sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3d73 | NBB | Pheromone-binding protein ASP1 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3d73 | NBB | Pheromone-binding protein ASP1 | / | 1.000 | |
| 3d74 | NBB | Pheromone-binding protein ASP1 | / | 0.724 | |
| 3d75 | NBB | Pheromone-binding protein ASP1 | / | 0.581 | |
| 3bjh | NBB | Odorant binding protein ASP1 | / | 0.567 | |
| 3d76 | NBB | Pheromone-binding protein ASP1 | / | 0.527 | |
| 3bfb | 9OD | Pheromone-binding protein ASP1 | / | 0.525 | |
| 2rl5 | 2RL | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.518 | |
| 3d77 | NBB | Pheromone-binding protein ASP1 | / | 0.514 | |
| 3bfa | 9OD | Odorant binding protein ASP1 | / | 0.510 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.501 | |
| 4a4o | 664 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.497 | |
| 4gg1 | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 0.494 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.492 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.488 | |
| 3p9t | TCL | Repressor | / | 0.488 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.486 | |
| 3be2 | RAJ | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.486 | |
| 4equ | G6I | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.486 | |
| 2h42 | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.485 | |
| 4i6f | 1C7 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.485 | |
| 4k9y | K9Y | Focal adhesion kinase 1 | 2.7.10.2 | 0.485 | |
| 3oez | STI | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.484 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.484 | |
| 4nc3 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.483 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.482 | |
| 2fb8 | 215 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.482 | |
| 2ij7 | TPF | Mycocyclosin synthase | 1.14.21.9 | 0.481 | |
| 3w1w | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.481 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.480 | |
| 2acl | L05 | Oxysterols receptor LXR-alpha | / | 0.480 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.479 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.479 | |
| 2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.478 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.478 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.477 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.477 | |
| 1yc2 | NAD | NAD-dependent protein deacylase 2 | / | 0.476 | |
| 4ux6 | H4B | Nitric oxide synthase, inducible | 1.14.13.39 | 0.476 | |
| 1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.475 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.475 | |
| 3d78 | NBB | Pheromone-binding protein ASP1 | / | 0.475 | |
| 4muw | 2F4 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.475 | |
| 5c6c | CMP | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.475 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.474 | |
| 2gvc | FAD | Thiol-specific monooxygenase | 1.14.13 | 0.474 | |
| 4at4 | T6E | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.474 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.473 | |
| 4dm6 | TTB | Retinoic acid receptor beta | / | 0.473 | |
| 1j3k | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.472 | |
| 3gie | ACP | Sensor histidine kinase DesK | 2.7.13.3 | 0.472 | |
| 4j52 | 1J3 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.472 | |
| 2pnu | ENM | Androgen receptor | / | 0.471 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.470 | |
| 2uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.470 | |
| 4bkj | STI | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.470 | |
| 4el9 | AFE | Ribosomal protein S6 kinase alpha-3 | 2.7.11.1 | 0.470 | |
| 4jda | A9S | Abscisic acid receptor PYL3 | / | 0.470 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.469 | |
| 2rku | R78 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.469 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.469 | |
| 4fny | I3K | ALK tyrosine kinase receptor | 2.7.10.1 | 0.469 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.469 | |
| 3o9l | LPN | Renin | 3.4.23.15 | 0.468 | |
| 3up0 | D7S | aceDAF-12 | / | 0.468 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.468 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.467 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.467 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.467 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.467 | |
| 3rey | XAC | Adenosine receptor A2a | / | 0.467 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 1xuo | LA1 | Integrin alpha-L | / | 0.466 | |
| 3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.466 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.466 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.466 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.466 | |
| 5iua | 6DX | Adenosine receptor A2a | / | 0.466 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.465 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.465 | |
| 2yac | 937 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.465 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.465 | |
| 4jv8 | 1M1 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.465 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.465 | |
| 1ly4 | COQ | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 2ovy | PFJ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.464 | |
| 4g34 | 924 | Eukaryotic translation initiation factor 2-alpha kinase 3 | 2.7.11.1 | 0.464 | |
| 4j53 | 1J4 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.464 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.464 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 2oci | TYC | Valacyclovir hydrolase | 3.1 | 0.463 | |
| 2p1u | 4TN | Retinoic acid receptor RXR-alpha | / | 0.463 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.463 | |
| 3qlz | QLZ | Uncharacterized protein | / | 0.463 | |
| 4fwj | FAD | Lysine-specific histone demethylase 1B | 1 | 0.463 | |
| 4g1n | NZT | Pyruvate kinase PKM | 2.7.1.40 | 0.463 | |
| 4iah | 1DX | Alr2278 protein | / | 0.463 | |
| 2io6 | 330 | Wee1-like protein kinase | 2.7.10.2 | 0.462 | |
| 2xk8 | 5R1 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.462 | |
| 3l9m | L9M | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.462 | |
| 3qpp | PFW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.462 | |
| 3u8h | BHP | Phospholipase A2, membrane associated | / | 0.462 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.462 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.462 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.462 | |
| 4heu | 15J | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.462 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.462 | |
| 1l2j | ETC | Estrogen receptor beta | / | 0.461 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.461 | |
| 2qd3 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.461 | |
| 3ans | S38 | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.461 | |
| 3b9l | AZZ | Serum albumin | / | 0.461 | |
| 3eel | 53T | Uncharacterized protein | / | 0.461 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.461 | |
| 1x8b | 824 | Wee1-like protein kinase | 2.7.10.2 | 0.460 | |
| 1ysx | 4EB | Serum albumin | / | 0.460 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.460 | |
| 3qly | 55V | Uncharacterized protein | / | 0.460 | |
| 3sl6 | JN8 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.460 | |
| 4cav | MYA | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.460 | |
| 4i6h | 1C8 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.460 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.459 | |
| 3irn | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.459 | |
| 3tvx | PNX | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | 3.1.4.53 | 0.459 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.459 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.459 | |
| 4eiy | ZMA | Adenosine receptor A2a | / | 0.459 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.459 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.459 | |
| 4xbf | FAD | Lysine-specific histone demethylase 1A | 1 | 0.459 | |
| 1k74 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.458 | |
| 1ly3 | COG | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 2pl0 | STI | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.458 | |
| 3ctj | 320 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.458 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.458 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.458 | |
| 5akk | 1P8 | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.458 | |
| 2hxz | H7J | Cathepsin S | 3.4.22.27 | 0.457 | |
| 2p1v | 5TN | Retinoic acid receptor RXR-alpha | / | 0.457 | |
| 3kjs | DQ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.457 | |
| 3qpo | PFR | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.457 | |
| 3t5i | SER_SER_CMT_FAR | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.457 | |
| 4blc | NDP | Catalase | 1.11.1.6 | 0.457 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.457 | |
| 4mt9 | 2D6 | Tankyrase-1 | 2.4.2.30 | 0.457 | |
| 1dr4 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1e79 | ADP | ATP synthase subunit alpha, mitochondrial | / | 0.456 | |
| 1e79 | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.456 | |
| 1mc5 | AHE | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.456 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.456 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.456 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.456 | |
| 3uza | T4G | Adenosine receptor A2a | / | 0.456 | |
| 2zb8 | IMN | Prostaglandin reductase 2 | 1.3.1.48 | 0.455 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.455 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.455 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.455 | |
| 4agw | NG7 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.455 | |
| 1s7g | NAD | NAD-dependent protein deacylase 2 | / | 0.454 | |
| 1vrq | FON | Subunit alpha of sarocosine oxidase | / | 0.454 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.454 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.454 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.454 | |
| 2blb | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.454 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.454 | |
| 3gcq | 1BU | Mitogen-activated protein kinase 14 | / | 0.454 | |
| 3hcr | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.454 | |
| 4fcd | 0T6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.454 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.454 | |
| 4qrc | 0LI | Fibroblast growth factor receptor 4 | 2.7.10.1 | 0.454 | |
| 5bvw | 1N1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.454 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.454 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.453 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 1yho | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 2fmn | 4HF | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.453 | |
| 2fs4 | PZ1 | Renin | 3.4.23.15 | 0.453 | |
| 2olc | ADP | Methylthioribose kinase | 2.7.1.100 | 0.453 | |
| 3ar5 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.453 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 4c1i | EH9 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.453 | |
| 4eev | L1X | Hepatocyte growth factor receptor | 2.7.10.1 | 0.453 | |
| 4jlk | 1NO | Deoxycytidine kinase | 2.7.1.74 | 0.453 | |
| 4tyj | 0LI | Fibroblast growth factor receptor 4 | 2.7.10.1 | 0.453 | |
| 3rfm | CFF | Adenosine receptor A2a | / | 0.453 | |
| 1gnw | GTX | Glutathione S-transferase F2 | 2.5.1.18 | 0.452 | |
| 1nqu | RDL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.452 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.452 | |
| 2agv | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.452 | |
| 2bxq | IMN | Serum albumin | / | 0.452 | |
| 3bgi | SAH | Thiopurine S-methyltransferase | 2.1.1.67 | 0.452 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 3oia | A31 | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.452 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.452 | |
| 4dsb | A8S | Abscisic acid receptor PYL3 | / | 0.452 | |
| 4i9z | 5BA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.452 | |
| 4ktl | 1CQ | Cytochrome P450 | / | 0.452 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.452 | |
| 3qak | UKA | Adenosine receptor A2a | / | 0.452 | |
| 2j0v | GDP | Rac-like GTP-binding protein ARAC7 | / | 0.451 | |
| 3d3e | D3E | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.451 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.451 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 1fvp | FMA | Non-fluorescent flavoprotein | / | 0.450 | |
| 1ro9 | 8BR | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.450 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.450 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 2xvw | 9NR | Serum albumin | / | 0.450 | |
| 3bqd | DAY | Glucocorticoid receptor | / | 0.450 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.450 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.450 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.450 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.450 | |
| 4cax | MYA | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.450 | |
| 4wo5 | 324 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.450 | |
| 5bsr | COA | 4-coumarate--CoA ligase 2 | 6.2.1.12 | 0.450 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.449 | |
| 1e1q | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.449 | |
| 1exa | 394 | Retinoic acid receptor gamma | / | 0.449 | |
| 1s3y | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1thn | ADP | Anti-sigma F factor | / | 0.449 | |
| 2hm9 | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.449 | |
| 2xvv | 9DN | Serum albumin | / | 0.449 | |
| 3exn | ACO | Probable acetyltransferase | / | 0.449 | |
| 3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 3inv | C50 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.449 | |
| 3tgu | WF3 | Cytochrome b | / | 0.449 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.449 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.449 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.449 | |
| 4g47 | TZF | Mycocyclosin synthase | 1.14.21.9 | 0.449 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.449 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.449 | |
| 4l9q | 9TP | Serum albumin | / | 0.449 | |
| 3pwh | ZMA | Adenosine receptor A2a | / | 0.449 | |
| 1daj | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1t13 | INI | 6,7-dimethyl-8-ribityllumazine synthase 2 | / | 0.448 | |
| 2c3l | IDZ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.448 | |
| 2get | COK | Pantothenate kinase | 2.7.1.33 | 0.448 | |
| 2gev | COK | Pantothenate kinase | 2.7.1.33 | 0.448 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.448 | |
| 2zsd | COA | Pantothenate kinase | 2.7.1.33 | 0.448 | |
| 3aba | FLI | Cytochrome P450 | / | 0.448 | |
| 3cqe | P91 | Wee1-like protein kinase | 2.7.10.2 | 0.448 | |
| 3cse | N22 | Uncharacterized protein | / | 0.448 | |
| 3ey4 | 352 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.448 | |
| 3fzs | B96 | Protein-tyrosine kinase 2-beta | 2.7.10.2 | 0.448 | |
| 3jq8 | DX3 | Pteridine reductase, putative | / | 0.448 | |
| 3jyo | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.448 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.448 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.448 | |
| 4dsc | A8S | Abscisic acid receptor PYL3 | / | 0.448 | |
| 4jv6 | 18F | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.448 | |
| 4m8h | R4M | Retinoic acid receptor RXR-alpha | / | 0.448 | |
| 1iyz | NDP | Probable quinone oxidoreductase | / | 0.447 | |
| 1ohk | COP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1q1r | FAD | Putidaredoxin reductase | 1.18.1.5 | 0.447 | |
| 2bak | AQZ | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 2bsx | NOS | Purine nucleoside phosphorylase | / | 0.447 | |
| 2hps | CTZ | Ca2+-triggered coelenterazine-binding protein 1 | / | 0.447 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.447 | |
| 3biz | 61E | Wee1-like protein kinase | 2.7.10.2 | 0.447 | |
| 3eta | 351 | Insulin receptor | 2.7.10.1 | 0.447 | |
| 3vg9 | ZMA | Adenosine receptor A2a | / | 0.447 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.447 | |
| 4a9y | AQZ | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 4g1y | 0VO | Vitamin D3 receptor A | / | 0.447 | |
| 4iae | 1DX | Alr2278 protein | / | 0.447 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.447 | |
| 4klr | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.447 | |
| 4ktk | KTK | Cytochrome P450 | / | 0.447 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.447 | |
| 1f8g | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.446 | |
| 1r2j | FAD | FkbI | / | 0.446 | |
| 2jkc | FAD | Flavin-dependent tryptophan halogenase PrnA | 1.14.19.9 | 0.446 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 3b8q | 900 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.446 | |
| 3ihg | VAK | Aklavinone 12-hydroxylase RdmE | / | 0.446 | |
| 3vev | 0H4 | Glucokinase | 2.7.1.2 | 0.446 | |
| 3vtc | TK3 | Vitamin D3 receptor | / | 0.446 | |
| 3w0a | DS5 | Vitamin D3 receptor | / | 0.446 | |
| 4hni | 16W | Casein kinase I isoform epsilon | 2.7.11.1 | 0.446 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 4ruo | BIV | Vitamin D3 receptor A | / | 0.446 | |
| 4ea3 | 0NN | Nociceptin receptor | / | 0.446 | |
| 1p8d | CO1 | Oxysterols receptor LXR-beta | / | 0.445 | |
| 1xdk | REA | Retinoic acid receptor beta | / | 0.445 | |
| 2dw4 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.445 | |
| 2fm0 | M98 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.445 | |
| 2lbd | REA | Retinoic acid receptor gamma | / | 0.445 | |
| 2qd5 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.445 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 3ar6 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.445 | |
| 3dhc | CYK | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.445 | |
| 3eon | 341 | Glutaryl-CoA dehydrogenase | / | 0.445 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 3lfe | Z84 | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 3t8x | T8X | T-cell surface glycoprotein CD1b | / | 0.445 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.445 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.445 | |
| 4e37 | NDP | Catalase | 1.11.1.6 | 0.445 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.445 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.445 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.445 | |
| 1efy | BZC | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.444 | |
| 1fp1 | HCC | Isoliquiritigenin 2'-O-methyltransferase | / | 0.444 | |
| 1o6r | R19 | Squalene--hopene cyclase | 4.2.1.129 | 0.444 | |
| 1zid | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 2acl | REA | Retinoic acid receptor RXR-alpha | / | 0.444 | |
| 2bjs | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 3mjr | AC2 | Deoxycytidine kinase | 2.7.1.74 | 0.444 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.444 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.444 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.444 | |
| 3uvv | REA | Retinoic acid receptor RXR-alpha | / | 0.444 | |
| 4g8b | HL6 | Alpha/beta hydrolase fold protein | / | 0.444 | |
| 4hw3 | 19G | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.444 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.444 | |
| 4li7 | 1XP | Tankyrase-1 | 2.4.2.30 | 0.444 | |
| 5c4f | UPG | Histo-blood group ABO system transferase | / | 0.444 | |
| 1eji | THF | Serine hydroxymethyltransferase, cytosolic | / | 0.443 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.443 | |
| 1fpq | SAM | Isoliquiritigenin 2'-O-methyltransferase | / | 0.443 | |
| 1i59 | ADP | Chemotaxis protein CheA | 2.7.13.3 | 0.443 | |
| 1mzn | BM6 | Retinoic acid receptor RXR-alpha | / | 0.443 | |
| 1og5 | SWF | Cytochrome P450 2C9 | / | 0.443 | |
| 1uwh | BAX | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.443 | |
| 2azz | TCH | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.443 | |
| 2fpc | SCG | Strictosidine synthase | 4.3.3.2 | 0.443 | |
| 2fyu | FDN | Cytochrome b | / | 0.443 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.443 | |
| 2pnj | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.443 | |
| 2qk8 | MTX | Dihydrofolate reductase | / | 0.443 | |
| 3c3d | FO1 | 2-phospho-L-lactate transferase | / | 0.443 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.443 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.443 | |
| 3jwm | 5WB | Dihydrofolate reductase | / | 0.443 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.443 | |
| 3pjc | PJC | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.443 | |
| 3w78 | CBD | FMN-dependent NADH-azoreductase | / | 0.443 | |
| 4a2j | AS0 | Progesterone receptor | / | 0.443 | |
| 4ea2 | RWZ | Dehydrosqualene synthase | / | 0.443 | |
| 4fk3 | 325 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.443 | |
| 4g1d | 0VK | Vitamin D3 receptor A | / | 0.443 | |
| 4gi2 | NAP | Crotonyl-CoA carboxylase/reductase | / | 0.443 | |
| 4imf | SI3 | N-acetylneuraminate lyase | / | 0.443 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.443 | |
| 4kd7 | 9DR | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 4msg | 2C6 | Tankyrase-1 | 2.4.2.30 | 0.443 | |
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.442 | |
| 1fml | RTL | Retinol dehydratase | / | 0.442 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1olm | VTQ | SEC14-like protein 2 | / | 0.442 | |
| 1pt8 | ACO | Formyl-CoA:oxalate CoA-transferase | / | 0.442 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.442 | |
| 1tg5 | 645 | 4-hydroxyphenylpyruvate dioxygenase | 1.13.11.27 | 0.442 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.442 | |
| 2acw | UPG | Glycosyltransferase | / | 0.442 | |
| 2xk4 | OL2 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.442 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.442 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 4fhi | 0S4 | Vitamin D3 receptor A | / | 0.442 | |
| 4g8c | C6L | Alpha/beta hydrolase fold protein | / | 0.442 | |
| 4hcy | 0YN | Transketolase | / | 0.442 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.442 | |
| 4zzj | CNA | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.442 | |
| 5bu2 | ADP | Uncharacterized protein | / | 0.442 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.441 | |
| 1m8h | 6NI | Nitric oxide synthase, inducible | 1.14.13.39 | 0.441 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.441 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 2bxm | IMN | Serum albumin | / | 0.441 | |
| 2i9p | NAD | 3-hydroxyisobutyrate dehydrogenase, mitochondrial | 1.1.1.31 | 0.441 | |
| 2in6 | 839 | Wee1-like protein kinase | 2.7.10.2 | 0.441 | |
| 2ntj | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 2uxh | QUE | HTH-type transcriptional regulator TtgR | / | 0.441 | |
| 2wd8 | VGF | Pteridine reductase | / | 0.441 | |
| 3dko | IHZ | Ephrin type-A receptor 7 | 2.7.10.1 | 0.441 | |
| 3gb4 | D3M | DdmC | / | 0.441 | |
| 3glu | LYS_VAL_MET | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.441 | |
| 3jzf | JZK | Biotin carboxylase | 6.3.4.14 | 0.441 | |
| 3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3l9l | L9L | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.441 | |
| 3vrv | YSD | Vitamin D3 receptor | / | 0.441 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.441 | |
| 4cjx | 9L9 | C-1-tetrahydrofolate synthase, cytoplasmic, putative | / | 0.441 | |
| 4e0u | 0MV | Cyclic dipeptide N-prenyltransferase | / | 0.441 | |
| 4h4o | 506 | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.441 | |
| 4jpg | 1OX | Pyruvate kinase PKM | 2.7.1.40 | 0.441 | |
| 4kwh | NAP | Reductase homolog | / | 0.441 | |
| 4l45 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.441 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.441 | |
| 5ai5 | BSU | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.441 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.440 | |
| 1lwl | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.440 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.440 | |
| 1s4d | SAH | Uroporphyrinogen-III C-methyltransferase | 2.1.1.107 | 0.440 | |
| 1s9d | AFB | Cytohesin-2 | / | 0.440 | |
| 1s9d | AFB | ADP-ribosylation factor 1 | / | 0.440 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.440 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 2b01 | TUD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.440 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.440 | |
| 2h44 | 7CA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.440 | |
| 2poq | ISD | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase | 1.3.1.20 | 0.440 | |
| 3dha | C6L | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.440 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.440 | |
| 3h18 | PMS | Esterase/lipase | / | 0.440 | |
| 3i0r | RT3 | Gag-Pol polyprotein | 2.7.7.49 | 0.440 | |
| 3oq1 | 3OQ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 3prf | FP3 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.440 | |
| 3qls | 55V | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 4g31 | 0WH | Eukaryotic translation initiation factor 2-alpha kinase 3 | 2.7.11.1 | 0.440 | |
| 4l5b | 1UX | Deoxycytidine kinase | 2.7.1.74 | 0.440 | |
| 4n4v | 2GY | Tankyrase-1 | 2.4.2.30 | 0.440 | |
| 4pnr | G18 | Tankyrase-2 | 2.4.2.30 | 0.440 | |
| 5cmx | 0G6 | Prothrombin | 3.4.21.5 | 0.440 | |
| 5d7q | AR6 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.440 |