sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3dtt | NAP | NADP oxidoreductase, coenzyme F420-dependent |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3dtt | NAP | NADP oxidoreductase, coenzyme F420-dependent | / | 1.000 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.518 | |
| 4o1m | NAD | Enoyl-acyl carrier reductase | / | 0.514 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.502 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.502 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.502 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.502 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.495 | |
| 3uf6 | COD | Lmo1369 protein | / | 0.493 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.492 | |
| 2psj | CEI | Renilla-luciferin 2-monooxygenase | 1.13.12.5 | 0.491 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.490 | |
| 4eso | NAP | Putative oxidoreductase | / | 0.489 | |
| 1v35 | NAI | Enoyl-ACP reductase | / | 0.488 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.487 | |
| 4an4 | DUD | Putative glycosyl transferase | / | 0.487 | |
| 1pt5 | ACO | Formyl-CoA:oxalate CoA-transferase | / | 0.486 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.486 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.485 | |
| 4oxy | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.485 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.484 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.484 | |
| 4cjx | 9L9 | C-1-tetrahydrofolate synthase, cytoplasmic, putative | / | 0.484 | |
| 4phl | PIL | Phosphodiesterase | / | 0.484 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.484 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.483 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.483 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
| 1a27 | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.480 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.480 | |
| 2yoz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.480 | |
| 4imo | PWZ | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.480 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.479 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.479 | |
| 5dcy | NAP | Iridoid synthase | 1.3.1.99 | 0.479 | |
| 1dis | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.478 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.478 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.478 | |
| 1rx8 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 2drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.477 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.477 | |
| 4eil | UMP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.477 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 4isk | 1JY | Thymidylate synthase | / | 0.477 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.476 | |
| 2hmy | SAM | Modification methylase HhaI | 2.1.1.37 | 0.476 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.476 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.476 | |
| 4zj8 | SUV | Orexin receptor type 1 | / | 0.476 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.475 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.475 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.475 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.475 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.474 | |
| 9mht | SAH | Modification methylase HhaI | 2.1.1.37 | 0.474 | |
| 4wec | NAD | Short chain dehydrogenase | / | 0.473 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 1wxy | FRK | Adenosine deaminase | 3.5.4.4 | 0.472 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.472 | |
| 2fr1 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.471 | |
| 2pmd | GNP | Translation initiation factor 2 subunit gamma | / | 0.471 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.471 | |
| 4s0v | SUV | Orexin receptor type 2 | / | 0.471 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.470 | |
| 2tpr | FAD | Trypanothione reductase | 1.8.1.12 | 0.470 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.469 | |
| 2xvw | 9NR | Serum albumin | / | 0.469 | |
| 4y9l | FAD | Acyl-CoA dehydrogenase family member 11 | / | 0.469 | |
| 1dyi | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 1h36 | R88 | Squalene--hopene cyclase | 4.2.1.129 | 0.468 | |
| 1kt8 | ILP | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.468 | |
| 3eld | SFG | Methyltransferase | / | 0.468 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.468 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.467 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 1dir | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.466 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.466 | |
| 3d4b | DZD | NAD-dependent protein deacetylase | / | 0.466 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.466 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.466 | |
| 10mh | SAH | Modification methylase HhaI | 2.1.1.37 | 0.465 | |
| 1dr5 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.465 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 4n5n | NAP | Acetoacetyl-CoA reductase | 1.1.1.36 | 0.465 | |
| 1dyj | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 2oc4 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.464 | |
| 2x0e | TYD | WsaF | / | 0.464 | |
| 3ai2 | NDP | NADPH-sorbose reductase | / | 0.464 | |
| 3gn7 | 3GN | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.464 | |
| 4j0j | E35 | Tannase | / | 0.464 | |
| 4m6j | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.463 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.463 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.463 | |
| 4z63 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.463 | |
| 1equ | EQI | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.462 | |
| 1p44 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.462 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.462 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.462 | |
| 3hk1 | B64 | Fatty acid-binding protein, adipocyte | / | 0.462 | |
| 3tqa | NDP | Dihydrofolate reductase | / | 0.462 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.462 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.461 | |
| 1skm | SAH | Modification methylase HhaI | 2.1.1.37 | 0.461 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.461 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.461 | |
| 4cuk | NAI | D-lactate dehydrogenase | / | 0.461 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.460 | |
| 1dyh | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.460 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.460 | |
| 2w3b | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.460 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.460 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.460 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.459 | |
| 1ra8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 2lfo | GCH | Fatty acid-binding protein, liver | / | 0.459 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 4a84 | DXC | Major pollen allergen Bet v 1-A | / | 0.459 | |
| 4g74 | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.459 | |
| 4j4v | SVR | Nucleocapsid protein | / | 0.459 | |
| 4p9d | TMP | Deoxycytidylate deaminase | / | 0.459 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.459 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 2ohv | NHL | Glutamate racemase | / | 0.458 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.458 | |
| 3aiq | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic | 3.2.1.182 | 0.458 | |
| 3clb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.458 | |
| 4boe | CLR | Japanin | / | 0.458 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.458 | |
| 4ktl | 1CQ | Cytochrome P450 | / | 0.458 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.458 | |
| 1dg8 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.457 | |
| 1rft | PXM | Pyridoxal kinase | 2.7.1.35 | 0.457 | |
| 1so2 | 666 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.457 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.457 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.457 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.457 | |
| 4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.457 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.457 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.457 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.457 | |
| 2d8a | NAD | L-threonine 3-dehydrogenase | / | 0.456 | |
| 2ieb | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.456 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.456 | |
| 3inv | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.456 | |
| 3ioc | A5D | Pantothenate synthetase | 6.3.2.1 | 0.456 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.456 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.456 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.456 | |
| 4ft4 | SAH | DNA (cytosine-5)-methyltransferase 1 | 2.1.1.37 | 0.456 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.456 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.456 | |
| 1ddr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1rb3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 3b9l | AZZ | Serum albumin | / | 0.455 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.455 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.455 | |
| 3tnl | NAD | Shikimate dehydrogenase (NADP(+)) | / | 0.455 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.455 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.455 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.455 | |
| 4zas | TYD | CalS13 | / | 0.455 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.454 | |
| 1eyq | NAR | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.454 | |
| 1o5r | FR9 | Adenosine deaminase | 3.5.4.4 | 0.454 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 2hu2 | NAD | C-terminal binding protein 1 | / | 0.454 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 2npn | SAM | Putative cobalamin synthesis related protein | / | 0.454 | |
| 2p9g | NAI | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.454 | |
| 2xvv | 9DN | Serum albumin | / | 0.454 | |
| 3ai3 | NDP | NADPH-sorbose reductase | / | 0.454 | |
| 3k4n | FAD | Pyranose 2-oxidase | / | 0.454 | |
| 3lfm | 3DT | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.454 | |
| 3u4c | NDP | NADPH-dependent reductase BacG | / | 0.454 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.454 | |
| 5dp2 | NAP | CurF | / | 0.454 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 1p33 | MTX | Pteridine reductase 1 | 1.5.1.33 | 0.453 | |
| 1vrq | FON | Subunit alpha of sarocosine oxidase | / | 0.453 | |
| 2abj | CBC | Branched-chain-amino-acid aminotransferase, cytosolic | 2.6.1.42 | 0.453 | |
| 2bf7 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.453 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.453 | |
| 2j62 | GSZ | O-GlcNAcase NagJ | / | 0.453 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 3qvp | FAD | Glucose oxidase | 1.1.3.4 | 0.453 | |
| 4a86 | H35 | Major pollen allergen Bet v 1-A | / | 0.453 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.453 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.453 | |
| 4j1f | 1HL | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 4xd2 | NAI | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.453 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.453 | |
| 1d3h | A26 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.452 | |
| 1f4g | TP4 | Thymidylate synthase | / | 0.452 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 1re7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 2j09 | FMN | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.452 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.452 | |
| 4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.452 | |
| 4g47 | TZF | Mycocyclosin synthase | 1.14.21.9 | 0.452 | |
| 5iua | 6DX | Adenosine receptor A2a | / | 0.452 | |
| 1dr2 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1lsj | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.451 | |
| 1q1r | FAD | Putidaredoxin reductase | 1.18.1.5 | 0.451 | |
| 2ges | COK | Pantothenate kinase | 2.7.1.33 | 0.451 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.451 | |
| 2wjo | QUD | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 3e8x | NAP | BH1520 protein | / | 0.451 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.451 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.451 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.451 | |
| 4hhz | 15S | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.451 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.451 | |
| 5std | UNN | Scytalone dehydratase | 4.2.1.94 | 0.451 | |
| 2b04 | CHO | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.450 | |
| 2zb4 | 5OP | Prostaglandin reductase 2 | 1.3.1.48 | 0.450 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.450 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.450 | |
| 4hwk | NAP | Sepiapterin reductase | 1.1.1.153 | 0.450 | |
| 4ie6 | UN9 | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.450 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.450 | |
| 4lnb | ED5 | CaaX farnesyltransferase beta subunit Ram1 | / | 0.450 | |
| 5cc9 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 5jsf | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.450 | |
| 1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.449 | |
| 1nyt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.449 | |
| 1tou | B1V | Fatty acid-binding protein, adipocyte | / | 0.449 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.449 | |
| 2gr1 | FAD | Ferredoxin reductase | / | 0.449 | |
| 2ix5 | FAD | Acyl-coenzyme A oxidase 4, peroxisomal | 1.3.3.6 | 0.449 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.449 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.449 | |
| 4emd | C5P | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.449 | |
| 4g0k | 0VS | Glutathionyl-hydroquinone reductase YqjG | 1.8 | 0.449 | |
| 4ib4 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.449 | |
| 4j1k | 1HG | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 4nc3 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.449 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.448 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.448 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.448 | |
| 2bxm | IMN | Serum albumin | / | 0.448 | |
| 2fto | TMP | Thymidylate synthase | / | 0.448 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.448 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.448 | |
| 3g70 | A5T | Renin | 3.4.23.15 | 0.448 | |
| 3i1y | 33N | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.448 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.448 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.448 | |
| 4bqp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.448 | |
| 4eu9 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.448 | |
| 4fhd | 0TT | Spore photoproduct lyase | / | 0.448 | |
| 4juf | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.448 | |
| 4k28 | NAD | Shikimate dehydrogenase family protein | / | 0.448 | |
| 1f8g | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.447 | |
| 1fdw | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.447 | |
| 1u2y | GOX | Pancreatic alpha-amylase | / | 0.447 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.447 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.447 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 2wpx | ACO | Orf14 | / | 0.447 | |
| 3bsy | ACO | UDP-N-acetylbacillosamine N-acetyltransferase | 2.3.1.203 | 0.447 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.447 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.447 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.447 | |
| 4ejg | NCT | Cytochrome P450 2A13 | 1.14.14.1 | 0.447 | |
| 4ydd | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.447 | |
| 1a9z | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.446 | |
| 1bim | 0QB | Renin | 3.4.23.15 | 0.446 | |
| 1h60 | STR | Pentaerythritol tetranitrate reductase | / | 0.446 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.446 | |
| 1lwl | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 1o6r | R19 | Squalene--hopene cyclase | 4.2.1.129 | 0.446 | |
| 2b36 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 2gfx | PMN | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.446 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.446 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.446 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.446 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.446 | |
| 4z64 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.446 | |
| 7cat | NDP | Catalase | 1.11.1.6 | 0.446 | |
| 7mht | SAH | Modification methylase HhaI | 2.1.1.37 | 0.446 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.446 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1rp0 | AHZ | Thiamine thiazole synthase, chloroplastic | / | 0.445 | |
| 1s3v | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1sd1 | FMC | S-methyl-5'-thioadenosine phosphorylase | / | 0.445 | |
| 1wnb | NAI | Gamma-aminobutyraldehyde dehydrogenase | 1.2.1.19 | 0.445 | |
| 1yp3 | ATP | Glucose-1-phosphate adenylyltransferase small subunit, chloroplastic/amyloplastic | 2.7.7.27 | 0.445 | |
| 2get | COK | Pantothenate kinase | 2.7.1.33 | 0.445 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.445 | |
| 3af3 | GCP | Pantothenate kinase | 2.7.1.33 | 0.445 | |
| 3h4v | DVP | Pteridine reductase 1 | 1.5.1.33 | 0.445 | |
| 3i6i | NDP | Putative leucoanthocyanidin reductase 1 | / | 0.445 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 3pww | ROC | Endothiapepsin | 3.4.23.22 | 0.445 | |
| 3wag | TYD | Glycosyltransferase | / | 0.445 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.445 | |
| 4kf1 | HT5 | Aryldialkylphosphatase | 3.1.8.1 | 0.445 | |
| 4kne | 1CY | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4lc7 | 1WP | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.445 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.445 | |
| 4djh | JDC | Kappa-type opioid receptor | / | 0.445 | |
| 1lrj | UD1 | UDP-glucose 4-epimerase | 5.1.3.2 | 0.444 | |
| 1lwi | NAP | 3-alpha-hydroxysteroid dehydrogenase | 1.1.1.50 | 0.444 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1mja | COA | Histone acetyltransferase ESA1 | / | 0.444 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1rb2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1t0l | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.444 | |
| 1wp4 | NDP | 3-hydroxyisobutyrate dehydrogenase | / | 0.444 | |
| 2ddo | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.444 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 3eku | CY9 | Actin-5C | / | 0.444 | |
| 3hbb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.444 | |
| 3hx4 | ANP | Calmodulin-domain protein kinase 1 | / | 0.444 | |
| 3l5b | BDO | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4i1i | NAD | Malate dehydrogenase | / | 0.444 | |
| 4wdf | A2P | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.444 | |
| 5ai5 | BSU | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.444 | |
| 1hdr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.443 | |
| 1ib0 | NAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.443 | |
| 1j3k | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.443 | |
| 1pjc | NAD | Alanine dehydrogenase | / | 0.443 | |
| 1q5m | NDP | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.443 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.443 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 2z6d | FMN | Phototropin-2 | 2.7.11.1 | 0.443 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.443 | |
| 3ics | COA | Coenzyme A disulfide reductase | / | 0.443 | |
| 3mtw | M3R | Xaa-Pro dipeptidase, putative | / | 0.443 | |
| 3orf | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.443 | |
| 3tyd | XHP | Dihydropteroate synthase | / | 0.443 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.443 | |
| 4fcd | 0T6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 4hbg | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.443 | |
| 1f4e | TPR | Thymidylate synthase | / | 0.442 | |
| 1q23 | FUA | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.442 | |
| 1qyw | 5SD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.442 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.442 | |
| 1x7g | NAP | Putative ketoacyl reductase | 1.3.1 | 0.442 | |
| 3cuk | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.442 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.442 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.442 | |
| 3s79 | ASD | Aromatase | 1.14.14.14 | 0.442 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.442 | |
| 4gkh | 0J9 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.442 | |
| 4hdr | DMD | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase | / | 0.442 | |
| 4hdr | DMD | ArsB | / | 0.442 | |
| 4udr | FAD | 5-(hydroxymethyl)furfural oxidase | / | 0.442 | |
| 5doz | NDP | JamJ | / | 0.442 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.442 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.442 | |
| 1eny | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 1fwk | ADP | Homoserine kinase | 2.7.1.39 | 0.441 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.441 | |
| 1uyh | PU0 | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 2hqp | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 2tct | CTC | Tetracycline repressor protein class D | / | 0.441 | |
| 2v2z | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.441 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3had | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.441 | |
| 3otb | DGT | Probable tRNA(His) guanylyltransferase | 2.7.7.79 | 0.441 | |
| 3qi4 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3qly | 55V | Uncharacterized protein | / | 0.441 | |
| 3rga | ILD | Epoxide hydrolase LasB | 5.5.1 | 0.441 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.441 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.441 | |
| 4k5s | PM0 | Oxygenase | / | 0.441 | |
| 1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1eio | GCH | Gastrotropin | / | 0.440 | |
| 1eji | THF | Serine hydroxymethyltransferase, cytosolic | / | 0.440 | |
| 1g2v | TTP | Glucose-1-phosphate thymidylyltransferase | / | 0.440 | |
| 1kc1 | NDP | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.440 | |
| 1vf2 | GTX | Glutathione S-transferase 3 | 2.5.1.18 | 0.440 | |
| 1xel | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.440 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.440 | |
| 2gvd | FKP | Adenylate cyclase type 2 | / | 0.440 | |
| 2gvd | FKP | Adenylate cyclase type 5 | / | 0.440 | |
| 2q46 | NAP | Uncharacterized protein At5g02240 | / | 0.440 | |
| 2v4l | ABJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.440 | |
| 3dej | RXC | Caspase-3 | 3.4.22.56 | 0.440 | |
| 3elu | SAM | Methyltransferase | / | 0.440 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.440 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.440 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.440 | |
| 3o03 | NAP | Dehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) | / | 0.440 | |
| 3znq | SS8 | D-amino-acid oxidase | 1.4.3.3 | 0.440 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.440 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 4er6 | AW2 | Histone-lysine N-methyltransferase, H3 lysine-79 specific | 2.1.1.43 | 0.440 | |
| 4ig0 | 1FG | Gag-Pol polyprotein | 2.7.7.49 | 0.440 | |
| 4y1b | NAP | AntE | / | 0.440 |