scPDB - Distribution of Cavity Similarity values of 3clb entry / Site 2

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
3clb	TMQ	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity
3clb	TMQ	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	1.000
3irn	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.530
3qly	55V	Uncharacterized protein	/	0.522
3cse	N22	Uncharacterized protein	/	0.518
3inv	C50	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.517
1vj3	TAB	Dihydrofolate reductase	1.5.1.3	0.506
3iro	2CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.503
3qlx	QLR	Uncharacterized protein	/	0.492
1s3y	TQT	Dihydrofolate reductase	1.5.1.3	0.491
3eem	53V	Uncharacterized protein	/	0.491
3kjs	DQ1	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.490
3um6	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.490
4ixe	IXE	Dihydrofolate reductase	1.5.1.3	0.487
2blb	CP7	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.483
2cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.482
1cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.479
4h98	14Q	Uncharacterized protein	/	0.479
2fzi	DH3	Dihydrofolate reductase	1.5.1.3	0.478
3eek	53S	Uncharacterized protein	/	0.476
3qgt	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.476
2blc	CP7	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.474
1j3j	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.473
4kbn	25U	Dihydrofolate reductase	1.5.1.3	0.473
3eej	53R	Uncharacterized protein	/	0.472
3irm	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.471
3qg2	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.470
4h97	53S	Dihydrofolate reductase	1.5.1.3	0.469
3qlw	N22	Dihydrofolate reductase	1.5.1.3	0.465
3um5	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.465
3qlz	QLZ	Uncharacterized protein	/	0.464
4h96	14Q	Dihydrofolate reductase	1.5.1.3	0.462
3qfx	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.461
1klk	PMD	Dihydrofolate reductase	1.5.1.3	0.459
1daj	MOT	Dihydrofolate reductase	1.5.1.3	0.458
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.457
1j3k	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.456
1m78	CLZ	Dihydrofolate reductase	1.5.1.3	0.455
3td8	D2R	Dihydrofolate reductase	1.5.1.3	0.455
2bl9	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.454
2fzh	DH1	Dihydrofolate reductase	1.5.1.3	0.454
3dg8	RJ6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.452
3jsu	KA5	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.452
3um8	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.450
4h95	06U	Dihydrofolate reductase	1.5.1.3	0.450
1ly3	COG	Dihydrofolate reductase	1.5.1.3	0.448
1e26	GPB	Dihydrofolate reductase	1.5.1.3	0.447
1aoe	GW3	Dihydrofolate reductase	1.5.1.3	0.445
1m7a	MQU	Dihydrofolate reductase	1.5.1.3	0.443
2bla	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.443
2w3v	TOP	Dihydrofolate reductase	/	0.443
1ia1	TQ3	Dihydrofolate reductase	1.5.1.3	0.442