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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.11.000
3cxw7CPSerine/threonine-protein kinase pim-12.7.11.10.671
4bzo676Serine/threonine-protein kinase pim-12.7.11.10.603
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.600
2bikBI1Serine/threonine-protein kinase pim-12.7.11.10.595
4bznUGXSerine/threonine-protein kinase pim-12.7.11.10.595
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.582
1yi4ADNSerine/threonine-protein kinase pim-12.7.11.10.581
2c3iIYZSerine/threonine-protein kinase pim-12.7.11.10.575
3qf9NM8Serine/threonine-protein kinase pim-12.7.11.10.575
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.572
2xj2985Serine/threonine-protein kinase pim-12.7.11.10.571
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.570
3c4eC4ESerine/threonine-protein kinase pim-12.7.11.10.564
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.560
3cy3JN5Serine/threonine-protein kinase pim-12.7.11.10.560
1yhsSTUSerine/threonine-protein kinase pim-12.7.11.10.559
3ma301ISerine/threonine-protein kinase pim-12.7.11.10.556
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.555
4dtk7LISerine/threonine-protein kinase pim-12.7.11.10.554
2j2iLY4Serine/threonine-protein kinase pim-12.7.11.10.553
3umxQ18Serine/threonine-protein kinase pim-12.7.11.10.553
4k0y1OASerine/threonine-protein kinase pim-12.7.11.10.544
2wihP48Cyclin-dependent kinase 22.7.11.220.543
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.542
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.540
3umw596Serine/threonine-protein kinase pim-12.7.11.10.539
4lmuQUESerine/threonine-protein kinase pim-12.7.11.10.539
3bgzVX3Serine/threonine-protein kinase pim-12.7.11.10.537
3r02UNMSerine/threonine-protein kinase pim-12.7.11.10.534
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.534
4n6z2HWSerine/threonine-protein kinase pim-12.7.11.10.530
3jpv1DRSerine/threonine-protein kinase pim-12.7.11.10.527
2o65MYFSerine/threonine-protein kinase pim-12.7.11.10.525
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.525
5dgzL20Serine/threonine-protein kinase pim-12.7.11.10.521
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.520
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.517
4a7cE46Serine/threonine-protein kinase pim-12.7.11.10.516
2xj1XJ1Serine/threonine-protein kinase pim-12.7.11.10.514
3vbq0F5Serine/threonine-protein kinase pim-12.7.11.10.514
4bgg844Activin receptor type-12.7.11.300.514
3uixQ17Serine/threonine-protein kinase pim-12.7.11.10.513
4gmy0X5Tyrosine-protein kinase JAK2/0.513
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.512
3bgpVX1Serine/threonine-protein kinase pim-12.7.11.10.512
4i41MIXSerine/threonine-protein kinase pim-12.7.11.10.511
4mbl26LSerine/threonine-protein kinase pim-12.7.11.10.510
2xiyXIYSerine/threonine-protein kinase pim-12.7.11.10.509
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.508
2qo9ANPEphrin type-A receptor 32.7.10.10.507
2xizXIZSerine/threonine-protein kinase pim-12.7.11.10.506
3mtfA3FActivin receptor type-12.7.11.300.504
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.504
1xwsBI1Serine/threonine-protein kinase pim-12.7.11.10.502
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.500
3l8p0CEAngiopoietin-1 receptor2.7.10.10.499
4dymIYZActivin receptor type-12.7.11.300.496
4enyJ19Serine/threonine-protein kinase pim-12.7.11.10.496
3pe2E1BCasein kinase II subunit alpha2.7.11.10.495
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.495
4ux9ANPMitogen-activated protein kinase 82.7.11.240.495
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.494
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.494
4y93746Tyrosine-protein kinase/0.494
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.493
3nga3NGCasein kinase II subunit alpha2.7.11.10.493
4i22IREEpidermal growth factor receptor2.7.10.10.493
2wxvWXVCyclin-dependent kinase 22.7.11.220.492
3hllI45Mitogen-activated protein kinase 14/0.492
4qmySTUSerine/threonine-protein kinase 242.7.11.10.492
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.491
2iw84SPCyclin-dependent kinase 22.7.11.220.491
2h96893Mitogen-activated protein kinase 82.7.11.240.490
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.490
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.490
4lm5Q17Serine/threonine-protein kinase pim-12.7.11.10.490
4qmpDKISerine/threonine-protein kinase 242.7.11.10.490
1oiyN41Cyclin-dependent kinase 22.7.11.220.489
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.489
2wouZZFTGF-beta receptor type-12.7.11.300.489
3axwTIDCasein kinase II subunit alpha2.7.11.10.489
3bhtMFRCyclin-dependent kinase 22.7.11.220.489
2bilBI1Serine/threonine-protein kinase pim-12.7.11.10.488
3dcv55ESerine/threonine-protein kinase pim-12.7.11.10.488
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.488
4jazSTLPeroxisome proliferator-activated receptor gamma/0.488
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.486
4btjATPTau-tubulin kinase 12.7.11.10.485
4w9wYDJBMP-2-inducible protein kinase2.7.11.10.485
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.484
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.483
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.483
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.483
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.483
1jpaANPEphrin type-B receptor 22.7.10.10.482
2excJNKMitogen-activated protein kinase 102.7.11.240.482
4grb0XGCasein kinase II subunit alpha2.7.11.10.482
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.482
4mq22C4Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.482
3dogNNNCyclin-dependent kinase 22.7.11.220.481
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.480
2wedPP6Penicillopepsin-13.4.23.200.480
4dgnLU2Casein kinase II subunit alpha2.7.11.10.480
1xjdSTUProtein kinase C theta type2.7.11.130.479
2cchATPCyclin-dependent kinase 22.7.11.220.479
2zjwREFCasein kinase II subunit alpha2.7.11.10.479
3at4CCKCasein kinase II subunit alpha2.7.11.10.479
3gxlQIGTGF-beta receptor type-12.7.11.300.479
1zp9ATPRIO-type serine/threonine-protein kinase Rio12.7.11.10.478
1zys199Serine/threonine-protein kinase Chk12.7.11.10.478
2wpa889Cyclin-dependent kinase 22.7.11.220.478
2i40BLZCyclin-dependent kinase 22.7.11.220.476
3v3vMYUMitogen-activated protein kinase 82.7.11.240.476
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.476
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.475
4c02TAKActivin receptor type-12.7.11.300.475
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.475
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.475
3owj1ELCasein kinase II subunit alpha2.7.11.10.474
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.474
1q1rFADPutidaredoxin reductase1.18.1.50.473
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.473
2pvnP63Casein kinase II subunit alpha2.7.11.10.473
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.473
3a60STURibosomal protein S6 kinase beta-12.7.11.10.473
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.473
5auwQUEDeath-associated protein kinase 12.7.11.10.473
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.472
2b1pAIZMitogen-activated protein kinase 102.7.11.240.472
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.472
2gdo12CSerine/threonine-protein kinase Chk12.7.11.10.472
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.472
2vuw5IDSerine/threonine-protein kinase haspin2.7.11.10.472
3sheI85MAP kinase-activated protein kinase 32.7.11.10.472
4gfo0X2Non-receptor tyrosine-protein kinase TYK22.7.10.20.472
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.471
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.471
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.471
2y6o1N1Ephrin type-A receptor 42.7.10.10.471
3du8553Glycogen synthase kinase-3 beta2.7.11.260.471
3t8oATPRhodopsin kinase/0.471
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.471
4fx360KCyclin-dependent kinase 22.7.11.220.471
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.470
2o0uC0MMitogen-activated protein kinase 102.7.11.240.470
2p33J07Mitogen-activated protein kinase 102.7.11.240.470
3q9xEMOCasein kinase II subunit alpha2.7.11.10.470
3r9hZ67Cyclin-dependent kinase 22.7.11.220.470
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.470
5e8wSTUTGF-beta receptor type-12.7.11.300.470
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.469
3kn5ANPRibosomal protein S6 kinase alpha-52.7.11.10.469
4e730NRMitogen-activated protein kinase 82.7.11.240.469
4f1sF1SPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.469
2ckeIQUDeath-associated protein kinase 2/0.468
2pvhP19Casein kinase II subunit alpha2.7.11.10.468
2znq401Peroxisome proliferator-activated receptor delta/0.468
3be9P04Casein kinase II subunit alpha2.7.11.10.468
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.468
4c57FEFCyclin-G-associated kinase2.7.11.10.468
4e4qRRHPeroxisome proliferator-activated receptor gamma/0.468
4ejn0R4RAC-alpha serine/threonine-protein kinase2.7.11.10.468
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.468
4gk2L66Ephrin type-A receptor 32.7.10.10.468
4qmzB49Serine/threonine-protein kinase 242.7.11.10.468
5cvhADPCasein kinase II subunit alpha2.7.11.10.468
2hog710Serine/threonine-protein kinase Chk12.7.11.10.467
2om9AJAPeroxisome proliferator-activated receptor gamma/0.467
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.467
4anmWULCasein kinase II subunit alpha2.7.11.10.467
4yuqKS1Calmodulin-like domain protein kinase/0.467
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.466
3lj3WYEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.466
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.466
4gii0X6Non-receptor tyrosine-protein kinase TYK22.7.10.20.466
5av2KMPDeath-associated protein kinase 12.7.11.10.466
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.465
1kkq471Peroxisome proliferator-activated receptor alpha/0.465
1rx8NAPDihydrofolate reductase1.5.1.30.465
1x2hLPALipoate-protein ligase A6.3.1.200.465
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.465
2q59240Peroxisome proliferator-activated receptor gamma/0.465
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.465
3cgoJNOMitogen-activated protein kinase 102.7.11.240.465
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.465
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.465
4afjSJJGlycogen synthase kinase-3 beta2.7.11.260.465
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.465
1ouk084Mitogen-activated protein kinase 14/0.464
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.464
1vyw292Cyclin-dependent kinase 22.7.11.220.464
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.464
2itqITQEpidermal growth factor receptor2.7.10.10.464
3bqr4RBDeath-associated protein kinase 3/0.464
3eljGS7Mitogen-activated protein kinase 82.7.11.240.464
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.464
3vf9477Tyrosine-protein kinase SYK2.7.10.20.464
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.464
1pmn984Mitogen-activated protein kinase 102.7.11.240.463
1vjy460TGF-beta receptor type-12.7.11.300.463
2i0y5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.463
2vu3LZECyclin-dependent kinase 22.7.11.220.463
2xa4AZ5Tyrosine-protein kinase JAK2/0.463
3gubGUBDeath-associated protein kinase 12.7.11.10.463
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.463
4dgo0JWCasein kinase II subunit alpha2.7.11.10.463
5auuLU2Death-associated protein kinase 12.7.11.10.463
1ay0TPPTransketolase 12.2.1.10.462
2wotZZGTGF-beta receptor type-12.7.11.300.462
2zbaZBATrichothecene 3-O-acetyltransferase/0.462
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.462
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.462
2pvlP55Casein kinase II subunit alpha2.7.11.10.461
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.461
3gb2G3BGlycogen synthase kinase-3 beta2.7.11.260.461
3pe6ZYHMonoglyceride lipase/0.461
3r3d4CO4-hydroxybenzoyl-CoA thioesterase3.1.2.230.461
4g170VNCasein kinase I isoform gamma-32.7.11.10.461
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.461
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.461
4hvi19STyrosine-protein kinase JAK32.7.10.20.461
4kzoNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.461
4riyADPEpidermal growth factor receptor2.7.10.10.461
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.461
1bygSTUTyrosine-protein kinase CSK/0.460
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.460
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.460
1zrzBI1Protein kinase C iota type2.7.11.130.460
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.460
2ittAEEEpidermal growth factor receptor2.7.10.10.460
2zdu446Mitogen-activated protein kinase 102.7.11.240.460
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.460
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.460
4gw83RASerine/threonine-protein kinase pim-12.7.11.10.460
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.460
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.459
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.459
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.459
2x1nX1NCyclin-dependent kinase 22.7.11.220.459
3emg685Tyrosine-protein kinase SYK2.7.10.20.459
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.459
3q3b55EGlycogen synthase kinase-3 beta2.7.11.260.459
4bbe3O4Tyrosine-protein kinase JAK2/0.459
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.459
4fkv61KCyclin-dependent kinase 22.7.11.220.459
5auvAGIDeath-associated protein kinase 12.7.11.10.459
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.458
2v4lABJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.458
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.458
3efwAK8Aurora kinase A2.7.11.10.458
3r3c4CO4-hydroxybenzoyl-CoA thioesterase3.1.2.230.458
4dgmAGICasein kinase II subunit alpha2.7.11.10.458
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.458
4jia1K3Tyrosine-protein kinase JAK2/0.458
4k33ACPFibroblast growth factor receptor 32.7.10.10.458
4wboANWRhodopsin kinase/0.458
1fmjRTLRetinol dehydratase/0.457
1zgaHMKIsoflavone 4'-O-methyltransferase/0.457
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.457
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.457
2w06FRVCyclin-dependent kinase 22.7.11.220.457
3f7z34OGlycogen synthase kinase-3 beta2.7.11.260.457
3gu83GUDeath-associated protein kinase 12.7.11.10.457
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.457
3ttiKBIMitogen-activated protein kinase 102.7.11.240.457
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.457
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.457
1eh4IC1Casein kinase I homolog 12.7.11.10.456
1m2pHNACasein kinase II subunit alpha2.7.11.10.456
2iw94SPCyclin-dependent kinase 22.7.11.220.456
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.456
3hx4ANPCalmodulin-domain protein kinase 1/0.456
3ormAGSSerine/threonine protein kinase/0.456
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.456
4aojV4ZHigh affinity nerve growth factor receptor2.7.10.10.456
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.456
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.456
5av4GENDeath-associated protein kinase 12.7.11.10.456
5cvcPLPSerine racemase/0.456
1fpqSAMIsoliquiritigenin 2'-O-methyltransferase/0.455
1m2qMNXCasein kinase II subunit alpha2.7.11.10.455
2aqiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.455
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.455
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.455
3kvxFMYMitogen-activated protein kinase 102.7.11.240.455
3oriAGSSerine/threonine protein kinase/0.455
3oroAGSSerine/threonine protein kinase/0.455
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.455
4bchT7ZCyclin-dependent kinase 92.7.11.220.455
4btjADPTau-tubulin kinase 12.7.11.10.455
4fob0USALK tyrosine kinase receptor2.7.10.10.455
4g1wG1WMitogen-activated protein kinase 82.7.11.240.455
4g2fC07Ephrin type-A receptor 32.7.10.10.455
4hyi1AOSerine/threonine-protein kinase Chk12.7.11.10.455
4j97ACPFibroblast growth factor receptor 2/0.455
4o1pANPRibonuclease L/0.455
4oacADPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.455
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.455
1u54ACPActivated CDC42 kinase 1/0.454
2bujSTUSerine/threonine-protein kinase 16/0.454
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.454
2j0m4STFocal adhesion kinase 12.7.10.20.454
2ociTYCValacyclovir hydrolase3.10.454
3f883HTGlycogen synthase kinase-3 beta2.7.11.260.454
3oqkS52Renin3.4.23.150.454
3r34COA4-hydroxybenzoyl-CoA thioesterase3.1.2.230.454
3ttjJBIMitogen-activated protein kinase 102.7.11.240.454
4jqeANPCasein kinase II subunit alpha2.7.11.10.454
5cshATPCasein kinase II subunit alpha2.7.11.10.454
5e8xSTUTGF-beta receptor type-12.7.11.300.454
1py5PY1TGF-beta receptor type-12.7.11.300.453
2c5nCK8Cyclin-dependent kinase 22.7.11.220.453
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
2igoFADPyranose 2-oxidase/0.453
2wmtZYTSerine/threonine-protein kinase Chk12.7.11.10.453
2zdt46CMitogen-activated protein kinase 102.7.11.240.453
3vn2TLSPeroxisome proliferator-activated receptor gamma/0.453
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.453
4fkw62KCyclin-dependent kinase 22.7.11.220.453
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.453
1cjkFOKAdenylate cyclase type 2/0.452
1cjkFOKAdenylate cyclase type 5/0.452
1u4dDBQActivated CDC42 kinase 1/0.452
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.452
3gc9B45Mitogen-activated protein kinase 112.7.11.240.452
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.452
4hnc0UTMandelate racemase/0.452
4iqlFMNEnoyl-(Acyl-carrier-protein) reductase II/0.452
4j95ACPFibroblast growth factor receptor 2/0.452
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.452
4xcvNDPProbable hydroxyacid dehydrogenase protein/0.452
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.452
4z63ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.452
5e8ySTUTGF-beta receptor type-22.7.11.300.452
1pmv537Mitogen-activated protein kinase 102.7.11.240.451
2i4zDRHPeroxisome proliferator-activated receptor gamma/0.451
2ignFADPyranose 2-oxidase/0.451
2izuP01Casein kinase I isoform gamma-32.7.11.10.451
2y3rTRKTamL/0.451
2ydjYDJSerine/threonine-protein kinase Chk12.7.11.10.451
3gwfFADCyclohexanone monooxygenase/0.451
3mb601ICasein kinase II subunit alpha2.7.11.10.451
3sd0TSKGlycogen synthase kinase-3 beta2.7.11.260.451
3tnwF18Cyclin-dependent kinase 22.7.11.220.451
3u4uLNHCasein kinase II subunit alpha2.7.11.10.451
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.451
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.451
4gk4L90Ephrin type-A receptor 32.7.10.10.451
4kz01UJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.451
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.451
4yryFADGlutamate synthase, beta subunit/0.451
5av3KMPDeath-associated protein kinase 12.7.11.10.451
1bxoPP7Penicillopepsin-13.4.23.200.450
1ppm0P1Penicillopepsin-13.4.23.200.450
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.450
2eufLQQCyclin-dependent kinase 62.7.11.220.450
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.450
3mdvCL6Cholesterol 24-hydroxylase/0.450
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.450
3okxSAMS-adenosyl-L-methionine-binding protein RPA0152/0.450
4hvh19RTyrosine-protein kinase JAK32.7.10.20.450
4q71FADBifunctional protein PutA/0.450
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.450
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.449
3qt62P0Mevalonate diphosphate decarboxylase/0.449
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.449
3vt8YI3Vitamin D3 receptor/0.449
4eji0QACytochrome P450 2A131.14.14.10.449
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.449
4mf129YTyrosine-protein kinase ITK/TSK2.7.10.20.449
4tuvCPZCytochrome P450 1191.140.449
1kfbIGPTryptophan synthase alpha chain/0.448
1m13HYFNuclear receptor subfamily 1 group I member 2/0.448
1om1IQACasein kinase II subunit alpha2.7.11.10.448
1q4u4CA4-hydroxybenzoyl-CoA thioesterase3.1.2.230.448
2a5uQYTPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
2uzlC94Cyclin-dependent kinase 22.7.11.220.448
3ig7EFPCyclin-dependent kinase 22.7.11.220.448
3ijdC2FMethylenetetrahydrofolate reductase/0.448
3mtlFEFCyclin-dependent kinase 162.7.11.220.448
3ncgBK1Calmodulin-domain protein kinase 1, putative/0.448
3r354CO4-hydroxybenzoyl-CoA thioesterase3.1.2.230.448
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.448
3zhrTPPMultifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.448
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.448
4bi0Z0WDual specificity protein kinase TTK2.7.12.10.448
4cax646Glycylpeptide N-tetradecanoyltransferase2.3.1.970.448
4gk3L87Ephrin type-A receptor 32.7.10.10.448
4gu94GUFocal adhesion kinase 12.7.10.20.448
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.448
4nk92K5Fibroblast growth factor receptor 1/0.448
1k74544Peroxisome proliferator-activated receptor gamma/0.447
1p4fDRGDeath-associated protein kinase 12.7.11.10.447
1pkdUCNCyclin-dependent kinase 22.7.11.220.447
1xddAAYIntegrin alpha-L/0.447
2bkzSBCCyclin-dependent kinase 22.7.11.220.447
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.447
2itzIREEpidermal growth factor receptor2.7.10.10.447
2y4gTIRTamL/0.447
3h86AP5Adenylate kinase/0.447
3lqfNADGalactitol dehydrogenase/0.447
3tm0ANPAminoglycoside 3'-phosphotransferase2.7.1.950.447
4b99R4LMitogen-activated protein kinase 72.7.11.240.447
4jboWPHAurora kinase A2.7.11.10.447
4jr7GNPCasein kinase II subunit alpha2.7.11.10.447
4nr42LKCREB-binding protein/0.447
3pblETQD(3) dopamine receptor/0.447
1gih1PUCyclin-dependent kinase 22.7.11.220.446
1q4l679Glycogen synthase kinase-3 beta2.7.11.260.446
2aqhNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
2btsU32Cyclin-dependent kinase 22.7.11.220.446
2cibCM6Lanosterol 14-alpha demethylase1.14.13.700.446
2hrcCHDFerrochelatase, mitochondrial4.99.1.10.446
2jkkBI9Focal adhesion kinase 12.7.10.20.446
2pmoHMDProtein kinase 7/0.446
2pwlACPFibroblast growth factor receptor 2/0.446
2r5tANPSerine/threonine-protein kinase Sgk12.7.11.10.446
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.446
3oom507Activin receptor type-12.7.11.300.446
3triNAPPyrroline-5-carboxylate reductase/0.446
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.446
3zrkZRKGlycogen synthase kinase-3 beta2.7.11.260.446
4dtiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
4gub0Y4Casein kinase II subunit alpha2.7.11.10.446
4ubsDIFPentalenic acid synthase1.14.15.110.446
4wkqIREEpidermal growth factor receptor2.7.10.10.446
4wsqKSAAP2-associated protein kinase 12.7.11.10.446
4z64ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.446
5cvfATPCasein kinase II subunit alpha2.7.11.10.446
1fvv107Cyclin-dependent kinase 22.7.11.220.445
1nxkSTUMAP kinase-activated protein kinase 22.7.11.10.445
2aqkNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.445
3ddqRRCCyclin-dependent kinase 22.7.11.220.445
3w1f1O5Dual specificity protein kinase TTK2.7.12.10.445
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.445
4b7tCWTGlycogen synthase kinase-3 beta2.7.11.260.445
4e4m0NHTyrosine-protein kinase JAK2/0.445
4eol1ROCyclin-dependent kinase 22.7.11.220.445
4jbpYPHAurora kinase A2.7.11.10.445
4ruoBIVVitamin D3 receptor A/0.445
4ure1PSCyclohexanol dehydrogenase/0.445
5auxKMPDeath-associated protein kinase 12.7.11.10.445
1bwsNDPGDP-L-fucose synthase/0.444
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
1jioDEB6-deoxyerythronolide B hydroxylase/0.444
1t85CAMCamphor 5-monooxygenase1.14.15.10.444
1u8vFAD4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase/0.444
1y0s331Peroxisome proliferator-activated receptor delta/0.444
2qblCAMCamphor 5-monooxygenase1.14.15.10.444
2w17I19Cyclin-dependent kinase 22.7.11.220.444
4a8v2ANMajor pollen allergen Bet v 1-J/0.444
4c4f7CEDual specificity protein kinase TTK2.7.12.10.444
4d0l093Phosphatidylinositol 4-kinase beta2.7.1.670.444
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.444
4ewqMWLMitogen-activated protein kinase 14/0.444
4ezl0SEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4fkr45KCyclin-dependent kinase 22.7.11.220.444
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.444
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.444
4fv7E94Mitogen-activated protein kinase 12.7.11.240.444
4mvh2F5cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.444
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.444
4zjuNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.444
1dawANPCasein kinase II subunit alpha2.7.11.10.443
1p44GEQEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
1rx8FOLDihydrofolate reductase1.5.1.30.443
2a4zBYMPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
2cdaNAPGlucose 1-dehydrogenase/0.443
2chlDKICasein kinase I isoform gamma-32.7.11.10.443
2e9p77ASerine/threonine-protein kinase Chk12.7.11.10.443
2g8yNADHydroxycarboxylate dehydrogenase B/0.443
2iebZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
2nniMTKCytochrome P450 2C8/0.443
2pvyACPFibroblast growth factor receptor 2/0.443
2wnsOMPUridine 5'-monophosphate synthase2.4.2.100.443
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.443
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.443
3kduNKSPeroxisome proliferator-activated receptor alpha/0.443
3q9zTXQCasein kinase II subunit alpha2.7.11.10.443
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.443
3zep1NXTyrosine-protein kinase JAK32.7.10.20.443
3zs5SB2Mitogen-activated protein kinase 14/0.443
4c4jX21Dual specificity protein kinase TTK2.7.12.10.443
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.443
4g34924Eukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.443
4hyu1BKMitogen-activated protein kinase 82.7.11.240.443
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.443
4ryvZEAProtein LlR18A/0.443
1fm9570Peroxisome proliferator-activated receptor gamma/0.442
1h1s4SPCyclin-dependent kinase 22.7.11.220.442
1oiuN76Cyclin-dependent kinase 22.7.11.220.442
1r6g442Thyroid hormone receptor beta/0.442
2p4yC03Peroxisome proliferator-activated receptor gamma/0.442
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.442
2po7CHDFerrochelatase, mitochondrial4.99.1.10.442
2xrwANPMitogen-activated protein kinase 82.7.11.240.442
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.442
3gu6ADPDeath-associated protein kinase 12.7.11.10.442
3hztJ60Calmodulin-like domain protein kinase isoform 3/0.442
3ielU5PRibonuclease TTHA02523.10.442
3och2MXDihydrofolate reductase1.5.1.30.442
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.442
4a86H35Major pollen allergen Bet v 1-A/0.442
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.442
4bbxLKFcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.442
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.442
4hvg19QTyrosine-protein kinase JAK32.7.10.20.442
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.442
4otpADPSerine/threonine-protein kinase RIO12.7.11.10.442
4wuoNAD3-isopropylmalate dehydrogenase1.1.1.850.442
5drdATPAurora kinase A2.7.11.10.442
1cjtFOKAdenylate cyclase type 2/0.441
1cjtFOKAdenylate cyclase type 5/0.441
1fm6BRLPeroxisome proliferator-activated receptor gamma/0.441
1k7l544Peroxisome proliferator-activated receptor alpha/0.441
1oguST8Cyclin-dependent kinase 22.7.11.220.441
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.441
1qoqIGPTryptophan synthase alpha chain/0.441
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.441
2hxzH7JCathepsin S3.4.22.270.441
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.441
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.441
2x8eX8ESerine/threonine-protein kinase Chk12.7.11.10.441
3a4pDFQHepatocyte growth factor receptor2.7.10.10.441
3bw4FMNPutative 2-nitropropane dioxygenase/0.441
3cisATPUniversal stress protein Rv2623/0.441
3d7kD7KBenzaldehyde lyase/0.441
3hekBD0Heat shock protein HSP 90-alpha/0.441
3iaeD7KBenzaldehyde lyase/0.441
3mwuBK3Calmodulin-domain protein kinase 1, putative/0.441
3qaqQAQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
3qu0X40Cyclin-dependent kinase 22.7.11.220.441
3r9oZ71Cyclin-dependent kinase 22.7.11.220.441
4aw3MYVMycinamicin IV hydroxylase/epoxidase/0.441
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.441
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
4c61LMMTyrosine-protein kinase JAK2/0.441
4ckiADNProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.441
4e37NDPCatalase1.11.1.60.441
4eok4SPCyclin-dependent kinase 22.7.11.220.441
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.441
5fwnNAPPutative dehydrogenase/0.441
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.440
1zz2B11Mitogen-activated protein kinase 14/0.440
2ivpATPtRNA N6-adenosine threonylcarbamoyltransferase/0.440
2qoqANPEphrin type-A receptor 32.7.10.10.440
2rhgIGPTryptophan synthase alpha chain/0.440
3at3ATKCasein kinase II subunit alpha2.7.11.10.440
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.440
3ddpRC8Cyclin-dependent kinase 22.7.11.220.440
3lltANPProtein serine/threonine kinase-1/0.440
3mb714ICasein kinase II subunit alpha2.7.11.10.440
3nux3NVCyclin-dependent kinase 62.7.11.220.440
3vt7VDXVitamin D3 receptor/0.440
3vvpBNUUncharacterized protein/0.440
3zw3ZW3Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4c58824Cyclin-G-associated kinase2.7.11.10.440
4idv13VMitogen-activated protein kinase kinase kinase 142.7.11.250.440
4j711JXGlycogen synthase kinase-3 beta2.7.11.260.440
4nbwNADShort-chain dehydrogenase/reductase SDR/0.440
4qpmADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.440