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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3e8xNAPBH1520 protein

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3e8xNAPBH1520 protein/1.000
3lqfNADGalactitol dehydrogenase/0.476
4bfsZVSPantothenate kinase2.7.1.330.476
2zsaADPPantothenate kinase2.7.1.330.467
4dbzNDPPutative ketoacyl reductase1.3.10.464
1ybmNAPUncharacterized protein At5g02240/0.463
2gjnFMNNitronate monooxygenase1.13.12.160.461
4hbgNDP3-oxoacyl-[acyl-carrier-protein] reductase1.1.1.1000.459
3af2ACPPantothenate kinase2.7.1.330.457
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.455
4egbNADdTDP-glucose 4,6-dehydratase/0.454
3v2uATPProtein GAL3/0.452
3af4GCPPantothenate kinase2.7.1.330.450
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.447
2zsbADPPantothenate kinase2.7.1.330.446
1qr6NADNAD-dependent malic enzyme, mitochondrial1.1.1.380.443
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.442
3d4pNADL-lactate dehydrogenase 11.1.1.270.441
4ktl1CQCytochrome P450/0.441
1c9k5GPBifunctional adenosylcobalamin biosynthesis protein CobU/0.440
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
4eywL0RCarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.440