sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
3drc	MTX	Dihydrofolate reductase	1.5.1.3

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
3drc	MTX	Dihydrofolate reductase	1.5.1.3	1.000
1dhi	MTX	Dihydrofolate reductase	1.5.1.3	0.664
1drb	MTX	Dihydrofolate reductase	1.5.1.3	0.638
1tdr	MTX	Dihydrofolate reductase	1.5.1.3	0.589
3och	2MX	Dihydrofolate reductase	1.5.1.3	0.587
1dhj	MTX	Dihydrofolate reductase	1.5.1.3	0.585
1dds	MTX	Dihydrofolate reductase	1.5.1.3	0.566
4dfr	MTX	Dihydrofolate reductase	1.5.1.3	0.565
1dra	MTX	Dihydrofolate reductase	1.5.1.3	0.555
1dyj	DDF	Dihydrofolate reductase	1.5.1.3	0.547
1ddr	MTX	Dihydrofolate reductase	1.5.1.3	0.530
1rb3	MTX	Dihydrofolate reductase	1.5.1.3	0.525
2drc	MTX	Dihydrofolate reductase	1.5.1.3	0.524
1jol	FFO	Dihydrofolate reductase	1.5.1.3	0.518
1re7	FOL	Dihydrofolate reductase	1.5.1.3	0.493
1dyh	DZF	Dihydrofolate reductase	1.5.1.3	0.477
1dyi	FOL	Dihydrofolate reductase	1.5.1.3	0.468
5hi6	MTX	Dihydrofolate reductase	/	0.464
1rb2	FOL	Dihydrofolate reductase	1.5.1.3	0.462