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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3ea5GDPGTP-binding nuclear protein Ran

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3ea5GDPGTP-binding nuclear protein Ran/1.000
5dhaGNPGTP-binding nuclear protein Ran/0.620
3a6pGTPGTP-binding nuclear protein Ran/0.616
5jljGNPGTP-binding nuclear protein Ran/0.611
3e5hGNPRas-related protein Rab-28/0.591
3nbzGTPGTP-binding nuclear protein Ran/0.574
3oesGNPGTPase RhebL1/0.573
1yhnGTPRas-related protein Rab-7a/0.570
1zbdGTPRas-related protein Rab-3A/0.570
3bbpGTPRas-related protein Rab-6A/0.570
3w3zGTPGTP-binding nuclear protein Ran/0.567
1k5dGNPGTP-binding nuclear protein Ran/0.565
3rabGNPRas-related protein Rab-3A/0.559
1yzqGNPRas-related protein Rab-6A/0.558
1vg8GNPRas-related protein Rab-7a/0.556
1t91GTPRas-related protein Rab-7a/0.555
1xtsGTPGTP-binding protein Rheb/0.550
4ol0GTPGTP-binding nuclear protein Ran/0.549
5b2zGNPGTPase HRas/0.549
3lbnGNPGTPase HRas/0.548
4o25GTPGTP-binding protein Rheb/0.548
2zetGTPRas-related protein Rab-27B/0.546
3rs5GNPGTPase HRas/0.545
1xtrGNPGTP-binding protein Rheb/0.544
4rkfGNPRas-related protein Rab-3/0.543
2bkuGTPGTP-binding nuclear protein Ran/0.541
1ibrGNPGTP-binding nuclear protein Ran/0.540
2ffqGSPRas-related protein Rab-6B/0.538
4dlwGNPGTPase HRas/0.538
4nyjGNPGTPase HRas/0.538
5difGNPGTP-binding nuclear protein Ran/0.538
2gilGTPRas-related protein Rab-6A/0.533
3i3sGNPGTPase HRas/0.532
3rs7GNPGTPase HRas/0.531
3bc1GNPRas-related protein Rab-27A/0.529
4dltGNPGTPase HRas/0.529
4lhwGNPRas-related protein Rab-8A/0.527
4kvgGTPRas-related protein Rap-1A/0.526
3oiuGNPGTPase HRas/0.524
3v4fGNPGTPase HRas/0.524
3tsoGNPRas-related protein Rab-25/0.523
1g17GNPRas-related protein SEC4/0.521
3oivGNPGTPase HRas/0.521
3kudGDPGTPase HRas/0.516
4mitGTPRho-related protein racC/0.511
2fe4GDPRas-related protein Rab-6B/0.506
4qxaGTPRas-related protein Rab-9A/0.506
3rs0GNPGTPase HRas/0.505
1oixGDPRas-related protein Rab-11A/0.504
3ddcGNPGTPase HRas/0.503
3rslGNPGTPase HRas/0.502
3a58GNPGTP-binding protein RHO1/0.499
3sbeGNPRas-related C3 botulinum toxin substrate 1/0.495
3x1zGNPRas-related protein Rap-1b/0.494
4nyiGNPGTPase HRas/0.493
2rgeGNPGTPase HRas/0.492
2rgbGNPGTPase HRas/0.491
3l8yGNPGTPase HRas/0.490
4cymGCPRas-related protein Rab-32/0.490
1zd9GDPADP-ribosylation factor-like protein 8A/0.489
1e96GTPRas-related C3 botulinum toxin substrate 1/0.488
3oiwGNPGTPase HRas/0.487
2rgcGNPGTPase HRas/0.486
4dlvGNPGTPase HRas/0.486
3wyfGTPGTP-binding nuclear protein/0.485
1ow3GDPTransforming protein RhoA/0.484
3kucGDPRas-related protein Rap-1A/0.484
3kz1GSPTransforming protein RhoA/0.484
4dlxGNPGTPase HRas/0.484
1kmqGNPTransforming protein RhoA/0.483
3pitGNPRas-related protein M-Ras/0.480
1s1cGNPTransforming protein RhoA/0.477
4dlzGNPGTPase HRas/0.476
3th5GNPRas-related C3 botulinum toxin substrate 1/0.475
4hdoGNPRas-related protein Rap-1b/0.475
4dsnGCPGTPase KRas/0.473
2c5lGTPGTPase HRas/0.472
4g0nGNPGTPase HRas/0.471
3eg5GNPCell division control protein 42 homolog/0.470
3lawGNPRas-related protein Rab-7a/0.470
1zc4GNPRas-related protein Ral-A/0.469
4l9wGNPGTPase HRas/0.469
2clsGTPRho-related GTP-binding protein Rho6/0.468
3tklGTPRas-related protein Rab-1A/0.466
5hpyGDPTransforming protein RhoA/0.466
3qbtGNPRas-related protein Rab-8A/0.465
3kkoGNPRas-related protein M-Ras/0.463
4js0GNPCell division control protein 42 homolog/0.462
4uj3GNPRas-related protein Rab-11A/0.462
1x27ASP_TYR_VAL_HIS_PTRTyrosine-protein kinase Lck2.7.10.20.461
4o2lGTPGTP-binding protein Rheb/0.461
1zc3GNPRas-related protein Ral-A/0.460
4o2rGDPGTP-binding protein Rheb/0.460
3lbhGNPGTPase HRas/0.458
3c14GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.456
1z2cGNPRho-related GTP-binding protein RhoC/0.454
2msdGNPMHC class I alpha chain/0.454
3rs4GNPGTPase HRas/0.453
3k8yGNPGTPase HRas/0.452
4gzlGNPRas-related C3 botulinum toxin substrate 1/0.452
4xoiGTPTransforming protein RhoA/0.452
2gcpGSPRho-related GTP-binding protein RhoC/0.451
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.451
4dlsGNPGTPase HRas/0.451
1cxzGSPTransforming protein RhoA/0.450
1d5cGDPGTPase (Rab6)/0.449
1m7bGTPRho-related GTP-binding protein RhoE/0.449
4dsoGSPGTPase KRas/0.449
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.447
3wygGTPGTP-binding nuclear protein GSP1/CNR1/0.446
1q12ATPMaltose/maltodextrin import ATP-binding protein MalK/0.445
1g16GDPRas-related protein SEC4/0.444
4gzmGSPRas-related C3 botulinum toxin substrate 1/0.444
4dxaGSPRas-related protein Rap-1b/0.443
4uj5GNPRas-related protein Rab-11A/0.440