sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
3dgz	FAD	Thioredoxin reductase 2, mitochondrial	1.8.1.9

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
3dgz	FAD	Thioredoxin reductase 2, mitochondrial	1.8.1.9	1.000
1grh	FAD	Glutathione reductase, mitochondrial	1.8.1.7	0.536
2nvk	FAD	Thioredoxin reductase 1, mitochondrial	1.8.1.9	0.535
1k4q	FAD	Glutathione reductase, mitochondrial	1.8.1.7	0.533
2v6o	FAD	Thioredoxin glutathione reductase	/	0.525
3grs	FAD	Glutathione reductase, mitochondrial	1.8.1.7	0.509
4gr1	FAD	Glutathione reductase, mitochondrial	1.8.1.7	0.498
3sqp	FAD	Glutathione reductase, mitochondrial	1.8.1.7	0.474
4j56	FAD	Thioredoxin reductase 2	1.8.1.9	0.456
1bwc	FAD	Glutathione reductase, mitochondrial	1.8.1.7	0.454
4kpr	FAD	Thioredoxin reductase 1, cytoplasmic	1.8.1.9	0.454
1gre	FAD	Glutathione reductase, mitochondrial	1.8.1.7	0.449
1grg	FAD	Glutathione reductase, mitochondrial	1.8.1.7	0.446