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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3eej53RUncharacterized protein

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3eej53RUncharacterized protein/1.000
3eel53TUncharacterized protein/0.707
3eem53VUncharacterized protein/0.675
4h9814QUncharacterized protein/0.650
3eek53SUncharacterized protein/0.612
3qly55VUncharacterized protein/0.568
3qlzQLZUncharacterized protein/0.527
3qlxQLRUncharacterized protein/0.526
3qlwN22Dihydrofolate reductase1.5.1.30.519
3cseN22Uncharacterized protein/0.507
3invC50Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.484
4h9506UDihydrofolate reductase1.5.1.30.473
4h9614QDihydrofolate reductase1.5.1.30.473
1cd2FOLDihydrofolate reductase1.5.1.30.465
2fziDH3Dihydrofolate reductase1.5.1.30.462
4h9753SDihydrofolate reductase1.5.1.30.461
3kjsDQ1Bifunctional dihydrofolate reductase-thymidylate synthase/0.457
3um61CYBifunctional dihydrofolate reductase-thymidylate synthase/0.451
2cig1DGDihydrofolate reductase1.5.1.30.447
1m78CLZDihydrofolate reductase1.5.1.30.446
3iro2CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.445
1j3iWRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.443
3td8D2RDihydrofolate reductase1.5.1.30.443
3qgtCP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.440