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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3chs4BULeukotriene A-4 hydrolase3.3.2.6

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3chs4BULeukotriene A-4 hydrolase3.3.2.61.000
4rsyB3NLeukotriene A-4 hydrolase3.3.2.60.576
2r59PH0Leukotriene A-4 hydrolase3.3.2.60.567
3fuj00GLeukotriene A-4 hydrolase3.3.2.60.560
3ful52DLeukotriene A-4 hydrolase3.3.2.60.554
3ftxBESLeukotriene A-4 hydrolase3.3.2.60.549
3fu5492Leukotriene A-4 hydrolase3.3.2.60.518
3fuhBESLeukotriene A-4 hydrolase3.3.2.60.512
3fun798Leukotriene A-4 hydrolase3.3.2.60.498
3ftxRE2Leukotriene A-4 hydrolase3.3.2.60.484
4gaaBESLeukotriene A(4) hydrolase/0.476