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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3cth319Hepatocyte growth factor receptor2.7.10.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3cth319Hepatocyte growth factor receptor2.7.10.11.000
3f82353Hepatocyte growth factor receptor2.7.10.10.528
3b8q900Vascular endothelial growth factor receptor 22.7.10.10.497
4fnyI3KALK tyrosine kinase receptor2.7.10.10.469
3tubFPUTyrosine-protein kinase SYK2.7.10.20.463
3ce31FNHepatocyte growth factor receptor2.7.10.10.452
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.448
2rl52RLVascular endothelial growth factor receptor 22.7.10.10.445
4uxq0LIFibroblast growth factor receptor 42.7.10.10.445
2jc6QPPCalcium/calmodulin-dependent protein kinase type 1D2.7.11.170.444
4tyj0LIFibroblast growth factor receptor 42.7.10.10.440