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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3efl706Vascular endothelial growth factor receptor 22.7.10.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3efl706Vascular endothelial growth factor receptor 22.7.10.11.000
3hng8STVascular endothelial growth factor receptor 12.7.10.10.641
3cp9C19Vascular endothelial growth factor receptor 22.7.10.10.622
2qu6857Vascular endothelial growth factor receptor 22.7.10.10.617
3vnt0JAVascular endothelial growth factor receptor 22.7.10.10.607
2xir00JVascular endothelial growth factor receptor 22.7.10.10.594
3dtwA96Vascular endothelial growth factor receptor 22.7.10.10.592
3b8q900Vascular endothelial growth factor receptor 22.7.10.10.590
3vhkBPKVascular endothelial growth factor receptor 22.7.10.10.588
4aseAV9Vascular endothelial growth factor receptor 22.7.10.10.570
2p2i608Vascular endothelial growth factor receptor 22.7.10.10.569
4c8b0LIReceptor-interacting serine/threonine-protein kinase 22.7.11.10.559
4fc00T2Serine/threonine-protein kinase B-raf2.7.11.10.545
4agwNG7Proto-oncogene tyrosine-protein kinase Src2.7.10.20.539
3g0fB49Mast/stem cell growth factor receptor Kit2.7.10.10.534
5hi2BAXSerine/threonine-protein kinase B-raf2.7.11.10.534
2hyySTITyrosine-protein kinase ABL12.7.10.20.531
4ksp1SUSerine/threonine-protein kinase B-raf2.7.11.10.528
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.525
3eta351Insulin receptor2.7.10.10.525
4o2z046Mitogen-activated protein kinase/0.521
1iepSTITyrosine-protein kinase ABL12.7.10.20.518
4aa0AA0Mitogen-activated protein kinase 14/0.511
2og81N8Tyrosine-protein kinase Lck2.7.10.20.505
3ctj320Hepatocyte growth factor receptor2.7.10.10.500
3hv5R24Mitogen-activated protein kinase 14/0.500
3zsh469Mitogen-activated protein kinase 14/0.499
4qrc0LIFibroblast growth factor receptor 42.7.10.10.494
3c7qXINVascular endothelial growth factor receptor 22.7.10.10.487
3kq7KQ7Mitogen-activated protein kinase 14/0.480
4eyjN61Mitogen-activated protein kinase 132.7.11.240.480
3lfbZ87Mitogen-activated protein kinase 14/0.474
3hub469Mitogen-activated protein kinase 14/0.462
3ce31FNHepatocyte growth factor receptor2.7.10.10.454
4kaoKAOFocal adhesion kinase 12.7.10.20.454
4eevL1XHepatocyte growth factor receptor2.7.10.10.453
4nka2K7Fibroblast growth factor receptor 1/0.450