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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3cjgKIMVascular endothelial growth factor receptor 22.7.10.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3cjgKIMVascular endothelial growth factor receptor 22.7.10.11.000
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.542
4nks2M2Fibroblast growth factor receptor 1/0.541
4nka2K7Fibroblast growth factor receptor 1/0.537
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.535
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.532
4f640S8Fibroblast growth factor receptor 1/0.529
4gmy0X5Tyrosine-protein kinase JAK2/0.511
2py3ACPFibroblast growth factor receptor 2/0.509
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.506
4j97ACPFibroblast growth factor receptor 2/0.506
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.500
4xli1N1Abelson tyrosine-protein kinase 22.7.10.20.500
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.497
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.496
4bc6XZNSerine/threonine-protein kinase 102.7.11.10.496
4ic7ANPMitogen-activated protein kinase 72.7.11.240.496
2pwlACPFibroblast growth factor receptor 2/0.494
5d12G97Proto-oncogene tyrosine-protein kinase Src2.7.10.20.494
3vjoANPEpidermal growth factor receptor2.7.10.10.490
4mxyDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.490
4mxzDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.490
5aaaVGHALK tyrosine kinase receptor2.7.10.10.488
4hvh19RTyrosine-protein kinase JAK32.7.10.20.487
4j95ACPFibroblast growth factor receptor 2/0.487
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.486
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.486
2hog710Serine/threonine-protein kinase Chk12.7.11.10.484
4anqVGHALK tyrosine kinase receptor2.7.10.10.484
3s4qNK0Mitogen-activated protein kinase 14/0.482
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.481
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.481
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.481
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.480
4fob0USALK tyrosine kinase receptor2.7.10.10.480
3zewSTUEphrin type-B receptor 42.7.10.10.479
4jia1K3Tyrosine-protein kinase JAK2/0.479
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.478
4gk2L66Ephrin type-A receptor 32.7.10.10.478
2of2547Tyrosine-protein kinase Lck2.7.10.20.477
4c62XWWTyrosine-protein kinase JAK2/0.477
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.476
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.476
2fgiPD1Fibroblast growth factor receptor 1/0.475
2of4979Tyrosine-protein kinase Lck2.7.10.20.475
4aotGW8Serine/threonine-protein kinase 102.7.11.10.475
4cd0AWJALK tyrosine kinase receptor2.7.10.10.475
4gk4L90Ephrin type-A receptor 32.7.10.10.475
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.474
2q0bACPFibroblast growth factor receptor 2/0.474
2xyuQ9GEphrin type-A receptor 42.7.10.10.474
2j7t274Serine/threonine-protein kinase 102.7.11.10.473
2hk51BMTyrosine-protein kinase HCK2.7.10.20.472
4f630S7Fibroblast growth factor receptor 1/0.472
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.471
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.470
1finATPCyclin-dependent kinase 22.7.11.220.469
1yolS03Proto-oncogene tyrosine-protein kinase Src2.7.10.20.469
4k33ACPFibroblast growth factor receptor 32.7.10.10.468
2itqITQEpidermal growth factor receptor2.7.10.10.467
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.467
2c6eHPMAurora kinase A2.7.11.10.466
2xp2VGHALK tyrosine kinase receptor2.7.10.10.466
2yn8STUEphrin type-B receptor 42.7.10.10.466
3c7qXINVascular endothelial growth factor receptor 22.7.10.10.466
5aacVGHALK tyrosine kinase receptor2.7.10.10.466
2qo9ANPEphrin type-A receptor 32.7.10.10.465
2xvdAS6Ephrin type-B receptor 42.7.10.10.465
3uvqFS8Mitogen-activated protein kinase 14/0.465
3w2sW2REpidermal growth factor receptor2.7.10.10.465
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.465
4nk92K5Fibroblast growth factor receptor 1/0.465
4wkqIREEpidermal growth factor receptor2.7.10.10.465
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.464
3c4xATPRhodopsin kinase/0.463
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.463
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.463
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.463
4id71G0Activated CDC42 kinase 1/0.463
2pzpACPFibroblast growth factor receptor 2/0.462
3vs3VSETyrosine-protein kinase HCK2.7.10.20.462
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.461
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.461
2vwu7X1Ephrin type-B receptor 42.7.10.10.461
4ansVGHALK tyrosine kinase receptor2.7.10.10.461
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.461
3a62STURibosomal protein S6 kinase beta-12.7.11.10.458
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.458
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.458
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.457
3cjfSAVVascular endothelial growth factor receptor 22.7.10.10.457
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.457
2yfxVGHALK tyrosine kinase receptor2.7.10.10.456
4gk3L87Ephrin type-A receptor 32.7.10.10.456
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.455
2qoqANPEphrin type-A receptor 32.7.10.10.455
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.455
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.455
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.455
2zybKSLTyrosine-protein kinase Lck2.7.10.20.454
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.454
4btkDTQTau-tubulin kinase 12.7.11.10.454
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.454
4hyu1BKMitogen-activated protein kinase 82.7.11.240.454
5dr9SKEAurora kinase A2.7.11.10.454
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.453
1pkdUCNCyclin-dependent kinase 22.7.11.220.453
2eb3ANPEpidermal growth factor receptor2.7.10.10.453
3vid4TTVascular endothelial growth factor receptor 22.7.10.10.453
4tyj0LIFibroblast growth factor receptor 42.7.10.10.453
4y95746Tyrosine-protein kinase/0.453
2etm7PYFocal adhesion kinase 12.7.10.20.452
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.452
3flsFLSMitogen-activated protein kinase 14/0.452
4g310WHEukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.452
4hvg19QTyrosine-protein kinase JAK32.7.10.20.452
4i231C9Epidermal growth factor receptor2.7.10.10.451
4riyADPEpidermal growth factor receptor2.7.10.10.451
5aabVGHALK tyrosine kinase receptor2.7.10.10.451
5auwQUEDeath-associated protein kinase 12.7.11.10.451
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.450
2i0ePDSProtein kinase C beta type2.7.11.130.450
2vd5BI8Myotonin-protein kinase2.7.11.10.450
3gc9B45Mitogen-activated protein kinase 112.7.11.240.450
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.450
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
2pzrACPFibroblast growth factor receptor 2/0.449
2y6o1N1Ephrin type-A receptor 42.7.10.10.449
4y93746Tyrosine-protein kinase/0.449
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.448
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.448
4eym0RXMitogen-activated protein kinase 132.7.11.240.448
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.447
2zm1KSFTyrosine-protein kinase Lck2.7.10.20.447
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.447
4bdgP3JSerine/threonine-protein kinase Chk22.7.11.10.447
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.446
3qc9ADPRhodopsin kinase/0.446
4e4m0NHTyrosine-protein kinase JAK2/0.446
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.446
1zyjBI5Mitogen-activated protein kinase 14/0.445
2itzIREEpidermal growth factor receptor2.7.10.10.445
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.444
3ad6KSCTyrosine-protein kinase Lck2.7.10.20.444
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.444
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.444
2bujSTUSerine/threonine-protein kinase 16/0.443
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.443
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.443
4hvi19STyrosine-protein kinase JAK32.7.10.20.443
5amnDTQProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.443
3eb0DRKUncharacterized protein/0.442
3oom507Activin receptor type-12.7.11.300.442
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.442
3w33W19Epidermal growth factor receptor2.7.10.10.442
4fstHK4Serine/threonine-protein kinase Chk12.7.11.10.442
1ir3ANPInsulin receptor2.7.10.10.441
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.441
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.441
3hx4ANPCalmodulin-domain protein kinase 1/0.441
4jrvKJVEpidermal growth factor receptor2.7.10.10.441
4qmlANPSerine/threonine-protein kinase 242.7.11.10.441
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.441
1yvj4STTyrosine-protein kinase JAK32.7.10.20.440
1zrzBI1Protein kinase C iota type2.7.11.130.440
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.440
2izsBRQCasein kinase I isoform gamma-32.7.11.10.440
2pz5ACPFibroblast growth factor receptor 2/0.440
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.440
3q92XNBKetohexokinase/0.440
3t8oATPRhodopsin kinase/0.440
3tnwF18Cyclin-dependent kinase 22.7.11.220.440
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.440
4ftn2HKSerine/threonine-protein kinase Chk12.7.11.10.440
4i0r1B4Tyrosine-protein kinase SYK2.7.10.20.440
4iebANPCalmodulin-domain protein kinase 1/0.440
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.440