5.1.30.447
3jpuTY4Transcriptional activator protein LasR/0.447
3lccSAHThiocyanate methyltransferase 1/0.447
4f9yGG5Mitogen-activated protein kinase 14/0.447
4l2yXXKPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/0.447
5aqzSGVHeat shock 70 kDa protein 1A/0.447
1dg7WRBDihydrofolate reductase1.5.1.30.446
1o5rFR9Adenosine deaminase3.5.4.40.446
1rdtL79Retinoic acid receptor RXR-alpha/0.446
1s1tUC1Gag-Pol polyprotein2.7.7.490.446
1th6OINBasic phospholipase A2 VRV-PL-VIIIa3.1.1.40.446
1xzqFONtRNA modification GTPase MnmE3.6.50.446
2gzl2AA2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase4.6.1.120.446
2iwuNP5ATP-dependent molecular chaperone HSP82/0.446
2op18PCEnoyl-ACP reductase/0.446
2ykeYKEHeat shock protein HSP 90-alpha/0.446
3cr0809Wee1-like protein kinase2.7.10.20.446
3m09RARDihydrofolate reductase1.5.1.30.446
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
3ppkFNISerine/threonine-protein kinase B-raf2.7.11.10.446
3q5kD1UHeat shock protein 83-1/0.446
4xe606UDihydrofolate reductase1.5.1.30.446
4yqfGDPSeptin-9/0.446
4zvmDM2Ribosyldihydronicotinamide dehydrogenase [quinone]/0.446
5bp7SAHSAM-dependent methyltransferase/0.446
5efwFMNNPH1-1/0.446
1ltzHBIPhenylalanine-4-hydroxylase1.14.16.10.445
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
1r0eDFNGlycogen synthase kinase-3 beta2.7.11.260.445
1uy7PU4Heat shock protein HSP 90-alpha/0.445
1vj3TABDihydrofolate reductase1.5.1.30.445
1w19T4P6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.445
1x8b824Wee1-like protein kinase2.7.10.20.445
1y2e5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
1yhoTRRDihydrofolate reductase1.5.1.30.445
2aouCQAHistamine N-methyltransferase2.1.1.80.445
2bl9CP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.445
2j2iLY4Serine/threonine-protein kinase pim-12.7.11.10.445
2jedLG8Protein kinase C theta type2.7.11.130.445
2pvrANPCasein kinase II subunit alpha2.7.11.10.445
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
3bgpVX1Serine/threonine-protein kinase pim-12.7.11.10.445
3cgyRDCVirulence sensor histidine kinase PhoQ2.7.13.30.445
3mtlFEFCyclin-dependent kinase 162.7.11.220.445
3negPYVAbscisic acid receptor PYL1/0.445
3ns2PYVAbscisic acid receptor PYL2/0.445
3qg2CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.445
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.445
3tnwF18Cyclin-dependent kinase 22.7.11.220.445
4i6h1C8Serine/threonine-protein kinase PLK22.7.11.210.445
4j26ESTEstrogen receptor beta/0.445
4jva1ORcAMP-dependent protein kinase type II-beta regulatory subunit/0.445
4kbn25UDihydrofolate reductase1.5.1.30.445
4pl9ADPEthylene receptor 1/0.445
5ifyTRHGlucose-1-phosphate thymidylyltransferase/0.445
5k2dZMAAdenosine receptor A2a/0.445
1k4gAIQQueuine tRNA-ribosyltransferase2.4.2.290.444
1ly4COQDihydrofolate reductase1.5.1.30.444
1s6qTPBGag-Pol polyprotein2.7.7.490.444
1tl3H20Gag-Pol polyprotein2.7.7.490.444
2c92TP66,7-dimethyl-8-ribityllumazine synthase2.5.1.780.444
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.444
2dr3ADPUPF0273 protein PH0284/0.444
2i1vADP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 32.7.1.1050.444
2ofv242Tyrosine-protein kinase Lck2.7.10.20.444
2qcuFADAerobic glycerol-3-phosphate dehydrogenase1.1.5.30.444
2vwz7X6Ephrin type-B receptor 42.7.10.10.444
2z3uCRRCytochrome P450/0.444
3anxMTAPolyamine aminopropyltransferase/0.444
3c72CX1Geranylgeranyl transferase type-2 subunit beta2.5.1.600.444
3cth319Hepatocyte growth factor receptor2.7.10.10.444
3dhbC6LN-acyl homoserine lactonase AiiA3.1.1.810.444
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
3inxJZCHeat shock protein HSP 90-alpha/0.444
3vw8DF6Hepatocyte growth factor receptor2.7.10.10.444
4ftcH6KSerine/threonine-protein kinase Chk12.7.11.10.444
4gh30EVQueuine tRNA-ribosyltransferase2.4.2.290.444
4jlj1NMDeoxycytidine kinase2.7.1.740.444
3emlZMAAdenosine receptor A2a/0.444
1ao8MTXDihydrofolate reductase1.5.1.30.443
1f28F89Thymidylate synthase2.1.1.450.443
1jq3AATPolyamine aminopropyltransferase/0.443
1jujLYAThymidylate synthase2.1.1.450.443
2fziDH3Dihydrofolate reductase1.5.1.30.443
2hb8MVDVitamin D3 receptor/0.443
2jfaRALEstrogen receptor/0.443
2np7NEAModification methylase TaqI2.1.1.720.443
2ovvPFHcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
2p3qSAHGenome polyprotein/0.443
2r6rGDPCell division protein FtsZ/0.443
3mnrSD1Heat shock protein HSP 90-alpha/0.443
3opxU5PSuppressor of disruption of TFIIS/0.443
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.443
4g310WHEukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.443
4grb0XGCasein kinase II subunit alpha2.7.11.10.443
4iaq2GM5-hydroxytryptamine receptor 1B/0.443
4j24ESTEstrogen receptor beta/0.443
4uyf73BBromodomain-containing protein 2/0.443
7dfrFOLDihydrofolate reductase1.5.1.30.443
2rh1CAUBeta-2 adrenergic receptor/0.443
1cg6MTAS-methyl-5'-thioadenosine phosphorylase/0.442
1dtnAPGMandelate racemase/0.442
1gs3EQUSteroid Delta-isomerase5.3.3.10.442
1lhuESTSex hormone-binding globulin/0.442
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.442
1yinCM3Estrogen receptor/0.442
2c3oTPPPyruvate synthase/0.442
2w5bAGSSerine/threonine-protein kinase Nek22.7.11.10.442
2wjoQUDBeta-secretase 13.4.23.460.442
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.442
3ec7NADInositol 2-dehydrogenase/0.442
3iggEFQCyclin-dependent kinase 22.7.11.220.442
3nhyA7BRibosyldihydronicotinamide dehydrogenase [quinone]/0.442
3nj0PYVAbscisic acid receptor PYL2/0.442
3q87SAMN6 ADENINE SPECIFIC DNA METHYLASE (METHYLTRANSFERASE SUPERFAMILY)/0.442
3qf9NM8Serine/threonine-protein kinase pim-12.7.11.10.442
3r1qX75Cyclin-dependent kinase 22.7.11.220.442
3rviRVIBeta-secretase 13.4.23.460.442
3v8s0HDRho-associated protein kinase 12.7.11.10.442
3zc5W9ZHepatocyte growth factor receptor2.7.10.10.442
4hqvQEIQueuine tRNA-ribosyltransferase2.4.2.290.442
4lmuQUESerine/threonine-protein kinase pim-12.7.11.10.442
4r3aANPBlue-light-activated histidine kinase 22.7.13.30.442
4u07ATPAdenosine monophosphate-protein transferase FICD2.7.7.n10.442
4uyg73BBromodomain-containing protein 2/0.442
5ikqJMSProstaglandin G/H synthase 21.14.99.10.442
1e26GPBDihydrofolate reductase1.5.1.30.441
1gwqZTWEstrogen receptor/0.441
1kzjCB3Thymidylate synthase/0.441
1olsTDP2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial1.2.4.40.441
1rfqLARActin, alpha skeletal muscle/0.441
1s4mLUMRiboflavin biosynthesis protein/0.441
2etkHFSRho-associated protein kinase 12.7.11.10.441
2fpcSCGStrictosidine synthase4.3.3.20.441
2gblATPCircadian clock protein kinase KaiC2.7.11.10.441
2ieaTDPPyruvate dehydrogenase E1 component1.2.4.10.441
2jc6QPPCalcium/calmodulin-dependent protein kinase type 1D2.7.11.170.441
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.441
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.441
2yee2ECHeat shock protein HSP 90-alpha/0.441
2yeiXQIHeat shock protein HSP 90-alpha/0.441
2yejXQKHeat shock protein HSP 90-alpha/0.441
3cy3JN5Serine/threonine-protein kinase pim-12.7.11.10.441
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3erdDESEstrogen receptor/0.441
3g5sFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.441
3kqjUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.441
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.441
3r8uZ31Cyclin-dependent kinase 22.7.11.220.441
3t2sAGSHeat shock protein HSP 90-alpha/0.441
3tvxPNXcAMP-specific 3',5'-cyclic phosphodiesterase 4A3.1.4.530.441
3uixQ17Serine/threonine-protein kinase pim-12.7.11.10.441
4eerFMNPhototropin-22.7.11.10.441
4g1z0VPVitamin D3 receptor A/0.441
4hvi19STyrosine-protein kinase JAK32.7.10.20.441
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.441
4z07PCGcGMP-dependent protein kinase 12.7.11.120.441
1dg5TOPDihydrofolate reductase1.5.1.30.440
1jlcFTCGag-Pol polyprotein2.7.7.490.440
1ne6SP1cAMP-dependent protein kinase type I-alpha regulatory subunit/0.440
1uy6PU3Heat shock protein HSP 90-alpha/0.440
2fk8SAMHydroxymycolate synthase MmaA42.1.10.440
2fzhDH1Dihydrofolate reductase1.5.1.30.440
2izt23DCasein kinase I isoform gamma-32.7.11.10.440
3c3eFO12-phospho-L-lactate transferase/0.440
3elePLPAminotransferase/0.440
3fr5I4AFatty acid-binding protein, adipocyte/0.440
3g5mFADRibosyldihydronicotinamide dehydrogenase [quinone]/0.440
3hz5Z64Heat shock protein HSP 90-alpha/0.440
3iw4LW4Protein kinase C alpha type2.7.11.130.440
3naxMP73-phosphoinositide-dependent protein kinase 12.7.11.10.440
3pldF90Endothiapepsin3.4.23.220.440
3sai9DRDihydrofolate reductase/0.440
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4c02TAKActivin receptor type-12.7.11.300.440
4h9506UDihydrofolate reductase1.5.1.30.440
4pb1RBVNucleoside permease/0.440
5k2bZMAAdenosine receptor A2a/0.440
3uzaT4GAdenosine receptor A2a/0.440