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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3eb0DRKUncharacterized protein

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3eb0DRKUncharacterized protein/1.000
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.516
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.488
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.475
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.469
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.467
4bcmT7ZCyclin-dependent kinase 22.7.11.220.460
4hvi19STyrosine-protein kinase JAK32.7.10.20.459
4i5cC5ITyrosine-protein kinase JAK1/0.459
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.455
2vn9GVDCalcium/calmodulin-dependent protein kinase type II subunit delta2.7.11.170.454
4f081RSTyrosine-protein kinase JAK2/0.453
4e4n0NLTyrosine-protein kinase JAK1/0.452
4hge15VTyrosine-protein kinase JAK2/0.452
2uzbC75Cyclin-dependent kinase 22.7.11.220.448
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.447
3nux3NVCyclin-dependent kinase 62.7.11.220.447
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.447
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.445
4aqc88ATyrosine-protein kinase JAK2/0.445
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.443
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.442
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.442