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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3cqeP91Wee1-like protein kinase2.7.10.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3cqeP91Wee1-like protein kinase2.7.10.21.000
3cr0809Wee1-like protein kinase2.7.10.20.707
2z2w770Wee1-like protein kinase2.7.10.20.682
3biz61EWee1-like protein kinase2.7.10.20.669
2io6330Wee1-like protein kinase2.7.10.20.649
1x8b824Wee1-like protein kinase2.7.10.20.643
3bi6396Wee1-like protein kinase2.7.10.20.636
2in6839Wee1-like protein kinase2.7.10.20.616
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.509
3ppkFNISerine/threonine-protein kinase B-raf2.7.11.10.491
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.482
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.478
4g34924Eukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.471
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.469
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.467
4g310WHEukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.466
4gmy0X5Tyrosine-protein kinase JAK2/0.461
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.460
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.460
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.454
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.451
2gjnFMNNitronate monooxygenase1.13.12.160.450
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.449
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.449
2yac937Serine/threonine-protein kinase PLK12.7.11.210.448
4a4o664Serine/threonine-protein kinase PLK12.7.11.210.448
2owb626Serine/threonine-protein kinase PLK12.7.11.210.445
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.444
3zh8C58Protein kinase C iota type2.7.11.130.444
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.444
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.442
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.441
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.440