sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3d8w | D8W | Carbonic anhydrase 2 | 4.2.1.1 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3d8w | D8W | Carbonic anhydrase 2 | 4.2.1.1 | 1.000 | |
| 1bn1 | AL5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.758 | |
| 1a42 | BZU | Carbonic anhydrase 2 | 4.2.1.1 | 0.750 | |
| 2h15 | B19 | Carbonic anhydrase 2 | 4.2.1.1 | 0.749 | |
| 1bn4 | AL9 | Carbonic anhydrase 2 | 4.2.1.1 | 0.743 | |
| 1bnn | AL1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.735 | |
| 3k2f | NKX | Carbonic anhydrase 2 | 4.2.1.1 | 0.733 | |
| 4mo8 | 2VQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.726 | |
| 3v2j | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.722 | |
| 3eft | 3BS | Carbonic anhydrase 2 | 4.2.1.1 | 0.719 | |
| 3d9z | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.710 | |
| 1kwr | SG2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.705 | |
| 3sbh | E65 | Carbonic anhydrase 2 | 4.2.1.1 | 0.705 | |
| 4ito | MPX | Carbonic anhydrase 2 | 4.2.1.1 | 0.702 | |
| 3daz | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.697 | |
| 1bnu | AL3 | Carbonic anhydrase 2 | 4.2.1.1 | 0.696 | |
| 2eu3 | FF3 | Carbonic anhydrase 2 | 4.2.1.1 | 0.693 | |
| 1if6 | FBU | Carbonic anhydrase 2 | 4.2.1.1 | 0.681 | |
| 1g1d | FSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.680 | |
| 1g52 | F2B | Carbonic anhydrase 2 | 4.2.1.1 | 0.679 | |
| 3dcc | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.679 | |
| 3n4b | WWZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.677 | |
| 3m5e | JDR | Carbonic anhydrase 2 | 4.2.1.1 | 0.669 | |
| 4kap | 1QV | Carbonic anhydrase 2 | 4.2.1.1 | 0.667 | |
| 1bnw | TPD | Carbonic anhydrase 2 | 4.2.1.1 | 0.664 | |
| 3p5l | IT5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.664 | |
| 3m2n | J74 | Carbonic anhydrase 2 | 4.2.1.1 | 0.663 | |
| 3b4f | TUO | Carbonic anhydrase 2 | 4.2.1.1 | 0.661 | |
| 3mho | J43 | Carbonic anhydrase 2 | 4.2.1.1 | 0.658 | |
| 3dc3 | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.656 | |
| 4bf6 | X0Q | Carbonic anhydrase 2 | 4.2.1.1 | 0.656 | |
| 3mhl | J71 | Carbonic anhydrase 2 | 4.2.1.1 | 0.655 | |
| 4bf1 | 9FK | Carbonic anhydrase 2 | 4.2.1.1 | 0.655 | |
| 3qyk | IE2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.654 | |
| 4ilx | 1EZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.652 | |
| 3dbu | D8W | Carbonic anhydrase 2 | 4.2.1.1 | 0.651 | |
| 3mzc | S6I | Carbonic anhydrase 2 | 4.2.1.1 | 0.649 | |
| 1cnw | EG1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.648 | |
| 2wej | FB2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.646 | |
| 1i9m | INW | Carbonic anhydrase 2 | 4.2.1.1 | 0.644 | |
| 3oik | WZB | Carbonic anhydrase 2 | 4.2.1.1 | 0.644 | |
| 1bnt | AL2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.642 | |
| 3ni5 | C1H | Carbonic anhydrase 2 | 4.2.1.1 | 0.640 | |
| 1i91 | INQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.639 | |
| 1if7 | SBR | Carbonic anhydrase 2 | 4.2.1.1 | 0.639 | |
| 1xpz | 4TZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.639 | |
| 3mna | DWH | Carbonic anhydrase 2 | 4.2.1.1 | 0.636 | |
| 3oy0 | OY0 | Carbonic anhydrase 2 | 4.2.1.1 | 0.636 | |
| 3oyq | OYQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.635 | |
| 1cil | ETS | Carbonic anhydrase 2 | 4.2.1.1 | 0.634 | |
| 1cny | EG3 | Carbonic anhydrase 2 | 4.2.1.1 | 0.634 | |
| 1i8z | INL | Carbonic anhydrase 2 | 4.2.1.1 | 0.633 | |
| 1i9n | IOA | Carbonic anhydrase 2 | 4.2.1.1 | 0.633 | |
| 1if4 | FBS | Carbonic anhydrase 2 | 4.2.1.1 | 0.632 | |
| 1zsb | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.628 | |
| 3ffp | LC1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.625 | |
| 3oys | OYS | Carbonic anhydrase 2 | 4.2.1.1 | 0.623 | |
| 2weh | FB1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.622 | |
| 3n0n | P9B | Carbonic anhydrase 2 | 4.2.1.1 | 0.622 | |
| 3dcw | EZL | Carbonic anhydrase 2 | 4.2.1.1 | 0.620 | |
| 1g4j | FFB | Carbonic anhydrase 2 | 4.2.1.1 | 0.618 | |
| 3po6 | DT9 | Carbonic anhydrase 2 | 4.2.1.1 | 0.618 | |
| 3dcs | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.617 | |
| 3mmf | D9H | Carbonic anhydrase 2 | 4.2.1.1 | 0.617 | |
| 1cnx | EG2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.616 | |
| 1ttm | 667 | Carbonic anhydrase 2 | 4.2.1.1 | 0.615 | |
| 3bl1 | BL1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.615 | |
| 3hku | TOR | Carbonic anhydrase 2 | 4.2.1.1 | 0.615 | |
| 4itp | 1GD | Carbonic anhydrase 2 | 4.2.1.1 | 0.615 | |
| 1okm | SAB | Carbonic anhydrase 2 | 4.2.1.1 | 0.613 | |
| 3l14 | I7B | Carbonic anhydrase 2 | 4.2.1.1 | 0.613 | |
| 4iwz | 1GO | Carbonic anhydrase 2 | 4.2.1.1 | 0.613 | |
| 3dd8 | 2C7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.611 | |
| 3m2y | BE0 | Carbonic anhydrase 2 | 4.2.1.1 | 0.611 | |
| 4m2r | BZ1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.611 | |
| 3ml2 | SU0 | Carbonic anhydrase 2 | 4.2.1.1 | 0.610 | |
| 4dz7 | D02 | Carbonic anhydrase 2 | 4.2.1.1 | 0.610 | |
| 1i90 | INM | Carbonic anhydrase 2 | 4.2.1.1 | 0.608 | |
| 2weo | FBW | Carbonic anhydrase 2 | 4.2.1.1 | 0.604 | |
| 3t84 | SG6 | Carbonic anhydrase 2 | 4.2.1.1 | 0.604 | |
| 4kni | E1E | Carbonic anhydrase 2 | 4.2.1.1 | 0.604 | |
| 3bet | CTF | Carbonic anhydrase 2 | 4.2.1.1 | 0.602 | |
| 4pxx | CHD | Carbonic anhydrase 2 | 4.2.1.1 | 0.602 | |
| 1kwq | SG1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.601 | |
| 3mhc | ARZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.601 | |
| 1g4o | BSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.600 | |
| 2h4n | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.596 | |
| 4knj | E1F | Carbonic anhydrase 2 | 4.2.1.1 | 0.596 | |
| 3n3j | WWV | Carbonic anhydrase 2 | 4.2.1.1 | 0.589 | |
| 3oim | VZ5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.588 | |
| 2pow | I7C | Carbonic anhydrase 2 | 4.2.1.1 | 0.587 | |
| 3f4x | KLT | Carbonic anhydrase 2 | 4.2.1.1 | 0.586 | |
| 3mhi | J90 | Carbonic anhydrase 2 | 4.2.1.1 | 0.585 | |
| 3rz8 | RZ8 | Carbonic anhydrase 2 | 4.2.1.1 | 0.585 | |
| 1if5 | FBT | Carbonic anhydrase 2 | 4.2.1.1 | 0.584 | |
| 3m98 | E02 | Carbonic anhydrase 2 | 4.2.1.1 | 0.584 | |
| 4n16 | CHD | Carbonic anhydrase 2 | 4.2.1.1 | 0.584 | |
| 4k0t | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.582 | |
| 1bnm | AL8 | Carbonic anhydrase 2 | 4.2.1.1 | 0.581 | |
| 1g45 | FSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.580 | |
| 3kig | DA4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.578 | |
| 1bn3 | AL6 | Carbonic anhydrase 2 | 4.2.1.1 | 0.577 | |
| 3n2p | AYX | Carbonic anhydrase 2 | 4.2.1.1 | 0.574 | |
| 3t82 | SG4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.574 | |
| 1oq5 | CEL | Carbonic anhydrase 2 | 4.2.1.1 | 0.573 | |
| 2q1q | OSP | Carbonic anhydrase 2 | 4.2.1.1 | 0.573 | |
| 2x7t | WZB | Carbonic anhydrase 2 | 4.2.1.1 | 0.573 | |
| 3s8x | E59 | Carbonic anhydrase 2 | 4.2.1.1 | 0.572 | |
| 3myq | E27 | Carbonic anhydrase 2 | 4.2.1.1 | 0.571 | |
| 5flt | VJJ | Carbonic anhydrase 2 | 4.2.1.1 | 0.570 | |
| 2weg | FBV | Carbonic anhydrase 2 | 4.2.1.1 | 0.567 | |
| 1eou | SMS | Carbonic anhydrase 2 | 4.2.1.1 | 0.565 | |
| 1okn | STB | Carbonic anhydrase 2 | 4.2.1.1 | 0.562 | |
| 1okl | MNS | Carbonic anhydrase 2 | 4.2.1.1 | 0.561 | |
| 3sax | E50 | Carbonic anhydrase 2 | 4.2.1.1 | 0.559 | |
| 3m67 | E36 | Carbonic anhydrase 2 | 4.2.1.1 | 0.558 | |
| 1bnq | AL4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.556 | |
| 1bnv | AL7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.550 | |
| 4kp8 | E1G | Carbonic anhydrase 12 | 4.2.1.1 | 0.547 | |
| 3mdz | EZL | Carbonic anhydrase 7 | 4.2.1.1 | 0.543 | |
| 3sbi | E90 | Carbonic anhydrase 2 | 4.2.1.1 | 0.541 | |
| 2wd2 | MS5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.540 | |
| 3igp | DT7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.538 | |
| 3nb5 | R21 | Carbonic anhydrase 2 | 4.2.1.1 | 0.537 | |
| 1g54 | FFB | Carbonic anhydrase 2 | 4.2.1.1 | 0.536 | |
| 3m96 | E38 | Carbonic anhydrase 2 | 4.2.1.1 | 0.532 | |
| 4k13 | ETS | Carbonic anhydrase 2 | 4.2.1.1 | 0.530 | |
| 1jd0 | AZM | Carbonic anhydrase 12 | 4.2.1.1 | 0.529 | |
| 4k0z | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.527 | |
| 3m40 | J45 | Carbonic anhydrase 2 | 4.2.1.1 | 0.525 | |
| 1yda | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.523 | |
| 1i9p | IOE | Carbonic anhydrase 2 | 4.2.1.1 | 0.522 | |
| 2x7u | WZA | Carbonic anhydrase 2 | 4.2.1.1 | 0.518 | |
| 3t85 | SG7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.518 | |
| 3dd0 | EZL | Carbonic anhydrase 2 | 4.2.1.1 | 0.517 | |
| 1xq0 | 4TR | Carbonic anhydrase 2 | 4.2.1.1 | 0.514 | |
| 1i9q | IOF | Carbonic anhydrase 2 | 4.2.1.1 | 0.513 | |
| 3s9t | E49 | Carbonic anhydrase 2 | 4.2.1.1 | 0.513 | |
| 4ht2 | V50 | Carbonic anhydrase 12 | 4.2.1.1 | 0.513 | |
| 4m2v | BZ1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.511 | |
| 5fl4 | 9FK | Carbonic anhydrase 9 | 4.2.1.1 | 0.507 | |
| 3f7u | AG4 | Carbonic anhydrase 4 | 4.2.1.1 | 0.502 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.501 | |
| 4kp5 | E1F | Carbonic anhydrase 12 | 4.2.1.1 | 0.500 | |
| 4xiw | AZM | Carbonic anhydrase, alpha type | / | 0.496 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.494 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.488 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.487 | |
| 3p0f | BAU | Uridine phosphorylase 2 | 2.4.2.3 | 0.484 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.484 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.483 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.480 | |
| 1xva | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.480 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.480 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.479 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.478 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.478 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.478 | |
| 1rj6 | AZM | Carbonic anhydrase 14 | 4.2.1.1 | 0.477 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.477 | |
| 3znc | BZ1 | Carbonic anhydrase 4 | 4.2.1.1 | 0.477 | |
| 4e2b | FMN | Dehydrogenase | / | 0.476 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.475 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.474 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.474 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.474 | |
| 4giu | 636 | Anthranilate phosphoribosyltransferase | / | 0.474 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.472 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.471 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.471 | |
| 1dmy | AZM | Carbonic anhydrase 5A, mitochondrial | 4.2.1.1 | 0.470 | |
| 1npd | NAD | Quinate/shikimate dehydrogenase | / | 0.470 | |
| 3dzk | NMN | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.470 | |
| 3fp0 | FP0 | 15-O-acetyltransferase | / | 0.470 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.469 | |
| 3jyq | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.469 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.469 | |
| 4lu3 | AZM | Carbonic anhydrase 14 | 4.2.1.1 | 0.469 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.468 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.468 | |
| 4knm | E1E | Carbonic anhydrase 13 | 4.2.1.1 | 0.468 | |
| 1a5b | IGP | Tryptophan synthase alpha chain | / | 0.467 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.467 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.467 | |
| 3fw3 | ETS | Carbonic anhydrase 4 | 4.2.1.1 | 0.467 | |
| 4dpt | AGS | Mevalonate diphosphate decarboxylase | / | 0.467 | |
| 4ehy | ADP | Tetraacyldisaccharide 4'-kinase | / | 0.467 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.466 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.466 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.465 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.465 | |
| 3aw9 | GDU | NAD-dependent epimerase/dehydratase | / | 0.465 | |
| 3jyo | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.465 | |
| 4kfq | KFQ | Glutamate receptor ionotropic, NMDA 1 | / | 0.465 | |
| 4x5s | AZM | Carbonic anhydrase (Carbonate dehydratase) | / | 0.465 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.463 | |
| 3qiz | QI2 | Botulinum neurotoxin type A | 3.4.24.69 | 0.463 | |
| 3tqx | PLP | 2-amino-3-ketobutyrate coenzyme A ligase | / | 0.463 | |
| 3w0n | ANP | Hygromycin-B 4-O-kinase | 2.7.1.163 | 0.463 | |
| 4xz3 | COA | Acyl-CoA synthetase (NDP forming) | / | 0.463 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.462 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.462 | |
| 4drj | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.462 | |
| 4drj | RAP | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.462 | |
| 4mr9 | 2BX | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.462 | |
| 2hve | ADP | Nucleoside diphosphate kinase A | 2.7.4.6 | 0.461 | |
| 3c1o | NAP | Eugenol synthase | / | 0.461 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.461 | |
| 3otb | DGT | Probable tRNA(His) guanylyltransferase | 2.7.7.79 | 0.461 | |
| 4w5k | PLP | Aspartate aminotransferase, mitochondrial | / | 0.461 | |
| 2q7o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.460 | |
| 3p8i | FMN | Pentaerythritol tetranitrate reductase | / | 0.460 | |
| 3w2e | NAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.460 | |
| 4a86 | H35 | Major pollen allergen Bet v 1-A | / | 0.460 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 1cjk | FOK | Adenylate cyclase type 2 | / | 0.459 | |
| 1cjk | FOK | Adenylate cyclase type 5 | / | 0.459 | |
| 1if8 | SBS | Carbonic anhydrase 2 | 4.2.1.1 | 0.459 | |
| 1m8j | NAD | Nicotinamide-nucleotide adenylyltransferase | 2.7.7.1 | 0.459 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.459 | |
| 5er0 | FAD | Uncharacterized NAD(FAD)-dependent dehydrogenase | / | 0.459 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.458 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.458 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.458 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.458 | |
| 4dpu | AGS | Mevalonate diphosphate decarboxylase | / | 0.458 | |
| 1h85 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.457 | |
| 1ppj | ANY | Cytochrome b | / | 0.457 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.457 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.457 | |
| 3sl2 | ATP | Sensor histidine kinase WalK | / | 0.457 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.456 | |
| 4j75 | TYM | Tryptophan--tRNA ligase | / | 0.456 | |
| 1cg6 | MTA | S-methyl-5'-thioadenosine phosphorylase | / | 0.455 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 3opx | U5P | Suppressor of disruption of TFIIS | / | 0.455 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.455 | |
| 4f0r | MTA | 5-methylthioadenosine/S-adenosylhomocysteine deaminase | / | 0.455 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.455 | |
| 4mr7 | 2BV | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.455 | |
| 4r81 | FMN | Predicted NADH dehydrogenase | / | 0.455 | |
| 4usq | FAD | Pyridine nucleotide-disulfide oxidoreductase | / | 0.455 | |
| 4xrb | NDP | Possible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc | / | 0.455 | |
| 1qgy | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.454 | |
| 1toj | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.454 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.454 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.454 | |
| 2vn1 | FK5 | Peptidylprolyl isomerase | / | 0.454 | |
| 2xvq | 9DS | Serum albumin | / | 0.454 | |
| 2yp0 | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.454 | |
| 2yq9 | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.454 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 3fsj | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.454 | |
| 3jun | AKD | Phenazine biosynthesis protein A/B | / | 0.454 | |
| 3lxe | TOR | Carbonic anhydrase 1 | 4.2.1.1 | 0.454 | |
| 4ho6 | UTP | Glucose-1-phosphate thymidylyltransferase | / | 0.454 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.454 | |
| 4rls | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.454 | |
| 1kh3 | ANP | Argininosuccinate synthase | / | 0.453 | |
| 1n77 | ATP | Glutamate--tRNA ligase | 6.1.1.17 | 0.453 | |
| 2f99 | AKV | Aklanonic acid methyl ester cyclase AcmA | 5.5.1.23 | 0.453 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.453 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.453 | |
| 1i7p | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.452 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.452 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.452 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.452 | |
| 1ivs | VAA | Valine--tRNA ligase | 6.1.1.9 | 0.451 | |
| 2bfq | AR6 | [Protein ADP-ribosylglutamate] hydrolase AF_1521 | 3.2.2 | 0.451 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.451 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.451 | |
| 3hx4 | ANP | Calmodulin-domain protein kinase 1 | / | 0.451 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.451 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.451 | |
| 4rp8 | ASC | Ascorbate-specific PTS system EIIC component | / | 0.451 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.450 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.450 | |
| 3sxj | SAM | Putative methyltransferase | / | 0.450 | |
| 5ftf | ADP | TPR domain protein | / | 0.450 | |
| 1b5e | DCM | Deoxycytidylate 5-hydroxymethyltransferase | 2.1.2.8 | 0.449 | |
| 1k27 | MTM | S-methyl-5'-thioadenosine phosphorylase | / | 0.449 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.449 | |
| 2vyq | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.449 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 3fzf | ATP | Heat shock cognate 71 kDa protein | / | 0.449 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.449 | |
| 3t4e | NAD | Quinate/shikimate dehydrogenase | / | 0.449 | |
| 3tyd | XHP | Dihydropteroate synthase | / | 0.449 | |
| 1a9y | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.448 | |
| 1zxm | ANP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.448 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.448 | |
| 2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.448 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 3f7b | AG5 | Carbonic anhydrase 4 | 4.2.1.1 | 0.448 | |
| 3ozc | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.448 | |
| 3reo | EUG | (Iso)eugenol O-methyltransferase | 2.1.1.146 | 0.448 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.448 | |
| 4rel | KMP | Glycosyltransferase | / | 0.448 | |
| 6gsu | GPS | Glutathione S-transferase Mu 1 | 2.5.1.18 | 0.448 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.447 | |
| 2r8v | ACO | Amino-acid acetyltransferase | / | 0.447 | |
| 3jyp | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.447 | |
| 3qi4 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 3toz | NAD | Shikimate dehydrogenase (NADP(+)) | / | 0.447 | |
| 3zbs | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.447 | |
| 4itm | ATP | Tetraacyldisaccharide 4'-kinase | / | 0.447 | |
| 5c3r | HMU | Thymine dioxygenase | / | 0.447 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.446 | |
| 1qpl | 587 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.446 | |
| 1rkw | PNT | HTH-type transcriptional regulator QacR | / | 0.446 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 1v45 | 3DG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.446 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.446 | |
| 1ygk | RRC | Pyridoxal kinase | 2.7.1.35 | 0.446 | |
| 2fj1 | CTC | Tetracycline repressor protein class D | / | 0.446 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 2v2z | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.446 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 3s55 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.446 | |
| 4ixd | 1HV | Integrin alpha-L | / | 0.446 | |
| 4j49 | 1J1 | Uncharacterized protein | / | 0.446 | |
| 5a01 | 12V | O-glycosyltransferase | / | 0.446 | |
| 1qoq | IGP | Tryptophan synthase alpha chain | / | 0.445 | |
| 1x1d | SAH | C-20 methyltransferase | / | 0.445 | |
| 2v2z | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.445 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.445 | |
| 3zv7 | NHG | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 4awo | 99B | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.445 | |
| 4xoq | F42 | Coenzyme F420:L-glutamate ligase | / | 0.445 | |
| 5cb3 | APR | O-acetyl-ADP-ribose deacetylase | / | 0.445 | |
| 8cat | NDP | Catalase | 1.11.1.6 | 0.445 | |
| 1gax | VAA | Valine--tRNA ligase | 6.1.1.9 | 0.444 | |
| 1ib0 | NAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.444 | |
| 1uxy | EPU | UDP-N-acetylenolpyruvoylglucosamine reductase | 1.3.1.98 | 0.444 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.444 | |
| 1w34 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.444 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.444 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 3ag6 | PAJ | Pantothenate synthetase | / | 0.444 | |
| 3aos | JH2 | Hemolymph juvenile hormone binding protein | / | 0.444 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.444 | |
| 4uov | AZM | Carbonate dehydratase | / | 0.444 | |
| 1nvt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.443 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.443 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.443 | |
| 1udb | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.443 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.443 | |
| 2bfr | ADP | [Protein ADP-ribosylglutamate] hydrolase AF_1521 | 3.2.2 | 0.443 | |
| 2jcx | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.443 | |
| 2yoj | 8Y6 | Genome polyprotein | 2.7.7.48 | 0.443 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.443 | |
| 3w6h | AZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.443 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.443 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.443 | |
| 4egb | NAD | dTDP-glucose 4,6-dehydratase | / | 0.443 | |
| 4hmx | FMN | Pyridoxamine 5'-phosphate oxidase | / | 0.443 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.443 | |
| 4v12 | POG | MaoC like domain protein | / | 0.443 | |
| 1i59 | ANP | Chemotaxis protein CheA | 2.7.13.3 | 0.442 | |
| 1so2 | 666 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.442 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.442 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.442 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.442 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.442 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.442 | |
| 2zcv | NDP | Quinone oxidoreductase 2 | 1.6.5.2 | 0.442 | |
| 3coy | 53H | Pantothenate synthetase | 6.3.2.1 | 0.442 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3f63 | GTX | Glutathione transferase GST1-4 | / | 0.442 | |
| 3ivc | FG4 | Pantothenate synthetase | 6.3.2.1 | 0.442 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 4b1i | A8P | Poly(ADP-ribose) glycohydrolase | 3.2.1.143 | 0.442 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.442 | |
| 4fgc | PQ0 | NADPH-dependent 7-cyano-7-deazaguanine reductase | 1.7.1.13 | 0.442 | |
| 4p9d | TMP | Deoxycytidylate deaminase | / | 0.442 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.441 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.441 | |
| 1h74 | ADP | Homoserine kinase | 2.7.1.39 | 0.441 | |
| 1m8k | NAD | Nicotinamide-nucleotide adenylyltransferase | 2.7.7.1 | 0.441 | |
| 1toi | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.441 | |
| 1vi2 | NAD | Quinate/shikimate dehydrogenase | / | 0.441 | |
| 2b58 | COA | Diamine acetyltransferase 1 | / | 0.441 | |
| 2c12 | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.441 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.441 | |
| 2pbw | DOQ | Glutamate receptor ionotropic, kainate 1 | / | 0.441 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 3e6e | DCS | Alanine racemase | / | 0.441 | |
| 3p82 | FMN | Pentaerythritol tetranitrate reductase | / | 0.441 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.441 | |
| 4x7u | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.441 | |
| 4xym | COA | Acyl-CoA synthetase (NDP forming) | / | 0.441 | |
| 4yp6 | NAP | Nicotinamide-nucleotide adenylyltransferase | 2.7.7.1 | 0.441 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 1foa | UD1 | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | 2.4.1.101 | 0.440 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.440 | |
| 1kw6 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.440 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.440 | |
| 1tll | FMN | Nitric oxide synthase, brain | 1.14.13.39 | 0.440 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 2b4t | AES | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.440 | |
| 2bjf | DXC | Choloylglycine hydrolase | 3.5.1.24 | 0.440 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.440 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 2yoz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.440 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.440 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.440 | |
| 4x7w | MVI | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.440 |