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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3e01PZ2Gag-Pol polyprotein2.7.7.49

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3e01PZ2Gag-Pol polyprotein2.7.7.491.000
3ffi3OBGag-Pol polyprotein2.7.7.490.559
4h4o506Gag-Pol polyprotein2.7.7.490.559
4mfb29TGag-Pol polyprotein2.7.7.490.530
2jleI15Reverse transcriptase/RNaseH/0.522
3dolGWIPol protein/0.516
3is9AC7Gag-Pol polyprotein2.7.7.490.490
3irxUDRGag-Pol polyprotein2.7.7.490.488
4h4m494Gag-Pol polyprotein2.7.7.490.481
4i2q1BTGag-Pol polyprotein2.7.7.490.461
1tvrTB9Gag-Pol polyprotein2.7.7.490.459
3c6tM14Gag-Pol polyprotein2.7.7.490.450
3c6uM22Gag-Pol polyprotein2.7.7.490.440