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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3dtwA96Vascular endothelial growth factor receptor 22.7.10.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3dtwA96Vascular endothelial growth factor receptor 22.7.10.11.000
3b8q900Vascular endothelial growth factor receptor 22.7.10.10.795
4c8b0LIReceptor-interacting serine/threonine-protein kinase 22.7.11.10.582
2qu6857Vascular endothelial growth factor receptor 22.7.10.10.580
3cp9C19Vascular endothelial growth factor receptor 22.7.10.10.575
3vnt0JAVascular endothelial growth factor receptor 22.7.10.10.568
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.562
3efl706Vascular endothelial growth factor receptor 22.7.10.10.559
3hng8STVascular endothelial growth factor receptor 12.7.10.10.555
4o2z046Mitogen-activated protein kinase/0.553
4aseAV9Vascular endothelial growth factor receptor 22.7.10.10.550
2hyySTITyrosine-protein kinase ABL12.7.10.20.549
4agwNG7Proto-oncogene tyrosine-protein kinase Src2.7.10.20.542
2xir00JVascular endothelial growth factor receptor 22.7.10.10.540
2p2i608Vascular endothelial growth factor receptor 22.7.10.10.537
4fc00T2Serine/threonine-protein kinase B-raf2.7.11.10.529
1iepSTITyrosine-protein kinase ABL12.7.10.20.511
2og81N8Tyrosine-protein kinase Lck2.7.10.20.510
3vhkBPKVascular endothelial growth factor receptor 22.7.10.10.510
3lfbZ87Mitogen-activated protein kinase 14/0.509
4aa0AA0Mitogen-activated protein kinase 14/0.508
3hv5R24Mitogen-activated protein kinase 14/0.500
5hi2BAXSerine/threonine-protein kinase B-raf2.7.11.10.498
3g0fB49Mast/stem cell growth factor receptor Kit2.7.10.10.496
3kq7KQ7Mitogen-activated protein kinase 14/0.488
3ce31FNHepatocyte growth factor receptor2.7.10.10.487
4ksp1SUSerine/threonine-protein kinase B-raf2.7.11.10.475
4eyjN61Mitogen-activated protein kinase 132.7.11.240.474
3c7qXINVascular endothelial growth factor receptor 22.7.10.10.463
3eta351Insulin receptor2.7.10.10.462
3ctj320Hepatocyte growth factor receptor2.7.10.10.458
4eevL1XHepatocyte growth factor receptor2.7.10.10.458
3zsh469Mitogen-activated protein kinase 14/0.447
4qrc0LIFibroblast growth factor receptor 42.7.10.10.441