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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3dh9FADThioredoxin reductase 1, mitochondrial1.8.1.9

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3dh9FADThioredoxin reductase 1, mitochondrial1.8.1.91.000
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.570
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.544
2nvkFADThioredoxin reductase 1, mitochondrial1.8.1.90.542
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.538
1grhFADGlutathione reductase, mitochondrial1.8.1.70.528
1gerFADGlutathione reductase1.8.1.70.518
3grsFADGlutathione reductase, mitochondrial1.8.1.70.518
1grgFADGlutathione reductase, mitochondrial1.8.1.70.516
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.513
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.512
1febFADTrypanothione reductase1.8.1.120.511
4j56FADThioredoxin reductase 21.8.1.90.509
1greFADGlutathione reductase, mitochondrial1.8.1.70.508
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.508
1gsnFADGlutathione reductase, mitochondrial1.8.1.70.500
1bzlFADTrypanothione reductase1.8.1.120.493
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.487
4nevFADTrypanothione reductase/0.480
3dghFADThioredoxin reductase 1, mitochondrial1.8.1.90.476
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.90.475
2r9zFADGlutathione amide reductase/0.469
4eqsFADCoenzyme A disulfide reductase/0.466
5fs7FADApoptosis-inducing factor 1, mitochondrial1.1.10.462
1yqzFADCoenzyme A disulfide reductase/0.461
1zk7FADMercuric reductase1.16.1.10.458
1onfFADGlutathione reductase1.8.1.70.457
4fx9FADCoenzyme A disulfide reductase1.8.1.140.455