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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3dfcANPDeath-associated protein kinase 12.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3dfcANPDeath-associated protein kinase 12.7.11.11.000
1jklANPDeath-associated protein kinase 12.7.11.10.555
3gu6ADPDeath-associated protein kinase 12.7.11.10.526
3gu7ADPDeath-associated protein kinase 12.7.11.10.524
2yaaATPDeath-associated protein kinase 2/0.518
1ig1ANPDeath-associated protein kinase 12.7.11.10.499
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.485
3be9P04Casein kinase II subunit alpha2.7.11.10.484
3lltANPProtein serine/threonine kinase-1/0.476
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.474
5av2KMPDeath-associated protein kinase 12.7.11.10.474
5av3KMPDeath-associated protein kinase 12.7.11.10.473
2ijmADPFocal adhesion kinase 12.7.10.20.472
3nieANPMitogen-activated protein kinase/0.468
2w4jADPDeath-associated protein kinase 12.7.11.10.466
4anmWULCasein kinase II subunit alpha2.7.11.10.465
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.464
1om1IQACasein kinase II subunit alpha2.7.11.10.463
4grb0XGCasein kinase II subunit alpha2.7.11.10.461
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.459
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.459
5dosATPAurora kinase A2.7.11.10.458
1dawANPCasein kinase II subunit alpha2.7.11.10.457
1m2pHNACasein kinase II subunit alpha2.7.11.10.457
3gubGUBDeath-associated protein kinase 12.7.11.10.456
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.456
2pvmP29Casein kinase II subunit alpha2.7.11.10.455
4hge15VTyrosine-protein kinase JAK2/0.453
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.452
3q9xEMOCasein kinase II subunit alpha2.7.11.10.451
1jkkANPDeath-associated protein kinase 12.7.11.10.449
5auvAGIDeath-associated protein kinase 12.7.11.10.449
3p23ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.448
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.448
4dgnLU2Casein kinase II subunit alpha2.7.11.10.446
4jboWPHAurora kinase A2.7.11.10.446
3i60E86Mitogen-activated protein kinase 12.7.11.240.444
1dayGNPCasein kinase II subunit alpha2.7.11.10.443
2vv9IM9Cyclin-dependent kinase 22.7.11.220.443
4aqc88ATyrosine-protein kinase JAK2/0.443
4hvi19STyrosine-protein kinase JAK32.7.10.20.443
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.442
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.442
4j99ACPFibroblast growth factor receptor 2/0.442
4ysjADPCalmodulin-like domain protein kinase/0.442
2vo3M04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440