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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3cquCQURAC-alpha serine/threonine-protein kinase2.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3cquCQURAC-alpha serine/threonine-protein kinase2.7.11.11.000
3l9nL9NcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.518
2uvyGVIcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.516
3l9mL9McAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.511
3l9lL9LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.502
2bilBI1Serine/threonine-protein kinase pim-12.7.11.10.498
2jdvL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.476
1e7qNAPGDP-L-fucose synthase/0.470
2ivpATPtRNA N6-adenosine threonylcarbamoyltransferase/0.463
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
2e0nSAHPrecorrin-2 C20-methyltransferase/0.459
4dymIYZActivin receptor type-12.7.11.300.457
4pnmNU1Tankyrase-22.4.2.300.457
4c36ZO9cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.455
4y9xUPGGlucosyl-3-phosphoglycerate synthase2.4.1.2660.455
1rt7UC4Gag-Pol polyprotein2.7.7.490.454
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
3g493G4Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.454
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.454
3cqwCQWRAC-alpha serine/threonine-protein kinase2.7.11.10.453
4bgg844Activin receptor type-12.7.11.300.453
2i9pNAD3-hydroxyisobutyrate dehydrogenase, mitochondrial1.1.1.310.452
2j4z626Aurora kinase A2.7.11.10.452
3glmCOOGlutaconyl-CoA decarboxylase alpha subunit/0.452
2gjlFMNNitronate monooxygenase1.13.12.160.451
4hfr14MCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.451
5uviZMAAdenosine receptor A2a/0.451
2j2iLY4Serine/threonine-protein kinase pim-12.7.11.10.450
2ydoADNAdenosine receptor A2a/0.449
4o71CPBBromodomain-containing protein 4/0.449
2j3jHC4NADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.447
3dtcVINMitogen-activated protein kinase kinase kinase 92.7.11.250.447
3h4vNAPPteridine reductase 11.5.1.330.447
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.447
2a4zBYMPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
2p1v5TNRetinoic acid receptor RXR-alpha/0.444
3ar6TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.444
4y6nUPGGlucosyl-3-phosphoglycerate synthase2.4.1.2660.444
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.443
2i4tUA2Purine nucleoside phosphorylase, putative/0.443
2jedLG8Protein kinase C theta type2.7.11.130.443
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
4nbb9CATerminal oxygenase component of carbazole/0.443
4pd6URINucleoside permease/0.443
3uixQ17Serine/threonine-protein kinase pim-12.7.11.10.442
4ifvT27Gag-Pol polyprotein2.7.7.490.442
4jv81M1Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.442
5d7q4I5NAD-dependent protein deacetylase sirtuin-23.5.10.442
1bwsNDPGDP-L-fucose synthase/0.441
2q4wFADCytokinin dehydrogenase 71.5.99.120.441
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.441
3bgpVX1Serine/threonine-protein kinase pim-12.7.11.10.440
3bgrT27Gag-Pol polyprotein2.7.7.490.440
3pqbVGPPutative oxidoreductase/0.440
4n3r2GUTankyrase-12.4.2.300.440