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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3d7tSTUTyrosine-protein kinase CSK

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3d7tSTUTyrosine-protein kinase CSK/1.000
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.541
3zewSTUEphrin type-B receptor 42.7.10.10.484
3cokANPSerine/threonine-protein kinase PLK42.7.11.210.483
3juhANPCasein kinase II subunit alpha2.7.11.10.481
4c57FEFCyclin-G-associated kinase2.7.11.10.478
4grb0XGCasein kinase II subunit alpha2.7.11.10.478
4id71G0Activated CDC42 kinase 1/0.476
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.474
1mqbANPEphrin type-A receptor 22.7.10.10.469
3bqr4RBDeath-associated protein kinase 3/0.469
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.468
2zjwREFCasein kinase II subunit alpha2.7.11.10.468
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.467
5d12G97Proto-oncogene tyrosine-protein kinase Src2.7.10.20.467
2x9fX9FEphrin type-B receptor 42.7.10.10.465
3c4xATPRhodopsin kinase/0.465
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.463
3t8oATPRhodopsin kinase/0.462
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.462
4btjATPTau-tubulin kinase 12.7.11.10.462
2hk51BMTyrosine-protein kinase HCK2.7.10.20.461
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.461
1i44ACPInsulin receptor2.7.10.10.460
3lltANPProtein serine/threonine kinase-1/0.460
2xvdAS6Ephrin type-B receptor 42.7.10.10.459
2yaaATPDeath-associated protein kinase 2/0.458
3q9xEMOCasein kinase II subunit alpha2.7.11.10.458
4a1zADPKinesin-like protein KIF11/0.458
4jia1K3Tyrosine-protein kinase JAK2/0.458
2cmwOLPCasein kinase I isoform gamma-12.7.11.10.457
4c4g7RODual specificity protein kinase TTK2.7.12.10.457
4gmy0X5Tyrosine-protein kinase JAK2/0.457
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.457
5av2KMPDeath-associated protein kinase 12.7.11.10.456
2csnCKICasein kinase I homolog 12.7.11.10.455
3axwTIDCasein kinase II subunit alpha2.7.11.10.455
3nux3NVCyclin-dependent kinase 62.7.11.220.455
4o0wADNAurora kinase A2.7.11.10.455
1ml6GBXGlutathione S-transferase A22.5.1.180.454
2j0k4STFocal adhesion kinase 12.7.10.20.454
2j7t274Serine/threonine-protein kinase 102.7.11.10.453
3f5p741Insulin-like growth factor 1 receptor2.7.10.10.453
4dgnLU2Casein kinase II subunit alpha2.7.11.10.453
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.452
4hvi19STyrosine-protein kinase JAK32.7.10.20.452
4k8aK8AFocal adhesion kinase 12.7.10.20.452
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.451
3be9P04Casein kinase II subunit alpha2.7.11.10.451
4btjADPTau-tubulin kinase 12.7.11.10.451
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.451
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.451
4bbe3O4Tyrosine-protein kinase JAK2/0.450
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.450
4o0uADNAurora kinase A2.7.11.10.450
1yvj4STTyrosine-protein kinase JAK32.7.10.20.449
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.449
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.449
4qmlANPSerine/threonine-protein kinase 242.7.11.10.449
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.448
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.448
2ijmATPFocal adhesion kinase 12.7.10.20.447
4i0r1B4Tyrosine-protein kinase SYK2.7.10.20.447
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.446
4ft3H1KSerine/threonine-protein kinase Chk12.7.11.10.446
4mf029ZTyrosine-protein kinase ITK/TSK2.7.10.20.446
4mvfSTUCalcium-dependent protein kinase 22.7.11.10.446
2j0m4STFocal adhesion kinase 12.7.10.20.445
3vt7VDXVitamin D3 receptor/0.445
4dgmAGICasein kinase II subunit alpha2.7.11.10.445
1q99ANPSerine/threonine-protein kinase SKY12.7.11.10.444
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.444
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.444
4anmWULCasein kinase II subunit alpha2.7.11.10.444
4nka2K7Fibroblast growth factor receptor 1/0.444
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.444
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.443
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.443
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.443
5cvfATPCasein kinase II subunit alpha2.7.11.10.443
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.442
3c4wATPRhodopsin kinase/0.442
4aguD15Cyclin-dependent kinase-like 1/0.442
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.441
4fv9E71Mitogen-activated protein kinase 12.7.11.240.441
4jbpYPHAurora kinase A2.7.11.10.441
4l3l5FIRibosomal protein S6 kinase beta-12.7.11.10.441
2henADPEphrin type-B receptor 22.7.10.10.440
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.440
3js2VM1Fibroblast growth factor receptor 1/0.440
3pxkPXKFocal adhesion kinase 12.7.10.20.440
3we45FIRibosomal protein S6 kinase beta-12.7.11.10.440
3zw9NADPeroxisomal bifunctional enzyme1.1.1.350.440
3zxtACPDeath-associated protein kinase 12.7.11.10.440
4c3pACPAurora kinase A2.7.11.10.440
4gu94GUFocal adhesion kinase 12.7.10.20.440